ENDOMETRIAL CANCER

This study tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein. Participants must have already tried at least one other cancer treatment. The goal is to see if the drug can shrink tumors or stop them from growing. This is not…

This early-phase study tests an experimental drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with…

This study is testing whether a shorter course of radiation (1 week instead of the usual 5 weeks) combined with chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The main goal is to see if most participants can complete all 6 pla…

This study tests personalized fertility-sparing treatments for young women (ages 18-45) with endometrial cancer. Researchers will use the tumor's genetic profile to assign the best therapy, such as hormone therapy or immunotherapy, aiming to eliminate cancer while preserving the …

This study tests a new treatment called KD01, a modified virus designed to infect and kill cancer cells while also boosting the immune system. It is for women with cervical or endometrial cancer, including those who want to preserve fertility. The trial has two phases: first to c…

This early-phase study tests a new drug called IPH5301 in people with advanced solid tumors that have spread. The drug aims to block a protein (CD73) that helps cancers hide from the immune system. The study first finds a safe dose of IPH5301 alone, then tests it combined with ch…

This study tests a combination of two or three drugs (BL-B01D1, pembrolizumab, and possibly bevacizumab) in people with cervical or endometrial cancer that has come back or spread. The goal is to see if the treatment shrinks tumors and controls the disease. About 96 adults aged 1…

This early-phase study tests a new drug called PHST001, alone or with chemotherapy, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and see if it can shrink tumors. About 272 people…

This early-phase study tests whether a new drug called NRM-823 is safe and can help people with advanced solid tumors that have not responded to other treatments. About 150 adults with cancers like lung, ovarian, or triple-negative breast cancer will receive NRM-823 alone or with…

This program provides the investigational drug selinexor to people with multiple myeloma, lymphoma, sarcoma, or other cancers who have run out of standard treatments and cannot join a clinical trial. Patients must get approval from their doctor and local regulators. The goal is t…

This early-stage study tests a new oral drug, MOMA-341, alone or with other treatments, in people with advanced solid tumors that have specific genetic changes (MSI-H or dMMR). The main goal is to check safety and find the best dose. About 132 adults whose cancer has not responde…

This study tests a new drug, puxitatug samrotecan, against standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 700 participants will be randomly assigned to receive either the new dr…

This study tests whether adding a collagen injection into the uterus to standard hormone therapy can help shrink or eliminate early-stage endometrial cancer or precancerous changes in women who want to preserve their fertility. About 30 participants will receive either hormone pi…

This early-phase study tests a new drug called SLV-154 in about 70 adults whose solid tumors (like head and neck, lung, breast, or ovarian cancer) have spread. The main goal is to find a safe dose and check how the body handles the drug. It is not a cure but aims to control the d…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors or stops them from growing. About 29 participants…

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This study is testing a new robotic surgery system (Medtronic Hugo™) for hysterectomy, a surgery to remove the uterus. The goal is to see if the robot is safe and works well for treating conditions like fibroids, endometriosis, and certain cancers. About 70 adult women who need a…

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancer that has come back or stopped responding to standard treatments. The drug is designed to help the body's immune cells attack cancer cells that have a specific marker c…

This study tests an experimental drug called ubamatamab, given alone or with another drug (cemiplimab), for people with ovarian cancer or other cancers that have come back. The goal is to find safe doses and see if the drugs can shrink tumors. About 890 adults with recurrent ovar…

This early-phase trial tests whether combining chemotherapy, radiation, and the immunotherapy drug dostarlimab is safe and can help control stage IIIC endometrial cancer that has spread to lymph nodes. About 21 participants will receive chemoradiation followed by chemotherapy plu…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can guide decisions to stop maintenance immune therapy after one year in people with advanced or recurrent endometrial cancer. About 30 participants will receive standard chemotherapy plus immune therapy for …

This study tests whether taking a daily pill called olaparib for one year after standard treatment can help prevent endometrial cancer from coming back. About 554 women with a specific genetic type of endometrial cancer (p53abn) will either receive olaparib or be observed. The go…

This study tests a new drug called TCC1727 combined with other cancer treatments (benmelstobart, olaparib, or topotecan) for people with advanced solid tumors like lung, stomach, endometrial cancer, or melanoma. The goal is to find the safest and most effective dose and see if th…

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors that have not responded to standard treatments. The main goal is to check the drug's safety. About 10 adults with cancers like liver, lung, or melanoma will take part.

