Opiate dependence

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This trial tests whether regular checkups after release from jail can help people with opioid use disorder stay in treatment. Researchers will compare standard re-entry care with two versions of a Recovery Management Checkups program, one with monthly meetings for three months an…

This trial tests whether a monthly injection of extended-release buprenorphine (Sublocade) helps people with opioid use disorder who use fentanyl reduce their opioid use more than the standard daily sublingual buprenorphine pills. Adults aged 18 to 65 with moderate to severe opio…

This study tests a refined computer alert that prompts emergency room doctors to order a consultation with an addiction counselor for patients with opioid use disorder. Researchers will enroll 300 adults with moderate to severe opioid use disorder who visit the ER. The goal is to…

This study tests whether a smartphone app can help people with opioid use disorder stay drug-free. Participants use the app to submit video-recorded saliva drug tests, earn rewards for staying abstinent, complete therapy modules, and get support from a peer. The study involves 25…

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults …

This study tests whether an app that gives financial rewards for drug-negative saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorder. Researchers will compare results between older and younger participants to see if age affects how well the app…

This trial tests whether a 'learning health system'—a structured partnership between juvenile justice agencies and community mental health centers—can improve the full continuum of substance use care for youth involved in the justice system. The approach uses local data to identi…

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This study tests whether adding the sleep medication suvorexant to standard buprenorphine treatment can improve sleep and medication adherence in people with opioid use disorder who have recently used fentanyl. Participants first stay in a residential setting for five days to sta…

This study tests a staged approach to help addiction treatment programs in Washington State increase their use of medications for opioid use disorder (MOUD). Clinics start with simple feedback reports and, if needed, move to more intensive support like workshops and coaching. The…

This trial uses brain scans to see whether 8 weeks of mindfulness-based group therapy changes how the brain processes reward, craving, and self-control in people with heroin addiction. About 157 adults on medication for opioid use disorder will be randomly assigned to mindfulness…

This study tests a home-based parenting program called BRIGHT for pregnant women receiving treatment for opioid use disorder. The program starts in the third trimester and continues for six months after birth, focusing on the parent-child relationship, mental health, and infant d…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This study tests a mobile app called KIOS that gives personalized advice and support to people receiving medication-assisted treatment for opioid use disorder. Over 12 weeks, 116 participants will either use the app plus standard counseling or just standard counseling. The goal i…

This pilot study looked at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder could help them cut down on smoking. The 36 participants were not trying to quit smoking at the start. Researchers measured how many people switched to …

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce methamphetamine use in people already receiving methadone maintenance therapy. Fifty-five adults with both opioid and methamphetamine use dis…

This study tests a text-message-based cognitive behavioral therapy (CBT) program called imFREE to help adults with opioid use disorder stick with their buprenorphine treatment and reduce opioid use. Participants receive daily text messages with CBT skills and relapse prevention t…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tested whether giving buprenorphine treatment in group medical visits (instead of one-on-one) helps people with opioid use disorder stay abstinent and remain in treatment. Eighteen adults already on buprenorphine but still using opioids took part in weekly 90-minute gr…

This completed trial tested a new approach for opioid use disorder: shining a specific type of near-infrared light on the scalp for just 4 minutes. The idea is to stimulate a healthier side of the brain to reduce addiction. Researchers compared the active light treatment to a sha…

This phase 2 trial tested whether cannabidiol (CBD) can reduce craving and anxiety in 76 adults with opioid use disorder who were already on opioid agonist therapy (like methadone). Participants took CBD or a placebo twice daily for 4 weeks, then all took a higher dose of CBD for…

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This trial tests whether a team-based approach, including a dedicated nurse care manager, can help primary care clinics provide medication treatment for opioid use disorder. The study involves 12 clinics across five U.S. states, with half using the new approach and half continuin…

This study tested a device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 36 adults with opioid addiction were randomly assigned to get the active device, withdrawal medication (lofexidine), or a placebo. The goal was to see if the device…

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study looked at different ways to help people with opioid use disorder start treatment. It compared usual care, patient navigation (help from a guide), and patient navigation plus starting buprenorphine right away. The goal was to see which approach gets more people into tre…

