Ocular growth disorder

This phase 3 trial tested a new type of corneal cross-linking that does not require removing the surface layer of the eye. It involved 398 people aged 8 to 45 with keratoconus, a condition that thins and bulges the cornea. The treatment uses riboflavin eye drops and ultraviolet l…

This trial tests two different contact lenses designed to slow down the progression of myopia (nearsightedness) in children aged 6 to 11. Each child wears one type of lens on each eye for six months, then switches, so researchers can compare how well each lens controls eye growth…

This phase 3 trial tested a new way to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The treatment uses special eye drops and ultraviolet light to strengthen the cornea without removing its outer layer. 396 people aged 8 to 45 took part …

This completed study tested a special lens called HAL for people with nearsightedness (myopia). 88 participants wore either the HAL lens or a standard single vision lens. Researchers measured reading speed and how well they could see at different distances and contrasts. The goal…

This study tested two types of advanced glasses—lenslet spectacles and violet filter glasses—against standard single-vision lenses to see if they could slow the worsening of nearsightedness (myopia) in 90 people aged 8 to 20. Participants wore the glasses during all waking hours …

This study tests whether a graft made from a patient's own or donor stem cells can repair the cornea's surface in people with limbal stem cell deficiency, a condition that causes pain, scarring, and vision loss. A small biopsy of limbal tissue is taken from a healthy eye or donor…

This study tested three low doses of atropine eye drops (0.01%, 0.03%, and 0.05%) in 95 children aged 6–18 with nearsightedness. The goal was to see which dose best slowed the worsening of myopia with the fewest side effects. Over 18 months, the 0.05% dose worked best at controll…

This study tested a drug called faricimab (VABYSMO®) against an existing treatment (ranibizumab) for people with vision loss caused by abnormal blood vessels growing in the back of the eye due to severe nearsightedness. The trial involved 280 participants who received either fari…

This study tested an eye drop called RMP-A03 in 77 healthy volunteers and people with pterygium, a fleshy growth on the eye. The goal was to see if it safely reduces redness and controls the condition. Participants received either a low dose, high dose, or placebo drops, and rese…

This study looked at whether adding bifocal glasses to daily atropine eye drops works better than atropine alone to slow down nearsightedness (myopia) in children. 210 kids aged 4-16 with worsening myopia took part. The main goal was to measure changes in their vision prescriptio…

This phase 3 study tested the long-term safety of LNZ101 eye drops, a combination of aceclidine and brimonidine, in 362 adults aged 45-75 with presbyopia (age-related blurry near vision). Participants used the drops regularly and were monitored for side effects. The study is comp…

This completed study tested whether bright light therapy, special glasses that create myopic defocus, low-dose atropine eye drops, or combinations of these can slow the progression of nearsightedness in schoolchildren. A total of 577 children aged 7-12 with myopia participated. T…

This completed Phase 1 trial tested the VisuMax femtosecond laser to correct nearsightedness (myopia) in 357 adults aged 22 and older. The procedure removes a small lens-shaped piece of the cornea to reshape the eye and improve vision. Researchers measured how well the treatment …

This study tested the safety and effectiveness of the EVO/EVO+ Visian Implantable Collamer Lens (ICL) in 327 adults with moderate to high nearsightedness (with or without astigmatism). The lens is surgically placed inside the eye to correct vision. Researchers tracked side effect…

This completed trial tested whether a specially designed spectacle lens (CARE1.02) can slow the progression of myopia (nearsightedness) in teenagers aged 12 to 17. About 796 teens in Guangzhou, China, wore either the CARE1.02 lens or a standard single-vision lens for one year. Re…

This study tested three strengths of atropine eye drops (0.01%, 0.04%, and 0.1%) in 219 children with high myopia (severe nearsightedness). The goal was to see which dose best slows the worsening of vision and eye growth over two years. Children received one drop in each eye ever…