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to prior treatments. The main goals are to check if the drug is safe and to find the best dose. About 282 participants will take part, …

This early-phase trial tests an experimental drug called MOv18 IgE in people with advanced ovarian, endometrial, or triple-negative breast cancers that have high levels of a protein called folate receptor alpha. The study has two parts: first, finding a safe dose, and second, che…

This early-phase study tests a new drug called BG-68501 in people with advanced solid tumors (like breast, ovarian, or lung cancer) that haven't responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors, either alone or combine…

This early-stage study tests an experimental oral drug, NKT5097, in adults with advanced solid tumors that have not responded to other treatments. The main goals are to find a safe dose and understand side effects. About 205 participants with breast, ovarian, endometrial, or othe…

This study is for people with early-stage endometrial cancer who have specific genetic markers (POLE-mutated or p53wt/NSMP). It tests whether using less intense treatment after surgery can still keep the cancer from coming back. About 393 participants will receive tailored therap…

This study tests whether the drug selinexor can help keep advanced or recurrent endometrial cancer from growing back after initial chemotherapy. About 276 adults with a specific type of endometrial cancer (p53 wild-type) who responded to platinum-based chemo will receive either s…

This early-phase study tests a new drug called DR-0202 in about 96 people with advanced solid tumors (like breast, lung, or pancreatic cancer) that have not responded to at least two prior treatments. The main goal is to check the drug's safety and find the right dose. Participan…

This early-stage study tests a new drug, PF-08046054/SGN-PDL1V, alone or with pembrolizumab, in people with advanced solid tumors like lung, head and neck, esophageal, and breast cancers. The main goal is to check safety and find the right dose. About 714 participants will take p…

This early-phase study tests a new drug called LNCB74 in people with advanced solid tumors (cancers that have spread and are hard to treat). The drug is designed to attach to a protein on cancer cells and deliver a toxic payload to kill them. The main goals are to find a safe dos…

This early-phase study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Ab…

This study tests an experimental drug called ART0380 in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with other chemotherapy drugs (gemcitabine or irinotecan). About 442 adults with certai…

This study tests a new drug called Rina-S against standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has come back or worsened after prior treatment. About 544 participants will be randomly assigned to receive either Rina-S or standard chemo.…

This study tests whether the drug elacestrant, alone or combined with abemaciclib, can shrink or control advanced or recurrent ER+ endometrial cancer. It is for people who have already tried platinum chemotherapy and a PD-1 inhibitor. The goal is to see how many patients respond …

This phase 3 trial tests whether the experimental drug BNT323 works better than standard chemotherapy for people with recurrent endometrial cancer that has a certain protein (HER2). About 480 adults will be split into two groups based on their HER2 level. The study measures how l…

This early-phase study tests a new drug called 177Lu-RAD204 in people with advanced solid tumors (like lung, breast, or skin cancer) that have not responded to other treatments. The drug delivers a small amount of radiation directly to cancer cells by targeting a protein called P…

This early-phase study tests a new drug called BL-M07D1 in people with advanced solid tumors that have a protein called HER2. The goal is to see if the drug is safe and can shrink tumors. About 280 adults with cancers like breast, lung, or stomach cancer who have tried at least t…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely to gynecologic cancers (endometrial, vaginal, vulvar) compared to standard cylinder applicators. Ten participants will receive brachytherapy with a personalized 3D-printed mold. The goal i…

This early-phase trial tests the safety of combining two drugs, atezolizumab and ONC201, in 58 women with advanced or recurrent endometrial cancer. The study compares how obese and non-obese patients respond to the treatment. The goal is to find the best dose and see if the combi…

This early-phase study tests a new drug called ADU-1805, alone or with another drug (pembrolizumab), in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and how the drug moves through the body. About 130 par…

This early-stage study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. About 319 participants will receive the drug to…

This study is testing a new drug called AZD8205, alone or with other cancer drugs, for people with advanced solid tumors like breast, ovarian, and lung cancer. The goal is to see if it is safe and helps control the disease. About 460 adults whose cancer has spread or returned aft…

This study tests an experimental drug called TER-2013 in people with advanced solid tumors (like breast, endometrial, ovarian, lung, head and neck, esophageal, or cervical cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The trial has two phases: first, fi…

