Head and neck cancer

This trial tests whether adding a vaccine called BNT113 to the immunotherapy drug pembrolizumab works better than pembrolizumab alone for people with advanced head and neck cancer linked to HPV16. About 350 participants will receive either the combination or the standard single d…

Researchers are testing a shorter radiation schedule for people with head and neck cancer who have had surgery. Standard radiation after surgery often takes several weeks, but this trial gives five treatments over five days. The study enrolls 50 adults with high-risk features, su…

This study provides continued access to the cancer drug palbociclib (IBRANCE) for up to 35 patients with breast or head and neck cancer who have already benefited from it in earlier Pfizer trials. Participants will keep taking their current treatment combination, which may includ…

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This early-phase study tests a new cancer vaccine (DPV-001) combined with two immunotherapy drugs in people with head and neck cancer that has returned or spread. The goal is to see if the combination is safe and can help control the cancer. About 56 adults with recurrent or meta…

This trial tests whether adding weekly thermotherapy, a treatment that heats the tumor and lymph nodes, to standard radiotherapy can help people with head and neck cancer who cannot receive chemotherapy. The goal is to find a safe dose of thermotherapy that does not cause severe …

This study tests a three-drug combination called CACTUX (cisplatin, nab-paclitaxel, and cetuximab) in 74 people with head and neck cancer that cannot be cured. The goal is to see if this mix works better and causes fewer side effects than the standard treatment. Participants have…

This trial tests whether giving a lower dose of radiation after initial chemoimmunotherapy can control advanced head and neck cancer as well as the standard higher dose. Adults with head and neck squamous cell carcinoma who respond well to 2-3 cycles of chemotherapy plus the immu…

This early-stage trial tests a personalized cell therapy called ADP-A2M4CD8 in people with certain cancers that have a specific marker (MAGE-A4). The therapy uses a patient's own immune cells, modified to better attack tumors, and is given alone or with standard immunotherapy dru…

This trial tests whether giving radiation to a smaller area of the neck can prevent throat cancer from returning while reducing side effects. People with p16-positive oropharynx cancer (a type linked to HPV) who are getting radiation therapy may be eligible. The goal is to see if…

This study tests a combination of the targeted drug amivantamab plus two chemotherapy drugs (carboplatin and paclitaxel) in 50 people with head and neck cancer that has come back or spread. The goal is to see if this treatment shrinks tumors or controls the disease. Participants …

This phase II trial is investigating whether giving immunotherapy before surgery can boost the immune system's attack on head and neck squamous cell carcinoma. Participants receive atezolizumab alone or combined with other immune-modulating agents, then undergo surgery. The study…

This phase II trial compares two types of radiation for people whose head and neck cancer has come back and cannot be removed with surgery. One method delivers high-dose radiation in fewer sessions, while the other uses standard daily doses over several weeks. The study aims to s…

This phase 2 trial tests whether it is safe to skip radiation on one or both sides of the neck that show no signs of cancer after surgery. The goal is to reduce side effects like dry mouth and trouble swallowing without increasing the chance of cancer returning. The study include…

This study tests whether a precise type of radiation called SBRT can restore the effectiveness of immunotherapy drugs in people whose metastatic cancer has started to progress. About 69 adults with melanoma, lung, bladder, kidney, or head/neck cancers will receive radiation to up…

This trial investigates whether giving the immunotherapy drug nivolumab along with a short course of radiation before surgery can safely shrink tumors and reduce lymph node involvement in people with head and neck squamous cell carcinoma. Participants receive either 3 or 5 days o…

This phase 2 trial tests an experimental drug called disitamab vedotin in people with advanced head and neck, lung, endometrial, or ovarian cancers that have a protein called HER2. The drug is designed to stick to cancer cells and kill them. Researchers want to see if it shrinks …

This trial is for people with advanced cancers who have already responded well to 6 months of standard immunotherapy. It compares continuing the same drugs at the usual frequency versus giving them every 3 months. The goal is to see if the reduced schedule can prevent cancer prog…

This phase 1 study tests whether adding a highly targeted, high-dose radiation boost (stereotactic body radiotherapy, or SBRT) to standard radiation and chemotherapy can safely treat head and neck cancer that has come back or spread. The trial includes two groups: patients whose …