This study tested whether a new type of spectacle lens (partition multi-point defocus lens) is as good as another advanced lens (aspherical lenslets) at slowing the progression of nearsightedness (myopia) in children. 194 children aged 8 to 13 years wore the lenses for two years.…

This study looked at how well a special lens implant, called the Visian Toric ICL, works over two years for people with nearsightedness and astigmatism. A total of 125 participants received the implant, which sits behind the iris. The main goal was to see if the lens stays in pla…

This study tested special glasses called C.A.R.E. lenses in 100 children aged 6-12 with nearsightedness. The lenses have rings that change how light hits the eye to slow down eye growth. After 12 months, researchers measured changes in eye length and prescription strength to see …

This study looked at how often eye pressure rises after getting an EVO ICL lens implant to correct nearsightedness and astigmatism. Researchers measured pressure in 205 people right after surgery. The goal was to see how many eyes had high pressure, which can be a risk after this…

This study tested whether orthokeratology (OK) lenses, worn overnight, can slow the progression of nearsightedness (myopia) in children aged 8 to 15. The lenses reshape the cornea to change how light focuses on the retina. Researchers measured changes in eye length and retinal fo…

This study tested a modified version of corneal collagen cross-linking, a procedure to strengthen the cornea, in 39 people with keratoconus who had thin corneas. Before the standard treatment, doctors added a small air bubble into the cornea to protect the inner layer. The goal w…

This study tested whether combining low-dose atropine eye drops with special soft contact lenses can slow the progression of high myopia (severe nearsightedness) in children aged 6-12. 120 children were split into three groups: one got the combo therapy, one got atropine alone wi…

This study tested whether a low-intensity red light device could slow the worsening of nearsightedness (myopia) in children aged 8 to 12. Forty children participated, with some using the red light treatment for 3 months while others did not. The main goal was to see if the treatm…

This study tested two different types of contact lenses worn overnight to treat moderate nearsightedness (myopia) with or without astigmatism. Forty adults aged 18 and older with myopia between -4.00 and -6.00 diopters participated. The goal was to see which lens design better im…

This study tested ACUVUE Abiliti 1-Day soft contact lenses designed to manage nearsightedness (myopia) in children. Over 1 to 2 years, researchers measured changes in eye length and vision in 75 participants. The goal was to see if these daily-use lenses can safely slow the worse…

This study tested a special intraocular lens (Vivity EDOF) in 10 adults who had cataracts and mild keratoconus, a condition that thins and bulges the cornea. All participants received the lens in both eyes during standard cataract surgery. The goal was to see if the lens could pr…

This study tested SYD-101 eye drops in 852 children with nearsightedness (myopia). The goal was to slow the worsening of vision over time. Children used the drops daily for up to 3 years. The study measured how much their eyesight changed, aiming to reduce the risk of serious eye…

This study tested whether special glasses (DIMS) are as good as overnight contact lenses (Ortho-K) at slowing myopia progression in children aged 6-12. Ninety kids wore either the glasses or the lenses for 18 months. The main goal was to see if the glasses were not worse than the…

This study tested a new virtual reality (VR) system designed to slow the worsening of nearsightedness (myopia) in children. 116 kids aged 6 to 12 with mild to moderate myopia used the VR training, which creates special visual signals to stop the eye from growing too long. The goa…

This study tested a new type of spectacle lens designed to slow the progression of myopia (nearsightedness) in children. 159 kids aged 6 to 12 wore either the test lens or a standard lens. Researchers measured changes in eye length and prescription strength over time to see if th…

This study tested a new laser system called Cheetah to correct nearsightedness (myopia) with or without astigmatism. About 286 adults with mild to moderate nearsightedness received the treatment. The main goal was to see how many patients achieved clear vision without glasses one…

This completed study compared two common surgeries for moderate nearsightedness: FemtoLasik and implantable collamer lens (ICL) implantation. Researchers looked at how stable the vision correction was, contrast sensitivity, and higher-order aberrations in 60 adults aged 21-40. Th…