This study looked at whether giving a special research e-cigarette to people who are stable on medication for opioid use disorder and smoke daily could help them smoke fewer regular cigarettes. 41 adults who weren't ready to quit smoking were randomly assigned to get the e-cigare…

This study tested whether offering medication for opioid use disorder (MOUD) via telehealth to women in jail helps them start treatment after release. 900 women across 9 Kentucky jails took part. Some also got a peer navigator for support. The goal was to see if these services in…

This study tested a program called the Transitions Clinic Network (TCN) for people leaving jail with opioid addiction. The program combines primary care, medication options, and a community health worker to address social needs. Researchers compared this to standard care and foll…

This early-stage study tested a new implant that slowly releases naltrexone, a medication used to treat opioid use disorder. The implant is placed under the skin and left for three months. The trial involved 16 healthy adults to check safety and how the drug enters the bloodstrea…

This study tested whether a once-monthly injection (XR-BUP) works as well as daily pills (SL-BUP) for treating opioid use disorder in rural settings. 140 adults with moderate to severe opioid use disorder took part. The goal was to see if the injection is practical and acceptable…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested whether adding a support person—like a family member or friend—to standard buprenorphine treatment helps people with opioid addiction stay in treatment longer. 439 patients and their support persons took part. The support persons learned CRAFT, a counseling prog…

This study tested whether cannabidiol (CBD) can reduce cravings and prevent relapse in people with opioid use disorder who are already taking standard medications like buprenorphine or methadone. Thirty-five participants received either CBD or a placebo for 28 days while in resid…

This study tested a smartphone app designed specifically for women to help them stay engaged with their medication for opioid use disorder. 39 women who had recently started medication treatment were randomly assigned to use the app plus standard care, or standard care alone. Res…

This study tested a comprehensive program to help women involved in the criminal justice system start and stay in opioid addiction treatment. The program included peer support, housing help, overdose training, and transportation or childcare. Half of the 42 women also joined a tr…

This study tested whether a pharmacist-led program could help people leaving jail get treatment for opioid use disorder and prevent overdoses. Participants received overdose training, Narcan nasal spray, counseling, and referrals to medication treatment after release. The goal wa…

This study tested a collaborative care model for people with opioid use disorder and depression, anxiety, or PTSD. 567 adults received medication (buprenorphine-naloxone or naltrexone) along with therapy and support from a primary care team. The goal was to reduce opioid use and …

This study tested a mobile app (uMAT-R) designed to help pregnant and postpartum women with opioid use disorder stay on their medication and treatment. 125 women participated in a pilot trial to see if the app was easy to use and helped reduce cravings and improve attitudes towar…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study tested whether adding mindfulness-based relapse prevention (MBRP) to standard care helps people with opioid use disorder stay on their medication (extended-release naltrexone) and avoid drug use after leaving a residential treatment program. About 105 participants were…

This early-stage study tested whether a brief therapy program plus a mobile app could help pregnant and postpartum women stay on their buprenorphine medication for opioid use disorder. Fifteen pregnant women took part, attending therapy sessions and using the app for up to 9 mont…

This study tested a program called RIMO that helps people who recently survived an opioid overdose get into medication-assisted treatment (MAT). The program uses motivational interviewing and support to encourage people to start and stay on MAT. Researchers worked with first resp…

This completed Phase 4 trial tested a new way to start oral opioid addiction therapy for people who use fentanyl. Participants received medically supervised IV fentanyl until comfortable, then were given tailored doses of methadone or slow-release oral morphine. The study enrolle…

This study tested a new injectable medication called INDV-6001 in 123 adults with moderate to severe opioid use disorder. The goal was to see how the drug moves through the body, if it is safe, and how well people tolerate it. Participants received multiple doses, and researchers…

This completed study tested deep brain stimulation (DBS) in just one person with severe, treatment-resistant opioid use disorder. The goal was to see if stimulating brain reward areas could reduce opioid use and improve safety. Because only one participant was enrolled, the resul…