This early-stage trial is testing a new drug called IDE161, alone or with the immunotherapy pembrolizumab, in adults with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The main goals are to check safety, find the right dose, and get a first look at wheth…

This phase 2 trial tests a weekly combination of two chemotherapy drugs (carboplatin and paclitaxel) plus the immunotherapy pembrolizumab in 31 patients with metastatic head and neck cancer who cannot receive the standard drug 5-fluorouracil. The goal is to see if this regimen sh…

This early-phase trial tests a new drug called NT219 combined with either pembrolizumab or cetuximab in 29 adults with head and neck cancer that has returned or spread. The goal is to see if the combination shrinks tumors. Participants receive weekly NT219 plus one of the other d…

This study was designed for people with advanced head and neck cancer that had spread or come back. It aimed to test a combination of two drugs: decitabine (a chemotherapy drug) and nivolumab (an immunotherapy drug). The goal was to see if the combination was safe and could help …

This phase 2 trial tests whether adding focused radiation to the immunotherapy drug pembrolizumab (Keytruda) can help people with head and neck cancer whose disease has worsened despite prior PD-1 therapy. The study enrolls 18 adults with metastatic or incurable head and neck can…

This early-phase trial tests whether injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions is safe and can shrink them. The study involves 18 adults with untreated oral lesions. The goal is to see if this local approach can reduce the risk of thes…

This early-phase study tests a new oral drug called E7386 in about 60 adults with advanced solid tumors (like desmoid tumors) that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. Researchers will also watch for any tu…

This early-phase study tests a personalized cell therapy for people with certain cancers (bladder, melanoma, head/neck, ovarian, lung, esophageal, stomach, or sarcoma) whose tumors have a specific marker called MAGE-A4. The treatment involves taking a patient's own immune cells, …

This study tests whether giving a combination of three drugs (finotonlimab, cetuximab, and docetaxel) before surgery can shrink tumors in people whose head and neck cancer has come back after prior immunotherapy and chemotherapy. The goal is to see if this approach leads to fewer…

This study looks at whether adding chemotherapy (cisplatin) to standard radiation therapy after surgery helps people with high-risk salivary gland tumors live longer without the cancer returning. About 252 adults whose tumors were removed took part. The goal is to see if the comb…

This phase II trial tests a combination of the immunotherapy drug pembrolizumab and a short course of radiation called QUAD SHOT in 30 adults with recurrent head and neck cancer that cannot be cured. The goal is to see if the combination is safe and can shrink tumors or improve q…

This phase 2 trial is testing whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard treatment—surgery, radiation, and sometimes chemotherapy—can help people with head and neck cancer live longer without the cancer returning. About 96 participants will receive…

This study tests two experimental vaccines (HB-201 and HB-202) given with standard chemotherapy drugs (carboplatin and paclitaxel) to people with HPV16-positive oropharyngeal cancer. The goal is to see if this combination can shrink tumors enough to allow less intensive follow-up…

This phase 2 trial tests giving the immunotherapy drug pembrolizumab (Keytruda) along with a short course of targeted radiation before surgery for people with advanced head and neck cancer. The goal is to see if this combination can shrink tumors more effectively and help preserv…

This phase 2 trial tests whether adding ramucirumab to pembrolizumab (Keytruda) works better than pembrolizumab alone for people with PD-L1 positive head and neck cancer that has come back or spread. About 37 participants will receive either the combination or the single drug. Th…

This study tests whether adding two experimental drugs (INCAGN02385 and INCAGN02390) to the immunotherapy retifanlimab can better control advanced head and neck cancer that has returned or spread. About 176 adults with PD-L1-positive tumors who have not had prior systemic therapy…

This early-stage study tests a new drug called DS-1055a in about 40 adults with advanced solid tumors (like head and neck, stomach, or lung cancer) that have come back or spread and no longer respond to standard treatments. The main goal is to check the drug's safety and find the…

This early-phase study is testing whether giving a shorter, more intense course of radiation before surgery is safe for people with head and neck cancer. The trial involves 12 adults with HPV-negative, surgically removable tumors. The main goal is to see if this condensed radiati…

This early-phase study tests whether injecting methylene blue (a dye) directly into tumors can make radiation therapy work better for people with head and neck cancer that has come back and is resistant to radiation. Ten participants will receive weekly tumor injections plus dail…

This study tests a new proton therapy machine called PROTEUS® PLUS in 47 adults with solid tumors. The goal is to see if it is safe and effective at controlling cancer. Researchers will measure tumor response and track side effects.

