University Of Colorado, Denver

This study tested a combination of two drugs, azacitidine and venetoclax, as an initial treatment for adults aged 60 and older with acute myeloid leukemia (AML) who had not received prior therapy. Participants received the drugs together as induction therapy, and those who respon…

This study looked at whether a shorter course of radiation therapy is safe and effective for women with breast cancer that had spread to their lymph nodes. 108 women who had already had surgery took part. The main goal was to track side effects like arm swelling, shoulder stiffne…

This study tested whether fresh frozen plasma (FFP) works better than albumin for fluid replacement in adults with severe burns covering over 20% of their body. Fifty-nine patients were randomly assigned to receive either FFP or albumin within 8 hours of injury. The goal was to s…

This early-stage study tested a precise type of radiation called stereotactic body radiation therapy (SBRT) in 15 women whose ovarian or uterine cancer had returned in a limited area. The goal was to find the safest dose and see if it could control the cancer without major side e…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve diabetes and kidney health in teens aged 12-21 with type 2 diabetes. Researchers measured how well the pancreas and kidneys worked before and after surgery. The goal was to see if surgery c…

This study tested the safety and effectiveness of tofacitinib, a drug that blocks certain immune signals, for treating skin conditions like eczema and psoriasis in people with Down syndrome. 47 adolescents and adults took part. The goal was to see if the drug could improve these …

This study tested whether the drug rucaparib can help keep metastatic or recurrent endometrial cancer from growing after chemotherapy. About 79 women who had already received 1-2 prior treatments were randomly assigned to take either rucaparib or a placebo pill. The main goal was…

This study tested whether semaglutide (Rybelsus), a drug used for diabetes, can help people with alcohol use disorder drink less. Fifty adults who wanted to cut down took either the drug or a placebo for 8 weeks. Researchers measured changes in alcohol cravings and daily drinking…

This study tested whether intermittent fasting (eating only during certain hours) helps people with obesity lose more weight than simply cutting calories every day. Over one year, 165 adults followed either approach with similar weekly calorie goals and support. The main goal was…

This study looked at 60 teenage girls with PCOS and obesity. They either took a weekly injection of semaglutide (a diabetes/weight-loss drug) or followed a special diet for 12 weeks. The goal was to see which approach better reduced liver fat and improved how the body uses insuli…

This early-phase study tested an oral drug called KPT-9274 in 16 adults with acute myeloid leukemia that had come back or not responded to prior treatments. The main goal was to find the safest dose and see how well patients tolerated the drug. The study is complete, but results …

This study tested a counseling program for couples in Zambia where the woman is pregnant and living with HIV. The goal was to help women stay on their HIV medication and keep the virus under control. 478 couples took part, and the program focused on strengthening the relationship…

This study tested whether providing birth control pills alongside a contraceptive implant helps young women (ages 14-22) continue using the implant instead of stopping early. 600 participants were given either the pills plus standard counseling or counseling alone. The goal was t…

This early-phase study tested a new treatment called IBC with MAS-1 adjuvant in 21 adults recently diagnosed with type 1 diabetes. The goal was to see if it is safe and can retrain the immune system to stop attacking the pancreas, potentially preserving natural insulin production…

This study tested a smart oxygen machine that automatically adjusts oxygen levels for hospitalized patients with serious injuries or illnesses. The goal was to keep oxygen in a safe range (90-96%) for the first 72 hours. 300 adults took part to see if the machine worked better th…

This early-phase study tested whether giving testosterone skin patches in cycles with the drug enzalutamide is possible and safe for men with castration-resistant prostate cancer. Thirty men on standard hormone therapy participated. The goal was to see if at least half of eligibl…

This study tested a way to identify pregnant women with HIV who are at risk of dropping out of care or having high virus levels. Researchers in Kenya gave extra support to those at highest risk. The goal was to help mothers stay healthy and prevent passing the virus to their babi…

This study looked at whether eating less fat and more fiber can lower the chance of a repeat Clostridioides difficile infection in people being treated for cancer. Eight patients with leukemia, lymphoma, or other cancers who had a recent C. diff infection took part. Researchers t…

This study tested the drug Acthar in 15 people with a kidney disease called FSGS who were getting a kidney transplant. The goal was to see if Acthar could lower the chance of FSGS coming back in the new kidney. Researchers measured how many patients had signs of FSGS in their tra…

This study tested whether putting antibiotic powder directly into open fracture wounds can help prevent infections. Open fractures are severe bone breaks that often get infected. The study included 20 adults with certain types of open fractures. Researchers applied vancomycin or …

This study tested a mobile health program called Mobile CHOICES to help urban American Indian and Alaska Native young women aged 16-20 avoid alcohol-exposed pregnancy. The program used social media to recruit participants and provided culturally adapted tools to reduce drinking a…

This study looked at how therapeutic horseback riding affects youth with autism who also have mental health conditions. Researchers measured changes in behavior, social skills, and emotional control in 250 participants. The goal was to understand how riding helps and how long the…

