Kidney failure

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

People with advanced chronic kidney disease often avoid nuts because of concerns about phosphorus and potassium. Researchers at Shahid Beheshti University of Medical Sciences are testing whether a daily 30-gram serving of pistachios, added to a standard kidney diet, changes level…

Researchers are testing whether a multidisciplinary care model helps people with type 2 diabetes and chronic kidney disease start and adjust five classes of heart and kidney protective medicines within four months. The trial enrolls about 570 adults at high or very high risk of k…

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This study tests whether medically tailored meals, prepared to support kidney and heart health, can improve blood pressure and kidney function in Veterans with chronic kidney disease. About 100 participants will be randomly assigned to receive these meals or usual care for three …

This trial tests a new feature called FlexPoint on a peritoneal dialysis machine used at home. The feature adjusts fluid volume and dwell time during treatment. Researchers will compare three different settings in 24 adults with chronic kidney disease to see which works best for …

Researchers are testing whether personalized nutrition, including special milk formulas, can improve growth, body composition, and muscle strength in children with chronic kidney disease. The study will enroll 128 children aged 6 to 12 with any stage of the disease. The goal is t…

This study compares two drugs, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have acute gastrointestinal bleeding and acute kidney injury. Both drugs are given intravenously for up to 5 days. The main goal is to see which drug better reverses kidney injury.…

This trial is testing whether dorzagliatin, an experimental oral medication, can improve blood sugar control in people with type 2 diabetes who also have moderate to severe chronic kidney disease. Participants will be randomly assigned to receive either dorzagliatin or linaglipti…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This study tests two drugs, finerenone and empagliflozin, in 30 African American veterans with diabetic kidney disease. The goal is to see if these drugs reduce kidney cell damage by measuring specific proteins in urine. Participants will take one or both drugs for 4 months to ch…

This trial tests whether a daily maqui berry supplement can improve gut health, reduce inflammation, and lower oxidative stress in people with stage 3-4 chronic kidney disease. Half of the 30 participants will take the maqui powder, while the other half receives a placebo, for th…

This trial tests whether finerenone, a drug already used for chronic kidney disease, is safe and tolerable for people hospitalized with acute kidney injury (AKI). About 72 adults with moderate-to-severe AKI will receive either finerenone or a placebo once daily for up to 45 days,…

This trial compares three different negative-pressure wound dressings (NPseal, PICO, and Prevena) applied after total knee replacement surgery. The study enrolls adults at higher risk for wound problems, such as those with diabetes, obesity, or chronic kidney disease. Participant…

This trial tests whether sending a letter and fact sheet to adults in Manitoba who are at high risk for kidney failure can encourage them to see a kidney specialist. The goal is to catch advanced chronic kidney disease earlier and reduce the number of people who progress to dialy…

This trial tests three experimental antibodies—REGN9933, REGN7508, and REGN9533—in people with end-stage kidney disease who are on hemodialysis. The goal is to see if these antibodies can safely reduce blood clot risk during dialysis, potentially offering an alternative to standa…

This study tests whether providing fruits and vegetables along with cooking and nutrition education can improve kidney health in adults with chronic kidney disease. Participants are randomly assigned to receive either fruits and vegetables alone or fruits and vegetables plus a 12…

This trial asks whether an oral medication called daprodustat can match the effectiveness of the injectable drug epoetin alpha in treating anemia linked to chronic kidney disease. Adults with stage 3-5 kidney disease who are not on dialysis and have low hemoglobin levels will rec…

Acute kidney injury is a frequent and serious complication after cardiac surgery, and effective prevention remains elusive. This study analyzes data from 5,000 adults who had heart surgery with a heart-lung machine to see whether giving the amino acid L-arginine within the first …

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

People on maintenance hemodialysis face a high risk of heart disease, and standard cholesterol drugs often fail to help. This trial tests whether high-dose fish oil (4 grams daily for 8 weeks) can improve the function of HDL, the 'good' cholesterol, which may become faulty in kid…

This trial tests whether reducing the dialysate flow rate during hemodialysis from the standard 500 mL/min to 400 mL/min can maintain adequate blood cleansing while cutting water use. About 250 adults on chronic hemodialysis will each try both flow rates for one month. The main g…

This phase 2 trial tests whether spironolactone, a drug usually used for heart failure and high blood pressure, can help treat anemia in children aged 6–18 who are on hemodialysis. Participants take spironolactone daily for 12 weeks alongside standard care, and researchers measur…

This trial tests whether tocilizumab, an anti-inflammatory drug, can stop the progression of calciphylaxis—a rare condition where calcium buildup blocks skin blood vessels, causing painful, non-healing wounds. Ten adults with calciphylaxis and end-stage kidney disease will receiv…

This study tests whether a dietary supplement called nicotinamide riboside (a form of vitamin B3) can be safely taken by adults with moderate chronic kidney disease. The main goal is to see if it's feasible for participants to take the supplement daily and complete study procedur…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This trial tests whether a prehabilitation program — combining exercise, nutrition advice, and psychological support — can improve fitness and recovery in people with advanced chronic kidney disease awaiting a kidney transplant. Researchers compare an in-person, hospital-based pr…