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This early-phase study tests a combination of two targeted drugs, palbociclib and gedatolisib, in people with advanced lung, pancreatic, head & neck, or other solid tumors that have stopped responding to standard treatments. The main goal is to find the safest dose and look for e…

This study tests whether a special scan (SPECT/CT) can map where a head and neck tumor drains lymph fluid. If the scan shows no drainage to the opposite side of the neck, doctors can safely avoid radiating that side, reducing side effects. About 90 patients with newly diagnosed h…

This study tests two immunotherapy drugs, nivolumab and ipilimumab, given before surgery to people with oral cavity squamous cell carcinoma. The goal is to see if these drugs can shrink tumors and are safe to use. About 30 adults with tumors larger than 2 cm or lymph node involve…

This study tests an oral drug called APG-157 given before standard treatment (surgery or radiation) for people with newly diagnosed head and neck cancer. The goal is to see if the drug can shrink tumors and improve outcomes. About 24 adults with early to advanced stage cancer wil…

This study tests a new proton therapy device, PROTEUS PLUS, in 47 adults with solid tumors. The goal is to see if it safely controls tumor growth. Participants receive targeted radiation, and researchers track side effects and disease response over time.

This phase III trial studies whether adding the drug cetuximab to modern radiation therapy improves survival for people with advanced head and neck cancer that has been surgically removed. About 700 participants received either radiation alone or radiation plus cetuximab. The stu…

This study tests whether the drug nivolumab (Opdivo) can reverse early, pre-cancerous changes in the lungs of current or former heavy smokers who are at high risk for lung cancer. Nineteen participants receive nivolumab to see if their lung tissue improves over six months. The go…

This study tests whether wrapping the spinal accessory nerve with a porcine (pig) tissue product during neck dissection for head and neck cancer can prevent shoulder problems. About 74 adults who have not had prior neck surgery will be enrolled. Researchers will measure shoulder …

This early-stage study tests a new treatment called T-Plex for people with advanced solid tumors (like head and neck, cervical, or melanoma) that haven't responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and…

This study was designed to see if adding low-dose radiotherapy to a combination of targeted therapy (Afatinib) and immunotherapy (Tislelizumab) before surgery could improve outcomes for people with resectable head and neck cancer. The trial was withdrawn before enrolling any part…

This study tests an experimental drug called BT5528, given alone or with another drug (nivolumab), in people with advanced solid tumors that have high levels of a protein called EphA2. The cancers include ovarian, bladder, lung, breast, head and neck, and stomach cancers. The mai…

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced solid tumors like bladder, breast, lung, or ovarian cancer. The drug targets a protein called Nectin-4 found on some cancer cells. The trial aims to find safe doses and …

This phase 2 trial tests whether giving cisplatin chemotherapy weekly alongside radiation causes fewer severe side effects than the standard every-3-week schedule in people with head and neck cancer. About 80 participants will receive one of the two schedules. The study also look…

This study looks at whether a special drink made with easily digested protein and MCT oil can help improve malnutrition in cancer patients who are having radiotherapy. The study will follow 132 adults with head and neck, lung, rectal, or esophageal cancer for 12 weeks. Researcher…

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than the standard chemotherapy drug cisplatin with radiation for patients with a certain type of head and neck cancer (p16-positive). About 126 adults with advanced or in…

This pilot study aimed to test the safety of adding the drug Temsirolimus (Torisel) to standard chemoradiotherapy for people with advanced head and neck cancer. The goal was to find a safe dose of Temsirolimus when given alongside radiation and other chemotherapy drugs like Cetux…

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

Radiation teams use cone beam CT scans to line up patients with the treatment beam, but standard images are not clear enough to map tumors or calculate doses. This study tests whether a new imaging system called HyperSight, built into the TrueBeam radiotherapy machine, can produc…

This early-phase trial is testing the safety of a new imaging drug called [18F]PARPi in 12 people with head and neck cancer. The drug is designed to make cancer cells show up more clearly on PET/CT scans. The goal is to see if this approach can provide better pictures of tumors t…

