ENDOMETRIAL CANCER

This early-stage trial is testing a drug called dostarlimab in 730 people with advanced solid tumors that have not responded to other treatments. Dostarlimab works by helping the immune system recognize and attack cancer cells. The study is checking for safe doses and any side ef…

This phase II trial is testing a combination of two drugs—atezolizumab (an immunotherapy) and bevacizumab (a drug that cuts off blood supply to tumors)—in 110 women with advanced, recurrent, or persistent endometrial cancer. The goal is to see how many patients experience tumor s…

This phase 3 trial compares the immunotherapy drug dostarlimab with standard chemotherapy in 260 women with advanced or recurrent endometrial cancer that has a specific DNA repair defect (MMR deficient). The goal is to see if dostarlimab can better delay cancer progression and im…

This early-stage trial is testing a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with various advanced solid tumors that have spread or come back. The main goals are to find a…

This early-stage trial tests a personalized cell therapy called ADP-A2M4CD8 in people with certain cancers that have a specific marker (MAGE-A4). The therapy uses a patient's own immune cells, modified to better attack tumors, and is given alone or with standard immunotherapy dru…

This phase II trial is testing an oral drug called giredestrant in 30 people with grade 1 endometrial cancer. The goal is to see if the drug can shrink or control the cancer over 6 months. Participants take one pill daily for up to 24 cycles, and doctors monitor tumor changes and…

This early-stage trial tests a new drug called IDE161, alone or with the immunotherapy pembrolizumab, in 216 adults with advanced solid tumors (like breast, ovarian, or lung cancer). The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. It i…

This early-stage trial is testing a new drug called tuvusertib, given together with either lartesertib or avelumab, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see how the body pr…

This study looks at whether giving chemotherapy after surgery can help people with early-stage endometrial cancer live longer. It includes 244 patients whose cancer was confined to the uterus but had features that raise the risk of return. Half received six cycles of carboplatin …

This study tests whether a home-based weight loss program, with or without resistance training, is practical for endometrial cancer survivors. Fifteen participants will follow a guided exercise and diet plan for 6 months. Researchers will check if people stick with the program an…

This study tests a combination of two drugs, cadonilimab and lenvatinib, in 32 people with advanced endometrial cancer that has spread or come back and no longer responds to standard chemotherapy. The goal is to see if the combination shrinks tumors and how long it keeps the canc…

This early-phase trial is testing whether adding the immunotherapy drug pembrolizumab to standard radiation and chemotherapy is safe and feasible for people with high-intermediate risk endometrial cancer. About 45 participants who have already had surgery to remove the uterus wil…

This study tests a drug called sacituzumab govitecan against standard chemotherapy in 640 people with endometrial cancer that has come back after platinum-based chemo and immunotherapy. The goal is to see if the new drug can slow cancer growth and help people live longer. Partici…

This study is testing a new robotic surgery system (Medtronic Hugo™) to see if it is safe and works well for hysterectomy. About 70 adult patients with conditions like fibroids, endometriosis, or certain cancers will have their surgery using this robot. The main goal is to see ho…

This study compares two surgical approaches for women with middle-to-high risk endometrial cancer that hasn't spread beyond the uterus. One group gets sentinel lymph node sampling (removing only a few key nodes), while the other gets standard pelvic lymphadenectomy (removing many…

This study tests an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors like ovarian, breast, pancreatic, and prostate cancer. The drug is given alone or combined with other anti-cancer agents. The main goals are to check safety, tolerability,…

This study tests a combination of two drugs, selumetinib and olaparib, in people with advanced or recurrent solid tumors (including breast, digestive, and reproductive organ cancers). The first phase finds the safest dose, and the second phase checks if that dose helps control th…

This study tests a new drug called BG-68501 in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 103 adults will take part in this e…

This early-stage trial tests a new drug, ALTA2618, in about 110 adults whose advanced solid tumors (like breast or endometrial cancer) have a specific genetic change called AKT1 E17K. The main goals are to check the drug's safety and find the right dose. Participants must have tr…

This early-phase study tests a new oral drug called E7386 in about 60 adults with advanced solid tumors (like desmoid tumors) that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. Researchers will also watch for any tu…

