Gallbladder disorder

This study looked at 484 high-risk surgical patients with acute cholecystitis (gallbladder inflammation) who first received a standard drainage tube through the skin. Some then had a newer procedure using an endoscope to place a metal stent inside the gallbladder. Researchers com…

This Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced bile duct cancer live longer. The study enrolled 158 Chinese adults with cancer that had spread or could not be removed by…

This study tested two methods to stop bleeding during laparoscopic gallbladder removal: standard titanium clips versus a device called LigaSure that seals blood vessels with energy. 114 patients were split into two groups. The LigaSure group lost less blood and achieved bleeding …

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine/cisplatin) helps people with advanced bile duct or gallbladder cancer live longer. Over 1,000 participants received either the combination or chemo plus a placebo. The goal…

This study tested a procedure called EUS-guided gallbladder drainage (EGBD) as an alternative to gallbladder removal surgery for 30 adults with acute cholecystitis (gallbladder inflammation). The goal was to see if it could safely resolve symptoms like fever and pain without need…

This study tested a combination of two experimental drugs, AK112 and AK117, with or without chemotherapy, in 154 people with advanced solid tumors. The goal was to see if the combo could shrink tumors and control the disease. The trial has finished, and researchers are now lookin…

This trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…

This trial tested a new device called GATT-Patch, a flexible, resorbable patch that helps stop bleeding during minimally invasive (keyhole) liver and gallbladder surgeries. 53 adults were randomly assigned to receive either GATT-Patch or a standard surgical patch. The main goal w…

This phase III trial tested whether adding nab-paclitaxel to the standard two-drug chemo (gemcitabine and cisplatin) helps people with newly diagnosed, advanced biliary tract cancers live longer. Over 450 patients took part. The goal is to see if the three-drug combo improves ove…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study looked at whether giving antibiotics after gallbladder removal surgery helps prevent infections in people with mild to moderate gallbladder inflammation. Over 400 adults took part, receiving either antibiotics or no medication after surgery. The goal was to see if anti…

This study tested a drug called ZW25 (zanidatamab) in 87 people with advanced or metastatic HER2-amplified biliary tract cancer that had worsened after standard chemotherapy. The goal was to see if the drug could shrink tumors and how long that effect lasted. The trial is now com…

This study tested two types of endoscopes used in ERCP, a procedure to treat bile duct and pancreas problems. One scope had a single-use plastic cover on its tip, while the other was a standard reusable scope. Researchers compared how well each worked and how often complications …

This early-phase trial tested an experimental immunotherapy called ELI-002 in 25 people with KRAS-mutated pancreatic, colorectal, lung, ovarian, or bile duct cancers who had signs of remaining disease after standard treatment. The therapy aims to train the immune system to attack…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study tested a new way to check gallbladder function using ultrasound after drinking special fatty acids. 100 adults with normal bile ducts took part. The goal was to see if this method can accurately measure how well the gallbladder squeezes and empties.

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This study tested whether a green dye injected into the blood can help surgeons see bile ducts better during gallbladder removal for acute cholecystitis, compared to the standard contrast dye. 156 adults with mild to moderate gallbladder inflammation took part. The goal was to se…

This study tested whether adding acupuncture to standard anti-nausea drugs could better prevent nausea and vomiting after laparoscopic gallbladder removal. 270 adults scheduled for surgery received either acupuncture plus standard drugs or standard drugs alone. The goal was to se…

This study tests whether preserving the cystic artery during laparoscopic gallbladder removal can reduce complications like bleeding. Two hundred patients with symptomatic gallstones will be split into two groups: one where the artery is preserved and one where it is clipped or b…

This study looked at whether emergency gallbladder removal (laparoscopic cholecystectomy) can be performed as an outpatient procedure, meaning patients go home the same day. Researchers measured patient satisfaction using a simple scale. The study enrolled 25 adults with acute ch…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested a personalized dose of a dye called indocyanine green (ICG) to help surgeons see bile ducts more clearly during emergency gallbladder removal. 21 patients with acute cholecystitis received a dye dose calculated from their MRI scans. The goal was to improve surgi…

This completed study tested a new painkiller called tegileridine in 150 adults who had gallbladder surgery. Participants received either the drug or a placebo through a vein, along with standard pain management. The goal was to see if tegileridine reduces pain and the need for ex…

This study looked at whether reducing noise during the start of anesthesia (when you go to sleep) can improve recovery after laparoscopic gallbladder removal. 105 adults having planned surgery were included. Researchers measured pain, nausea, vomiting, heart rate, blood pressure,…

