Ocular growth disorder

This study tests two treatments to slow the progression of myopia (nearsightedness) in children aged 5 to 12. One treatment uses special glasses with tiny lenslets that may reduce eye growth, and the other uses low-dose atropine eyedrops. Over 300 children will be followed for 2 …

This early-stage study tests a new drug called azirkitug, alone or with other cancer medicines, in people with advanced solid tumors like lung, head/neck, and pancreatic cancers. The goal is to find safe doses and check side effects. About 694 adults will take part worldwide, rec…

This study tests whether it is safe and possible to perform corneal cross-linking on both eyes on the same day in people with keratoconus, a condition where the cornea thins and bulges. Fifteen participants will receive riboflavin eye drops and UV-A light treatment in both eyes a…

This early-phase study tests a new drug called DSB2455 in adults with advanced cancers (breast, ovarian, prostate, pancreatic, or brain metastases) that have a specific DNA repair problem. The main goals are to check safety and see if the drug shrinks tumors. About 180 participan…

This study tests if a special red light device can slow down damage to the back of the eye in people with severe nearsightedness (pathologic myopia). About 158 adults will use the device or a fake one for 3 minutes, twice a day, 5 days a week for a year. Researchers will check if…

This study tests a new type of eyeglass lens designed to slow down nearsightedness (myopia) in children aged 6 to 14. The new lens is compared to an older version to see which works better. Each child will wear both lenses over a year, and researchers will measure eye growth and …

This study compares two special contact lenses (MiSight 1 Day and Abiliti 1-Day) to see which one better slows the worsening of nearsightedness in Chinese children aged 6-12 living in New Zealand. Each child will wear a different lens in each eye for 6 months. The goal is to find…

This study tests whether T10430 eye drops can safely slow or stop the progression of nearsightedness (myopia) in children aged 6 to 12. Myopia often starts in childhood and can lead to serious eye problems later in life. The trial will enroll 200 children to check for side effect…

This study tests INTACS prescription inserts, small plastic implants placed in the cornea, to reduce astigmatism and improve vision in people with keratoconus. The goal is to help patients who can no longer see well with glasses or contacts and may otherwise need a corneal transp…

This study looks at three ways to correct nearsightedness in children: special glasses, regular glasses, and overnight contact lenses. It will track 90 kids aged 7–17 for one year to see how each method affects their quality of life, vision, and family costs. The goal is to help …

This study tests whether a very low dose of atropine eye drops (0.01%) given once nightly can slow the progression of nearsightedness (myopia) in children aged 4 to 16. Over 6 months, 60 children will either receive the drops or be in a control group. The goal is to see if the dr…

This phase 3 study tests whether low-dose atropine eye drops (0.025% and 0.05%) can slow the progression of myopia (nearsightedness) in children and teens aged 3 to 17. About 234 participants across Europe will use the drops once nightly for 2 years. The goal is to see if these d…

This Phase 2 trial tests whether GLK-221 eye drops can safely slow the progression of keratoconus, a condition that thins and bulges the cornea. About 100 adults with keratoconus will use the drops twice daily for several months. The main goal is to see if the drops reduce the st…

The DYMOND study is testing a digital app called TrackSight that may slow myopia (nearsightedness) in children aged 6 to 12. The app uses eye-tracking to keep central vision clear while slightly blurring the edges of the screen, based on principles that influence eye growth. Abou…

This study tests special glasses called MiYOSMART iQ that use tiny lens segments to create a blur signal on the side of the eye, which may slow down the worsening of nearsightedness in children. About 35 kids aged 8-11 will wear these glasses for 6 months, and their results will …

This phase 3 trial tests whether a shorter 18-minute ultraviolet (UVA) light exposure works as well as the standard 24-minute exposure during corneal crosslinking for keratoconus and similar conditions. The treatment uses riboflavin (vitamin B2) eye drops followed by UVA light to…

