University Of Colorado, Denver

This study looks at whether taking omega-3 fatty acid supplements can lower very high triglyceride levels in pregnant women. High triglycerides are linked to larger babies and potential birth complications. The study involves 40 pregnant women with elevated triglycerides and aims…

This study tests a combination of two drugs, omacetaxine and azacitidine, in people with a high-grade form of myelodysplastic syndromes (MDS), a bone marrow disorder. The goal is to find the safest dose and see how many patients achieve remission. About 28 adults with newly diagn…

This study tests a new treatment approach for people with advanced stomach or gastroesophageal junction cancer that has spread. Participants first receive targeted radiation and a drug called olaparib, followed by a combination of olaparib and pembrolizumab. The goal is to see if…

This early-phase study tests whether giving trastuzumab directly into the spinal fluid, along with an immune-boosting drug called GM-CSF, is safe for children whose ependymoma has come back. About 33 children aged 1 to 21 will take part. The goal is to see if the drug reaches the…

This study tests whether helping families eat more meals together and improve the quality of those meals can lower children's risk for obesity and heart disease. About 500 kids ages 5-10 and their caregivers will use video recordings and text message tips over 12 months. The goal…

This study tests a computer alert that reminds doctors to prescribe naloxone—a medicine that reverses opioid overdoses—when they give patients high-risk opioid painkillers. The goal is to see if the alert increases naloxone co-prescribing and reduces overdoses. About 200,000 pati…

This study tests whether a diabetes medicine called empagliflozin is safe and tolerable for people with autosomal dominant polycystic kidney disease (ADPKD). About 50 adults with moderate kidney function will take either the drug or a placebo for 12 months. The goal is to see if …

This study tested whether the drug nivolumab can reverse precancerous spots in the lungs of heavy smokers or people with a history of lung or head and neck cancer. Nineteen participants received the drug to see if their lung tissue improved. The goal was to stop these spots from …

This early-phase study tests whether adding an oral drug (DEC-C) to the immunotherapy nivolumab can help the immune system better attack mucosal melanoma, a rare and hard-to-treat skin cancer. The trial includes 8 adults with advanced disease that cannot be removed by surgery. Th…

This study tests a two-drug combination (cabozantinib and nivolumab) in people with advanced colorectal cancer that is microsatellite stable (MSS) and has stopped responding to standard treatments. The goal is to see if the combination can control the cancer for at least 16 weeks…

This early-phase study tests a new drug, amivantamab, combined with standard targeted therapies (TKIs) in 12 adults with advanced non-small cell lung cancer that has specific gene changes (ALK, ROS1, or RET). The goal is to see if the combination can overcome resistance that ofte…

This study tests a drug called tocilizumab in children with a rare brain tumor called adamantinomatous craniopharyngioma. First, a small group gets one dose before surgery to see if the drug reaches the tumor. If it does, more children will receive the drug every two weeks for ab…

This study tests a new treatment plan for people with a certain type of esophageal cancer. Before surgery, patients receive a specific chemotherapy combination (FLOT) followed by chemoradiation. The goal is to see if this approach can destroy more cancer cells and improve surviva…

This early-stage study tests a new type of genetic medicine (called an antisense oligonucleotide) in just one person with PCARP, a rare disease that causes vision loss and trouble with balance. The main goal is to see if the treatment is safe and tolerable. The participant will r…

This study tests whether adding two immunotherapy drugs (zalifrelimab and balstilimab) to standard chemotherapy (doxorubicin) can help people with advanced or metastatic soft tissue sarcoma live longer without their cancer growing. About 65 adults aged 18-100 who have not had pri…

This study tests a combination of three drugs (tiragolumab, atezolizumab, and bevacizumab) in 13 people with advanced colorectal cancer that has not responded to prior treatment and is microsatellite stable (a type that typically does not respond to immunotherapy alone). The goal…

This study tests a personalized approach using the drug selinexor combined with other medications for people whose multiple myeloma has returned or stopped responding to treatment. 18 adults with active disease after at least one prior therapy will receive one of three drug combi…

This study looks at how vericiguat, a new heart failure drug, improves heart function during rest and exercise. Thirty adults with heart failure will take either vericiguat or a placebo for about three months. Researchers will measure blood flow, blood pressure, and quality of li…

This study tests whether using an over-the-counter continuous glucose monitor (CGM) every 30 or 90 days helps people with type 2 diabetes who do not use insulin better manage their blood sugar. About 188 participants will wear the Dexcom Stelo sensor periodically over six months.…

This study tests three medications—lorazepam, IVIG, and tofacitinib—in 66 people with Down syndrome (ages 8-30) who have developed a serious condition called Down Syndrome Regression Disorder (DSRD). DSRD causes sudden loss of skills, catatonia, and other severe symptoms. The goa…

