Gallbladder disorder

This early-phase study tests a personalized mRNA cancer vaccine (XH001) given alongside standard treatment after surgery for people with high-risk solid tumors (bile duct, gallbladder, pancreatic, liver, or stomach cancer). The main goals are to check safety and see if the vaccin…

This study compares two treatments for acute cholecystitis (inflamed gallbladder) in patients aged 75 and older. One is the standard laparoscopic surgery to remove the gallbladder. The other is a newer, less invasive procedure called EUS-guided gallbladder drainage, where a small…

This study tests whether adding a targeted, tumor-destroying treatment (like focused radiation or heat ablation) can help people with certain gastrointestinal cancers—such as colorectal, small bowel, or pancreatic cancer—continue their current systemic therapy longer when only a …

This phase 3 trial tests a new drug called nanvuranlat in 480 adults with advanced biliary tract cancer that has worsened after prior treatment. Participants receive either nanvuranlat or one of several standard treatments. The main goal is to see if nanvuranlat helps people live…

This study tests a drug called tivozanib in people with bile duct cancer that cannot be removed by surgery and has already been treated with chemotherapy. The goal is to find the safest dose and see if the drug can shrink tumors or slow the cancer. Participants take tivozanib by …

This early-stage study tests a new drug called MK-4884 in about 120 people with advanced or metastatic solid tumors (colorectal, kidney, lung, or bile duct cancer). The main goal is to check the drug's safety and find the right dose. Researchers will monitor side effects and how …

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This study is testing whether giving chemotherapy (capecitabine or S-1) together with radiation after surgery can help prevent bile duct and gallbladder cancers from coming back. It includes 92 patients whose cancers had high-risk features, like positive lymph nodes or narrow sur…

This phase 2 trial tests whether a series of procedures to remove cancerous tumors, given one after another, can improve outcomes for people with stage IV foregut cancers (like stomach, pancreas, or bile duct cancer) who have no detectable cancer DNA in their blood after initial …

This global Phase 3 trial is testing whether adding the experimental immunotherapy rilvegostomig to standard chemotherapy helps people with advanced biliary tract cancer live longer, compared to adding the approved drug durvalumab. About 1,100 participants with inoperable or meta…

This study tests whether adding an experimental drug (D07001) to standard chemotherapy (capecitabine) helps people with advanced bile duct cancer live longer. About 195 adults whose cancer has not responded to earlier treatments will receive either D07001 or a placebo, plus capec…

This study tests a new therapy called EB-HC01, which uses specially engineered natural killer (NK) immune cells to attack cancer cells that have two specific markers (HER2 and CEACAM5). The trial enrolls adults with advanced bile duct or gallbladder cancers that have worsened aft…

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This study tests whether adding tivozanib (a drug that targets blood vessel growth) to atezolizumab (an immunotherapy) can help the immune system attack cancers that normally resist immunotherapy. The trial includes people with several cancer types like bile duct, pancreatic, pro…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This early-phase study tests a new cell therapy for people with advanced biliary tract cancer (bile duct or gallbladder cancer) that has not responded to standard treatments. The therapy uses the patient's own immune T cells, enhanced with a protein called CD160 to better target …

This study tests two surgical techniques for bile duct cancer that has spread to nearby lymph nodes. One method removes the bile duct completely to take out all affected lymph nodes, while the other leaves the bile duct in place but may leave some lymph tissue behind. The goal is…

This phase 3 trial is testing whether giving a targeted therapy after initial standard chemotherapy can help people with advanced biliary cancer live longer without their disease getting worse. Participants must have a tumor with a specific genetic change and stable disease after…

This study tests a new drug called ivonescimab against standard chemotherapy (FOLFOX) for people with advanced bile duct cancer that has worsened after initial treatment. About 72 participants who were in the SAFIR-ABC10 trial will be randomly assigned to receive either ivonescim…