This Phase 3 trial tests a treatment called corneal crosslinking (CXL) for people with Down syndrome who have keratoconus, a condition where the cornea thins and bulges, blurring vision. The procedure uses vitamin B2 eye drops and ultraviolet light to strengthen the cornea. Resea…

This study tests whether combining a laser vision correction (PRK) with corneal cross-linking improves eyesight and corneal shape better than cross-linking alone in people with keratoconus, a condition that thins and bulges the cornea. Fifty adults aged 18-40 with mild to moderat…

This study tests whether a low-level red-light device can slow the progression of myopia (nearsightedness) in children aged 8 to 13. Participants use the device for 3 minutes twice a day. The goal is to see if it reduces eye growth and prevents worsening vision, building on promi…

This study tests if a special red-light device, used at home for 3 minutes twice a day, can safely improve eye health in adults with nearsightedness (myopia). Fourteen adults aged 18-50 will use the light for 28 days. The goal is to see if the therapy thickens a layer in the eye …

This early study tests a tiny, permanent metal mesh (nitinol) implant placed inside the cornea to stabilize the eye and improve vision in people with advanced keratoconus. The trial involves 12 adults who are not candidates for other treatments and are currently recommended for a…

This study tests a new surgical method for pterygium, a growth on the eye's surface. Instead of cutting the growth out completely, surgeons move it to a different spot and stitch it down, preserving healthy tissue. The goal is to see if this lowers the chance of the pterygium com…

This study tests a new device called the Gebauer Lenticule, a tiny implant made from pig collagen, for people with severe keratoconus or post-LASIK ectasia. The implant is placed inside the cornea to strengthen it and improve stability, potentially delaying or avoiding the need f…

This study tests whether low-dose atropine eye drops (0.025%) can safely slow the progression of myopia (nearsightedness) in children aged 5 to 10. Over two years, 144 children will receive either the active drops or a placebo. The goal is to see if the drops reduce how quickly t…

This study tests two types of special glasses (D.S.D.O. lenses) designed to slow the progression of nearsightedness (myopia) in children aged 6 to 14. About 120 children will wear the glasses daily for one year and have regular eye checkups. The goal is to see if these lenses can…

This study tests whether special spectacle lenses can slow the progression of myopia (nearsightedness) in children aged 6 to 8. About 150 kids will wear either the test lenses or regular lenses for up to 3 years. Researchers will measure changes in eye focus and eye length to see…

This study tests special spectacle lenses designed to slow the progression of nearsightedness (myopia) in Chinese children. About 175 children who completed a prior study will wear the lenses for 12 months. Researchers will measure changes in eye length to see if the lenses help …

This study tests whether a probiotic called MR-61 can help slow the worsening of nearsightedness (myopia) in children and teens aged 3 to 18. Participants will take either the probiotic or a placebo daily for a period, and researchers will measure changes in their vision and eye …

This study tests whether using a violet light lamp at home can slow the progression of myopia (nearsightedness) in children. 72 kids aged 5 to 12 will use either a violet light lamp or a regular white light lamp for 12 months. Researchers will measure changes in eye length and vi…

This study tests a device that uses riboflavin (vitamin B2) drops and UV light to stiffen the cornea, the clear front part of the eye. It is for people with keratoconus or similar conditions that cause the cornea to bulge and blur vision. The goal is to see if the treatment safel…

This study tests whether wearing specialized soft contact lenses for short periods each day can slow the progression of nearsightedness (myopia) in children. Eighty kids who already wear contacts will use one of two lens types daily for a year. Researchers will measure changes in…

This study tests whether contact lenses with A.R.R.E.S.T.® technology can slow the progression of myopia (nearsightedness) in children compared to standard single-vision lenses. About 80 children aged 7 to 15 will wear either the special or standard lenses for 12 months, with sev…

This study compares a new type of LASIK (Ray-Tracing Guided) with three other common laser eye surgeries (SMILE, Wavefront Optimized LASIK, and Topography Guided LASIK) to see which one provides the best vision after surgery. Researchers will enroll 120 people with nearsightednes…