This study tests whether adding a single dose of infliximab to a short course of prednisone helps people recover kidney function faster after immunotherapy-related acute kidney injury. Participants receive either the combination or standard prednisone alone. The goal is to see if…

This study tests whether a personalized nursing program can prevent acute kidney injury (AKI) in people with liver cancer who undergo interventional therapy. Researchers first use a prediction model to classify patients into low, moderate, or high risk for AKI. Then, they provide…

This trial compares two sedatives—remimazolam and propofol—given during liver or pancreas surgery to see which better prevents acute kidney injury after the operation. The study includes adults aged 19 to 85 scheduled for elective hepatobiliary-pancreatic surgery. Researchers aim…

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This pilot study tests a new dialysis catheter coated with Endexo technology, designed to resist blood clots and reduce infections. Researchers will compare its performance to older catheters in 50 adults with end-stage kidney disease. If successful, it could improve quality of l…

This Phase 2 trial tests whether the drug SAL0140 can reduce protein in the urine, a sign of kidney damage, in 249 adults with chronic kidney disease. Participants will receive either SAL0140 or a placebo for 16 weeks. The goal is to see if the drug can help control the disease a…

This study compares two common ways to access the blood for dialysis: a tunneled catheter (a tube placed in a large vein) versus a surgically created fistula (connecting an artery to a vein). The trial will enroll 220 patients aged 60 or older (or younger but with multiple health…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study looks at whether changing the filter in a kidney dialysis machine more often than usual can lower the chance of new infections in critically ill patients with severe acute kidney injury. About 100 adults in intensive care will be randomly assigned to have their filter …

This Phase 3 trial tests whether BHV-1400 can safely reduce protein in the urine and preserve kidney function in 420 adults with IgA nephropathy. Participants are randomly assigned to receive either the drug or a placebo by injection. The main goal is to see if BHV-1400 lowers pr…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This study tests a new medicine called ABP-671 in 80 adults with chronic kidney disease and high uric acid levels. Participants will receive either the drug or a placebo for 40 weeks. The main goal is to see if the drug reduces protein in the urine, a sign of kidney damage.

This large Phase 3 study tests whether the drug HRS-7535 can help people with chronic kidney disease (CKD) avoid serious outcomes like kidney failure, dialysis, or heart-related death. About 3690 adults with CKD will receive either the drug or a placebo, added to their usual care…

This phase 3 trial tests whether a combination of two drugs (balcinrenone and dapagliflozin) works better than dapagliflozin alone for people with advanced chronic kidney disease (stages 3b and 4). About 2,800 participants will take the combination or a placebo daily, alongside s…

This study compares two blood thinners used during continuous dialysis in adults with sepsis and acute kidney injury. About 1,162 participants will receive either nafamostat mesylate or standard citrate anticoagulation. The main goal is to see which approach reduces death, ongoin…

This early-stage study tests a new drug called PMG1016 in 30 healthy adults to see if it is safe and how the body processes it. The drug is given as a single IV infusion. This is the first time PMG1016 is being tested in humans, and it aims to gather safety data before moving to …

This study looks at whether giving more protein (1.5-1.7 grams per kilogram per day) to critically ill patients with acute kidney injury who need continuous dialysis can reduce muscle wasting compared to standard protein intake (1.0-1.2 g/kg/d). About 56 adults will be randomly a…

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study will test whether a supplement made from jaboticaba peel can reduce inflammation, oxidative stress, and gut bacteria imbalances in people with chronic kidney disease. Thirty adults will take either the jaboticaba extract or a placebo for one month. Researchers will mea…

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study tests whether using a special ultrasound technique (mVExUS) to guide how much fluid is removed during dialysis can improve outcomes for critically ill patients with acute kidney injury. 126 adults in the ICU will be randomly assigned to either standard care or the ultr…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This pilot study tests whether using a cap containing chlorhexidine on dialysis catheters can reduce infections compared to standard caps. Sixty adults with kidney failure who need dialysis through a central line will be randomly assigned to one of the two caps. The main goal is …

This study tests a new wearable device that gently removes extra fluid between dialysis sessions. Many dialysis patients struggle with fluid buildup because standard treatments remove it too quickly, causing heart and brain damage. The device is worn at home for a few hours after…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage, better than standard care. Participants must already be on stable blood pressure medication and have mod…

This study tests a new pre-mixed fluid that contains phosphate for patients in the ICU who need continuous kidney replacement therapy (CRRT). The standard fluid often washes out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the…

This study tests whether adding a weekly injection called dulaglutide to two standard pills (SGLT-2 inhibitors and finerenone) can better protect the kidneys of Chinese adults with type 2 diabetes and mild-to-moderate chronic kidney disease. About 468 participants will be randoml…

This study tests whether adding pea fiber to the daily diet of people on dialysis can lower harmful waste products in their blood. 72 adults on dialysis will eat baked goods with or without pea fiber for 8 weeks. Researchers will measure changes in toxin levels and heart health m…

