ENDOMETRIAL CANCER

This early-phase study tests a personalized cell therapy (ADP-A2M4CD8) for people with advanced cancers like lung, ovarian, or melanoma that have a specific marker called MAGE-A4. The treatment uses the patient's own immune cells, modified to better attack the cancer, and is give…

This early-stage study tests adding an immunotherapy drug (TSR-042) to standard radiation for people with early-stage endometrial cancer who cannot have surgery. The goal is to see if the combination is safe and can help the immune system fight the cancer more effectively. Ten pa…

This early-phase trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in adults with advanced solid tumors that have not responded to standard treatments. The main goal is to find a safe dose and check for side effects. About 120 people with various canc…

This study tests a drug called pembrolizumab in about 1,600 people with advanced solid tumors (like anal, bile duct, or endometrial cancer) that have stopped responding to standard treatments. The goal is to see if the drug can shrink or control the tumors. Participants receive p…

This study tested whether a combination of two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer. 42 participants with progressive or recurrent disease were enrolled. The goal was to see if the tumors shrank or stopped growing, and to chec…

This study compares a new drug, MK-2870, to standard chemotherapy in 710 people with endometrial cancer that has worsened after platinum-based chemo and immunotherapy. The goal is to see if MK-2870 helps people live longer and keeps the cancer from growing. Participants are rando…

This study tests a combination of two drugs, abemaciclib and letrozole, in people with advanced or returning endometrioid endometrial cancer that cannot be cured by surgery or radiation. The main goal is to see how many patients have no cancer growth after 6 months of treatment. …

This study tests a drug called giredestrant in 30 people with Grade 1 endometrial cancer. The goal is to see if the drug can shrink or control the cancer over 6 months without surgery. Participants take the drug daily and have regular biopsies to check progress.

This study tests whether adding an experimental drug (DKN-01) to an existing immunotherapy (pembrolizumab) can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer are taking part. The mai…

This study tests whether the immunotherapy drug dostarlimab works better than standard chemotherapy for women with advanced or recurrent endometrial cancer that has a specific genetic feature (MMR deficient). About 260 participants will be randomly assigned to receive either dost…

This study tests a program called Journey Ahead for 30 women with gynecologic cancers like ovarian or uterine cancer. The program focuses on improving coping skills and communication to reduce depressive symptoms and distress. Participants will complete surveys over time to measu…

This study looks at whether a 10-week exercise program done at home can improve physical fitness in women who have finished treatment for endometrial cancer. Ten participants will follow guided exercises and be tested on strength, balance, and endurance. The goal is to see if thi…

This study looks at whether group or one-on-one peer support helps Black patients with endometrial cancer complete their treatment. About 252 participants will be randomly assigned to group support, one-on-one support, or standard care. The main goal is to see if social support i…

This study looks at ways to help people who have genetic changes that increase cancer risk. The goal is to see if certain programs can help them follow medical guidelines for managing their cancer risk and share their genetic test results with family members. About 720 adults wit…

This study collects fresh tumor tissue from 416 people with various advanced cancers to train a new diagnostic platform. The goal is to see how accurately the platform can predict whether a patient will respond to immunotherapy. Participants provide tissue samples, and researcher…

This study tests whether a personalized surgical approach for endometrial cancer can safely reduce the extent of lymph node removal. Doctors use a real-time tissue analysis during surgery to decide how much lymph node dissection is needed. The goal is to lower surgical risks and …

This study looks at 100 women with breast or gynecological cancer to see if what they eat before starting chemotherapy is linked to a protein called hepcidin and whether they can receive the full planned dose of chemo. Researchers want to understand how diet might influence treat…

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that makes the body burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer. Nineteen participants will follow the diet before their surgery. The m…

This study looks at whether a special website and a genetic counselor can help more family members of people with hereditary cancer get tested for cancer genes. About 205 adults who have a known cancer gene mutation and their close relatives will take part. The goal is to see if …