This study tests whether specially designed spectacle lenses can slow the progression of myopia (nearsightedness) in children aged 6 to 12. Over two years, 185 children will wear either the special lenses or standard single-vision lenses. The goal is to see if the special lenses …

This study tests two types of atropine eye drops and special glasses with tiny lenslets to slow myopia (nearsightedness) in children aged 3-6. About 508 kids will use one of these treatments nightly or daily. The goal is to see if these methods can prevent rapid worsening of eyes…

This study compares two approaches to control myopia (nearsightedness) in children aged 7 to 9: low-dose atropine eye drops and special glasses called DIMS lenses. Over 24 months, researchers will measure changes in vision and eye structure to see which treatment works better for…

This study tests whether low-dose atropine eye drops (0.02% or 0.04%) combined with special glasses (DIMS) can slow the progression of moderate to high myopia (nearsightedness) in children aged 6 to 12. About 410 children will be assigned to different treatment groups and followe…

This study tests a laser-guided procedure to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The procedure uses OCT scans to plan a custom laser treatment that smooths the cornea and strengthens it with cross-linking. Researchers aim to se…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study will enroll 500,000 people with high myopia and cataracts to develop an artificial intelligence model that helps doctors calculate the correct lens power and grade cataracts more accurately. The goal is to improve vision outcomes and reduce complications after surgery.…

This study tests whether a computer program (a deep neural network) can accurately predict the best lens size and position for people having surgery to correct nearsightedness. About 326 adults aged 18-45 will have their eyes scanned before surgery, and the AI's predictions will …

This study is testing whether artificial intelligence can analyze eye images to better detect and predict vision-threatening changes in people with high myopia (severe nearsightedness). Researchers will collect eye scans from 1,000 patients and use AI to identify a condition call…

This study is testing a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of 168 volunteers, including healthy people and those with keratoconus or post-LASIK ectasia, t…

This long-term study is looking for the best methods to detect glaucoma and track its worsening over time, especially in people with nearsightedness (myopia) and those of African or European descent. Researchers will use advanced eye imaging to monitor changes in the back of the …

This study tests whether showing cartoon video clips and using character voices during a visual field test can help children aged 5-8 stay focused and give more reliable results. Twenty children with certain eye conditions will be tested twice, once with the cartoon intervention …

This study aims to improve how doctors detect, classify, and treat irregular corneas caused by conditions like keratoconus, dry eye, and corneal scars. Researchers will use a special imaging device called optical coherence tomography (OCT) to get detailed measurements of the corn…

This study tests whether a nightly drop of low-dose atropine in both eyes can delay the start of nearsightedness in children aged 6–11 who are not yet nearsighted. Over 600 kids will be randomly assigned to get either the atropine drops or placebo drops for two years. The main go…

This study tests a device that makes reading feel like looking at something far away, to prevent myopia in children aged 6-12 who are at risk. Eighty kids will use the device for at least an hour daily during homework, and researchers will compare their eye changes to a group doi…

This study tests two ways to prevent or slow myopia (short-sightedness) in children aged 7 to 10. One group gets special classroom lights that mimic sunlight, another group's parents get a smartphone app that encourages more outdoor time, and a third group gets standard care. Ove…

This study compares two laser platforms used in SMILE surgery to correct short-sightedness (myopia). The standard VISUMAX 500 will be tested against the newer VISUMAX 800 in 100 participants. Researchers want to see if the newer platform provides the same or better vision results…

This study will test how comfortable and clear TOTAL30 Multifocal contact lenses feel after wearing them for up to 16 hours. About 36 adults who already wear multifocal contacts will rate their comfort and vision at several points during the day over one month. The goal is to see…

This study looks at how quickly and comfortably children aged 6 to 12 with nearsightedness (myopia) get used to special A.M.L. glasses. Forty children will wear the lenses for two weeks and report any discomfort. The goal is to see if most kids adapt within 4 to 6 days without pr…

This study compares two LASIK techniques to see which one corrects nearsightedness and astigmatism better. 70 adults aged 22 and older with healthy eyes will have one eye treated with each method. The goal is to find out if one approach leads to sharper vision without glasses.