This study tested two types of daily disposable contact lenses—Buttermere and MiSight 1 Day—in 10 children and teenagers with myopia (nearsightedness). Each participant wore one lens type for a week, then switched to the other for a week. Researchers measured how clearly they cou…

This study tested whether Deseyne daily disposable contact lenses work as well as 1-Day Acuvue Moist lenses for people with nearsightedness. 81 adults wore both types of lenses and had their vision and eye health checked. The goal was to see if Deseyne is a safe and effective alt…

This study followed 20 people with progressive keratoconus for one year after they received either a standard 30-minute or a faster 10-minute corneal cross-linking treatment. The goal was to see how well each method stopped the disease from getting worse and improved eye shape an…

This study tested a new silicone hydrogel contact lens (MSiHy) for correcting nearsightedness. 134 adults who already wore contacts were randomly assigned to try either the new lens or a standard monthly lens. The goal was to see if the new lens provides clear vision and is safe …

This study tested two ways to treat keratoconus, a condition where the cornea thins and bulges. One method removes the cornea's outer layer before treatment, while the other keeps it intact and customizes the light pattern. Researchers followed 135 adults for 24 months to see whi…

This early safety study tested a bioengineered corneal implant called LinkCor in 20 adults with advanced keratoconus, a condition that thins and bulges the cornea. The implant is placed inside the cornea to flatten it and improve vision, without needing human donor tissue. Resear…

This completed study tested how well delefilcon A contact lenses with different diameters and base curves fit the eyes of 257 people with nearsightedness. Researchers checked lens movement and centration right after insertion and again after 6 hours. The goal was to find which le…

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps a…

This completed early-phase study tested a daily drink called Baby Drink, which contains lutein, blueberry extract, vitamins, and minerals, in 20 adults with mild myopia (nearsightedness less than 700 degrees). Participants took one 20 ml pack per day for one month. Researchers tr…

This study tested an eye drop called LNZ101 to help people with presbyopia (age-related trouble seeing up close) read without glasses. 469 adults aged 45-75 received the drops, and researchers measured how many gained clear near vision without losing distance vision on the first …

This study compared two types of lasers used to create the flap in LASIK eye surgery for nearsightedness. 120 adults each had one eye treated with the Intralase laser and the other with the Visumax laser. The goal was to see which laser caused less discomfort during surgery and l…

This study looked at how well contact lenses perform and how comfortable people find them. It included 36 adults who already wear soft contact lenses and have nearsightedness or farsightedness. Participants wore the lenses and had their vision tested after 10 hours.

This study compared two types of soft multifocal contact lenses (Proclear 1 Day and Clariti 1 Day) to see which one people liked better. 67 adults who already wore contact lenses and needed reading glasses tried both lenses and rated their overall satisfaction. The goal was to he…

This study compared two types of soft contact lenses to see which one people liked better for vision and comfort. 52 adults who wear contacts took part. They rated the lenses on a scale from 0 to 100. The goal was to find out if one lens performed better in everyday use.

This study tested how comfortable two different daily soft contact lenses feel right after putting them in. 45 adults who already wear contacts and have mild to moderate nearsightedness rated each lens on a 0-100 comfort scale. The goal was to see if one lens feels better than th…

This study tested two types of soft contact lenses—Proclear 1 Day and MyDay sphere—to see which one feels more comfortable. 44 adults who already wear contact lenses rated comfort on a scale from 0 to 100. The goal was simply to compare the lenses, not to treat or cure any eye di…

This study tested two types of soft contact lenses—Myday Sphere and Myday Toric—in 32 people who already wear spherical lenses but have low astigmatism. Participants wore each lens type for one week and rated comfort on a 0-100 scale. The goal was to see if the toric lens offers …

This Phase 3 trial tested LNZ101 eye drops in 229 people aged 45-75 with presbyopia, a condition that makes it hard to see up close. The drops combine aceclidine and brimonidine to temporarily improve near vision. The main goal was to see if participants could read three lines be…

This study tested two types of soft contact lenses in 73 children and teenagers (ages 8 to 18) with nearsightedness. Researchers checked how well the lenses stayed centered on the eye and moved with each blink after at least three hours of wear. The goal was to see which lens per…

This study tested whether a numbing gel (lidocaine) works as well as a needle injection for pain relief during pterygium surgery. 41 adults having pterygium removal took part. The goal was to see if the gel causes less pain and eye dryness after surgery.

