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Walnuts vs. pretzels: which snack tricks your brain into eating less?

NCT ID NCT07428187

Knowledge-focused Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how different snacks (walnuts or pretzels) change brain activity related to food cravings and fullness during a 12-week weight-loss diet. Researchers will use brain scans to measure responses to food pictures and track changes in body fat and appetite. The goal is to understand which snack might help people stick to their diet better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 25-45 years old * BMI at least 27 kg/m2 * Comfortable completing a weight-loss intervention\\ * Willing to consume a daily snack of either walnuts or pretzels Exclusion Criteria: * Nut or wheat allergy * History of bariatric surgery * Current eating disorder * Current illicit substance use * Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum * Uncontrolled hypertension (\>160/100 mmHg) * Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results * Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment * Taking weight-loss medications, or steroids within \~3 months prior to study participation (e.g., GLP-1 receptor agonists) * Significant mental health changes within \~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns) * Neurological illnesses or injury that would be anticipated to affect MRI data * Weight change greater than 10% within 3 months prior to study participation * Currently participating in another weight-loss study * Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan) * MRI-specific exclusion criteria (e.g., metal in the body, weight \>500 lbs

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Conditions

The condition(s) this trial relates to.

Body Weight Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Overweight/obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Colorado Anschutz Medical Campus

    RECRUITING

    Aurora, Colorado, 80045, United States

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