This study looked at whether giving doctors a simple urine drug test in their office helps people stay on buprenorphine treatment for opiate addiction. About 42 patients starting buprenorphine with their family doctor took part. The goal was to see if these tests improve treatmen…

This pilot study tested a program where trained peer recovery specialists meet regularly with patients starting medication for opioid use disorder. The goal was to see if the program is practical and acceptable to patients. 13 adults took part, and the results will help design a …

This study tested two different doses (100 mg vs 300 mg) of a monthly buprenorphine injection in 785 adults with moderate to severe opioid use disorder. The goal was to see which dose helped people stay in treatment and reduce opioid use. The study also compared a faster versus s…

This study looked at whether adding computer-based cognitive behavioral therapy (CBT4CBT) and peer recovery coaching to standard buprenorphine treatment helps reduce illicit drug use. 92 adults with opioid use disorder were randomly assigned to receive buprenorphine alone, bupren…

This study looked at 240 prisoners with opioid addiction to see if getting a long-acting naltrexone shot at home after release works better than going to a clinic. Participants got one shot in prison and six monthly shots either at a clinic or at their home. The goal was to see i…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone therapy reduce methamphetamine use and improve HIV outcomes. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to sup…

This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks…

This study tested a new drug called INDV-2000 in 300 adults with moderate to severe opioid use disorder who wanted to stop using opioids. Participants were randomly assigned to receive different doses of INDV-2000 or a placebo for 3 months. The main goal was to see if the drug co…

This study looked at whether giving buprenorphine treatment directly at syringe exchange programs helps people with opioid addiction more than sending them to a community health center. About 100 syringe exchange participants in New York City took part. The goal was to see if sta…

This study tested whether a once-monthly injection of extended-release buprenorphine helps hospitalized patients with moderate to severe opioid use disorder stay in treatment better than usual care (like daily pills or methadone). Over 300 adults were randomly assigned to receive…

This pilot study tested two behavioral programs to help people with opioid use disorder take their medication as prescribed. One group could win gift cards when their urine tests showed they were taking their medicine. The other group had one-on-one sessions to set goals, find fu…

This study tested whether delivering pre-made meals to the homes of people in treatment for opioid use disorder could help with food insecurity. Fifty adults were split into two groups: one got nutrition education and community resources, while the other also received weekly meal…

This study tested whether training people on methadone to become peer educators could help their friends who inject drugs and have HIV get into treatment. The peer educators talked to their social network members about medication for drug dependence and accompanied them to the cl…

This study tested whether a trained peer recovery specialist could help low-income, minority individuals stick with their methadone treatment for opioid use disorder. 200 participants in Baltimore were assigned to either the peer-led support program or standard care. The goal was…

This study looked at whether peer support specialists (recovery coaches) can help people with opioid use disorder begin and continue buprenorphine treatment. 90 adults from rural South Carolina mobile health clinics took part. Researchers compared their treatment progress to past…

This completed study followed 480 adults with opioid use disorder who were already taking SUBLOCADE, a long-acting buprenorphine injection. Researchers observed participants for up to 4 years to see if they achieved remission, reduced opioid misuse, and improved their physical, m…

This pilot study tested a telehealth platform designed to encourage people with opioid use disorder to start and stay on medication treatment. 33 participants with a history of opioid overdose used the platform, which included chat-based support. The study measured whether they a…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This study tested whether offering hepatitis C treatment at the same clinic where people receive opioid therapy leads to better outcomes than referring them to a separate infectious disease clinic. About 298 people on opioid therapy with chronic hepatitis C took part. The goal wa…

This study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…

Researchers are testing whether a four-week group program can help people who inject drugs and are in methadone treatment reduce their risk of HIV. The program teaches skills like cleaning needles and using condoms, and it is compared with a support group that does not focus on t…

This study tested new ways to prevent opioid misuse and addiction in teens and young adults (ages 16-30) who visited the emergency department. Participants received support starting in the ER and continuing through telehealth after they went home. The goal was to find the most ef…

This study tested a simple checklist and peer coaching program for people who inject drugs and are hospitalized with serious infections. The goal was to see if these tools could help start HIV prevention medication (PrEP) and addiction treatment. Sixty HIV-negative adults with op…

