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Kidney trouble may keep ICU patients on ventilators longer

NCT ID NCT07477652

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how acute kidney injury (AKI) impacts the process of removing a breathing tube (weaning) in critically ill adults in the ICU. Researchers will track 85 patients to see if AKI makes weaning harder, slower, or more risky. The goal is to learn whether kidney problems are a key factor in weaning success or failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 85 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Critically ill patients 18 years or above with acute kidney injury.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Age ≥ 18 years of either sex. * Admission to the ICU and receiving invasive mechanical ventilation via endotracheal tube. * Expected duration of mechanical ventilation ≥ 24 hours. * Hemodynamically stable or stabilized at the time of first spontaneous breathing trial (SBT) according to unit protocol (e.g., mean arterial pressure ≥ 65 mmHg with or without low dose vasopressors). * Availability of baseline and daily serum creatinine, urine output, and relevant clinical data to diagnose and stage acute kidney injury according to KDIGO criteria. Exclusion Criteria: * Pre existing end stage renal disease on chronic dialysis (hemodialysis or peritoneal dialysis). * Known advanced chronic kidney disease (e.g., baseline estimated GFR \< 30 mL/min/1.73 m²) if baseline creatinine is available. * Previous tracheostomy before current ICU admission. * Neuromuscular diseases or spinal cord injury causing chronic ventilatory dependence. * Severe pre existing cognitive impairment or brain death at ICU admission. * Do not intubate or comfort care only orders at time of eligibility assessment. * Re intubation after ICU discharge (only the first ICU admission episode will be considered). * Patients or legal representatives refusing or withdrawing consent

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Conditions

The condition(s) this trial relates to.

acute kidney injury Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AKI Critical illness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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Other studies related to the condition(s) this trial covers.