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New study aims to solve diagnostic puzzle for kidney patients with lung fluid

NCT ID NCT07547852

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (CKD). Researchers will test 100 adults to see if standard diagnostic methods work well for these patients. The goal is to improve accuracy so doctors can treat the right cause, whether it's fluid overload, heart failure, or infection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors more accurately diagnose the cause of lung fluid in kidney disease patients, leading to better targeted treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not change current practice, and results might not apply to all kidney disease patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population comprises adult patients (≥18 years) with a confirmed diagnosis of Chronic Kidney Disease (CKD) Stages 3, 4, or 5 (eGFR \< 60 mL/min/1.73 m² for ≥3 months) who present with a radiologically confirmed pleural effusion. The cohort includes both pre-dialysis patients and those currently on maintenance hemodialysis or peritoneal dialysis. Participants will be enrolled from Assiut University Hospitals. Patients with acute kidney injury, trauma-related effusions, active malignancies, post-surgical effusions, or those who are pregnant are excluded from the sample.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged ≥18 years of either sex * Confirmed diagnosis of CKD Stage 3-5 based on eGFR \< 60 mL/min/1.73 m² for ≥3 months, as per KDIGO 2012 guidelines * Radiologically confirmed pleural effusion on chest X-ray (CXR) or thoracic ultrasound * Patients on hemodialysis or peritoneal dialysis, as well as those not yet on dialysis (CKD Stage 3-5 pre-dialysis) * Willingness to provide written informed consent Exclusion Criteria: * Patients with Acute Kidney Injury (AKI) or acute-on-chronic kidney disease without prior CKD diagnosis * Trauma-related pleural effusion (hemothorax, chylothorax) * Known active malignancy with suspected malignant effusion * Patients with post-surgical or iatrogenic pleural effusion * Patients who refuse consent or are unable to undergo thoracentesis due to coagulopathy or other contraindications * Pregnancy

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome Pleural Effusion

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease Pleural effusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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