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MRI scans could unlock secrets of kidney disease and brain health

NCT ID NCT02421497

Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive problems. The goal is to improve diagnosis and monitoring without using contrast dyes or invasive procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could improve how doctors use MRI to monitor kidney disease and detect brain changes without invasive tests.
What could go wrong
This is an early-stage technical development study, not testing a treatment. It may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2028

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study populations vary across specific aims: normal healthy or control volunteers for Specific Aim 1, CKD patients and renal transplant recipients for Specific Aim 2.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

For Specific Aim 1: MRI Technical Development Studies Inclusion Criteria: 1\. Healthy Volunteer Exclusion Criteria: 1. Ferromagnetic implants 2. Any foreign metal objects in the body 3. History of shrapnel or shot gun injury 4. Cardiac pacemakers 5. Defibrillator 6. Neuronal stimulator 7. Magnetic aneurysm clip 8. Large tattoos on the abdomen or the brain and neck 9. Hip replacement 10. Too large to fit in the magnet (body mass index \>= 40, approx.) 11. Severe claustrophobia 12. Women with pregnancy For Specific Aim 2: Pilot Studies with Patients Studies for CKD Inclusion 1. English- speaking as primary language. 2. Age 45 years and older 3. Able to complete an approximately 90 minute cognitive testing battery. 4. Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so. 5. GFR \< 90 ml/min/1.73m2 Exclusion 1. Acute psychiatric illness that would impede cognitive testing 2. Active chemical dependence, such as alcohol, narcotics or other drugs 3. Legally blind or unable to complete cognitive tests due to visual loss or deafness 4. Dialysis dependent or renal transplant recipient at time of screening or baseline 5. Chronic obstructive pulmonary disease 6. Severe CI unable to complete the Modified Mini-Mental State Examination \[3MSE\] Studies for Renal Transplantation Inclusion 1. Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so. 2. Age 45 years and older Exclusion 1. Not on dialysis due to allograft failure 2. Chronic obstructive pulmonary disease

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome Cognition Disorders cognitive disorder wild type ABeta2M amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney diseases Cognition disorders Dialysis Kidney transplantation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Center for Magnetic Resonance Research

    Minneapolis, Minnesota, 55455, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.