This study compares two stitching methods used during surgery for pterygium, a growth on the eye's surface. Forty people with primary pterygium will be randomly assigned to receive either a new compression continuous suture or the traditional suture technique. The goal is to see …

This study tests whether Wavelight Plus LASIK, an advanced laser eye surgery, improves vision in both normal and dim lighting for people with nearsightedness and astigmatism. Fifty adults will receive the surgery and be followed for 3 months. Researchers will measure visual sharp…

This study tracks how satisfied 52 people with nearsightedness and astigmatism are after getting Wavelight Plus LASIK, a personalized laser eye surgery. Researchers will measure vision quality, daily life impact, and any visual symptoms like glare or halos for up to 3 months afte…

This study investigates how the eye's focusing ability changes after 20 minutes of looking at a screen up close (25 cm) compared to looking at a distant object (10 m). Healthy adults aged 18-35 will perform focusing tasks while a wavefront sensor measures their eye's response. Th…

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This pilot study is testing how well children aged 6 to 16 adapt to Essilor Stellest myopia-control spectacle lenses. The goal is to see if kids find them comfortable and easy to wear in real life, which is important for long-term use. Fifty children with progressive myopia will …

This study aims to uncover the genetic causes of a group of eye conditions called MAC (microphthalmia, anophthalmia, and uveal coloboma), which can lead to vision loss or blindness. Researchers will collect DNA samples from 600 people—both those with MAC and their close relatives…

This study looks at how nearsightedness (myopia) and other vision problems affect the quality of life of Swedish children and teens. Researchers will translate a vision questionnaire into Swedish and test it on 300 healthy kids aged 0-17. Participants will get a full eye exam and…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study checks if a French version of the MEPS/MEPI elbow score works well for children aged 4 to 17. It includes kids with and without elbow injuries to see if the score accurately measures elbow pain and function. The goal is to make sure doctors can use this tool reliably i…

This study follows 60 children aged 7-12 for three years to measure their daily visual environment, including how far they look, light brightness and color, and eye movements. Researchers want to find which factors most influence the development and worsening of nearsightedness (…

This study is creating a large database of eye measurements from 3,000 people with inflammatory eye diseases like diabetic retinopathy and age-related macular degeneration. Researchers will use advanced imaging to collect detailed information from both the front and back of the e…

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study follows 60,000 people with cataracts, including those with high myopia (severe nearsightedness), to see how their vision changes after cataract surgery. Researchers will also look at genetic and environmental factors that might affect cataract development and surgical …

This research study aims to learn more about children born with small or missing eyes (Microphthalmia, Anophthalmia, and Coloboma, or MAC) and how genetic changes may cause these conditions. Researchers will collect medical histories, saliva, and blood samples, and perform physic…

This pilot study aims to see if using five gene signatures from a patient's tumor can help doctors choose the best first chemotherapy for advanced pancreatic cancer. About 85 people with metastatic pancreatic cancer will have their tumor genes analyzed to pick between two standar…

This study tracks where children aged 7 to 14 look through special spectacle lenses designed to slow nearsightedness (myopia). Researchers want to see if kids look through different parts of the lens depending on what they're doing, like reading or playing. The goal is to underst…

This study looks at whether special glasses for slowing down nearsightedness (myopia) affect how children move and react in daily life. Twenty kids aged 6 to 12 will wear both regular and myopia-control lenses while researchers measure their reaction time, movement speed, and wal…

This study follows thousands of people with keratoconus, a condition that makes the cornea thin and bulge. Researchers measure the eye's shape and vision over many years to understand how the disease starts and changes. No new treatments are tested—the goal is simply to learn mor…