This study looks at whether eating only during certain hours of the day (time-restricted eating) helps adults with obesity lose weight and improve health. About 162 participants will be assigned to eat early in the day, late in the day, or simply reduce daily calories for one yea…

This study tests a new drug called NT219 combined with either pembrolizumab or cetuximab in people with head and neck cancer that has come back or spread. The goal is to see if the combination can shrink tumors. About 29 adults with incurable head and neck squamous cell carcinoma…

This study tests a new, less invasive device called the Esophageal String Test (EST) to diagnose and monitor eosinophilic esophagitis (EoE), a rare inflammatory condition of the esophagus. Instead of a traditional biopsy, patients swallow a small string that collects samples to m…

This study looks for markers in blood, sputum, or urine that can help doctors decide if a lung nodule found on a CT scan is cancer or not. About 550 adults with lung nodules will provide samples before any procedure. The goal is to reduce the need for invasive biopsies by using a…

This study tests if offering the HPV vaccine to children at age 9-10, instead of the usual 11-12, leads to more kids getting fully vaccinated before they are exposed to the virus. The goal is to prevent HPV-related cancers later in life. About 3,100 children in Colorado and Calif…

This study tests whether Pain Reprocessing Therapy (PRT) works better than Cognitive Behavioral Therapy (CBT) or usual care for adults with chronic back pain. About 150 diverse participants will try one of the three approaches. The goal is to see which treatment lowers pain and i…

This early-stage study tests whether a smartphone app and remote therapy sessions can help military members and active young adults recover from a mild concussion. The goal is to improve recovery and lower the chance of getting hurt again. The study involves 88 people and focuses…

This study tests a mobile health program called 'Forward to Quit' designed specifically for transgender adults who smoke. The program was created with input from transgender people and their doctors. Researchers want to see if the program is easy to use and helps people stop smok…

This study tests a sleep screening and support program for teens with type 1 diabetes. Researchers want to see if doctors can easily use the program during clinic visits. About 50 teens who use a continuous glucose monitor will take part.

This study looks at whether a daily 1-hour music listening program can help adults who are getting a stem cell transplant feel better during their long hospital stay. The goal is to see if the program is easy to use and if it improves well-being. About 35 patients will take part.

This study tests a 3-month intermittent fasting program for adults who have had breast cancer and are overweight or obese. Participants follow a 4:3 fasting schedule (3 modified fast days per week) and aim for 150 minutes of physical activity weekly. The goal is to see if the pro…

This study looks at three ways to manage pain after surgery for pectus excavatum, a chest wall deformity often fixed in teenagers. The goal is to find which method works best to reduce pain and the need for strong painkillers. About 158 patients aged 12 to 21 will be randomly ass…

This study tests whether an online training program helps people who recently quit smoking stay smoke-free and support others in their social network to quit. About 940 adults who have been smoke-free for 2 to 8 weeks will take part. Participants will complete surveys and provide…

This study tests a nutrition program for cancer survivors who are overweight or obese. It combines one-on-one dietitian counseling, behavioral skills training, and group support. The goal is to see if the program is practical and well-liked by participants and staff. About 73 adu…

This study tests whether a carefully controlled low-fat diet can increase reproductive hormones in women with obesity who have infertility. Researchers will measure hormone levels in urine before and after the diet. The goal is to see if diet alone can improve fertility without m…

This study aimed to see if a new monitoring schedule could better detect early signs of ovarian damage in young women and girls who had chemotherapy or radiation. It planned to compare a new algorithm against standard care to help patients get fertility treatments sooner. However…

This study looks at how obesity may cause fertility problems by disrupting hormones and metabolism. Researchers will measure hormone levels and insulin response in 84 women with a healthy weight. The goal is to understand the link between obesity and infertility to guide future t…

This study looks at how cannabis use changes the body's natural endocannabinoid and opioid systems in adolescents aged 14 to 25. Researchers will measure cannabinoid and endorphin levels in blood to find biomarkers that may help predict which teens will relapse and which will sta…

This study looks for clues in the blood that might help doctors predict which cancer patients will have serious side effects from immunotherapy drugs. Researchers are comparing patients who get immunotherapy with those who get standard chemotherapy. The goal is to find markers th…

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short exercise sessions at different times, with their blood sugar and sleep tracked. However, the study was wi…

This study looks at whether a new care planning method, called ABC123, is practical and acceptable for people over 60 with advanced, incurable cancer. About 70 participants will try the framework during their first doctor visit and be followed for 6 months. The goal is to see if …

This study looks at whether stopping cannabis use for 42 days can improve memory, attention, and mood. It involves 100 identical twins who both use cannabis regularly. One twin will be asked to stop using cannabis with support, while the other continues as usual. The goal is to s…

