ENDOMETRIAL CANCER

This study tests a new way to deliver radiotherapy for endometrial cancer after surgery. Using real-time MRI guidance, doctors can target radiation more accurately and reduce damage to nearby organs like the bowel and bladder. About 61 women will receive five high-dose sessions o…

This study compares two surgical approaches for women with early-stage, high-risk endometrial cancer that has a p53 gene mutation. One group will get the standard extensive lymph node removal, while the other gets a less invasive sentinel node biopsy. The goal is to see if the si…

This study tests a drug called enfortumab vedotin in up to 12 women with advanced endometrial cancer that has worsened after prior treatments, including immunotherapy. The drug targets a protein on cancer cells to deliver a toxin that kills them. Researchers will measure how many…

This phase 2 trial tests whether adding the targeted drug fruquintinib to standard chemotherapy (paclitaxel and carboplatin) works better than chemo alone for advanced or recurrent endometrial cancer that is mismatch repair-proficient (pMMR). About 128 participants will be random…

This study tests whether daily adaptive radiotherapy (ART) can safely deliver shorter, more intense radiation treatments for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to standard radiation or ART, which uses daily imagin…

This study tests whether a 28- to 54-week pre-surgery program—including weight-loss medication, a hormone-releasing IUD, nutrition, and exercise—can safely improve outcomes for women with early-stage endometrial cancer and a BMI of 40 or higher. About 80 participants will be rand…

This study tests a daily pill called hetrombopag to see if it can safely raise low platelet counts in women with gynecological cancers (like ovarian or cervical cancer) after chemotherapy. About 244 women whose platelets dropped too low will take the drug to help them complete th…

This study tests an experimental drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants w…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This study tests whether using AI to analyze CT scans of muscle mass can help doctors adjust chemotherapy doses to reduce side effects. About 294 women with endometrial or ovarian cancer will be split into two groups: one where the AI helps guide dosing, and one where standard do…

This early-phase trial is testing SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreas, or breast cancer) that have not responded to standard treatments. The study will first find the best dose and then check if the ther…

This Phase 3 trial tests a new biologic drug (PF-08634404) plus chemotherapy against the approved drug Keytruda plus chemotherapy in 600 women with advanced or recurrent pMMR endometrial cancer. The goal is to see if the new combination helps patients live longer without their ca…

This phase 2 trial is testing a daily pill called Inavolisib in about 48 people with advanced endometrial cancer that has a specific genetic change (PIK3CA mutation). The drug targets that mutation to try to shrink tumors or stop them from growing. Researchers will measure how ma…

This study tests whether adding a weight-loss shot (tirzepatide) to standard hormone therapy can better treat early-stage uterine cancer or pre-cancer in overweight women. About 30 participants will either get the standard progesterone IUD alone or the IUD plus tirzepatide. The g…

This study tests two immunotherapy drugs (iparomlimab and tuvonralimab) in 30 women with a specific type of endometrial cancer that is mismatch repair-deficient. The goal is to see if the treatment can make the cancer disappear or shrink enough to avoid surgery. Participants must…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will receive either tirzepatide or no additional treatment for 4 weeks be…

This study tests a new drug called INV-8989 in people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to see if the drug is safe and can shrink tumors. About 178 adults with cancers like pancreatic, lung, or colorectal cancer will take…

This study tests a new molecular test called CISENDO that looks for DNA changes in cells collected from a routine cervical smear. The goal is to see if it can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. Researchers will compare th…

This early study will test a new type of PET scan that uses two targets (FAPI and PSMA) at once to find and stage solid tumors like prostate, liver, ovarian, and endometrial cancers. About 20 adults with suspected or confirmed tumors will get this new scan, and doctors will compa…

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancers. The goal is to see if this less invasive method can accurately detect these cancers compared to standard tests. About 300 women, some with c…

This study tests a new way to deliver radiation therapy for endometrial cancer using daily MRI scans to guide the beam. The goal is to give a higher dose of radiation to the tumor while sparing nearby organs like the bowel and bladder. Thirty participants will receive 15 sessions…

This study tests if a newer, shorter course of radiation therapy (MH-ART) is as good as the standard longer course (CF-IMRT) for women who have had surgery for cervical or endometrial cancer. The goal is to see if the new approach causes fewer side effects and improves quality of…

This study looks at whether hand and foot exercises can reduce nerve pain (numbness, tingling) and improve quality of life in adults aged 65+ with gynecological cancer who are on chemotherapy. About 74 participants will do these exercises to see if they help with chemotherapy sid…

This study aims to find how often people with endometrial cancer have inherited changes in certain genes, including BRCA. Researchers will analyze blood samples from 20 participants who have a tumor with a BRCA mutation. The goal is to better understand the genetic factors behind…

This study will ask 50 people with abnormal uterine bleeding to collect daily urine samples and track their bleeding for one month. Researchers will use a home monitor to measure hormone levels and see if patterns can predict uterine cancer or precancerous changes. The goal is to…

This study looks back at the medical records of 200 people treated for gynecological cancers (like ovarian, cervical, or uterine cancer) at Assiut University Hospital between 2022 and 2025. The goal is to measure how long patients survive after diagnosis and compare those numbers…

This study compares two minimally invasive surgical methods—standard laparoscopy (small belly cuts) and vNOTES (surgery through the vagina)—for checking lymph nodes in early-stage endometrial cancer. Researchers will enroll 160 women to see how well each method finds sentinel lym…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study looks at whether a blood test that detects tumor DNA can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 women will be followed for two years. Those with a negative blood test may safely skip radiation, while others re…

This study will examine tissue samples from 50 people with type 1 endometrial cancer to measure levels of a protein called METTL-14. Researchers want to see if higher or lower amounts of this protein are linked to how aggressive the cancer is and how long patients live without th…