This early-phase study tested the safety of PRO-201 eye drops (a low-dose atropine solution) in 29 healthy adults aged 18 to 35. The main goal was to see if the drops cause unexpected side effects or light sensitivity. Researchers also checked vision, eye pressure, and comfort. T…

This study tested new multifocal contact lenses designed for people with both presbyopia (age-related blurry near vision) and astigmatism (blurry vision due to an irregularly shaped cornea). 95 habitual contact lens wearers wore the lenses for 30 days, and researchers measured ho…

This study tested whether a 'dynamic defocus' display mode can help reduce visual fatigue in adults who regularly use screens. 36 participants watched videos with different display settings, and researchers measured eye focus ability and tiredness. The goal is to find a simple wa…

This study tested a special lens implant (EVO+ Visian ICL) in 47 adults to correct or reduce nearsightedness, farsightedness, astigmatism, and age-related reading problems (presbyopia). The lens was placed inside the eye to improve vision at all distances without removing the nat…

This study tested how well DAILIES TOTAL1 daily disposable contact lenses work for people with myopia (nearsightedness) who use digital devices for at least 8 hours a day. 41 adults rated their comfort, dryness, and vision clarity after a day of screen use. The goal was to see if…

This study tested whether switching from Acuvue Oasys contact lenses to PRECISION7 lenses improves comfort and reduces dry eye symptoms. Seventy-one adults who were happy with their current lenses wore PRECISION7 lenses for two weeks. They completed surveys about their experience…

This study tested two different multifocal contact lenses in 106 people with presbyopia, an age-related condition that makes it hard to see up close. Participants wore each lens for a week to see how well they could see at different distances. The goal was to compare the performa…

This completed study tested a new daily disposable contact lens called DSiHy for correcting nearsightedness (myopia). 134 adults who already wore contacts were randomly assigned to use either the new lens or a standard daily lens. The goal was to see if the new lens provides clea…

This study tested whether a program of eye exercises could improve visual function and quality of life in 40 adults with refractive errors like nearsightedness, farsightedness, or astigmatism. Participants did 20-minute sessions three times a week for eight weeks, plus home exerc…

This study measured how three common eye surgeries—LASIK, PRK, and corneal cross-linking (CXL)—change the stiffness of the cornea. Using a device called Corvis ST, researchers assessed 150 adults who had undergone one of these procedures at least a month earlier. The goal was to …

This study investigates how low doses of atropine eye drops (0.01%, 0.02%, and 0.05%) affect pupil size and the eye's ability to focus in healthy adults aged 18 to 40. Researchers aim to compare different dosing methods and recovery times, and to see if iris color influences the …

This study tested whether surgeons can safely use an Apple Vision Pro headset to view a microscope during cataract and other eye surgeries. 45 adults having elective eye surgery took part. The goal was to see if the headset is safe and comfortable for the surgeon, not to change h…

This study explores whether things a mother is exposed to during early pregnancy might cause uveal coloboma, a rare eye condition present at birth. Researchers will survey mothers of affected children and compare their answers to historical data. The goal is to identify possible …

This study examined 39 people with severe nearsightedness to see if lower levels of a natural eye pigment (macular pigment) are linked to tiny cracks in the back of the eye called lacquer cracks. These cracks can lead to vision loss. The researchers measured the pigment's optical…

This study followed 248 children with nearsightedness who wore soft bifocal contact lenses for two years and then switched to regular lenses for a third year. Researchers measured eye growth, light exposure, and pupil responses to understand why some children's nearsightedness ge…

