University Of Colorado, Denver

This study is testing whether adding an oral drug called DEC-C to a standard immunotherapy (nivolumab) can make treatment more effective for people with advanced mucosal melanoma that cannot be removed by surgery. The goal is to see if this combination is safe and can better cont…

This study is testing the safety and effectiveness of combining two drugs, omacetaxine and azacitidine, for people with high-grade myelodysplastic syndromes (MDS), a serious bone marrow disorder. The goal is to find the best dose and see if the combination can control the disease…

This study is testing a new, two-step treatment plan for people with a type of cancer where the esophagus meets the stomach. The goal is to shrink the tumor as much as possible before surgery. First, patients receive a strong combination of chemotherapy drugs (called FLOT). Then,…

This study is testing whether the drug nivolumab can help the body's immune system recognize and clear abnormal, pre-cancerous cells in the lungs of high-risk current and former smokers. Participants receive four doses of the drug over eight weeks and undergo lung exams to see if…

This study is testing a new automated device that adjusts a patient's oxygen levels, similar to a smart thermostat. It aims to keep oxygen levels in a safe, ideal range for critically ill or injured patients, potentially reducing risks from too much or too little oxygen. The tria…

This small study is testing whether a 3-month lifestyle program can help breast cancer survivors who are overweight or obese. The program involves three modified fasting days per week and aims to increase physical activity. Researchers want to see if this approach is safe, feasib…

This study is testing whether a shorter, 4-week course of radiation is as safe and effective as the standard 6-week treatment for breast cancer patients whose cancer has spread to their lymph nodes. The trial involves 108 women who have already had breast cancer surgery. Research…

This study is testing whether the timing of meals is more effective for weight loss than simply counting calories. Researchers are comparing three approaches: eating all meals within an early 8-hour window, eating within a late 8-hour window, or traditional daily calorie restrict…

This early-stage study is testing whether adding a new drug called amivantamab to standard targeted therapies can help control advanced lung cancer that has started growing again. It will involve about 12 adults whose cancer has specific genetic changes and has become resistant t…

This early-stage study is testing whether tocilizumab, a drug used for arthritis, can reach and potentially control a rare childhood brain tumor called craniopharyngioma. The trial has two parts: first checking if the drug gets into the tumor after one dose before surgery, then t…

This study aims to understand exactly how the medication vericiguat helps people with chronic heart failure. Researchers will test 30 patients to see if the drug improves how the heart and blood vessels work, especially during exercise. Participants will take either the real drug…

This study is testing whether a combination of two drugs, cabozantinib and nivolumab, can help control advanced colorectal cancer that has stopped responding to standard treatments. It will involve about 48 adults whose cancer has spread and is a specific type called microsatelli…

This study is testing a new clinic program to help spot and address sleep issues in teenagers with type 1 diabetes. About 50 teens will fill out a sleep questionnaire before their regular doctor's visit. If a problem is found, their doctor gets information and suggestions to disc…

This study tests whether doctors can choose effective drug combinations for patients with multiple myeloma that has returned or stopped responding to previous treatments. Eighteen participants will receive one of three different drug combinations based on their doctor's judgment,…

This early-phase study is testing a new way to treat children whose brain cancer (ependymoma) has come back. Researchers are giving a targeted drug directly into the spinal fluid, along with an immune-boosting shot, to see if the drug reaches the tumor and to check for side effec…

This study is testing three different treatments for Down Syndrome Regression Disorder (DSRD), a serious condition where individuals with Down syndrome suddenly lose skills, stop speaking, and experience other severe symptoms. The trial will compare the safety and effectiveness o…

This study tests if an online training program helps people who recently quit smoking stay smoke-free. The program teaches them how to have supportive conversations with other smokers in their life. Researchers want to see if this approach helps the quitter build a more supportiv…

This study is testing whether a combination of three immunotherapy drugs can help control advanced colorectal cancer that has stopped responding to standard chemotherapy. It is for adults whose cancer has spread and has a specific genetic profile called 'microsatellite stable.' T…

This study is testing a family coaching program to see if it can lower the risk of obesity and heart disease in children. It involves 500 children, aged 5 to 10, and their families. The program uses smartphone tips, home visits, and video feedback of family meals over 6 months to…

This study is testing if a pop-up alert in a patient's electronic health record can help doctors follow guidelines to prescribe naloxone, a drug that can reverse an opioid overdose, at the same time they prescribe high-risk opioid painkillers. It will involve about 200,000 patien…

This study is testing a new smartphone program called 'Forward to Quit,' designed specifically to help transgender adults stop smoking. Researchers want to see if the program is easy to use and acceptable to participants, and if it shows early signs of helping people quit. The go…

This study is testing whether listening to music daily during a long hospital stay for a stem cell transplant can help patients feel better. Researchers want to see if this simple, self-guided activity is practical for patients and if it improves their quality of life, reduces an…