This study tests if temporarily restricting blood flow to an arm (called ischemic preconditioning) before kidney cancer surgery can reduce kidney damage. About 174 adults having partial nephrectomy will be randomly assigned to receive this technique or standard care. The goal is …

This study looks at whether giving vitamin C through a vein can help very sick patients with liver failure and severe infections recover from kidney injury. About 110 patients will get either standard care alone or standard care plus vitamin C. The goal is to see if vitamin C hel…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study tests a new way to guide fluid treatment in patients with septic shock (a severe infection causing low blood pressure). The goal is to see if using a non-invasive arm cuff to measure blood flow pressure can help doctors give the right amount of fluids to prevent acute …

This study tests whether giving amino acids (protein building blocks) through a vein can help prevent or reduce acute kidney injury in adults on ECMO life support in the ICU. About 40 participants will receive either amino acids or a placebo. The goal is to see if this simple tre…

This study tests whether a daily synbiotic supplement (probiotics plus prebiotics) can lower inflammation and improve digestive symptoms in adults with chronic kidney disease stages 3 to 5 who are not yet on dialysis. One hundred participants will receive either the supplement or…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether the investigational drug QRX-3 can help hospitalized children and adults with acute tubular necrosis, a type of sudden kidney failure. About 500 participants will receive either QRX-3 or a placebo alongside standard care. The main goal is to see if QRX-3 …

This study tests whether giving intravenous fluids and a blood-pressure-raising drug (norepinephrine) together early can prevent acute kidney injury in adults with septic shock. Researchers will treat 100 patients in the ICU or emergency department and monitor kidney function and…

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either the drug or standard care for 2 years. Researchers will track kidney funct…

This study tests whether giving amino acids through the dialysis machine twice a week for a year can help protect the heart and blood vessels in people with kidney failure. About 120 adults on stable dialysis will receive either amino acids or a placebo (saline). Researchers will…

This study tests whether cooling the dialysis fluid slightly can help preserve memory and thinking in people with kidney failure who need hemodialysis. Many patients on dialysis experience a decline in brain function, possibly due to drops in blood flow during treatment. The tria…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This early-phase study tests whether adding the drug venetoclax to standard transplant preparation is safe for people with chronic kidney disease and a blood cancer. Only 3 adults aged 18-70 will take part. The goal is to see if the combination helps the new stem cells and kidney…

This early study will test whether gentle ultrasound pulses applied to the kidneys can improve kidney function in 20 adults with chronic kidney disease (CKD). Participants will receive the ultrasound treatment three times a week for four weeks. Researchers will measure changes in…

This early-stage trial tests whether a single intravenous infusion of stem cells from donated umbilical cord tissue can safely improve kidney function in 32 adults with stage 3 or 4 chronic kidney disease caused by diabetes or high blood pressure. Participants will be randomly as…

This study compares two intravenous fluids—human albumin and saline—to see which better resolves acute kidney injury in people with decompensated cirrhosis. About 114 adults with moderate to severe kidney damage will receive either treatment. The goal is to improve kidney functio…

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or obesity. Participants receive weekly injections for three months. The goal is to see if this drug can help manage weight and …

This study tests whether the drug finerenone can protect the retina (the light-sensitive layer at the back of the eye) in people with chronic kidney disease. Researchers will measure changes in retinal nerve thickness over time in 40 adults with stage 2-4 kidney disease. The goal…

This study tests whether adding ganagliflozin tablets to standard care can slow kidney disease progression in 1,244 adults with type 2 diabetes and chronic kidney disease. Participants will take either ganagliflozin or a placebo daily for 120 weeks. The main goal is to measure ch…

This study tests whether the drug aminophylline can protect the kidneys of children receiving cisplatin chemotherapy. Twenty-four children will be randomly assigned to receive either aminophylline or a placebo alongside their standard chemo hydration. Researchers will measure kid…

This study tests a weekly injection called survodutide in 120 people with chronic kidney disease and high protein in their urine. The goal is to see if the drug can lower protein levels and protect kidney function over 36 weeks. Participants must be on stable standard treatments …

This study tests whether N-Acetylcysteine (NAC), a common supplement, can protect kidney function in cancer patients receiving cisplatin chemotherapy. 72 adults will take either NAC or a placebo for seven days around their chemo session. Researchers will measure kidney injury mar…

This study tests whether adding levocarnitine injections to standard care can lower the amount of anemia medication needed by people on hemodialysis. About 94 adults with kidney failure and anemia will receive either levocarnitine after each dialysis session or usual care alone f…

This trial tests a new drug called QRX3 in 3,000 people with chronic kidney disease whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow the need for dialysis. Participants take QRX3 capsules, and researchers measure changes in kidne…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

Researchers are studying whether the total time from heart attack symptom onset to balloon inflation during angioplasty helps predict contrast-induced nephropathy, a kidney complication that can occur after the procedure. The trial enrolls 400 adults with ST-segment elevation myo…