This early-phase trial explores whether two experimental PET/CT tracers, 68Ga-FAPI-46 and 68Ga-PSMA-11, can accurately highlight various non-prostate cancers, including breast, lung, and pancreatic tumors. Participants scheduled for surgery will receive the tracers before their s…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study tests a new dye, called cRGDY-PEG-Cy5.5-C dots, to help surgeons see cancer in lymph nodes during head and neck melanoma surgery. About 67 people will receive the dye injection around their tumor before or during surgery. The dye is not a treatment, but may improve how…

This pilot study tests a radioactive imaging agent called 111In-panitumumab in 28 people with head and neck cancer. The goal is to see if it can safely and accurately find cancer in lymph nodes compared to the standard dye method used during surgery. The study is currently suspen…

This study tests whether starting physiotherapy early—before any swelling appears—can prevent lymphedema in people treated for head and neck cancer. Twenty participants will either use a home compression device daily or receive standard care. Researchers will track swelling and u…

This study tests whether a superoxide dismutase (SOD) spray can prevent severe radiation dermatitis (skin burns) in 140 head and neck cancer patients undergoing radiotherapy. The spray aims to neutralize free radicals that cause skin damage. If effective, it could reduce treatmen…

This study tests whether a superoxide dismutase (SOD) spray can prevent severe radiation dermatitis (skin burns) in 140 head and neck cancer patients undergoing radiotherapy. The spray aims to neutralize free radicals that cause skin damage. Researchers will check patients weekly…

This study was designed to test whether an oral drug called SPI-1005 could prevent hearing loss and ringing in the ears caused by platinum-based chemotherapy. It was planned for adults with advanced lung or head and neck cancer. The study was withdrawn before enrolling any partic…

This study tests whether using home sensors to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE sensor system plus standard care, or standard care alone. The goal is …

This Phase 3 trial tests whether acupuncture can prevent dry mouth (xerostomia) in 435 head and neck cancer patients receiving radiation. Participants are split into two different acupuncture groups or a standard care group. The study compares which approach better reduces dry mo…

Researchers at Uppsala University are testing whether an internet-based support program called Carer eSupport helps informal caregivers of head and neck cancer patients feel more prepared for their role. The trial enrolls 110 caregivers whose relatives are about to start or have …

This study is testing whether a 12-week virtual program of mind-body classes (like yoga, dance therapy, and tai chi) can reduce fatigue and improve quality of life for people with head and neck, thoracic, gynecologic, or other cancers. About 480 adults currently receiving cancer …

This phase 3 trial tests whether a 'miracle fruit' cube (miraculin) can improve taste loss in head and neck cancer patients undergoing radiation therapy. Taste problems are common and hard to treat during radiation. The study will compare the fruit cube to a placebo in 40 patient…

This study tests whether manual therapy—gentle massage and stretching of the neck, throat, jaw, and mouth—can improve swallowing and movement in head and neck cancer survivors who have long-term swallowing problems due to tissue scarring (fibrosis). About 24 survivors who finishe…

This early-phase study tests whether injecting a person's own bone marrow stem cells into their salivary glands is safe and tolerable for treating dry mouth caused by radiation therapy for head and neck cancer. About 23 participants who finished radiation at least 2 years ago wil…

This study looks at whether a yoga program can improve physical performance, quality of life, and reduce symptoms for cancer patients undergoing radiation therapy and their partners. About 600 patients with lung, head and neck, or esophageal cancer, along with their partners, wil…

This study tests a preventive program to stop taste changes in head and neck cancer patients receiving radiation therapy. About 80 participants will either get the program (mouth massage, ice, taste training) or standard care. The goal is to help patients enjoy food and avoid wei…

This study compares a new counseling approach called Acceptance and Commitment Therapy (ACT) with standard counseling to help people with head and neck, lung, breast, gastrointestinal, or genitourinary cancer stop smoking. About 51 adults who smoke at least one cigarette per day …

This pilot study looks at whether giving fluoride varnish during regular cancer checkups can help protect the teeth of head and neck cancer patients who have had radiation and lack easy access to a dentist. About 43 uninsured or underinsured adults will receive 4-5 fluoride treat…

