New hope for bile duct cancer: experimental drug takes on chemo

NCT ID NCT06529718

First seen Nov 17, 2025 · Last updated May 24, 2026 · Updated 25 times

Summary

This study tests whether a new drug called ivonescimab works better than standard chemotherapy (FOLFOX) for people with advanced bile duct cancer that has worsened after initial treatment. About 72 participants who were part of a prior trial (SAFIR-ABC10) will be randomly assigned to receive either ivonescimab or FOLFOX. The goal is to see if ivonescimab can slow cancer growth or improve survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • APHM - CHU La Timone

    RECRUITING

    Marseille, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • APHP - Hopital Henri Mondor

    NOT_YET_RECRUITING

    Créteil, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • APHP - Hôpital Beaujon

    RECRUITING

    Clichy, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • APHP - Hôpital Paul Brousse

    NOT_YET_RECRUITING

    Villejuif, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • APHP - Hôpital Saint Antoine

    RECRUITING

    Paris, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CH Cornouaille

    NOT_YET_RECRUITING

    Quimper, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CH Valence

    NOT_YET_RECRUITING

    Valence, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CH de Pau

    RECRUITING

    Pau, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHRU de Nancy

    RECRUITING

    Nancy, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Amiens Picardie

    RECRUITING

    Amiens, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Besançon

    NOT_YET_RECRUITING

    Besançon, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Charles Nicolle

    NOT_YET_RECRUITING

    Rouen, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Dupuytren

    RECRUITING

    Limoges, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Estaing de Clermont Ferrand

    NOT_YET_RECRUITING

    Clermont-Ferrand, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Nantes - Hôtel Dieu

    NOT_YET_RECRUITING

    Nantes, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Poitiers

    NOT_YET_RECRUITING

    Poitiers, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU Toulouse

    RECRUITING

    Toulouse, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU de Bordeaux - Hôpital Haut-Leveque

    NOT_YET_RECRUITING

    Bordeaux, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU de Dijon

    RECRUITING

    Dijon, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU de Reims

    RECRUITING

    Reims, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Antoine Lacassagne

    NOT_YET_RECRUITING

    Nice, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Eugène Marquis

    RECRUITING

    Rennes, France

    Contact

    Contact

  • Centre François Baclesse

    NOT_YET_RECRUITING

    Caen, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Jean Perrin

    RECRUITING

    Clermont-Ferrand, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Leon Bérard

    RECRUITING

    Lyon, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Oscar Lambret

    NOT_YET_RECRUITING

    Lille, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Chu Lille

    NOT_YET_RECRUITING

    Lille, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Groupe hospitalier mutaliste de Grenoble - Institut Daniel Hollard

    RECRUITING

    Grenoble, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Gustave Roussy

    NOT_YET_RECRUITING

    Villejuif, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hopital Saint Joseph

    NOT_YET_RECRUITING

    Marseille, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpital Foch

    RECRUITING

    Suresnes, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpital du Confluent Nantes

    NOT_YET_RECRUITING

    Nantes, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut Curie - Saint Cloud

    NOT_YET_RECRUITING

    Saint-Cloud, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut Jean Godinot

    RECRUITING

    Reims, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut Paoli Calmettes

    NOT_YET_RECRUITING

    Marseille, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut de Cancer de Montpellier

    NOT_YET_RECRUITING

    Montpellier, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut de cancerologie de l'Ouest - Angers

    NOT_YET_RECRUITING

    Angers, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut de cancerologie de l'Ouest - St Herblain

    NOT_YET_RECRUITING

    Saint-Herblain, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institut du Cancer Avignon Provence

    RECRUITING

    Avignon, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Institute Mutualiste Montsouris

    NOT_YET_RECRUITING

    Paris, France

    Contact

    Contact

  • University College London

    NOT_YET_RECRUITING

    London, United Kingdom

    Contact

    Contact

Conditions

Explore the condition pages connected to this study.