This study looks at a new way to provide eye care to children in rural China. It will involve about 20,000 kids aged 3 to 18 from schools in several counties. The goal is to see if a coordinated program across local health centers and schools can improve eye screening rates and h…

This observational study looks at whether different eyeglass prescriptions change how close teenagers hold objects during everyday tasks. It includes 100 adolescents aged 12-17, both with and without myopia. Participants wear motion-capture and eye-tracking gear while performing …

This study looks at the structure of children's eyes using MRI and standard eye exams. The goal is to understand why some kids respond better to myopia treatments than others. By collecting detailed images and measurements from 100 children, researchers hope to pave the way for m…

This study looks at 200 highly myopic adults in France, the Netherlands, and Spain to understand why some develop a condition called posterior staphyloma, where the back of the eye bulges outward. Researchers will analyze blood samples and eye images to find genetic and molecular…

This study takes skin or blood cells from 20 people with eye malformations and turns them into stem cells, which are then grown into tiny 3D eye-like structures (organoids) in a dish. Researchers will study these mini eyes to understand what goes wrong during development and test…

This pilot study looks at whether refractive surgeries like LASIK change the results of optical coherence tomography (OCT), a common eye scan used to monitor conditions like glaucoma. Researchers will measure the thickness of the retina and other eye layers before and after surge…

This observational study in 120 healthy young adults aged 21-25 examines whether facial features are linked to eye measurements like eye length, which affects nearsightedness or farsightedness. Participants undergo non-invasive eye exams and 3D facial scans. The goal is to better…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study follows 800 children born with eye malformations like microphthalmia, anophthalmia, aniridia, or anterior segment defects. Researchers will track their vision, brain development, and overall health for up to 10 years to better predict outcomes. No new treatments are be…

This early-stage trial is testing whether IVMED-85 eye drops are safe for healthy adults aged 18 to 49. About 36 participants will use the eye drops or a placebo twice daily for 6 weeks. The study focuses on vision changes and eye discomfort, not on treating any disease.

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study is testing whether a computer program called EpiMaster can accurately predict how well laser eye surgery (PTK-PRK) will correct nearsightedness. Researchers will compare the software's predictions to the actual vision results in 150 patients six months after surgery. T…

This observational study is measuring the eye length of 30,000 Chinese children aged 3 to 18 years to create standard growth charts for healthy eyes. Researchers will follow each child for three years with yearly check-ups. The goal is to better understand how eyes grow and when …

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

This study follows 1,000 myopic children in Europe for 5 years, measuring their eye growth every 6 months. The goal is to understand how nearsightedness progresses in this population, since most research has been done in Asia. Participants will have regular eye exams, including a…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study involves 135 adults getting a cornea transplant. Surgeons will use a new method to check the health of donor eye tissue before surgery. The goal is to see if this check helps predict how well the transplant will work long-term, reducing the chance of graft failure.

This study looks at whether a special eye scanner (AO-SLO) can reliably measure cone cells in the retina. It also compares people who have used repeated low-level red-light therapy for myopia with those who haven't. The goal is to see if the therapy changes cone cell density. 180…

This study is testing whether a special eye scanner (OCT) can help fit scleral contact lenses more accurately than the usual method. Researchers will enroll 258 people with conditions like keratoconus or scarred corneas. Each participant will have lenses fitted both the standard …

This study is testing whether three different prototype soft contact lenses can cause a short-term change in the thickness of the choroid (a layer at the back of the eye) in people with nearsightedness (myopia). Twenty volunteers aged 18 to 25 will wear each lens for one hour, an…

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, over two years. Researchers will track changes in vision, corneal shape, and thickness, and analyze tear proteins to better understand how the disease progresses. Some participants will …

This study will compare different laser techniques used in eye surgeries for cataracts and myopia. Researchers want to see which method causes less inflammation and oxidative stress, and leads to better vision recovery. 1,000 patients will be followed for three months after surge…