This study looks at four different tools to help cancer survivors improve their diet, physical activity, and body weight. About 353 adults who have finished treatment for several cancer types will use these tools for up to 48 weeks. The goal is to see which tools work best to hel…

This study tests a drug called TPST-1495 in people with endometrial or colorectal cancer who are scheduled for surgery. The drug aims to help the immune system fight cancer by blocking certain signals. Researchers will check blood and tumor samples before and after treatment to s…

This study tested a combination of two drugs—mirvetuximab soravtansine and pembrolizumab—in 18 people with a specific type of uterine cancer (endometrial cancer) that had returned or persisted and was microsatellite stable (MSS). The goal was to see if the combo could shrink tumo…

This early-stage study tests an experimental pill, ATV-1601, in adults with advanced solid tumors or certain breast cancers that have a specific AKT1 gene change. The main goals are to find a safe dose and check how the drug moves through the body. About 134 participants will tak…

This early-stage study tests an experimental drug called SGN-MesoC2 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to attach to cancer cells and kill them. The study aims to find a safe dose and check for side effects in …

This study tests a drug called ceralasertib, alone or with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, and endometrial cancers. The goal is to see if these combinations can shrink tumors by blocking enzymes that help cancer grow.…

This study tested whether a combination of three drugs—everolimus, letrozole, and metformin—can help control advanced or recurrent endometrial cancer. The 62 participants had cancer that came back or spread and had limited prior treatments. The goal was to see how many patients h…

This early-stage trial tests a combination of two drugs (naptumomab estafenatox and durvalumab) in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to find the safest dose and see if the combination can shrink tumors. About 120 …

This study tested whether a combination of two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer. 42 participants whose cancer had returned or worsened despite prior treatment were enrolled. The goal was to see if the tumors shrank or stop…

This early-stage trial tests a new drug (AGEN1181) alone or with another drug (balstilimab) in people with advanced solid tumors that haven't responded to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 499 adults with …

This early-phase study tests adding an immunotherapy drug (TSR-042) to standard radiation for people with early-stage endometrial cancer who cannot have surgery. The goal is to see if the combination is safe and helps the immune system fight the cancer better. Ten participants wi…

This study tests the drug pembrolizumab in about 1,600 people with various advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink or control the tumors. Participants receive pembrolizumab and are monitored for tumor respons…

This study tests a combination of two drugs, abemaciclib and letrozole, in people with advanced or recurrent endometrioid endometrial cancer that cannot be cured by surgery or radiation. The main goal is to see how many participants have no cancer growth after 6 months of treatme…

This early-phase study tests whether combining two drugs, DKN-01 and pembrolizumab, can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer will receive the combination. The main goals ar…

This early-phase study tests a new drug called IMGN151 in adults with gynaecological cancers that have come back after standard treatments. The drug is designed to target a protein on cancer cells and deliver a chemotherapy-like payload directly. The main goals are to find a safe…

This study tests a special device that combines a vaginal dilator with a drug delivery tube to help prevent vaginal narrowing and scarring after pelvic radiation therapy. About 76 women aged 18-70 who have completed radiation for pelvic tumors will use the device regularly. The g…

This early-phase study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug works by blocking a protein (WRN) that these tumors need to survive. The study aims to see if the drug, alone or w…

This study tests whether the drug selinexor can help keep advanced or recurrent endometrial cancer from growing back after initial chemotherapy. About 276 adults whose cancer has a normal p53 gene and who responded to platinum-based chemo will receive either selinexor or a placeb…

This study tests whether giving the immunotherapy drug pembrolizumab before standard surgery can shrink tumors in people with a specific type of uterine cancer (MMRd). Twelve participants will receive 9 cycles of pembrolizumab before their hysterectomy. The goal is to see how man…

This study tests a new drug, MK-2870, against standard chemotherapy in about 710 people with endometrial cancer that has worsened after platinum chemo and immunotherapy. The goal is to see if MK-2870 helps people live longer and delays cancer growth. Participants are randomly ass…