Acute kidney injury is a common complication after coronary artery bypass grafting. This observational study examines whether two measurements from kidney Doppler ultrasound, the renal augmented velocity index and the renal resistive index, can predict which patients will develop…

Doctors use iodinated contrast dye during CT scans, and in some patients this dye can stress the kidneys, a condition called contrast-associated acute kidney injury. Current safety checks rely on an estimated kidney function that assumes an average body size, which may not reflec…

This study tests whether blood samples collected at home using small capillary devices, like finger pricks, give the same results as traditional blood draws from a vein. Researchers will compare both methods in about 1,000 people with chronic conditions such as kidney disease, au…

This pilot trial tests whether a structured ultrasound assessment can help doctors manage fluids better in patients recovering from cardiac surgery. Participants are randomly assigned to either standard care or an ultrasound-guided strategy that measures fluid tolerance and respo…

This trial is testing whether a urine test called ProNephro AKI™ (NGAL) can accurately predict which critically ill adults in the intensive care unit (ICU) will develop moderate to severe acute kidney injury within 48 to 72 hours of admission. The study will enroll 800 adults who…

This study tests a wearable device that continuously measures kidney function in ICU patients with acute kidney injury (AKI). The device uses a fluorescent tracer and a chest patch to track GFR in real time. Researchers will compare its accuracy to standard lab tests in 50 adults…

This pilot study tests a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow in tiny vessels of transplanted kidneys. The goal is to see if changes in these vessels can predict how well the kidney will work early after transplant, includin…

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study will test whether a kidney ultrasound and a urine test can predict acute kidney injury in people with sepsis. Researchers will measure kidney blood flow and specific urine markers in 130 adults shortly after sepsis diagnosis. The goal is to see if these tests can spot …

This study tests whether a simple blood test called the Systemic Immune Inflammation Index (SII) can help diagnose and predict acute kidney injury (AKI) in people with liver cirrhosis. AKI is a common and serious complication in cirrhosis, but current tests are often unreliable. …

This study will check if a new urine test can find early signs of chronic kidney disease and track its progress. Researchers will also look at how well common diabetes drugs (SGLT2 inhibitors) help protect the kidneys. About 300 adults with mild-to-moderate kidney disease will ta…

This study looks at whether the triglyceride-glucose (TyG) index, a simple measure from a blood test, can predict insulin resistance in people with pre-diabetes and chronic kidney disease. Researchers will enroll 60 adults with and without kidney problems to see how well the TyG …

This study will test a new handheld device that measures creatinine (a kidney health marker) from a fingerstick blood sample at home. Researchers will compare its accuracy to standard lab tests and ask 200 adults with kidney disease to try the device and rate how easy it is to us…

This study tests a new computer tool that helps doctors figure out the cause of acute kidney injury (AKI) in hospitalized veterans. AKI is common and serious, but its cause can be hard to diagnose quickly. The tool uses rules and artificial intelligence to guide doctors toward th…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

Acute kidney injury is a common complication after major liver surgery. This trial tests whether adjusting anesthesia care based on real-time kidney oxygen readings, measured with near-infrared spectroscopy, can reduce kidney injury after elective hepatectomy. About 1,200 adults …

This trial tests whether a single high dose of nicotinamide (a form of vitamin B3) taken on the morning of heart surgery can reduce the risk of acute kidney injury afterward. The study enrolls 20 adults undergoing coronary bypass or valve surgery with a heart-lung machine who are…

This trial tests whether terbinafine, a common antifungal drug, can prevent acute kidney injury in adults undergoing heart surgery with a heart-lung machine. Participants at high risk of kidney damage will receive terbinafine or a placebo before and after surgery. The study track…

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests an 8-week health literacy program designed to help people aged 55-74 who take 5 or more medications daily. The goal is to see if the program improves their understanding of medication management and reduces their risk of developing chronic kidney disease. Half of…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participan…

This study tests if giving a simple amino acid infusion during heart surgery can prevent acute kidney injury, a common complication. Researchers will measure kidney damage markers in the urine of 130 adults before and after surgery. Half will receive standard care, and the other …

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in high-risk patients. AKI is a common and serious complication after heart surgery with no approved prevention. The trial will include 330 adults undergoing elective h…

This study tests whether giving a common antibiotic (TMP/SMX) to adults who recently had acute kidney injury can prevent infections after they leave the hospital. About 120 participants will receive either the antibiotic or a placebo for 90 days. The goal is to see if this approa…

This study tests whether a simple home exercise program can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4-5). 124 participants will either do low-intensity walking and strength exercises or receive standard care. …

People with advanced kidney disease often face fatigue, itching, pain, and sleep problems that disrupt daily life and strain caregivers. Researchers are testing a nurse-led program called COMFORT that helps patients and their informal caregivers recognize and manage these symptom…

Researchers are testing whether a breathing muscle training program done during hemodialysis can improve breathing strength and physical function in adults with advanced kidney disease. Participants train with a handheld electronic device three times a week for 12 weeks while rec…