This study is testing whether a new talk therapy called Pain Reprocessing Therapy (PRT) works better than standard Cognitive Behavioral Therapy (CBT) or usual care for adults with chronic back pain. Researchers are enrolling 150 racially and ethnically diverse adults to try these…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with psychological support, can help people with treatment-resistant depression who struggle with anhedonia—the inability to feel pleasure. The trial involves 40 adults who have not respo…

This study is testing a new 40-week training program designed to help people with above-the-knee amputations walk more evenly with their bone-anchored prosthetic leg. Researchers will compare the new training, which uses real-time feedback on weight-bearing, to standard rehabilit…

This study aims to understand how total hip or knee replacements affect the quality of life and function of children and young adults. It focuses on patients who needed the surgery for reasons other than a solid tumor, such as side effects from leukemia treatment, injury, or cong…

This study aims to discover if tiny molecules called miRNAs found in saliva, blood, or tissue samples can help doctors detect or monitor head and neck cancer. Researchers are collecting samples from 225 people, including those with cancer and those without, to compare these molec…

This study is testing whether a wearable glucose monitor is practical and easy to use for children and young adults in the hospital. Researchers want to know if patients, families, and nurses find the device helpful compared to standard finger-prick checks. The goal is to gather …

This study aims to understand how different protein-rich foods given to babies between 5 and 12 months old affect their growth and the development of their gut bacteria. Researchers will follow 267 healthy, full-term infants to see how their diet influences these factors as they …

This study is testing a new, simpler way to measure how much energy a person's body uses each day. Researchers will compare water samples from the breath and saliva of 60 healthy adults to the standard method that uses urine. The goal is to see if the new method works as well but…

This study aims to understand why some women reject or disagree with their personalized breast cancer risk estimates. Researchers will survey 750 women aged 39-74 to identify factors that lead to risk rejection and see how this affects their actual mammogram screening behavior ov…

This study aims to find new drug targets for a rare childhood brain tumor called craniopharyngioma. Researchers will analyze tumor tissue from up to 250 children and young adults (ages 0-21) to identify specific molecules that could be targeted by future medications. The goal is …

This study follows 192 toddlers who have already experienced wheezing episodes to learn how asthma develops in early childhood. Researchers will track these children over time to identify patterns and factors that lead to persistent asthma. The goal is to gather information that …

This study aims to understand why obesity makes it harder for women to get pregnant. Researchers are putting healthy-weight women on a temporary high-fat diet to see if it causes changes in hormones linked to fertility, similar to what happens in obese women. The goal is to learn…

This study is checking in with people three years after they finished an 18-month weight loss program. Researchers want to see how their weight has changed and measure their current daily habits like physical activity, sleep, and eating patterns. The goal is to learn which daily …

This study aimed to test a new monitoring plan to help spot early signs of fertility problems in young women who had cancer treatments. It planned to look back at past patient records and follow new patients to see if the new plan could identify risks sooner and help women access…

This study is testing whether a decision guide helps women aged 39-49 make more informed choices about mammogram screening. 700 participants will read the guide and complete surveys over one year to see how it affects their knowledge, conversations with doctors, and final screeni…

This study is testing a new system designed to give doctors a more complete picture of an older patient's overall health and life circumstances when planning cancer treatment. It combines questions about aging, daily function, mental health, and social needs like housing and food…

This study is testing a new support framework for clinics that run lung cancer screening programs. Researchers are asking staff at up to 8 clinics across the US to try this new approach and give their feedback. The goal is to see if the framework is practical, acceptable, and som…

This study aimed to learn if exercising in the morning or evening is better for improving the body's blood sugar control in adults with prediabetes and obesity. It planned to have participants complete short periods of morning exercise, evening exercise, and no exercise while clo…

This study aims to see if measuring a medication's level in a simple dried blood spot can help predict whether a person's HIV will stay under control. Researchers will follow 384 adults with HIV who are already taking a specific medication (TAF) for 48 weeks. The goal is to learn…

This pilot study is testing whether a new care planning framework called ABC123 is practical and acceptable for older adults with advanced, incurable cancer. The framework combines expertise from geriatrics, oncology, and palliative care to help ensure treatment plans match what …

This study aims to learn if following a specific low-fat diet for one month changes reproductive hormone levels in women with obesity. It involves 30 women who will track their menstrual cycles and provide urine and blood samples over about four months. The goal is to gather info…

This study aims to learn how the time of day you exercise and whether you eat beforehand affects how your body burns energy and fat. Researchers will measure these effects in 20 healthy, active adults who are overweight or have obesity. The goal is to gather basic knowledge about…

This study aims to find signs in the blood that might predict which cancer patients will experience serious side effects from a newer type of drug called immune checkpoint inhibitors. It involves 69 adults with metastatic cancer who are starting either this immunotherapy or stand…

This study tests whether group discussions help older adults plan for future medical decisions. It compares two 2-hour group sessions led by a doctor and social worker to simply mailing information packets. The goal is to see which approach better helps people document their care…

This study aims to understand how stopping cannabis affects memory, attention, and mental health. Researchers are recruiting 100 pairs of identical twins who both use cannabis regularly. One twin in each pair will be paid to stop using cannabis for 42 days, while the other contin…