University Of Colorado, Denver

This early-stage trial tests a new treatment for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to target a protein …

This study tests whether completing the methadone clinic intake process while still in the hospital helps people with opioid use disorder stay in treatment after discharge. Researchers will compare usual care (referral at discharge) to a hospital-based approach where staff help f…

This study tests montelukast, an asthma drug, in 50 teens and young adults (ages 14–24) with type 2 diabetes. The goal is to see if it can reduce inflammation that damages kidneys and blood vessels. Participants will take the drug for 6 months, and researchers will measure change…

This study tests whether a combination of nicotinamide riboside (a form of vitamin B3) and pterostilbene (a plant compound) can safely improve low blood counts in people with certain bone marrow conditions. Ten adults with lower-risk myelodysplastic syndrome or high-risk clonal c…

This study looks at whether a single injection of platelet-poor plasma (PPP) can help athletes recover from muscle injuries better than standard treatment. About 90 athletes aged 18-45 with leg muscle strains will receive either PPP plus standard care or standard care alone. The …

This study tests whether a daily supplement called equol can improve blood vessel function in postmenopausal women with moderate chronic kidney disease (CKD). The 12-week trial will measure changes in artery health and blood pressure. Researchers hope to find a simple way to lowe…

This study tests whether adding the drug epoprostenol to standard frostbite care can lower the number of amputations. About 66 adults with severe frostbite will receive either epoprostenol or a placebo through an IV. The goal is to see if the drug helps restore blood flow and sav…

This study tests a clinical decision support tool that reminds doctors to follow CDC guidelines when reducing opioid doses in patients. About 200,000 primary care patients will be included. The goal is to lower the risk of withdrawal, overdose, and poisoning by encouraging safer …

This pilot study will test whether banana leaves can be used as a primary dressing for partial-thickness burns (second-degree burns). About 30 adults with small burns will receive banana leaf dressings, and their pain, healing time, and need for painkillers will be compared to pa…

This study tests whether an interactive website called Man Therapy can help reduce problematic anger in male military service members. About 226 participants who screen positive for anger issues will either use the program right away or wait and receive it later. The goal is to s…

This study tests a new outpatient therapy for children ages 7-12 who have self-injurious thoughts and behaviors (SITBs). The therapy focuses on improving emotion regulation and executive functioning. Researchers will compare it to standard treatment to see if it is more engaging,…

This study looks at whether watching online videos about sexual health can help women with newly diagnosed breast cancer feel more confident talking to their doctors about this topic. About 200 women will either get access to the videos or receive usual care, and will fill out su…

This study tests whether taking iron supplements can improve exercise performance in low-oxygen conditions, like at high altitudes. Five healthy adults aged 18-60 will take iron pills and then exercise on a bike to measure their maximum workload and oxygen use. The goal is to see…

This study tests whether a fully online mindfulness program is a practical and helpful option for teenagers who get migraines. Researchers will compare a virtual mindfulness group to a virtual headache education group. The goal is to see if teens will join and stick with the prog…

This study tests whether a high-CBD cannabis extract is safe and helps relieve symptoms in people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effec…

This study compares two minimally invasive needle treatments for gluteal tendinosis, a painful tendon condition in the buttock area. About 110 adults who haven't improved with standard care will receive either a traditional needle tenotomy or a newer ultrasound-guided needle teno…

This study tests a program called ThriveCircle, where small groups of faculty members meet over shared meals to talk about work and support each other. The goal is to see if these guided conversations reduce burnout and improve well-being. About 160 faculty from the University of…

This study tests a short program in the emergency department for people with dementia who have fallen. The program includes the patient and their caregiver to help prevent future falls. About 700 people will take part to see if the program reduces the number of fall-related ER vi…

This study will observe 180 adults who had hand or wrist surgery with suture anchors in the past 10 years. Researchers want to see if PEEK (plastic) anchors cause more bone loss around the anchor site compared to metal or bioabsorbable anchors. They will also check if any bone lo…

This study tests a computer alert that notifies doctors when a patient is about to move from short-term to long-term opioid use. The goal is to help doctors review the patient's pain and risks before prescribing more opioids. About 200,000 patients will take part, and researchers…

This study aims to see if text message reminders can encourage more adults aged 45-75 to complete at-home colorectal cancer screening. Researchers will work with community health centers to design and test different message versions. The goal is to increase screening rates and en…

This study tests whether a blood test that looks for cancer DNA (ctDNA) can help doctors decide which patients with stage 2 or 3 rectal cancer can safely avoid surgery and just be watched closely. About 200 adults will be followed to see if the test improves detection of cancer r…

This study tests whether a computer alert can help primary care doctors identify patients with opioid use disorder and guide them to prescribe effective medications like buprenorphine. About 200,000 patients will be involved, with some clinics getting the alert and others not. Th…

This early-stage study tests whether a fluorescent dye called 5-ALA can help surgeons see soft tissue sarcoma tumors more clearly during surgery. About 20 adults with grade 2 or 3 sarcoma will take the dye by mouth before their operation. The main goal is to see if the dye makes …

This study looks at whether using a smaller, newer tool (NanoScope) for ACL knee surgery costs less than the usual method. About 42 adults with ACL tears will be randomly assigned to one of the two surgery types. Researchers will track costs and ask patients how satisfied they ar…

This study will test a physical activity support program called Movámonos for Spanish-speaking adults who are overweight or obese and not very active. The goal is to see if the program is acceptable and feasible for this group. Researchers will interview participants and use surv…

This study will create a decision aid to help people with dementia, their caregivers, and doctors talk through medication options together. About 100 participants will test the tool to see if it reduces confusion and improves confidence in treatment decisions. The goal is to make…

This study looks at whether a small device worn on the thigh can reliably measure daily activity in people with Functional Neurologic Disorder (FND). Current doctor assessments only capture a single moment, missing day-to-day changes. The study will involve 40 participants (20 wi…