This study tests whether wrapping the nerve that controls the shoulder with a protective cover during neck cancer surgery can reduce pain and improve shoulder function a year later. About 90 adults with head and neck cancer who need neck dissection are taking part. The goal is to…

This study compares two approaches to treating lymphedema (swelling) in people who have had head and neck cancer. One group gets all their therapy in a clinic, while the other starts with a few in-person sessions and then continues via video calls at home. The goal is to see if t…

This study compares two pain management approaches—neurofeedback (brain wave training) and a supportive care team—against standard care in 28 head and neck cancer patients at risk of misusing opioids. The goal is to see if these methods can lower pain and reduce the need for stro…

This study aimed to compare three tube feeding methods—bolus, gravity, and pump—in 60 head and neck cancer patients undergoing chemoradiation. The goal was to see which method leads to the least weight loss and best tolerance. However, the trial was withdrawn before any patients …

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. It includes remote monitoring and home visits to reduce the need for hospital stays or emergency room visits. The goal is to see if this approach improves quality…

This small pilot study tests whether neurofeedback training can help reduce pain caused by radiation therapy in head and neck cancer patients. Participants learn to modify their own brain waves using EEG and computer software. The goal is to see if this technique can lower pain p…

This study looks at whether exercising the muscles used for coughing and swallowing can reduce the risk of pneumonia in people who had radiation for head and neck cancer. About 175 survivors are involved. The main goal is to see if stronger cough muscles help prevent food or sali…

This study looks at whether a yoga program designed for both head and neck cancer patients undergoing radiation and their family caregivers is practical and helpful. About 236 patient-caregiver pairs will take part. The goal is to see if yoga can improve quality of life, reduce f…

This study tests whether a spray made from spirulina (a type of algae) can prevent or reduce severe mouth sores in people receiving radiation for head and neck cancer. About 70 patients will use either the spirulina spray or a placebo spray during their radiotherapy. The goal is …

This study tests whether a chatbot that texts patients and tracks their phone activity can catch cancer treatment symptoms early. About 70 adults with lung, gastrointestinal, or head and neck cancers will use the chatbot during chemo and radiation. The goal is to see if this appr…

This study tests an online program called Empowered Survivor, designed to help people who have had oral or throat cancer feel more confident managing their health after treatment. Researchers are comparing it to a free online tool already available for cancer survivors. The goal …

This study tests a nurse-led digital tool for adults who have finished treatment for head and neck cancer. The tool helps track symptoms, offers self-care tips, and connects patients with nurses. Researchers want to see if it improves quality of life compared to standard follow-u…

This phase 3 trial tests whether injecting a fluid (tumescence) before harvesting a skin graft helps the graft heal better after head and neck cancer surgery. About 58 adults having reconstructive surgery will be randomly assigned to receive tumescence or standard care. The main …

This pilot study tested whether kava, a herbal supplement, could safely reduce anxiety and stress in 43 cancer survivors who had completed treatment. Participants took either kava or a placebo for 14 days, then switched after a washout period. The trial is currently suspended, an…

This study tests whether the antiviral drug valacyclovir can prevent or reduce painful mouth sores (oral mucositis) in adults receiving radiotherapy for head and neck cancer. Researchers will give either valacyclovir or a placebo to 84 participants during their radiation treatmen…

This study tests a prehabilitation program for 80 adults with head and neck cancer. The program provides personalized education and support before and during cancer treatment to improve emotional well-being, reduce distress, and enhance quality of life. Participants are compared …

This study tests a new low-cost device designed to help people who developed lockjaw (trismus) after radiation treatment for head and neck cancer. The device is a non-invasive jaw stretcher with sensors that measure pressure and how wide the mouth opens, giving real-time feedback…

This study tests whether far infrared therapy (gentle heat) and TENS (mild electrical pulses) can reduce pain and improve neck movement in people recovering from head and neck cancer surgery. 90 patients will be split into three groups: one getting usual care, one getting TENS, a…

This study compares proton beam radiation to standard photon radiation (IMRT) for people with head and neck cancer. The goal is to see if proton therapy causes fewer side effects, like painful mouth sores, by exposing less healthy tissue to radiation. About 108 adults with certai…

This study tests whether a smartphone app called MyFood can help head and neck cancer patients track their diet, symptoms, and weight during treatment. The goal is to reduce malnutrition and improve quality of life. About 125 patients will use the app to record their food intake …