This study tests a mix of three chemotherapy drugs (gemcitabine, cisplatin, nab-paclitaxel) plus an immunotherapy drug (durvalumab) in people with advanced gallbladder cancer that cannot be removed by surgery. The goal is to see if this combination shrinks tumors and how safe it …

This study tests whether adding the drug zanidatamab to standard chemotherapy (with or without an immunotherapy) can help people with advanced HER2-positive bile duct cancer live longer without their cancer growing. About 286 adults with inoperable or metastatic bile duct cancer …

This study is testing a treatment strategy for biliary tract cancer, a group of aggressive cancers with poor survival. The approach combines hepatic arterial infusion chemotherapy (HAIC) with systemic drugs like bevacizumab and an immunotherapy. The goal is to shrink tumors and i…

This phase 2 trial is testing whether adding an experimental immunotherapy drug called ZG005 to standard chemotherapy (gemcitabine and cisplatin) can help people with advanced gallbladder cancer. About 60 participants will receive either the combination or standard treatment. The…

This study tests whether giving heated chemotherapy directly into the abdomen during surgery is safe for people with high-risk gallbladder cancer. The treatment aims to prevent cancer from coming back in the belly lining. Ten participants will be enrolled to check for complicatio…

This study compares two endoscopic procedures to drain an infected gallbladder in people who are too frail or ill for surgery. About 90 participants will be randomly assigned to one of two drainage methods using a scope. The goal is to see which approach works better and causes f…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This study looks at whether removing the gallbladder soon (within 3 days) or later (after 1 month) after a procedure to clear bile duct stones leads to better outcomes. About 40 adults with gallstones and bile duct stones will be randomly assigned to one of the two timing groups.…

This study tests whether draining the gallbladder using a thin tube passed through the mouth (EUS-GBD) right away is better than starting with antibiotics alone for elderly or very sick patients with mild to moderate gallbladder infection who cannot have surgery. About 110 partic…

This early-phase trial tests a new drug called emavusertib added to standard chemotherapy and immunotherapy for people with untreated advanced bile duct cancer. The goal is to see if the combination is safe and to find the best dose. About 48 participants will be enrolled.

This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can improve tumor control and survival in 240 people with advanced liver or gallbladder cancer who also have depression or anxiety. Participants will receive either fluoxetine or a pl…

This study tests a new combination of four drugs—two standard chemotherapies plus an immunotherapy and a cholesterol drug—in people with advanced bile duct cancer. All 29 participants will receive the same treatment. Researchers will check how many patients see their tumors shrin…

This trial compares two doses of a dye called indocyanine green (ICG) given before laparoscopic gallbladder removal. The dye helps surgeons see the bile ducts clearly, which may reduce the risk of accidental injury. One group gets the standard dose hours before surgery; the other…

This phase II trial is testing a combination of two chemotherapy drugs—trifluridine/tipiracil (pills) and oxaliplatin (IV)—in people with advanced or metastatic biliary tract cancer whose first treatment stopped working. The goal is to see if this combo can control the cancer bet…

This study is testing whether a specific diet can help people pass very small gallstones (sludge) without surgery. One hundred adults with tiny stones (less than 2 mm) will be randomly assigned to a special diet or a control diet. The main goal is to see if the diet can completel…

This study compares placing one versus two small stents in the gallbladder to prevent repeat symptoms like pain and infection in people who cannot have their gallbladder removed. About 30 adults will be randomly assigned to get one or two stents during an endoscopic procedure. Re…

This phase 2 trial is testing whether adding the immunotherapy drug pembrolizumab to standard chemotherapy or the targeted drug lenvatinib can help people with advanced biliary tract cancer live longer and control their tumors better. The study will enroll 60 adults whose cancer …

This early-phase study tests whether adding heat therapy and a special type of radiation to standard chemoimmunotherapy is safe and feasible for people with advanced bile duct cancer that cannot be removed by surgery. About 15 participants will receive the combination treatment. …

