New hope for bile duct cancer: experimental drug takes on chemo
NCT ID NCT06529718
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called ivonescimab against standard chemotherapy (FOLFOX) for people with advanced bile duct cancer that has worsened after initial treatment. About 72 participants who were in the SAFIR-ABC10 trial will be randomly assigned to receive either ivonescimab or FOLFOX. The goal is to see if ivonescimab can slow cancer growth better than chemo.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHM - CHU La Timone
RECRUITINGMarseille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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APHP - Hopital Henri Mondor
NOT_YET_RECRUITINGCréteil, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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APHP - Hôpital Beaujon
RECRUITINGClichy, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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APHP - Hôpital Paul Brousse
NOT_YET_RECRUITINGVillejuif, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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APHP - Hôpital Saint Antoine
RECRUITINGParis, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CH Cornouaille
NOT_YET_RECRUITINGQuimper, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CH Valence
NOT_YET_RECRUITINGValence, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CH de Pau
RECRUITINGPau, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHRU de Nancy
RECRUITINGNancy, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Amiens Picardie
RECRUITINGAmiens, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Besançon
NOT_YET_RECRUITINGBesançon, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Charles Nicolle
NOT_YET_RECRUITINGRouen, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Dupuytren
RECRUITINGLimoges, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Estaing de Clermont Ferrand
NOT_YET_RECRUITINGClermont-Ferrand, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Nantes - Hôtel Dieu
NOT_YET_RECRUITINGNantes, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Poitiers
NOT_YET_RECRUITINGPoitiers, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Toulouse
RECRUITINGToulouse, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Bordeaux - Hôpital Haut-Leveque
NOT_YET_RECRUITINGBordeaux, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Dijon
RECRUITINGDijon, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Reims
RECRUITINGReims, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Antoine Lacassagne
NOT_YET_RECRUITINGNice, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Eugène Marquis
RECRUITINGRennes, France
Contact
Contact
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Centre François Baclesse
NOT_YET_RECRUITINGCaen, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Jean Perrin
RECRUITINGClermont-Ferrand, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Leon Bérard
RECRUITINGLyon, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Oscar Lambret
NOT_YET_RECRUITINGLille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Lille
NOT_YET_RECRUITINGLille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Groupe hospitalier mutaliste de Grenoble - Institut Daniel Hollard
RECRUITINGGrenoble, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gustave Roussy
NOT_YET_RECRUITINGVillejuif, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hopital Saint Joseph
NOT_YET_RECRUITINGMarseille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Foch
RECRUITINGSuresnes, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital du Confluent Nantes
NOT_YET_RECRUITINGNantes, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Curie - Saint Cloud
NOT_YET_RECRUITINGSaint-Cloud, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Jean Godinot
RECRUITINGReims, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Paoli Calmettes
NOT_YET_RECRUITINGMarseille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut de Cancer de Montpellier
NOT_YET_RECRUITINGMontpellier, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut de cancerologie de l'Ouest - Angers
NOT_YET_RECRUITINGAngers, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut de cancerologie de l'Ouest - St Herblain
NOT_YET_RECRUITINGSaint-Herblain, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut du Cancer Avignon Provence
RECRUITINGAvignon, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institute Mutualiste Montsouris
NOT_YET_RECRUITINGParis, France
Contact
Contact
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University College London
NOT_YET_RECRUITINGLondon, United Kingdom
Contact
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can freezing tumors boost immunotherapy in hard-to-treat bile duct cancers?
- Triple attack on bile duct cancer: chemo, targeted drug, and immunotherapy aim to make the inoperable operable
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- New drug cocktail aims to outperform standard immunotherapy in bile duct cancer
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