This study aimed to see if using MRI scans to guide radiation away from the main saliva ducts could reduce dry mouth in people with oropharynx cancer. The trial planned to compare standard radiation with a new approach that spares these ducts. However, the study was withdrawn bef…

This study tests a new program designed to help head and neck cancer patients who feel depressed. The goal is to see if the program is practical and liked by patients, and if it can improve their mood and help them follow through with swallowing exercises and dental care. About 1…

This study tracks 125 head and neck cancer patients after surgery to see how many end up using opioid painkillers long-term. Researchers will also look at factors like symptom burden and risk of opioid misuse. The goal is to better understand who is most at risk and why.

This study investigates whether head and neck cancers caused by HPV have different genetic profiles compared to those linked to alcohol and tobacco use. By analyzing tumor biopsies, researchers aim to identify genetic markers that could predict how well a patient responds to chem…

This pilot study tests whether a newer type of CT scanner (photon counting detector CT, or PCD-CT) can improve the quality of PET images for people with head and neck cancer. Twenty adults who are already scheduled for a standard PET-CT scan will also receive a PCD-CT scan. Resea…

This trial tests whether an artificial intelligence program can automate two key steps in radiotherapy planning: outlining areas at risk of tumor spread or radiation damage, and designing the radiation beams. The AI tool is compared against the standard manual process done by onc…

This study follows people who have received photodynamic therapy (PDT) for various cancers, including head and neck, lung, and skin tumors. PDT uses a light-sensitive drug and a special light to destroy cancer cells while sparing healthy tissue. Researchers will review medical re…

This observational study collects extra tumor tissue from 416 people with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) during routine biopsies. The goal is to develop and train a 'live tumor diagnostic platform' that can predict whe…

This study is testing whether a blood test can find tiny bits of tumor DNA (ctDNA) or HPV DNA in patients with high-risk head and neck cancer after standard treatment. The goal is to see if this test can detect cancer that remains or comes back earlier than usual scans. The study…

This study collects blood, urine, and tissue samples from 330 adults with advanced lung or head and neck cancer to improve precision medicine. Researchers will analyze genetic changes in these samples and grow some tumors in mice to compare DNA. The goal is to refine liquid biops…

This study is a long-term follow-up for 400 people who previously received A2 Bio gene therapy for various solid tumors, including colorectal, lung, pancreatic, and ovarian cancers. No new treatment is given; instead, researchers will track participants over time to check for del…

This study looks at whether extra MRIs and blood tests can help doctors predict how head and neck tumors change during radiation therapy. Up to 100 people (80 patients and 20 healthy volunteers) will take part. The goal is to learn more about tumor growth and response, not to tes…

This study tests whether creating a virtual 3D map of a patient's removed tumor helps doctors plan radiation therapy more precisely. Researchers will compare standard radiation plans with plans that include the 3D map to see if it changes the treatment area or reduces radiation t…

This study looks at whether giving doctors a patient's genetic information can help them personalize chemotherapy doses and reduce serious side effects. About 860 adults with certain cancers (like breast, stomach, or head and neck) will be randomly assigned to have their doctors …

This study is testing a new, non-invasive device that uses light to monitor blood flow in transplanted skin after head and neck cancer surgery. The goal is to catch poor blood supply early so doctors can intervene and save the tissue. The study will enroll 60 adults undergoing th…

This study tests whether artificial intelligence (AI) can analyze medical scans (CT, MRI, PET) to predict how well head and neck cancer patients will respond to radiation therapy and whether they will have side effects. The goal is to personalize treatment for better outcomes. Ab…

This study tests a new imaging tool called HyperSight that takes clearer, faster pictures during radiation therapy for cancers of the head/neck, breast, lungs, upper GI, or pelvis. The goal is to see if these images are good enough to help doctors plan treatment more precisely, p…

This study was designed to test whether automatic software could accurately outline tumors and healthy organs on daily CT scans during radiation therapy for head and neck cancer. The goal was to save time and improve precision compared to manual contouring. However, the study was…

This study checks if a special scale can accurately measure muscle and fat in 50 head and neck cancer patients getting radiation therapy. The goal is to see if the scale can spot muscle loss early, helping doctors decide when to add nutrition support or a feeding tube. Participan…