This phase 2 trial is testing whether adding two immunotherapy drugs (tuvonralimab and iparomlimab) to standard chemotherapy before surgery can improve outcomes for people with bile duct or gallbladder cancer. About 45 adults with resectable or borderline-resectable cancer will r…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare or hard-to-treat cancers will receive …

This early-stage trial is testing a powerful mix of five chemotherapy drugs for people with advanced upper gastrointestinal cancers, including pancreatic and stomach cancers. The study uses each person's genetic profile to adjust the dose of one of the drugs (irinotecan) to try t…

This study looks at 64 adults with moderate to severe gallbladder inflammation who had a drainage tube placed. It compares removing the gallbladder early (during the same hospital stay) versus waiting over 6 weeks. The goal is to see which timing leads to fewer complications and …

This study tests a combination of four drugs—gemcitabine, cisplatin, nab-paclitaxel, and tislelizumab—in people with advanced biliary tract cancer (bile duct or gallbladder cancer) that has not been treated before. The goal is to see if this mix can shrink tumors and improve surv…

This study compares robotic-assisted surgery to traditional open surgery for gallbladder cancer. About 94 patients will be randomly assigned to one of the two procedures. The main goal is to see which approach helps patients recover faster after surgery, measured by pain control,…

This study compares standard ultrasound (done on the outside of the belly) with laparoscopic ultrasound (done inside the abdomen during weight-loss surgery) to see which finds more gallstones and other gallbladder issues. The goal is to better identify patients who could benefit …

This study tests a new, faster MRI scan for the abdomen and pelvis that uses artificial intelligence to create clear images. About 300 adults who need an MRI as part of their care will get both the standard scan and the fast version. The goal is to see if the fast scan is just as…

This study looks at whether a new type of PET scan (FAPI PET/CT) can find and stage gallbladder and bile duct cancers better than the standard scan. About 60 adults with suspected or confirmed cancer will get both scans to compare accuracy. The goal is to improve detection of can…

This study is testing a new method to measure how well the gallbladder contracts, using protein bars and olive oil instead of a fatty meal. Researchers will compare this to the standard fried-egg test in 120 healthy volunteers. The goal is to find the best time to take ultrasound…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study is testing a blood test that looks for DNA changes from tumors to help diagnose and manage biliary tract cancers, which are often found late and have a low survival rate. Researchers will enroll 1,800 participants with confirmed cancers to see how accurate the test is.…

This phase 3 trial tests whether the nerve pain medication duloxetine can prevent pancreatitis, a serious complication that sometimes occurs after an ERCP procedure. Researchers will give duloxetine or a placebo to 44 adults with biliary disease before their ERCP. The main goal i…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study compares two methods of removing the gallbladder during laparoscopic (keyhole) surgery: through a port near the belly button or one below the breastbone. The goal is to see which approach causes less pain and fewer wound problems like infection. The trial will involve …

This study compares two types of nerve blocks—erector spinae plane block and modified thoracoabdominal nerve block—for pain control after laparoscopic gallbladder removal. Fifty adults aged 30-65 will receive one of the two blocks with bupivacaine. Researchers will measure how lo…

This study tests a new tablet called 4-MUST to see if it reduces pain and discomfort in people with chronic gallbladder inflammation and bile duct issues. About 300 adults aged 18-70 will receive either the drug or a placebo for 29 days. The main goal is to measure pain relief us…

This study compares two ultrasound-guided nerve blocks to control pain after laparoscopic gallbladder removal. Seventy adults will receive either a modified thoracoabdominal nerve block or a recto-intercostal fascial plane block. The goal is to see which block reduces the need fo…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study compares two types of gallbladder removal surgery for non-cancerous conditions like gallstones or polyps. About 276 adults will be randomly assigned to either robotic or standard laparoscopic surgery. The main goal is to see if robotic surgery is as safe as the traditi…