This trial tests whether a comprehensive, community-wide strategy can reduce opioid overdose deaths by 40% in 67 communities hardest hit by the crisis. The approach, called Communities That HEAL, brings together local leaders, healthcare, justice, and community groups to implemen…

This study tested a program called TACUNA plus Wellness Circle, designed to prevent opioid misuse among American Indian and Alaska Native young adults aged 18-25 in California. The program uses motivational interviewing and traditional practices in virtual workshops. Researchers …

This study tested a digital program designed to prevent teens from starting to misuse opioids. About 533 high school students who had never misused opioids but were at higher risk took part. The program aimed to increase their understanding of the serious risks of misusing prescr…

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This study tested whether text message reminders can encourage people to keep their opioid pain medication in a safe place and throw away any leftover pills after treatment. About 479 adults who received an opioid prescription took part. The goal was to reduce the chance of these…

This completed trial tested two school-based programs—Connect and CMCA—to prevent drug and alcohol misuse among 10th graders in rural Cherokee Nation high schools. Over 900 students from 20 schools participated, with some schools receiving the programs and others serving as contr…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids. 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress and depression, and preve…

This study tested whether giving homeless young people (ages 18-24) a place to live plus support services could help them avoid developing opioid use disorder. 240 participants who were homeless but did not yet have opioid addiction were randomly assigned to receive either housin…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This study tested whether a virtual reality experience where people see an avatar of their future self could help those in early recovery from opioid use disorder reduce drug use and stay abstinent. 104 participants were split into a VR group and a control group. Researchers meas…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study looks at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) can control pain after wisdom tooth removal just as well as, or better than, prescription opioids. About 1,800 people having their wisdom teeth removed will be randomly…

This study looked at whether a sleep medication called suvorexant can improve sleep and reduce stress in people recovering from opioid addiction. About 138 participants on medications like methadone or buprenorphine were given either suvorexant or a placebo for 8 weeks. The goal …

This study tested two types of nerve blocks (erector spinae plane block and serratus anterior plane block) to see which provides better pain relief after breast reduction surgery. 80 women received one of the two blocks, and researchers measured how much pain medication they need…

This study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This pilot trial tests whether adding microcurrent neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard care alone. MCN uses scalp sensors to deliver barely perceptible electrical pulses tailored to each person's brain …

This study tests whether an AI chatbot called Suzy can help people recovering from opioid use disorder stay engaged with their care. Over 12 weeks, 55 participants will use the chatbot to prepare for appointments, find community resources, and learn coping techniques. Researchers…

This pilot study tested whether wearing bright light therapy glasses can improve sleep and reduce cravings in people being treated for opioid use disorder. Twenty-three adults on stable medication-assisted treatment (methadone or buprenorphine) with insomnia used either active or…

This pilot study tested whether an 8-week group therapy program delivered over Zoom could help adults with both chronic pain and opioid use disorder. The therapy, called Emotional Awareness and Expression Therapy (EAET), teaches people to understand and express their emotions as …

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This early-phase study tested whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could reduce withdrawal symptoms in 25 adults with opioid use disorder who were gradually reducing their methadone dose. Participants received either real HBOT at two …

This completed trial tested a program called REDOCVR for 174 adults with chronic pain. The program combines group education, emotional support, and virtual reality experiences to help people reduce their pain medications. Researchers measured changes in medication use, mental wel…

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This study tested whether a heart rate variability biofeedback program—using a sensor and smartphone app to guide slow breathing—is practical and helpful for adults in residential treatment for opioid use disorder. Thirty-two participants practiced daily for three weeks. Research…

This study looked at whether adding lofexidine to standard buprenorphine treatment can improve symptoms of both PTSD and opioid use disorder in veterans. 84 veterans on stable buprenorphine therapy were enrolled. The goal was to see if the combination reduced opioid use and PTSD …

