New DNA test on pap smears could spot hidden uterine cancer
NCT ID NCT07298707
First seen Jan 05, 2026 · Last updated Jun 19, 2026 · Updated 20 times
Summary
This study tests a new molecular test called CISENDO that looks for DNA changes in cells collected from a routine cervical smear. The goal is to see if it can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. Researchers will compare the test results to standard hysteroscopy with biopsy in 3,500 participants, and some will be followed for up to a year to track changes over time.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CISENDO test (DNA methylation test on cervical cytology samples)
What this could lead to
If successful, this could provide a simple, non-invasive screening test to detect endometrial cancer early and monitor disease progression without repeated invasive procedures.
What could go wrong
This is an observational study, not a treatment trial. The test may not be accurate enough to replace standard diagnosis, and results may not apply to all populations.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.