This study tests whether a structured family conversation program, called Family TIME, can be delivered successfully to adults receiving hemodialysis for chronic kidney disease and their family members. Participants either receive usual care or usual care plus three family conver…

This trial tests whether a super high-flux dialyzer, a more efficient filter used during hemodialysis, can remove more middle-molecule toxins from the blood than standard high-flux dialyzers. The study includes 40 adults with end-stage kidney disease who are on maintenance dialys…

This trial compares two drug-free therapies—leg massage and mechanical vibration—against standard care for reducing muscle cramps and improving comfort in people undergoing hemodialysis. About 160 patients on maintenance dialysis will be randomly assigned to receive either 20-min…

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This trial tests whether adding palliative care to standard treatment helps people with advanced chronic kidney disease (stages 4 and 5, including those on dialysis) feel better. Participants are randomly assigned to receive either usual kidney care or usual care plus integrated …

This study investigates whether a simple breathing exercise called the 4-7-8 technique can reduce fatigue and improve sleep in people undergoing hemodialysis for chronic kidney disease. Eighty adult patients are randomly assigned to either practice the breathing exercise twice da…

This study tests whether a 4-7-8 breathing exercise can reduce pain when needles are inserted into the arm for hemodialysis. About 80 adults on dialysis will either learn the breathing technique or receive standard care. The goal is to see if this easy, drug-free method makes the…

This study tests whether doing simple handgrip exercises at home for 8 weeks can lower blood pressure in people with chronic kidney disease (CKD). Researchers will measure changes in resting blood pressure, blood vessel function, and stiffness. The study involves 50 adults aged 4…

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This study looks at whether hydromorphone sustained-release tablets can safely relieve moderate to severe cancer pain in elderly patients who also have kidney issues. Researchers will compare these patients to those with normal kidney function, monitoring pain relief, kidney func…

This study will test whether a sodium bicarbonate enema can help relieve constipation and reduce harmful waste products in people with chronic kidney disease (CKD). The researchers believe the gut can act as an extra filter to remove toxins that build up when kidneys fail. They p…

This study tests whether adding a special breathing feedback device to standard breathing exercises can reduce symptoms and improve quality of life in adults with chronic kidney disease. Twenty-four participants will practice the exercises three times daily for six weeks. The goa…

This study compares a new 'tubeless' anesthesia method (using a laryngeal mask and lighter sedation) to standard breathing-tube anesthesia in 60 kidney transplant patients. The goal is to see if it reduces the need for muscle relaxants and other drugs, and improves recovery. Part…

This study looks at whether doing aerobic or free exercises during dialysis sessions can reduce fatigue, improve walking ability, and help thinking in people with kidney failure. Sixty-nine adults aged 50 to 60 on maintenance hemodialysis will be assigned to different exercise ro…

This study tests whether doing virtual reality exercise during dialysis can help patients with end-stage kidney disease keep their electrolytes (sodium, potassium, calcium, phosphorus) in a healthier range. Forty adults on regular dialysis will either do 30 minutes of VR cycling …

This study tests whether breathing low-oxygen air during exercise (simulated high-altitude training) can improve walking ability and reduce fatigue in people with stage 3-4 chronic kidney disease. Sixty adults aged 40-65 will be split into three groups: simulated altitude trainin…

This study tests whether taking probiotics daily can help chronic kidney disease patients on dialysis better respond to anemia medication (erythropoietin). About 80 adults will receive either erythropoietin alone or erythropoietin plus probiotics for 3 months. Researchers will tr…

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults who have been on dialysis for at least three months will be randomly assigned to use the app daily for four…

This study tests whether therapeutic touch—a gentle, non-invasive technique—can lower stress and boost comfort in people on hemodialysis. About 60 patients will be randomly assigned to receive touch sessions or standard care only. Researchers will measure stress and comfort level…

This study will test a mobile app called Smart Kidney that helps adults with chronic kidney disease track and manage their symptoms remotely. Sixty participants in Vietnam will use the app for 6 weeks. The goal is to see if the app is easy to use and helpful for symptom managemen…

This trial tests whether a structured training program for ICU nurses, focusing on respiratory and renal care with case-based discussions, improves their clinical reasoning, knowledge, and collaboration with doctors. The study involves 140 participants, including nurses and mecha…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

Researchers at Assiut University Hospitals compare adults with kidney failure who receive hemodialysis twice a week versus three times a week. The study tracks health-related quality of life, dialysis adequacy, urine output, and hospitalizations over time. About 130 participants …

Researchers at Assiut University are studying how common secondary hyperparathyroidism is among people with end-stage kidney disease who receive hemodialysis three times a week. The study also checks whether the quality of dialysis, measured by standard clearance formulas, relate…

Doctors often see creatinine rise in patients taking vancomycin plus piperacillin-tazobactam, a common antibiotic pair. It is unclear whether that rise means real kidney injury or a harmless lab change. This study follows 304 adults on either that pair or vancomycin plus meropene…