This study is testing a new system that combines aging, mental health, and social needs checks for cancer patients aged 65 and older. The goal is to help doctors provide care that fits each patient's life. About 35 people with different cancers will try it during their first visi…

This study looks at why some women disagree with their personalized breast cancer risk estimate given during mammography screening. Researchers will ask 726 women aged 39-74 about their risk, offer them extra screening information, and check their future screening plans. The goal…

This study looks at how different ways of explaining mammography affect women's trust in screening information. About 1,900 women ages 39-49 without breast cancer will read different messages online. Researchers want to see which approach reduces skepticism and influences screeni…

This study tests whether a 40-week limb-load biofeedback training program helps people with a leg prosthesis (osseointegrated) walk more symmetrically. About 15 participants will be split into two groups: one gets the training, the other gets standard care. Researchers will measu…

This study tests whether a new method called the Engaged Approach to Lung Cancer Screening (EA-LCS) is practical and acceptable in different screening programs across Colorado and the US. About 40 staff members from up to 8 screening sites will try the approach and share their fe…

This study looks at whether group discussions about advance care planning help older adults (70+) document their healthcare wishes. About 516 participants will either join two group sessions led by a doctor and social worker, or receive mailed materials. The goal is to see if gro…

This study tests a new computer tool that gives doctors personalized reminders to prescribe the best medications for heart failure. The tool is designed to show only the information each doctor needs, avoiding irrelevant alerts. About 764 doctors in outpatient clinics are taking …

This study follows 60 adults who completed an 18-month weight loss program 3 years ago. Researchers will measure changes in weight, body fat, and muscle, and track physical activity, sleep, and eating patterns using wearable devices and a phone app. The goal is to understand how …

This study tests whether adding a sleep health program to a standard weight loss plan helps overweight adults lose more weight and sleep better. About 25 participants will take part for 6 months. The goal is to see if the program is practical and liked by participants, not to pro…

This study looks at why many people with type 1 diabetes still develop kidney disease, even with modern glucose monitors and insulin pumps. Researchers will use kidney biopsies and advanced imaging to find hidden risk factors like insulin resistance and inflammation. The goal is …

This study looks at whether continuous glucose monitors (CGMs) are practical for youth and young adults (ages 2–25) admitted to the hospital with high blood sugar from diabetes or other causes. Researchers will compare CGM readings with standard finger-stick tests and survey pati…

This study looks at whether giving a fermented milk supplement (Inkomasi) to pregnant women with HIV or to their babies at 6 months old can change the babies' gut bacteria. The goal is to see if these changes can help protect HIV-exposed but uninfected infants from severe infecti…

This study collects saliva, blood, and tissue samples from 225 adults with or without head and neck cancer to find tiny genetic markers called miRNAs. Researchers want to see if these markers can help predict how the disease will progress or aid in diagnosis. Participants include…

This study follows 192 toddlers aged 18 to 36 months who are at high risk for asthma. Researchers track their health over time to learn how asthma starts and progresses in early childhood. The goal is to help doctors find better ways to prevent and treat asthma in young kids. No …

This study collects tumor tissue from children with a rare brain tumor called craniopharyngioma. Researchers will analyze the samples to find specific molecules that could be targets for future treatments. The goal is to improve therapy and reduce side effects, but this study doe…

This study looks at how exercising in the morning versus the evening, and on an empty stomach versus after eating, changes the way your body burns energy. Researchers will measure energy use and fat burning in 20 healthy adults with overweight or obesity during treadmill workouts…

This study looks at whether losing weight over two years can improve how the kidneys use oxygen and how the body responds to insulin in people with autosomal dominant polycystic kidney disease (ADPKD) who are overweight. Researchers will use PET scans and a special test to measur…

This study tests a new computer tool that helps doctors prescribe the right heart failure medications during phone or video visits. Researchers will compare the new tool to an existing one in 20 cardiology clinics. The goal is to see if the tool works well and can be used fairly …

This study looks at how different protein-rich foods given to babies around 5 to 12 months old affect their growth and the bacteria in their gut. Researchers will follow 267 healthy, full-term infants through school age to see how early eating habits shape long-term health. The g…

This study aims to see if measuring natural water isotopes in breath and saliva can replace urine tests for tracking energy expenditure. About 60 healthy adults aged 18-45 will provide samples. The goal is to make it easier and faster to study how many calories people burn.

This study measures certain substances in the blood (biomarkers) of infants with a rare heart condition called single-ventricle. The goal is to see how these biomarkers relate to lung blood flow before and after a surgery called the superior cavo-pulmonary anastomosis (SCPA). Res…