This study tested a Spanish-language program called Unstuck and On Target for children ages 8-11 with ADHD or autism in Ecuador. Twenty families took part to see if the program was easy to use and helpful for improving thinking and problem-solving skills. The program ran for 8 we…

This early-phase study tested alpha lipoic acid, a dietary supplement, in 5 people with head and neck cancer undergoing chemoradiation. The goal was to find a safe dose that might reduce treatment-related pain and side effects. Researchers looked for the highest dose without seri…

This small pilot study tested whether psilocybin, the active ingredient in magic mushrooms, combined with psychological support could help people with treatment-resistant depression who have lost the ability to feel pleasure (anhedonia). Twenty adults with major depressive disord…

This study tested whether CBD (a compound from cannabis) can help people reduce their use of painkillers and opioids, while also easing pain and anxiety. 126 adults with opioid use disorder who wanted to cut back on opioids took either CBD or a placebo for 12 weeks. Researchers m…

This study tested whether two types of CBD (a cannabis compound) could improve thinking and reduce symptoms in people who had a mild or moderate traumatic brain injury. 43 adults took either CBD or a placebo for 12 weeks. Researchers measured changes in memory, attention, and moo…

This study looked at whether high-intensity interval training (HIIT) can improve fitness and ease breathing symptoms in veterans who developed new respiratory issues after deployment to Southwest Asia. Twelve veterans completed 12 weeks of supervised cycling and home exercise. Re…

This study tested a new securement device for gastrostomy buttons (feeding tubes) in children to reduce common problems like leakage, dislodgement, and skin irritation. About 182 children aged 1 month to 18 years were randomly assigned to use either the new device or standard dre…

This study looked at women having mastectomy with immediate implant-based breast reconstruction. It compared those who went home the same day of surgery versus those who stayed overnight. The goal was to see if same-day discharge leads to similar complication rates, pain control,…

This study tested a drug called riociguat in 10 adults who still had trouble exercising at least 6 months after surgery for chronic blood clots in the lungs. The goal was to see if the drug could improve blood pressure in the lungs and help patients walk farther. The study measur…

This study tested a special recovery program (called ERAS) for children having surgery to remove pelvic or abdominal cancers. The program included steps to help kids heal faster and with fewer problems. Researchers tracked complications, hospital stays, and pain in 74 children at…

This study looked at 20 obese teenagers (ages 13-20) who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how the surgery affects liver health and metabolism, not t…

This study looked at whether doing memory and thinking tests over video at home works as well as doing them in person for people with suspected Alzheimer's disease. 116 older adults with typical or atypical Alzheimer's took part. The goal was to see if video assessments are a pra…

This study tested whether an educational video series about sexual health is acceptable and useful for women undergoing breast cancer treatment. 32 women with early-stage breast cancer watched the videos and gave feedback. The goal was to see if this approach could help address s…

This study looked at 236 adults with breast, pancreatic, or colorectal cancer who sought a second opinion at the University of Colorado. Researchers reviewed medical records to understand why some patients stayed for treatment while others did not. The goal is to learn more about…

This study looked at how to better counsel transgender and gender diverse teens about birth control, specifically the shot called DMPA. Researchers talked to 35 teens aged 15-21 to understand what they liked and didn't like about the shot. The goal was to help doctors provide mor…

This study followed 384 people with HIV who were already taking the medication TAF. Researchers wanted to see if measuring drug levels in dried blood spots could predict whether the virus stays suppressed. Participants had up to 3 visits over 48 weeks. The goal was to better unde…

This study tested an online program called "Safety in Dementia" for caregivers of people with dementia who have access to firearms. The goal was to see if the program helps caregivers feel more prepared and confident in making safety decisions. 500 caregivers from across the US t…

This study tested whether adding a nutrition program (BfedBwell) to an existing exercise program (BfitBwell) is practical and well-liked by cancer survivors who are overweight or obese. Twenty adults who finished cancer treatment within the last five years took part. The main goa…

This study looked at whether a computer tool that reminds doctors to check a state database before prescribing opioids or sedatives helps them follow the law and reduce risky prescribing. Nearly 90,000 patient visits were tracked across emergency rooms, clinics, and hospitals in …

This study looked at why doctors and patients skip screening for Barrett's esophagus, a condition that can lead to esophageal cancer. Researchers surveyed over 700 doctors and patients at seven U.S. health centers to identify knowledge gaps and barriers. The goal is to improve sc…

This study looked at two new methods to understand why some labors slow down or stop. Researchers measured fluid in the womb and muscle signals from the uterus in 42 healthy pregnant women. The goal was to learn more about labor problems so doctors can better diagnose and manage …

This study looked at whether working night shifts for a few days can change how your body builds and breaks down bone. Twenty healthy adults aged 20-40 were studied during simulated night shifts. Researchers measured bone markers in the blood to see if the body's natural sleep-wa…

This study looked at how sex hormones, like estrogen, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. The goal was to understand why women with CKD have higher …

This study looked at whether two anti-inflammatory drugs—fish oil and celecoxib—could reduce inflammation and slow tumor growth in women with pregnancy-associated breast cancer. 42 women with breast cancer stages I to IV took one of the drugs for at least a week before their plan…

