ENDOMETRIAL CANCER

This phase 2 study tested a drug called retifanlimab, which helps the immune system attack cancer, either alone or combined with other targeted drugs. It enrolled 206 women with advanced or metastatic endometrial cancer that had worsened after platinum-based chemotherapy. The goa…

This early-stage trial tested a combination of three drugs—afuresertib, sintilimab, and chemotherapy—in 22 adults with solid tumors (like lung, cervical, or stomach cancer) that had stopped responding to prior immunotherapy. The goal was to find a safe dose and see if the combo c…

This early-phase trial tested an experimental oral drug called TPST-1495, given alone or with the immunotherapy Keytruda, in 89 people with advanced solid tumors (like colorectal, lung, and head/neck cancers) that had stopped responding to standard treatments. The main goals were…

This early-phase study tested the safety and effectiveness of a new drug called STRO-002 in 19 Chinese adults with advanced ovarian, endometrial, or other solid tumors that had not responded to other treatments. The goal was to find the best dose and see if the drug could shrink …

This study tested a combination of three drugs (bevacizumab, atezolizumab, and rucaparib) in 30 people with endometrial cancer that had come back or continued to grow despite prior treatment. The goal was to see how many participants' tumors shrank or disappeared. The approach ai…

This study tested a drug called selinexor in 263 women with advanced or recurrent endometrial cancer who had finished chemotherapy and were in remission or partial remission. Participants took either selinexor or a placebo once a week to see if the drug could keep the cancer from…

This study tested a high-dose internal radiation therapy (brachytherapy) in 43 adults with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver the right dose. Participants received the…

This study tested an experimental drug combination (MK-4280A) in 163 people with either a type of skin cancer (cutaneous squamous cell carcinoma) or endometrial cancer. The goal was to see if the treatment could shrink or eliminate tumors. Participants received either the new com…

This study tested a new drug called RP903 in 69 people with advanced solid tumors (like ovarian, breast, or cervical cancer) who had run out of standard options. The main goals were to check safety, find the best dose, and see if the drug shrinks tumors. It is an early-phase tria…

This study tested a shorter course of pelvic radiation (about 1 week instead of the usual 5-6 weeks) given after hysterectomy for advanced endometrial cancer. The goal was to see if this shorter treatment causes fewer side effects while still controlling the cancer. The study inc…

This study looked at whether a drug called oliceridine is safe and effective for putting patients to sleep before gynecologic laparoscopic surgery for endometrial cancer. Researchers compared it to another drug, sufentanil, by checking changes in blood pressure and heart rate dur…

This study looked at whether a 12-week program of aerobic and strength exercises could improve heart health and fitness in women who finished treatment for endometrial cancer. Thirty-three survivors in remission took part. They received exercise equipment and a Fitbit, and had he…

This study tested whether adding the drug aprepitant to standard anti-nausea medicine helps women with gynecologic cancers (like ovarian or cervical cancer) who are getting chemotherapy. 143 women took part. The goal was to see if the extra drug could better prevent nausea and vo…

This study tested a shorter course of pelvic radiation for women with endometrial cancer after surgery. The goal was to see if this approach is safe and tolerable. Eight patients participated, and researchers monitored side effects and quality of life for three months after treat…

This study tested a physical activity program for breast and endometrial cancer survivors who were not getting enough exercise. The program used technology like fitness trackers and electronic health records to provide support, with extra help for those who needed it most. The go…

This study tested a home-based, personalized brain training program for 60 women with gynecologic cancer (ovarian, endometrial, cervical, or vulvar) who had finished chemotherapy and reported memory or thinking issues. The goal was to see if the program was practical and acceptab…

This study measured 14 trace elements in blood samples from 40 women with endometriosis, ovarian cancer, endometrial cancer, or healthy controls. Researchers wanted to see if levels of elements like iron, selenium, or lead differ between these groups. The goal is to find clues th…

This study tested a new follow-up model for people treated for gynecologic cancers like ovarian, endometrial, cervical, or vulvar cancer. Instead of seeing a doctor at every visit, patients saw a nurse every other visit and used a smartphone app focused on health and well-being. …

This completed study followed 102 women with ovarian, fallopian tube, or endometrial cancer receiving standard chemotherapy (carboplatin and paclitaxel). Researchers measured taste changes, muscle loss, and nutritional decline at three points during treatment. The goal was to und…

This study compared two types of hysterectomy surgery: vNOTES (done through the vagina) and total laparoscopic hysterectomy (done through small belly cuts). Researchers measured the thickness of the optic nerve sheath, which can indicate pressure inside the skull. The goal was to…

This study tested whether a modified dye injection method, where surgeons watch the dye travel through lymph channels in real time, works better than the standard method for finding sentinel lymph nodes in women with early-stage endometrial cancer. Eighty patients having robotic …

This study looked at how much extra tissue around a tumor needs to be treated with radiation after surgery for endometrial or cervical cancer. Using a special technique called online adaptive radiotherapy, doctors adjusted the radiation plan each day to see if they could safely u…

This study tested whether a few sessions of high-intensity interval training (HIIT) before surgery could affect cancer cells in women with endometrial cancer. Thirty women with early-stage disease did 4 to 6 exercise sessions before their scheduled hysterectomy. Researchers then …

This study tested whether a special survivorship clinic could help women after breast or gynecologic cancer treatment. Two hundred women visited the clinic and used an app to report symptoms. The goal was to see if this approach is practical and acceptable for routine follow-up c…

This study looked at how well the drug T-DXd works compared to standard treatments for people with several types of HER2-positive cancers that have spread. Researchers used data from past trials and real-world patient records to compare survival. The goal was to see if T-DXd offe…

This study looked at medical records from 509 adults in Taiwan to find out how often advanced cervical, endometrial, and ovarian cancers have a specific marker called HER2 IHC 3+. Researchers also described the patients' health details to better understand who might benefit from …

This study looked at how chemotherapy after surgery affects the overall quality of life of women with stage II or III endometrial cancer. Researchers surveyed 51 women who had completed treatment at least two years earlier using standard quality-of-life questionnaires. The goal w…

This study looked at 78 women having hysterectomy or related surgery to compare robotic-assisted laparoscopy with conventional laparoscopy. The main goal was to see how long each type of surgery takes. Researchers also tracked time under anesthesia, blood loss, and other details …

This study looked at 150 women with intermediate- or high-risk endometrial cancer to compare two types of surgery: removing lymph nodes from the lower part of the abdomen versus removing nodes from both the lower and upper abdomen. The goal was to see which approach gives doctors…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…