Ultra-Runners' kidneys under the microscope: new study aims to prevent Race-Day injury
NCT ID NCT07519408
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will follow 30 runners in the Western States Endurance Run, a 100-mile race, to see how their kidneys handle the extreme stress. Researchers will use sensitive urine tests to detect early signs of kidney injury and test whether a sodium bicarbonate supplement can help. The goal is to better understand and reduce kidney risks for endurance athletes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Sodium Bicarbonate (dietary supplement) and Placebo
- What this could lead to
- If successful, this study could help identify risk factors for kidney stress during extreme endurance events and guide safer training and medical practices.
- What could go wrong
- This is a small, early-stage observational study with only 30 participants, so results may not apply to all runners. The supplement tested may not reduce kidney injury as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Running in the Western States Endurance Run in either 2026, 2027 or 2028 * No contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire (PAR-Q+) as prepared by the American College of Sports Medicine (ACSM) * Not currently taking medicine or experiencing illness that may influence the cardiovascular or neuromuscular system * Age ≥18 and ≤ 50 years old and injury free (skeletal muscle) for \> 3 months Exclusion Criteria: * Minors (under 18) * Adults who are unable to consent (impaired decision-making capacity) * Prisoners * Pregnant Women * Individuals with known kidney disease, or are on any medication that specifically effects kidney function (e.g., diuretics)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.