This study looked at how physical activity, fitness, and sitting time relate to diabetes risk in 40 female breast cancer survivors taking hormone therapy (aromatase inhibitors or SERMs). Researchers measured insulin resistance, body composition, and exercise capacity. The goal wa…

This study tested whether it's possible to collect information on how integrative therapies (like yoga, massage, or acupuncture) affect the quality of life of 100 children with cancer. The goal was not to treat the cancer itself, but to see if these therapies help with symptoms l…

This study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in 77 adults who regularly use both alcohol and cannabis. Participants tracked their daily alcohol use and cravings, gave blood and stool samples, and completed thinking …

This study tested whether a voice journaling app called Kintsugi is practical and liked by teenagers with cystic fibrosis (CF). Twenty teens aged 14-18 used the app for three months. The goal was to see if they would use it regularly and find it helpful, and to measure any change…

This study looked at whether giving pregnant women a nutrient called phosphatidylcholine (a type of fat) could improve their child's brain development. About 216 healthy pregnant women took either the supplement or a placebo from around 16 weeks of pregnancy until birth. Research…

This study looked at how pelvic radiation therapy affects bladder function and bone health in people who survived childhood cancer. Researchers measured urine flow and bone density in 32 survivors who had completed treatment at least a year earlier. The goal was to better underst…

This study examined how doctors and nurses in 12 Colorado hospitals treat patients with opioid use disorder. Researchers surveyed 400 healthcare workers to understand current practices and track changes in prescribing medications like buprenorphine and methadone. The goal was to …

This study looked at how women ages 39-49 react to scientific evidence about mammography's benefits and harms. Researchers measured feelings like disbelief, distrust, and thinking the information doesn't apply to them. The goal was to understand what influences their choices abou…

This study looked at what happens when people drink alcohol and use high-THC cannabis concentrates together. 146 heavy drinkers and regular cannabis users took part in a mobile lab session. Researchers measured blood alcohol, heart rate, and drug effects to see if the order of us…

This study looked at how 80 teenagers with asthma actually take their daily control medications using an electronic monitor that tracks every puff. Researchers wanted to see if teens who take their medicine regularly have better asthma control than those who don't. The study did …

This study looked at why some women disagree with their personalized breast cancer risk estimate. Researchers gave 781 Black or African American women aged 39-74 their Gail Model risk score and asked if they agreed. The goal was to understand this rejection and how it affects the…

This study looked at whether electrical impedance tomography (EIT), a radiation-free imaging method, can detect lung damage in children and young adults with cystic fibrosis (CF). Researchers compared EIT results to CT scans to see if it can spot air trapping and lung changes. Th…

This study followed 59 nurses during their first year of work to see if working night shifts affects bone health compared to day shifts. Researchers measured bone turnover markers and bone density at the start and after one year. The goal was to understand if night shift work is …

This study tested whether a special 2D grid can improve the quality of cone-beam CT (CBCT) images used during radiation therapy for prostate, head/neck, and abdomen cancers. Researchers compared standard CBCT images with those taken using the new grid in 43 participants. The goal…

This study looked at whether high-intensity rehabilitation can improve recovery for older adults in skilled nursing facilities after a hospital stay. Over 4,300 people took part. The goal was to see if this approach works and can be put into practice.

This study looked at the sexual health needs of 93 women diagnosed with breast cancer. Researchers wanted to understand how sexual well-being changes during treatment and what educational resources patients currently receive and prefer. The goal was to develop better educational …

This study follows over 1,000 mothers and their first-born children 29 years after they took part in a program where nurses visited them at home during pregnancy and early childhood. Researchers are measuring things like weight, blood pressure, cholesterol, and other health marke…

This study tested two ways to help doctors communicate better with patients who have speech, language, voice, or hearing disabilities. One approach trained healthcare teams on communication strategies; the other added a patient prompt list that lets patients share their preferred…

This study tested three different computer tools that help doctors check a state database before prescribing strong painkillers or sedatives. The goal was to see if these tools make it easier for doctors to spot patients at high risk for overdose. Over 3,600 patients and their do…

This study looked at 10 men to understand why androgen deprivation therapy (ADT) for prostate cancer can lead to high blood pressure. Researchers checked if problems with the nervous system or kidneys were to blame. The goal is to find ways to prevent heart disease in prostate ca…

This study looked at how women aged 39 to 49 make decisions about mammography screening after reading a guide that explains both the benefits and harms. About 500 women completed surveys over a year to share their thoughts, intentions, and whether they actually got screened. The …

This study looked at how a drug called tolcapone affects people who have both alcohol use disorder and ADHD. Researchers measured how the drug changed their response to alcohol, decision-making, and brain activity. The goal was to learn more about the connection between these con…

This study looked at whether a type of corn with extra nutrients (biofortified maize) can help children absorb more zinc and iron than regular corn. Researchers studied 56 school-aged children in Guatemala who ate tortillas made from this special corn. The goal was to see if this…