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This study tested a mobile app called OPY that helps patients manage pain and safely use opioids after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription took part. The app provided daily tips, tracked pain and side effects, and encouraged p…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This study looked at whether listening to music can help lower cravings for opioids when people see drug-related cues. Twenty-eight adults with opioid use disorder, all on stable medication treatment, either listened to their favorite relaxing songs or sat in silence. Researchers…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This study looked at whether giving a tiny amount of the opioid remifentanil right after surgery could prevent a condition called opioid-induced hyperalgesia, where opioids actually make pain worse. It involved 41 women with breast cancer having breast surgery under total intrave…

This study tested whether peer-led therapy sessions could ease depression and anxiety in people recovering from opioid use disorder in rural areas. Forty adults receiving medication for opioid use disorder took part, with some getting extra support from a certified peer specialis…

This study tested a walking program for veterans with opioid use disorder and chronic pain. Sixty veterans receiving medication for opioid addiction took part. The program included pain education and a step-by-step walking plan using a pedometer. The goal was to see if this appro…

This study tested whether taking melatonin for three nights before wisdom tooth surgery could lower pain and the need for pain medication afterward. Sixty adults aged 18-35 took either melatonin or a placebo before their surgery. Researchers measured how many pain pills they used…

This study tested a program called TOPPS for people taking buprenorphine for opioid addiction who also have chronic pain. The program uses counseling and education to help patients manage pain and avoid turning to substance misuse. 163 adults from primary care clinics took part, …

This study tested whether giving nerve pain medications pregabalin or gabapentin alongside standard opioids could lower the amount of opioids needed by adults hospitalized with orthopedic injuries. 109 participants were randomly assigned to receive one of the two add-on drugs. Th…

This study tested whether suvorexant, a sleep medication, can reduce drug use and cravings while improving sleep and stress in people being treated for both opioid and stimulant use disorders. Twenty adults stable on methadone or buprenorphine took either suvorexant or a placebo …

This study tested a digital program called 'Empowered Relief: On-Demand' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults with chronic pain and opioid misuse were randomly assigned to either the digital pain relief program or a health e…

This study tested a short video and a 3-week text messaging program for adults who recently experienced sexual assault. The goal was to see if these tools could help prevent or reduce posttraumatic stress disorder (PTSD) and opioid misuse. Fifty participants received the video du…

This study tested whether CBD (a compound from cannabis) can help people who want to reduce their pain and opioid use. 126 adults took either CBD or a placebo for 12 weeks. Researchers measured changes in pain, opioid use, and other factors like anxiety and sleep.

This early-phase study tested whether cannabidiol (CBD) could safely help people with both opioid use disorder and chronic pain. Seven adults on methadone or buprenorphine received single doses of CBD (400, 800, or 1200 mg) or a placebo in a crossover design. Researchers measured…

This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive eith…

This study tested a smartphone app designed to reduce anxiety and depression in people already receiving medication for opioid use disorder. 63 adults were randomly assigned to use the app for four weeks or to continue their usual care. The goal was to see if the app was feasible…

This study tested whether blocking a nerve cluster called the SPG can reduce withdrawal symptoms in people with opioid use disorder. Only 3 people took part, and the goal was to see if the approach is safe and worth studying further. It did not provide addiction treatment or medi…

This study looked at how cannabidiol (CBD) affects the brain in people with opioid use disorder who are also taking methadone. Researchers used brain scans to see if CBD could reduce cravings and anxiety. The study involved 66 adults and tested a single dose of CBD or a placebo, …

This study tested whether a type of brain stimulation called theta burst stimulation (TBS) could reduce cravings and attention to drug-related cues in 23 people with both opioid and tobacco use disorders. Participants received four sessions of real or fake TBS in one day while th…

This small, early-stage study tested whether a dietary supplement called palmitoylethanolamide (PEA) could help people with opioid use disorder feel less stress, craving, and pain. Twelve adults already on stable medication for opioid use took PEA or a placebo for three weeks. Th…

This small pilot study tested whether a 12-week supervised walking program could help middle-aged adults with opioid use disorder reduce pain and improve mobility. Only 6 people took part, and the main goal was to see if such a program was feasible—whether people would join and s…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This study looks at how stress changes the way opioid painkillers work in people with chronic back pain. Researchers will give participants oxycodone, a pain blocker, or a placebo in a lab setting to measure pain relief and drug liking. The goal is to understand why some people m…

