University Of Colorado, Denver

Researchers are studying whether adding daily atorvastatin to standard chemotherapy and surgery changes the immune cells inside advanced high grade serous tumors of the ovary, fallopian tube, or peritoneum. The trial enrolls 40 adults with Stage III or IV disease who cannot have …

This trial tests whether two existing drugs, simvastatin and baricitinib, can help people with acute respiratory distress syndrome (ARDS), a severe lung condition that causes breathing failure. Participants are grouped by biological markers into subtypes, then randomly assigned t…

After major surgery, patients are often asked to do deep-breathing exercises using a plastic device called an incentive spirometer to keep oxygen levels up. This trial tests whether automatic reminders — a dim light and a soft buzz every 20 minutes while awake — encourage patient…

This trial tests whether a culturally tailored, Spanish-language onboarding and support program helps Latino youth aged 10–20 with type 1 diabetes adopt and consistently use the Medtronic MiniMed 780G automated insulin delivery system. Participants receive one-on-one nutrition su…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This study investigates how semaglutide (the drug in Ozempic and Wegovy) changes brain activity related to appetite and eating in people with obesity. Researchers will compare teenagers (ages 12–18) and adults (ages 30–45) using brain scans and meal tests to see if the drug affec…

This study looks at whether improving sleep habits can help teenagers with overweight or obesity better regulate blood sugar and energy. Researchers will enroll 60 teens aged 14-19 who get less than 7 hours of sleep on school nights. For two weeks, participants will follow a slee…

This study tests whether completing methadone clinic intake during a hospital stay helps people with opioid use disorder stay connected to treatment after leaving. Researchers will compare usual care (a referral at discharge) to a program where hospital staff complete key steps l…

This study tests whether a single injection of platelet-poor plasma (PPP) into an acute muscle injury helps athletes heal better than standard care. About 90 athletes aged 18-45 with leg muscle strains will receive the injection plus physical therapy. Researchers will use MRI sca…

This study tests whether the drug epoprostenol, given alongside standard care, can reduce the need for amputation in people with severe frostbite. About 66 adults with grade 2-4 frostbite will receive either the drug or a placebo within 72 hours after rewarming. The goal is to se…

Researchers are studying whether do-it-yourself air cleaners placed in homes, along with an educational video about indoor air quality, can reduce exposure to fine particles and improve health. The trial enrolls 550 people aged 7 and older in Colorado's San Luis Valley and West D…

This pilot trial tests a program called EAAA+ that combines alcohol and cannabis education with sexual assault resistance training for college women aged 18–24 who drink and use cannabis. Participants are randomly assigned to either the program or an assessment-only group. Resear…

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

Alcohol withdrawal affects many hospitalized patients and standard sedative treatments have serious side effects. Researchers at the University of Colorado are testing whether intravenous sodium acetate, a natural byproduct of alcohol that the brain can use as fuel, is safe and p…

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This study tests a new therapy for children ages 7-12 who have self-injurious thoughts and behaviors (SITBs). The goal is to see if the new therapy helps families engage better and improves symptoms compared to usual care. About 52 children and their families will take part in we…

This study tests a new group self-management program for adults with brain cancer. The goal is to see if the program is practical and helps improve mental health and quality of life more than standard care. Researchers will compare changes in well-being between the group program …

This study tests if a newer ultrasound-guided needle works better than a standard needle to treat gluteal tendinosis—a painful tendon condition in the buttock area. About 110 adults who haven't improved after 3 months of other treatments will be randomly assigned to one of the tw…

This early-phase study tests whether taking iron supplements for 30 days can improve exercise performance in low-oxygen conditions. Five healthy adults will take ferrous sulfate pills daily and then exercise on a stationary bike. The goal is to see if iron helps the heart and lun…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will have their wounds covered with banana leaves, and their pain and healing will be compared to past patients. The goal is to see if this simple, l…

This study tests whether an online sexual health video series can help women newly diagnosed with breast cancer feel more confident talking to their doctors about sexual health. About 200 women will be randomly assigned to watch the videos or receive usual care. Researchers will …

This study tests whether a high-CBD cannabis extract is safe and helps relieve symptoms in people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effec…

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy, such as from short-term to long-term use. The alert prompts doctors to review the patient's pain and goals, following CDC guidelines. Researchers will study…

Researchers are studying how the antibiotic linezolid moves through the bodies of newborns and young infants. Up to 40 hospitalized infants will either receive linezolid as part of their routine care or a single study dose. Blood samples will measure drug levels over time, and re…

Researchers are testing whether the format of a breast cancer risk estimate affects how much women believe it. Women aged 39 to 74 will receive a personalized risk estimate online, with some seeing risk over 5, 10, or 30 years, and others seeing it out of 100 or 1,000 women. Some…

This early-stage study tests whether a fluorescent dye called 5-ALA can make soft-tissue sarcoma tumors glow during surgery, helping surgeons see the edges more clearly. About 20 adults with grade 2 or 3 sarcoma will take the dye by mouth before their standard surgery. The main g…

This study aims to find the best text messages to remind people to complete at-home colorectal cancer screening. Researchers will work with 7,220 adults aged 45-75 at community health centers. They will test different message versions to see which ones lead to more screening and …

This study looks at whether exercise can help protect the body from health problems caused by shift work, which disrupts natural sleep-wake cycles. Sixteen healthy but inactive adults will spend 5 days in a lab, simulating day shifts then night shifts, with some doing exercise. R…

This study tests whether transcranial magnetic stimulation (TMS), a noninvasive brain stimulation technique, can temporarily improve social cognition and brain function in 60 adults with high psychopathic traits. Participants will receive either real or sham TMS over three sessio…

This study tests a short program in the emergency department for people with dementia who have fallen. The program includes the patient and their caregiver and aims to reduce future fall-related ER visits. About 700 participants will be split into two groups: one gets the new pro…

This study is testing a new physical activity support program called Movámonos for Spanish-speaking adults who are overweight or obese and not very active. The goal is to see if the program is something people like and can stick with. About 20 people will take part to help resear…

This pilot study will compare the costs and patient satisfaction of ACL knee surgery using a smaller, newer camera system (NanoScope) versus the traditional arthroscopy method. About 42 adults aged 18-60 with an ACL tear will be randomly assigned to one of the two surgical approa…

This study will check how often bone loss happens around PEEK (a type of plastic) suture anchors used in hand and wrist surgeries, compared to metal or dissolving anchors. Researchers will review X-rays from 180 patients who had surgery in the past 10 years. They want to see if P…

This study aims to create a decision aid to help people with dementia, their caregivers, and doctors talk through medication options together. Researchers will test the tool with 100 patients, caregivers, and clinicians to see if it reduces confusion and improves shared decision-…