Researchers at Assiut University Hospital survey adults with advanced chronic kidney disease about arteriovenous fistula creation, the surgically connected vein and artery used for hemodialysis. The study includes pre-dialysis patients and people already on maintenance hemodialys…

People with advanced chronic kidney disease often develop calcium buildup in their coronary arteries, which raises the risk of heart problems. Researchers want to know whether a protein called CXCR2 on white blood cells can predict whose arteries will harden fastest. About 100 ad…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

Researchers are testing whether people with rheumatoid arthritis have early, symptom-free kidney problems more often than healthy people of the same age and sex. The study compares kidney function and urine protein levels between 120 participants, including those with rheumatoid …

Researchers are studying how a single injection of the experimental medicine NNC0537-1482 moves through the body in people with different levels of kidney function. About 54 participants with normal, mildly, moderately, or severely reduced kidney function receive one dose under t…

This study will collect information from 100,000 critically ill patients worldwide who receive continuous renal replacement therapy (CRRT), a type of kidney dialysis, in intensive care units. Researchers want to understand how CRRT is used and how it affects patient survival and …

This study looks at how well a specific kidney filter (multiFlux 160) works when used with two different blood thinners—heparin or citrate—during continuous kidney replacement therapy. The goal is to see which approach keeps the filter working effectively while avoiding side effe…

This study follows 190 adults with chronic kidney disease who are not yet on dialysis. Over 24 months, researchers track clinical and lab measures to see who experiences a rapid drop in kidney function, defined as a sustained decline of more than 5 mL/min per year. The goal is to…

This study asks whether levels of a protein called vascular endothelial growth factor (VEGF) in blood and urine can predict which patients will develop acute kidney injury after heart surgery that uses a heart-lung machine. Researchers will follow 220 adults having planned heart …

This phase 1 trial examines how severe kidney impairment or end-stage kidney disease affects the levels of ribupatide, an experimental drug, after a single injection. Researchers compare drug exposure in 32 participants: some with normal kidney function and others with severe kid…

This trial tests how the drug PKN605 moves through the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers give a single oral dose and measure drug levels in the blood over time. The goal is to see if reduced kidney function increa…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This trial is investigating how different levels of kidney function affect the way the body processes a single dose of the antibiotic afabicin. About 60 adults with varying degrees of kidney impairment, from mild to severe, will receive either an oral tablet or an intravenous inf…

This study looks at whether children with chronic kidney disease, especially those on dialysis, have higher levels of PFAS chemicals in their blood. PFAS are found in many everyday products and may interfere with bone development. The study compares PFAS levels in children with k…

This study looks back at medical records of critically ill adults who needed emergency dialysis in the emergency department. It compares two methods—standard hemodialysis and a continuous version called CVVHDF—to see how patients fare during their hospital stay. The main focus is…

This study looks at how the experimental drug golcadomide is processed by the body in people with severe kidney impairment or end-stage renal disease compared to those with normal kidney function. The goal is to understand how kidney function affects drug levels and safety after …

This study tests whether a non-invasive sensor placed on the back can detect early signs of kidney injury in adults undergoing off-pump coronary artery bypass surgery. Kidney injury is common after such surgery, but current detection relies on blood tests that rise days later. Th…

This study tests whether a pop-up alert in electronic medical records helps doctors prescribe more recommended medications for chronic kidney disease (CKD). About 1,000 patients with CKD will be included, and their doctors will either see the alert or not. The goal is to see if t…

This study looks at whether a blood-thinning method called citrate anticoagulation is safe and practical for critically ill patients with acute kidney injury who may not process citrate normally. It follows 50 ICU patients who need kidney replacement therapy and are at risk for c…

This trial is testing whether a connected urine test strip device, called URIKI, can help people with stage 4 or 5 chronic kidney disease monitor their diet from home. Participants will use the device daily for 10 days, logging meals and other health information in a mobile app. …

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study examines how the severity of chronic kidney disease (CKD) affects the breakdown of a protein called FGF23, which is linked to bone health, anemia, and heart problems. Researchers will measure different forms of FGF23 in blood samples from 80 men with CKD stages 3a to 5…

This study looks at whether the bacteria in your gut and the substances they produce can help predict a serious complication called acute kidney injury (AKI) after heart surgery. Researchers will collect stool and blood samples from about 180 adults before and after their operati…

This study looks at whether the biological age of a person's blood vessels, measured before heart surgery, can help predict their risk of acute kidney injury afterward. Researchers will assess vascular aging using noninvasive tests and routine lab results in about 470 adults unde…

Acute kidney injury is a common and dangerous complication in intensive care, but current tests often detect it too late. This observational study tests whether a pressure gradient in the veins — the difference between the driving force for blood return and the central vein press…

This study looks at how the drug D-2570 moves through the body in people with reduced kidney function compared to those with normal kidneys. About 40 adults aged 18 to 70 will receive a single dose of D-2570. Researchers will measure drug levels in the blood and monitor for side …

This study examines the treatment costs of acute kidney injury (AKI) in patients who undergo cardiac surgery at a UK hospital. By comparing medical records of patients with and without AKI, researchers aim to calculate the financial burden of each stage of kidney injury. The find…