This study looks at whether older adults (55+) in methadone treatment for opioid use disorder can use smartphone-based cognitive games to track and possibly improve their thinking skills. Thirty participants will play short brain-training tasks twice a day for 15 days. The main g…

This study follows 1600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how peo…

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study looks at how different e-cigarette flavors appeal to adults who have opioid use disorder and are on buprenorphine treatment. Participants will smell and rate 11 flavors for sweetness, coolness, strength, and how likely they'd use them again. The goal is to find flavors…

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder. Researchers looked at whether the tool increased the use of standard assessments and buprenorphine treatment. The study involved 267 adults with moder…

This study aims to create a better tool for measuring opioid cravings in people being treated for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to improve how cravings …

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This study tested a web-based toolkit called MOM CARE designed to help jail staff provide better care for pregnant people with opioid use disorder. The toolkit includes medical guidance and best practices from intake to release. Researchers worked with 22 jail staff members to se…

This study tested a coaching and training program for addiction clinics to help them better treat opioid use disorder. The program included training on tracking patient progress, using medications for opioid use disorder, and improving patient retention. Researchers worked with n…

This completed early-phase study looked at how opioid use disorder changes the way people make decisions. Twelve adults with moderate to severe opioid use disorder completed gambling tasks and had brain scans while receiving oxycodone, placebo, or remifentanil. The goal was to un…

This study tested a harm reduction program designed specifically for Black adults who misuse opioids or stimulants. 63 participants completed surveys before and after the program to see if their knowledge, confidence, and willingness to use overdose prevention techniques improved…

This study tested whether doctors can use simple decision guides to better manage opioid misuse behaviors in patients on long-term opioid therapy for chronic pain. Researchers worked with 49 clinicians at community clinics to see if the guides were easy to use and helpful. The go…

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study tested a program designed to make medication for opioid use disorder more culturally appropriate for American Indian and Alaska Native communities. Researchers worked with four healthcare sites to help them better support patients starting and staying on these medicati…

This study looked at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers used special PET/CT scans on 12 adults, including those with opioid use disorder and healthy volunteers. The goal was to understand lo…

This study tested a training program for prenatal healthcare providers to help them use medication-assisted treatment (MAT) for opioid use disorder during pregnancy. Researchers looked at data from over 1,000 patients to see if the program increased use of MAT and improved health…

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study looked at whether changes in a person's voice can help detect opioid use in people being treated for opioid use disorder. Researchers collected voice samples from 41 patients and used machine learning to find patterns linked to opioid intoxication or withdrawal. The go…

This study looked at how opioid maintenance therapy affects sensation, balance, walking, posture, and reaction time in people with opioid use disorder. Researchers compared 80 adults on buprenorphine/naloxone therapy to healthy individuals. They measured things like foot sensatio…

This study tested whether a training program called Modeling to Learn (MTL) helps clinic staff improve how many veterans start and finish evidence-based treatments for PTSD, depression, and opioid use disorder. The program uses computer simulations to let staff try out changes to…

This study looked at how the supplement n-acetylcysteine (NAC) affects brain glutamate levels and drug cravings in 12 people who use both opioids and cocaine. Participants were given either NAC or a placebo while on a steady dose of hydromorphone, and then underwent brain scans a…

This study tested a special parenting program (mABC) for pregnant women recovering from opioid addiction. 174 mothers and their babies took part. The program focuses on helping mothers be more sensitive and nurturing, which could improve the baby's emotional and physical developm…

This study looked at how hospital doctors, nurses, and social workers feel about treating opioid use disorder (OUD) while patients are in the hospital. Researchers surveyed 400 healthcare workers across 12 hospitals in Colorado. The goal was to understand current practices and se…

This study looked at whether using regular patient surveys to guide treatment can help people with opioid use disorder stay in treatment and stop using opioids. Researchers worked with 35 clinic leaders and providers to train them on this approach. They compared patient attendanc…

This study tested a mobile app called App for Independence-O (A4i-O) designed to support people with opioid use disorder. Fourteen adults used the app for one month while receiving outpatient treatment. The goal was to see if the app works well and is easy to use, not to measure …