This study tracks 130 adults who have had their voice box removed (laryngectomy) to see how often they use a special breathing filter called a heat-moisture exchanger (HME). Researchers at MD Anderson Cancer Center want to learn what factors—like patient habits or clinical follow…

This study looks at blood samples from 25 cancer patients receiving radiation therapy. Researchers want to find specific genes that show how each person's body responds to radiation. The goal is to better understand individual reactions and possibly personalize radiation treatmen…

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study collects tumor tissue, blood, and saliva from 2500 people with various solid cancers to analyze their genetic makeup. The goal is to understand why some tumors become resistant to targeted therapies. Samples may also be grown in special mice to study how genetics affec…

This study follows 100 head and neck or lung cancer patients who are current or former smokers and receive radiation therapy. Researchers track who stays smoke-free at 1, 6, and 12 months after treatment ends, and what factors help or hinder abstinence. The goal is to learn how t…

This study uses three advanced MRI techniques to see if they can predict how well head and neck cancer patients will respond to surgery or chemo-radiation. About 272 adults with head and neck cancer will get these scans before and early during treatment. The goal is to find marke…

This study tests a friendly computer character that talks with cancer patients to help them report their symptoms more completely. About 100 adults with gastrointestinal or head and neck cancer who are getting chemotherapy or radiation will use this system. The goal is to see if …

This study follows 100 head and neck cancer patients receiving standard radiotherapy to see how their teeth, gums, and saliva change over time. Researchers measure gum health, tooth condition, and quality of life before and after treatment. The goal is to better understand these …

This pilot study aimed to see if a mobile health app could help track symptoms and quality of life in people with recurrent head and neck or gynecologic cancers. Participants would have used the app to report their feelings, side effects, and barriers to care. However, the study …

This study looks at dental and jaw problems in children who had proton beam therapy for head and neck cancer. Researchers will survey survivors and review dental records to see how often these side effects occur and how they relate to radiation dose. The goal is to gather informa…

This study tests whether a special type of MRI, called diffusion MRI, can accurately measure how head and neck tumors change during chemotherapy and radiation. Researchers will scan 16 patients before and during treatment to see if the MRI can predict whether the cancer shrinks o…

This study aimed to create a simple, safe teaching plan for family caregivers of head and neck cancer patients with a temporary tracheostomy. The goal was to help caregivers feel confident and prepared to manage the tracheostomy at home. However, the study was withdrawn before an…

This study screens up to 1,150 people with advanced solid tumors like head and neck, cervical, or lung cancer. Researchers test blood and tumor samples to see if participants have the right genetic markers for future T-cell therapy trials. The goal is to find who might benefit fr…

This study aimed to see if a personalized online education program could help people having major head or neck surgery feel more prepared and satisfied, and reduce trips to the hospital. The study was withdrawn before any participants were enrolled, so no results are available.

This study was designed to explore how the glossopharyngeal nerve varies in shape and size, and whether electrically stimulating it could open the airway during surgery. It planned to enroll adults with head and neck cancer or sleep apnea, but was withdrawn before any participant…

This study was designed to track sleep quality in people with head and neck cancer undergoing surgery. Researchers planned to measure factors like time to fall asleep and nighttime awakenings to understand how treatment impacts sleep. The study was withdrawn before enrolling any …

This study examines head and neck cancers that occur during pregnancy or within 12 months after giving birth. Researchers will check for certain viruses (HPV and EBV) and look at tumor types and pregnancy complications. The goal is to better understand these rare cases, not to te…

This pilot study tests a new FDA-approved cone-beam CT imaging system (Halcyon 4.0) for planning radiation therapy. Researchers will compare its image quality and ease of use to standard CT scans in 27 adults with various cancers. The goal is to see if the new system can improve …

This study looks at how well immunotherapy works in people with advanced lung or head and neck cancers. Researchers will take blood samples before and after treatment to measure how the body clears the drug and how tumor cells in the blood change. The goal is to find markers that…

This study looks at whether starting scapular-focused exercises early after neck dissection helps head and neck cancer patients regain shoulder function better than waiting. Participants are adults aged 20–65 with shoulder issues after surgery. They will do weekly 60-minute exerc…