This study tests whether combining cabozantinib (a drug that blocks blood vessel growth) with dostarlimab (an immunotherapy) can help control recurrent gynecologic carcinosarcoma, a rare and aggressive cancer. About 37 women whose cancer returned after at least one prior chemothe…

This study is collecting vaginal fluid samples from 4,200 women to help develop a test that can detect endometrial cancer and related conditions. Participants include women with abnormal uterine bleeding or a new diagnosis of endometrial cancer. The goal is to use these samples t…

This study looks at whether people with Lynch syndrome can collect their own vaginal samples at home to check for early signs of uterine cancer. About 30 participants will use a self-collection kit and answer surveys. The goal is to see if this method is practical and acceptable,…

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors (like lung, bladder, and ovarian cancers) better than current scans. About 400…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will check if the test can find cancer early, tell which type it is, and detect any remaining cancer after treatment or a relapse before …

This study looks at whether buying over-the-counter pain relievers and digestive aids can be an early warning sign for ten types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people recently diagnosed with cancer…

This study explores whether a tampon can collect samples to detect endometrial and ovarian cancer early. Researchers will look for DNA changes in the tampon and compare them to tissue samples from surgery. About 1,500 women scheduled for hysterectomy or ovary removal will partici…

This study compares two methods for finding cancer cells in lymph nodes removed during surgery for early-stage endometrial cancer. About 1,922 participants will be randomly assigned to have their lymph nodes checked either with the standard ultrastaging method or the newer OSNA m…

This study aims to create a test that can find endometrial, ovarian, and cervical cancers using special DNA markers in vaginal fluid or blood. Researchers at Mayo Clinic will collect samples from over 3,000 women to see how well the test works. The goal is to make cancer detectio…

This study looks at whether a 16-week virtual exercise program (aerobic and strength training) can help women with ovarian or endometrial cancer who are on chemotherapy after surgery. The goal is to see if it improves leg function and reduces numbness or tingling in hands and fee…

This study is testing a shorter course of pelvic radiation for women with endometrial cancer. The goal is to see if giving slightly higher daily doses over fewer days is safe and causes fewer bowel and bladder side effects. About 100 women who have had surgery for non-spreading c…

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The main goal is to see how RAD301 moves through the body and how much radiation reaches orga…

This study tests whether changing the dose and storage of a dye called indocyanine green can improve detection of cancer spread in lymph nodes for people with cervical, endometrial, or vulvar cancer. About 30 participants will receive the optimized dye during surgery. The goal is…

This study looks at whether showing short educational videos to people with ovarian or endometrial cancer can increase the number who get genetic testing. About 30 patients will watch a video and may fill out a satisfaction survey. Researchers will compare testing rates before an…

This study aims to collect and analyze genetic information from 25,000 people who either have cancer or are at risk for it. Researchers will combine this genetic data with detailed health records to learn more about what drives cancer and how to personalize treatment. Participant…

This study looks at when to send messages to encourage physical activity in older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity levels and pain ratings to find the best timing for these prompts. The goal is to learn ho…

This study is checking how often women with cervical or endometrial cancer experience long-term side effects in their bowels or bladder after receiving a modern type of radiation therapy called IMRT. Researchers will look back at the records of 300 patients treated at a major hos…

This study is collecting tissue samples, medical data, and family history from 1,120 adults who are being screened for colorectal or endometrial cancer. The goal is to discover new genes and immune system clues that could lead to better prevention and targeted treatments in the f…

This study is observing how well a new robotic system (da Vinci SP) performs staging surgery for endometrial cancer. About 564 patients will take part to see if the surgery meets guideline standards and to track any complications. The goal is to gather information, not to test a …

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…

This study looks at whether using a uterine manipulator during minimally invasive surgery for early-stage endometrial cancer causes cancer cells to appear in the abdominal fluid. About 278 adults with suspected early-stage cancer will be randomly assigned to have surgery with or …

This study tests whether a special ultrasound (mpUS) can measure changes in vaginal tissue caused by internal radiation therapy (IVRT) for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method can detect side effects like …

This study is testing whether an artificial intelligence (AI) tool can help connect cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers and use the AI to suggest trials based on their tumor's genetic markers. The goal i…