This study tests whether injecting a radioactive sugar tracer (18F-FDG) into the cervix before a PET/CT scan can better show which pelvic lymph nodes contain cancer in women with early-stage cervical or high-grade endometrial cancer. The goal is to improve surgical planning by mo…

This study tests a program called Journey Ahead designed to help women with gynecologic cancer improve their coping and communication skills. About 30 women with ovarian, endometrial, cervical, or uterine cancer are taking part. The program focuses on reducing depressive symptoms…

This study looks at whether a 10-week exercise program done at home can improve physical fitness in women who have finished treatment for endometrial cancer. Ten participants will do exercises like chair stands and arm curls, guided by video coaching. The goal is to see if this a…

This study tests a newer type of radiation therapy called online adaptive radiotherapy (oART) for people who have had surgery for endometrial or cervical cancer. The goal is to see if using smaller treatment margins can reduce side effects while still effectively targeting any re…

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that makes the body burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer before they have surgery. Nineteen participants were enrolled to see if…

The IMPACT Study is testing two web-based tools—GeneSHARE and LivingLabReport—to help people with inherited cancer gene variants share their genetic test results with family members and follow cancer screening guidelines. The study involves 720 adults with certain inherited cance…

This pilot study aimed to see if a mobile health app could help track symptoms and quality of life in people with recurrent head and neck or gynecologic cancers. Participants would have used the app to report their feelings, side effects, and barriers to care. However, the study …

This study follows 100 women with breast or gynecologic cancers to see if their diet before chemotherapy is linked to levels of a protein called hepcidin, and whether hepcidin levels affect how much chemo they can receive. The goal is to understand if eating certain foods might h…

This study tests a personalized post-cancer care plan for women who have finished treatment for ovarian or endometrial cancer. About 99 participants will receive a day of support care and a tailored plan to address their needs. The goal is to see if this approach improves their l…

This study follows 21 patients who had a very extensive surgery called pelvic exenteration for recurrent gynecologic cancer. The goal is to understand how the surgery affects their quality of life and sexuality using standard questionnaires. The results will help doctors better p…

This study tests whether using a real-time tissue analysis during surgery can help doctors decide which patients with endometrial cancer need extensive lymph node removal. The goal is to avoid unnecessary surgery and reduce side effects for low-risk patients while still treating …

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having a baby after cancer. Researchers will use the results to help future patients make informed decisions about treatment and family planning. About 1,410 participants…

This study looks at how a person's genes and medical history might help predict nerve damage caused by chemotherapy. Researchers will follow 300 people with certain cancers who are scheduled for specific chemo drugs. The goal is to find patterns that could help prevent or reduce …

This study tests a new FDA-cleared vaginal speculum for endometrial biopsies in 100 women aged 18-90 who have had a previous biopsy. The goal is to see if it gives doctors better views of the cervix, is easier to use, and causes less discomfort than standard tools. Participants w…

This study looks at how diet, lifestyle, and genetics influence the risk of endometrial cancer. Researchers will compare hundreds of women with and without the disease to identify factors that may increase or decrease risk. Participants complete questionnaires about their health …

This study collects information from about 300 endometrial cancer patients across Asia to see how doctors use cancer cell features to choose treatments. The goal is to learn which patients need stronger therapy and which can avoid extra side effects. No new treatments are tested—…

This study collects fresh tumor samples from 416 people with various cancers to develop a live diagnostic platform. The goal is to train the platform to predict whether a patient will respond to immunotherapy, using standard imaging as the reference. Participants provide tissue a…

This study aimed to see if a type of PET/MRI scan could predict which women with early endometrial cancer or a precancerous condition would respond to hormone therapy. It planned to enroll 8 women and follow them for 6 months. However, the study was withdrawn before any participa…

This study looks at how safe and doable different amounts of aerobic exercise are for people about to have surgery for solid tumors like breast, endometrial, or prostate cancer. About 60 participants will exercise at home while using apps and devices to track their activity. The …

This study looks at whether group support or one-on-one peer support helps Black patients with endometrial cancer complete their treatment. About 252 participants will be randomly assigned to one of three groups: group support, one-on-one peer support, or enhanced usual care. The…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…