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This study follows thousands of people with chronic kidney disease (stages 3 to 5) to understand how the disease progresses and leads to complications. Researchers will collect data from medical records and existing patient groups to build models that could help doctors make bett…

This study will test whether using a special ultrasound technique called VeXUS to guide fluid treatment can help protect kidney function in 100 ICU patients with acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and lasting kidney damage. Th…

This observational study looks at whether two urine markers, NGAL and KIM-1, can detect early kidney injury in women undergoing gynecologic laparoscopic surgery. The surgery involves gas inflation and a head-down position that can stress the kidneys. Researchers will compare thes…

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having bypass or valve surgery will be enrolled. Researchers will measure kidney injury markers and track how much fluid is given, ai…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study explores how Black and Caucasian patients with kidney disease communicate with their transplant doctors during evaluation visits. Researchers will record these conversations and survey patients to find out which communication styles lead to more living donor referrals …

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study follows 150 adults waiting for a kidney transplant to track how their physical and emotional health changes over time. Researchers will use a mobile app and interviews to measure frailty and quality of life. The goal is to identify patients who need extra support and i…

This study will follow 200 adults hospitalized with upper gastrointestinal bleeding to see how many develop acute kidney injury. Researchers will also look for factors that make kidney damage more likely, such as the cause of bleeding. No new treatments are being tested—patients …

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This pilot study tests whether a structured discharge summary template and a chat-based educational messaging program can improve care transitions for adults leaving the hospital after acute kidney injury (AKI). Researchers will enroll 160 adults with moderate-to-severe AKI and c…

This study looks at two ways to prevent blood clots during dialysis in people with end-stage kidney disease. Twenty adults will try both methods—one using standard heparin and the other using a citrate-based approach—to see which causes less inflammation and removes waste better.…

This study tests whether a machine-learning tool built into electronic health records can help doctors reduce kidney injury after surgery. Over 25,000 adults having non-emergency surgery will take part. Doctors are randomly assigned to see the tool's risk prediction, see it with …

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This study looks at whether a blood test measuring the ratio of two substances (IGF-1 and albumin) can help identify muscle loss (sarcopenia) in people with end-stage kidney disease on dialysis. Researchers will compare the test results to standard muscle assessments in 110 adult…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This very early study (Phase 1) will give a single dose of a radioactive-labelled drug called HRS-1780 to 6 healthy men. The goal is not to treat disease but to track exactly how the drug is absorbed, broken down, and eliminated from the body. Results will help design future stud…

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (CKD). Researchers will test 100 adults to see if standard diagnostic methods work well for these patients. The goal is to improve accuracy so doctors can treat the right cause…

This study looks at how sex hormones from gender-affirming therapy change kidney function. Researchers will measure kidney performance, blood flow, and insulin sensitivity in 60 transgender people before and after one year of hormone treatment. The goal is to understand why men a…

This study examines whether blood electrolyte levels are linked to kidney damage in people who have a stroke and undergo a clot-removal procedure. Researchers will review medical records from 250 patients treated between 2018 and 2026. The goal is to identify risk factors that co…

This study looks at how certain metabolic changes in the body might help predict kidney injury after heart surgery. Researchers will study 540 high-risk patients to find patterns that could warn doctors early. The goal is to improve patient safety and outcomes by catching kidney …

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This study aims to find early warning signs of acute kidney injury in children admitted to the intensive care unit. Researchers will monitor 100 children, tracking their medical history, daily fluid intake, urine output, and lab tests. The goal is to identify which risk factors—l…

This study will follow 30 runners in the Western States Endurance Run, a 100-mile race, to see how their kidneys handle the extreme stress. Researchers will use sensitive urine tests to detect early signs of kidney injury and test whether a sodium bicarbonate supplement can help.…

This study tracks 120 adults having heart surgery to see if continuous monitoring of blood pressure and brain oxygen levels can predict problems like confusion, memory loss, or kidney injury afterward. Researchers will measure how long and how severely these levels drop during su…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease may be related. Researchers will examine mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role in the link between the two conditions. The goal is to bett…

This early-stage study tests whether a new formulation of the antibiotic polymyxin B (VRP-034) is safer for the kidneys than the current version. It involves 48 healthy adult men who will receive one or more doses of either the new or standard drug. Researchers will measure kidne…

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study tests whether shorter or standard-length dialysis sessions using expanded hemodialysis can remove waste products from the blood as well as a more intensive technique called high-volume hemodiafiltration. Fifteen adults with end-stage kidney disease will try three diffe…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study will develop a computer model that uses machine learning to predict a patient's risk of developing acute kidney disease after heart surgery. Researchers will collect data from 820 adults undergoing certain heart procedures to build and test the model. The goal is to cr…

This study looks at how acute kidney injury (AKI) impacts the process of removing a breathing tube (weaning) in critically ill adults in the ICU. Researchers will track 85 patients to see if AKI makes weaning harder, slower, or more risky. The goal is to learn whether kidney prob…