This study tested two different nerve block methods to control pain after laparoscopic gallbladder removal. Sixty adults having elective surgery received either a modified thoracoabdominal nerve block or a standard abdominal plane block. Researchers measured recovery quality and …

This study tested a new way to remove the gallbladder using a harmonic scalpel instead of metal clips to seal blood vessels and bile ducts. The trial involved 158 adults with gallstones who were scheduled for elective surgery. The goal was to see if the clipless method reduces su…

This study tested a different surgical method (fundus-first) versus the standard method for removing difficult gallbladders in 174 adults. The goal was to see if the new method lowers the risk of bile duct injury, a serious complication. Participants had conditions like acute cho…

This study tested whether using a needle to drain a swollen gallbladder during laparoscopic removal makes the operation easier and safer. 70 patients with acute cholecystitis, gallbladder mucocele, or empyema were randomly assigned to have their gallbladder drained or not. The go…

This study tested whether aromatherapy foot massage can reduce pain, improve sleep, and speed recovery after laparoscopic gallbladder removal. 103 adults received two 10-minute foot massages with essential oils after surgery. Researchers measured pain, sleep quality, and recovery…

This study tested whether adding acupuncture at a specific point (GB34) to standard medical care could help people with mild gallbladder inflammation (acute cholecystitis). Thirty hospitalized adults received either acupuncture plus usual treatment or usual treatment alone. The g…

This study tested whether lidocaine, a common numbing drug, works as well as remifentanil (an opioid) for pain after laparoscopic gallbladder removal. 138 adults took part. The goal is to find effective pain relief with fewer opioid side effects.

This study tested whether using a stress ball before gallbladder removal surgery helps reduce patients' fear, anxiety, and stress while improving comfort. Ninety adults scheduled for laparoscopic gallbladder removal were randomly assigned to either use a stress ball or receive st…

This study tested whether a TENS device (which sends mild electrical pulses through the skin) can help people recover after laparoscopic gallbladder removal. 140 adults were randomly assigned to receive TENS or standard care in the first 24 hours after surgery. Researchers measur…

This study looked at whether the amount of three types of bacteria in stool samples is linked to gallbladder cancer risk. Researchers compared 230 South American patients with gallstones, some who had gallbladder cancer and some who did not. The goal was to confirm earlier findin…

This study looked at 120 South American patients with gallstones to confirm if certain bacteria in stool are linked to gallbladder cancer risk. Researchers measured three types of gut bacteria using advanced DNA sequencing. The goal was to validate earlier findings that these bac…

This study explored whether the Mallampati score, a simple visual check of the mouth, can help predict complications and patient satisfaction after laparoscopic gallbladder removal. Researchers studied 470 adults aged 20-50 with a BMI of 35 or less. The goal was to gather informa…

This study compared two ways to manage a patient's airway during laparoscopic gallbladder surgery: a video laryngeal mask and an endotracheal tube. Researchers measured how long each took to insert and checked breathing and pressure readings. The goal was to see if the video mask…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This study looked at 120 adults with breast, pancreatic, or biliary cancer to see if a new 3D measurement method (TDTP-RECIST) is better than the standard way (RECIST 1.1) for tracking tumor shrinkage before surgery. Researchers compared imaging results with actual tumor tissue r…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study tested a new artificial intelligence (AI) tool designed to help doctors safely drain an infected gallbladder in patients who cannot have surgery. The AI was used during an endoscopic ultrasound procedure to guide placement of a special stent. Researchers compared the A…

This study looked back at the medical records of 609 people treated for gallbladder inflammation (cholecystitis) in Villavicencio, Colombia, between 2019 and 2022. The goal was to understand how quickly patients received care, what treatments they got, and how many had complicati…

This study looked at 150 adults having gallbladder surgery to see if fatty liver disease (MAFLD) makes a special imaging technique less clear. The imaging uses a dye to help surgeons see bile ducts. Researchers found that fatty liver can reduce image quality and created a way to …

This completed study followed over 1,000 people who had an ERCP procedure to see if having chronic gallbladder disease increases the chance of complications like infection or inflammation. Researchers tracked issues such as post-ERCP cholecystitis, pancreatitis, and cholangitis. …

This study tested whether using a dye called indocyanine green along with infrared light helps surgeons see the bile ducts more clearly during gallbladder removal surgery. Over 600 adults having their gallbladder taken out were randomly assigned to either standard white light or …

This study looked at 559 patients who had their gallbladder removed laparoscopically to find out when surgical drains are truly needed. Drains are sometimes placed to prevent fluid buildup or infection, but many studies show they aren't always necessary. The goal is to help docto…