This study tested a new questionnaire to better understand eye rubbing habits in people with or suspected keratoconus, a condition where the cornea thins and bulges. Researchers enrolled 292 participants to see if the questionnaire is reliable and useful. The goal is to improve h…

This study looked at how nearsightedness (myopia) affects the quality of life of children and adults. Researchers surveyed parents of nearsighted children and adults with long-term complications from myopia. The goal was to understand the real-world impact of the condition, not t…

This study tested a new device called the EYESTAR 900, which uses light to take detailed measurements of the eye's shape. 29 people with healthy eyes, corneal scarring, or irregular astigmatism took part. The goal was to see how well the new scanner measures eye geometry compared…

This completed study looked at how satisfied 300 people were with their vision at least one year after having Wavelight LASIK surgery for nearsightedness (myopia). Researchers also checked for dry eye symptoms using standard questionnaires. The goal was to understand real-world p…

This study looked at data from 1100 people who had SMILE laser eye surgery to fix nearsightedness. Researchers used a computer model to predict how well patients would see one year after surgery. The goal was to see if the model could give more accurate results than the usual pla…

This study followed 609 nearsighted adults who had lens surgery to see if a natural eye change called posterior vitreous detachment (PVD) affects their risk of retinal detachment. Participants were grouped by whether they had PVD before surgery or not, and were monitored for up t…

This study looked at 154 people with keratoconus, a condition that thins and bulges the cornea, to understand why it is often worse in one eye than the other. Researchers compared those with uneven severity to those with similar severity in both eyes, focusing on eye rubbing habi…

This study tested a digital color scale to objectively measure scarring of the eye's surface in people with recurrent pterygium, a growth that can come back after surgery. Researchers took photos of 25 patients' eyes and used software to analyze the scar tissue. The goal was to s…

This study tested a device called IOLMASTER 700 TK to see if it can more accurately measure the eye's curvature in people who had laser vision correction and now need cataract surgery. Researchers compared four different lens calculation methods in 155 adults. The goal was to imp…

This completed study gathered detailed measurements of the eye's surface and visual imperfections from 52 adults with keratoconus, a condition that thins and bulges the cornea. Researchers used a special scanner to map the cornea and sclera. The goal is to use this real-world dat…

This study looked at whether a central monitoring station outside the operating room could safely replace having an anesthesia nurse in each room during eye surgeries like cataract removal. Researchers compared the rate of complications (like high blood pressure or low oxygen) be…

This study examined 152 people with hereditary ichthyosis to find out how common eye problems are. Participants received a full eye exam, including tests for dry eye, corneal shape, and vision. The goal was to detect hidden issues like keratoconus, which can lead to vision loss i…

This study looked at two methods for fixing a tissue graft after removing a pterygium, a growth on the eye's surface. In 30 patients with pterygium in both eyes, one eye received stitches and the other did not. Researchers used special imaging to compare healing, comfort, and gra…

This study looked at how light enters and focuses in the eyes of 23 nearsighted children. Researchers measured both central and side vision to better understand myopia. No treatment was given—the goal was simply to gather information.

This study looked at 52 soft contact lens wearers to see if a computer program (ImageJ) can measure eye redness more accurately than the standard grading system. The goal is to catch early signs of eye irritation. Participants wore lenses for two weeks and had their eyes checked …

This completed study looked at 100 people with low-to-moderate nearsightedness who chose either SMILE or LASEK laser eye surgery. Researchers measured contrast sensitivity and eye-brain signals to see how visual quality changed after surgery. The goal was to understand how age af…

This study used tiny temperature sensors hidden in glasses frames to track how often children wore their myopia-control spectacles. Fifty-three kids aged 6 to 15 who already used these glasses for at least three months took part. The goal was to understand real-world wearing patt…

This completed study tested a virtual eye model system (VEMoS) to help personalize cataract and refractive surgery. Researchers collected eye measurements from over 500 participants, including those having surgery and those with healthy eyes. The goal was to find which measuremen…