This study will follow 225 adults with end-stage kidney disease who are on regular dialysis. Researchers want to see if missing a dialysis session raises the risk of heart problems like heart attack or stroke within the next 72 hours. Participants will have heart tests after a mi…

This study will follow 290 Mexican adults with advanced chronic kidney disease who are on dialysis (hemodialysis or peritoneal dialysis). Researchers will track how many patients die, how often they are hospitalized, and how many infections they get. The goal is to better underst…

This study looks at whether a new way of measuring kidney function (using an injection of iohexol and finger-prick blood tests) can better predict when people with advanced kidney disease will start feeling sick from kidney failure. It also checks if this method can accurately me…

This study looks at two ways of giving fluids during liver surgery: one that limits fluids and one that gives more. The goal is to see which approach leads to fewer serious problems after surgery, especially kidney injury. About 90 adults having planned liver surgery will take pa…

This study will follow 1000 kidney transplant patients for one year to see if monthly blood tests for certain viruses (CMV, BK, and TTV) can help predict and prevent serious infections and kidney damage. The goal is to learn how the body's immune system and virus levels relate to…

This observational study looks at whether a diet that promotes inflammation can make gum disease worse in people with chronic kidney disease. Researchers will assess the diets and gum health of 100 adults with kidney disease. The goal is to understand if eating more inflammatory …

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study looks at whether ultrasound can help predict a sudden drop in blood pressure when ICU patients start a type of dialysis. Researchers will monitor 80 adults using heart and body scans before and during treatment. The goal is to find early warning signs to prevent compli…

This study tests whether a digital program (videos, texts, and optional phone support) can help people with kidney failure get more inquiries from potential living donors. About 430 adults referred for a kidney transplant will be randomly assigned to get the program with or witho…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with chronic kidney disease (stages 3B-5). Participants will try four different 10-day diets, all provided for free, to see which foods …

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study looks at how the blood thinner enoxaparin works in critically ill ICU patients with kidney failure, some on dialysis and some not. Researchers will measure drug levels in the blood over 24 hours after a daily shot. The goal is to see if current dosing is enough to prev…

This study looks at ICU patients with kidney failure who need blood thinners to prevent dangerous clots. Doctors currently use different types of heparin, but it's unclear which is safest and works best when kidneys are weak. The study will track over 1,100 patients to compare bl…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will follow 120 critically ill adults in the ICU to see if the amount of fluid they receive in the first 48 hours is linked to developing acute kidney injury (AKI). Researchers will track fluids hourly and check kidney function for up to 7 days. The goal is to find pat…

This study looks at how the drug anaprazole sodium is processed by the body and whether it is safe for people with liver or kidney issues, as well as for older adults. About 60 participants will be enrolled to measure drug levels and track any side effects. The goal is to underst…

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…

This study looks at whether the ratio of C-reactive protein to albumin (CAR) in the blood can help predict acute kidney injury in people with acute pancreatitis. Researchers will measure CAR in 150 adults admitted to Assiut University Hospitals and see how it relates to kidney pr…

This study aims to develop and test artificial intelligence (AI) tools to help doctors prescribe and deliver acute dialysis better for patients in intensive care. Researchers will analyze data from 7,500 patients to create algorithms that can predict the best treatment approaches…

This study looks at whether combining two blood markers—uric acid/albumin ratio and lactate—can help predict which older adults (65+) with sepsis will develop kidney injury, need blood pressure support, or die within 28 days. Researchers will follow 80 ICU patients who do not hav…

This study looks at whether levels of a protein called uromodulin in the blood can help predict how well kidneys recover in adults with sepsis-related acute kidney injury. Researchers will measure uromodulin at the start, after one week, and at hospital discharge in 30 patients. …

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study will take small kidney tissue samples from 42 liver transplant patients who have hepatorenal syndrome (HRS), a condition where the kidneys stop working properly due to severe liver disease. Researchers want to see if the kidneys are actually damaged or just temporarily…

This study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will examine why some people with chronic kidney disease in Spain may have a harder time getting a kidney transplant than others. Researchers will survey 3,000 patients and interview doctors and patients to understand barriers like age, income, or where someone lives. …

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This study will check if a tool called the STARZ score can accurately predict acute kidney injury in newborns admitted to the NICU. Researchers will enroll 140 infants and compare the score's predictions to standard tests. If validated, this simple score could help doctors identi…

This observational study tests whether tiny chemicals in breath, called VOCs, can show if a hemodialysis session is effective. About 22 dialysis patients and 23 healthy adults will provide breath and blood samples. The goal is to find a simple, non-invasive way to assess dialysis…

This study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…

This study tests a structured shared decision-making program for family members of ICU patients with acute kidney injury who need urgent dialysis. One hundred family members will be randomly assigned to receive either the program or standard care. Researchers will measure decisio…

This study will examine how quality of life changes after parathyroid surgery in 60 adults with kidney failure and secondary hyperparathyroidism. Researchers will use a database to compare quality-of-life scores, anxiety, and depression before and after surgery. The goal is to be…