ENDOMETRIAL CANCER

This study tests a program called Primary Care Connect (PC2) that helps cancer survivors with heart risks stay connected to their primary care doctor during cancer treatment. About 266 adults with early-stage breast, prostate, bladder, or endometrial cancer who also have high blo…

This study tests a new way to give radiation for prostate, endometrial, cervical, and rectal cancers. Instead of standard daily doses, it uses daily scans to adjust the radiation beam precisely to the tumor, allowing fewer but stronger treatments. The goal is to see if this appro…

This study compares two surgical approaches for people with early-stage, high-risk endometrial cancer that has a p53 gene mutation. Half of the 374 participants will receive the standard extensive lymph node removal, while the other half will get a less invasive sentinel node bio…

This study tests whether adding the targeted drug fruquintinib to standard chemotherapy helps shrink tumors and delay cancer growth in people with advanced pMMR endometrial cancer. About 128 adults aged 18-75 with stage III/IV or recurrent disease will be randomly assigned to rec…

This early-phase study tests an experimental drug called CGT6297 in adults with advanced solid tumors that have a specific genetic change (PIK3CA mutation). The main goals are to check the drug's safety and find the best dose, while also seeing if it can shrink tumors. About 90 p…

This study tests a new drug called QLS5132 combined with other cancer treatments for people with advanced solid tumors, including stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination can shrink tumors. About 626 participants w…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will either receive tirzepatide or standard care for 4 weeks before their…

This study will test a new type of PET/CT scan that uses a special tracer called 18F-T2 to find tumors that have high levels of a protein called CAIX. About 200 adults with cancers like kidney, bladder, lung, or breast cancer will get this new scan along with a standard one to se…

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancers. The goal is to see if this less invasive method can detect cancer-related markers as well as or better than current tests. About 300 women, …

This study tests a new FDA-cleared vaginal speculum designed to make endometrial biopsies easier and less uncomfortable. About 100 women who have had this biopsy before will try the new tool. Doctors will rate how well they can see the cervix, how easy the tool is to use, and whe…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 women will be followed for 3 years. Those with no ctDNA in their blood may skip radiation and be monitore…

This study will look for inherited gene changes in 20 people with endometrial cancer who already have a tumor BRCA mutation. Researchers want to learn how common these inherited changes are and how they might affect the disease. The goal is to better understand endometrial cancer…