This study compares two ways to manage pain after laparoscopic gallbladder removal. One group gets standard local anesthesia at the incision sites, while the other also receives a nerve block guided by the surgery camera. The goal is to see if the added block reduces pain and the…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This early-stage study is testing a new tablet called 4-MUST in 45 healthy volunteers. Researchers want to see if taking the drug with food changes how much gets into the blood, and how safe and tolerable it is after single and repeated doses. The results will help design future …

This study looks at whether using lung ultrasound right after gallbladder surgery can find breathing problems like collapsed lung tissue (atelectasis) early. About 110 adults having laparoscopic gallbladder removal with low-flow anesthesia will be checked. The goal is to see if e…

This study compares two types of breathing tubes used during gallbladder surgery: the standard endotracheal tube and a laryngeal mask airway. Researchers want to see if one requires less propofol (anesthesia medicine) to keep patients asleep. 160 adults having elective gallbladde…

This study looks at better ways to diagnose bile duct stones, which can be dangerous if missed. Current methods often lead to unnecessary procedures. Researchers will test if changes in liver enzyme levels can improve accuracy. About 2000 adults with suspected stones will take pa…

This study is creating a detailed record of 6,000 adults who had an ERCP procedure for bile duct or pancreas problems. Researchers are collecting information before, during, and after the procedure to track complications like pancreatitis or bleeding. The goal is to better unders…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders. Researchers will use a cutting-edge technique called spatial transcriptomics to map gene activity directly inside gut tissue. The goal is to better…

This study collects tissue and blood samples from 1,500 people with biliary tree cancers, plus healthy volunteers, to look for genetic changes and risk factors. Researchers hope to build models that predict how the cancer develops and responds to treatment. The goal is to better …

This registry will follow 510 adults undergoing therapeutic endoscopic ultrasound (EUS) for conditions like stomach or bile duct blockages, pancreatic fluid collections, or gallbladder inflammation. The goal is to see how well these procedures work over the long term and what fac…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find genetic changes in advanced bile duct cancer as well as a traditional tissue biopsy. The goal is to make it easier and less invasive to identify which patients might benefit from targeted therapi…

This study is testing whether a camera can accurately measure heart rate, blood pressure, and oxygen levels by recording a patient's face during surgery. The goal is to replace some of the sticky sensors and cuffs that touch the skin, which can cause infections or injuries in fra…

This study observes 340 patients in Norway who need gallbladder surgery and also have bile duct stones. Doctors will use one of two methods to remove the stones during surgery: a laparoscopic technique through the bile duct or an endoscopic procedure. The goal is to see which met…

This study looks back at the records of 2,000 adults who had liver surgery with their gallbladder left in place. Researchers want to know if a technique called the Pringle maneuver, which temporarily stops blood flow to the liver during surgery, increases the chance of developing…

This study is collecting health data and biological samples from 15,000 people in Europe and Latin America to find markers that could predict gallbladder cancer risk or catch it early. Participants include patients with gallbladder cancer or gallstones. The goal is to improve pre…

This study compares a new orally disintegrating form of Trimedat (trimebutine) to the standard tablet in 36 healthy adults. The goal is to see if the new version is absorbed similarly and is safe. This trial does not treat any disease; it only gathers data on how the drug behaves…

This study compares two imaging techniques—laparoscopic ultrasound and a special dye called indocyanine green—to help surgeons see important bile duct structures during difficult gallbladder removal surgery. About 62 adults with conditions like acute cholecystitis, prior abdomina…

This study tracks 1,000 patients undergoing major liver, pancreas, or bile duct surgery to see if the time it takes for their albumin levels to return to normal can predict complications and length of hospital stay. Albumin is a protein that drops after surgery due to inflammatio…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

This study follows 800 people with gallstones and belly pain who are scheduled for gallbladder removal surgery. Researchers will track their symptoms and quality of life before and three months after surgery. The goal is to create a simple tool that predicts who will actually get…