This study tested a group well child care program for mothers in treatment for opioid use disorder and their infants. Instead of standard one-on-one checkups, mother-infant pairs attended group visits together from 1 to 18 months of age. The goal was to see if this approach impro…

This completed Phase 1 study looked at how marijuana and an opioid drug influence each other's use in healthy adults aged 18-50 who had experience with both substances. Eight participants lived at a research unit for about 6.5 weeks and could earn doses of each drug under control…

This study tested a digital version of a family training program called CRAFT. It was designed to help concerned family members (called CSOs) encourage a loved one with opioid use disorder to enter treatment. 45 adults who had a loved one struggling with opioid use participated. …

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study tested a program where community health workers were trained to help people with opioid addiction get and stay in treatment, with support from their families. Over 1,600 adults who use drugs took part in communes across Vietnam. The goal was to see if this community-ba…

This study looked at pregnant women being treated for opioid use disorder with two different forms of buprenorphine: a monthly shot and a daily tablet. Researchers measured drug levels in the mother's blood and checked the baby's heart rate to see how each treatment affected both…

This study looked at 71 babies born to mothers who took either a monthly injection or a daily tablet of buprenorphine for opioid use disorder during pregnancy. Researchers measured the babies' thinking, language, and motor skills using a standard child development test. The goal …

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This completed study tested different strategies to help emergency doctors start buprenorphine treatment for people with opioid use disorder. Researchers used a computer system to prompt nurses and doctors, and gave patients educational materials. The goal was to see which combin…

This completed study looked at 12 people with opioid use disorder who had been stable on SUBLOCADE injections for at least 9 months. Researchers wanted to see if they could successfully stop the medication without relapsing or restarting long-term treatment. The goal was to under…

This study tested a new brain-training method to help people with heroin addiction reduce cravings. Participants watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further along in recovery. The goa…

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study tested a patient decision aid designed to help adults with opioid use disorder choose the best medication-assisted treatment for them. Over 7,500 people took part, and researchers tracked their drug use, treatment retention, and health outcomes for up to 24 months. The…

This completed study surveyed 257 adults with sickle cell disease to understand how they use painkillers at home, including opioids and cannabis. Researchers wanted to find out how common opioid addiction is in this group. Patients answered a one-time questionnaire at three speci…

This completed Phase 1 study at Yale University looked at how vitamin D (calcitriol) affects dopamine receptors in the brains of people with opioid use disorder. Five participants received either vitamin D or a placebo and had PET scans to measure brain activity. The goal was to …

This study looked at how to help more veterans with opioid use disorder get effective medication. Researchers combined six pilot projects across 63 VA sites to find the best ways to increase access to these treatments. The goal was to see if a structured support program for healt…

This study developed a computer program that can scan hospital records to find patients who may be misusing drugs or alcohol. Researchers tested it on nearly 65,000 adults admitted to the hospital. The goal was to see if the tool could help doctors offer counseling and support to…

This completed Phase 1 study tested how the body processes different doses of oral buprenorphine compared to an intravenous dose. Eighteen healthy adults with past opioid use received three different doses in separate visits. Researchers measured drug levels in the blood over 24 …

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This study tested whether sending letters to doctors about their patients' opioid overdoses would reduce how often they prescribe strong painkillers. Researchers looked at 61 clinicians who had prescribed opioids to patients who later had a non-fatal or fatal overdose. The goal w…

This study tested a program that brings in family and friends to support people receiving methadone treatment for opioid use disorder in Tanzania. The goal was to see if this social support approach is acceptable and practical, and whether it helps people stick to their methadone…

This study tested a computer tool called the Opioid Wizard that helps primary care doctors identify and treat patients with opioid use disorder. Over 10,000 patients from 30 clinics participated. The tool works within the electronic health record to provide tailored treatment rec…

This study looks at whether a patient navigation program can help more people with opioid use disorder start treatment after being in the hospital. The program, called NavSTAR, was tested in 4 Philadelphia hospitals with 32 patients. The goal is to learn how to make this program …