CNS demyelinating autoimmune disease

This early-stage trial tests a single infusion of allogeneic CAR-T cells, called RN1201, in 18 adults with autoimmune diseases that have not responded to standard treatments. The therapy aims to reset the immune system by targeting and eliminating faulty immune cells. Before the …

Researchers are testing whether adding terfenadine to standard first-line disease-modifying therapy is safe and may improve outcomes for adults with relapsing-remitting multiple sclerosis. About 100 participants aged 18 to 65 will be randomly assigned to receive either terfenadin…

This study compares a stem cell transplant (using a person's own cells) against the best available medications for people with relapsing multiple sclerosis that hasn't responded to treatment. About 156 participants will be randomly assigned to one of the two approaches and follow…

This phase 2 trial tests whether a 3-day course of high-dose corticosteroids (methylprednisolone or prednisone) can help heal ring-enhancing brain lesions in people with multiple sclerosis. Thirty adults with MS and a specific type of active lesion will be randomly assigned to re…

This Phase 3 trial tests an oral drug called orelabrutinib against a placebo in about 990 people with non-active secondary progressive multiple sclerosis (MS). The goal is to see if the drug can delay worsening disability over 24 to 60 months. Participants are randomly assigned t…

This Phase 3 trial tests whether a simple injection of frexalimab every 4 weeks works as well as the standard IV infusion for adults with relapsing or non-active progressive multiple sclerosis. About 160 participants will be randomly assigned to one of the two methods. The study …

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This phase 3 trial tests whether the oral drug orelabrutinib can slow disability progression in people with primary progressive multiple sclerosis (PPMS). About 705 adults aged 18–60 with PPMS will receive either orelabrutinib or a placebo for up to 5 years. The study measures ti…

This study compares two daily pills, ozanimod and fingolimod, to see which works better at preventing MS relapses in children and teens aged 10 to 17. Participants will be randomly assigned to one of the two drugs and monitored for about two years. The goal is to find a more effe…

This study tests an oral drug called fenebrutinib in 12 children and adolescents aged 10 to 17 with relapsing multiple sclerosis. The goal is to see how the drug moves through the body, how safe it is, and whether it reduces new brain lesions seen on MRI. Participants can choose …

This early study tests a new treatment called azercabtagene zapreleucel (azer-cel) for people with B-cell mediated autoimmune disorders like multiple sclerosis and neuromyelitis optica. The treatment uses a patient's own immune cells that are modified in a lab to target and destr…

This phase 1b trial is testing whether ixazomib, a drug already used for multiple myeloma, is safe for people with multiple sclerosis. The study will enroll 72 adults with relapsing-remitting or progressive MS. Participants will receive either ixazomib or a placebo for up to 24 m…

This study looks at whether people with multiple sclerosis can safely switch from their current anti-CD20 therapy to a new under-the-skin version of ocrelizumab. About 100 participants will be followed for up to 48 weeks to see if brain lesions stay stable and if they are satisfi…

This trial tests whether short sprint interval training, involving repeated 5-second high-intensity cycling bursts, can improve walking, strength, fatigue, and cognitive speed in people with multiple sclerosis. Participants are randomly assigned to either the sprint program or th…

This study tests whether giving two strong medications one after the other—rituximab then cladribine—is safe and works well for people with relapsing-remitting multiple sclerosis (MS). Sixty adults aged 18 to 50 with active MS within the last year will receive the treatment and b…

This study tests a small device implanted on the vagus nerve in the neck to see if it can help repair myelin (the protective coating around nerves) in people with relapsing-remitting multiple sclerosis. About 60 adults aged 22–50 will take part. Two-thirds will receive active sti…

This study tests whether changes in spinal fluid biomarkers can predict which drug or drug combination works best for people with progressive multiple sclerosis (MS). Participants will take one or two of five drugs (cilostazol, leucovorin, pirfenidone, dantrolene, or pioglitazone…

This Phase 3 trial is testing a modified dosing schedule of ublituximab (BRIUMVI) in 800 people with relapsing multiple sclerosis. The study has three parts: one open-label part to see if the new regimen reduces brain lesions, a placebo-controlled part to measure drug levels, and…

This phase 3 trial is testing whether a daily pill called remibrutinib works as well as the standard infusion or injection ocrelizumab for people with relapsing multiple sclerosis. About 360 adults aged 40–70 who are stable on ocrelizumab will either switch to remibrutinib or sta…

This early-stage trial is testing a new treatment called AZD0120 for people with multiple sclerosis (MS) that has not responded to other therapies. AZD0120 is a type of immune cell therapy (CAR-T) designed to target and reset the immune system. The study will enroll 24 adults age…

This study tests the drug ublituximab in children aged 10 to 18 with relapsing multiple sclerosis (MS). It compares ublituximab to another drug, fingolimod, to see which better controls relapses. The trial involves 240 participants and will also monitor long-term safety and effec…

This study looks at two approved medications for multiple sclerosis—Kesimpta (ofatumumab) and Ocrevus (ocrelizumab)—to see how they compare in real-world use. Researchers will analyze health records from thousands of patients to measure relapse rates and healthcare costs. The goa…

This study tests a drug called ublituximab, given as a shot under the skin, in 350 people with relapsing multiple sclerosis. Researchers want to see how the drug moves through the body when injected in different spots (like the belly or thigh) and whether an autoinjector pen work…

This trial is testing an experimental oral drug called rocbrutinib (LP-168) in people with relapsing-remitting multiple sclerosis (RRMS) who have a specific type of brain lesion called paramagnetic rim lesions. The study compares rocbrutinib to an existing treatment, dimethyl fum…

This study tests whether adding a new drug (RO7268489) to the standard MS treatment ocrelizumab can slow disability progression in adults with progressive multiple sclerosis. About 360 participants will receive either the new drug or a placebo, and researchers will track walking …

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This early-phase trial is testing a new treatment called KITE-363 for people with certain autoimmune nerve diseases that have not responded to standard therapies. KITE-363 is a type of CAR T-cell therapy that uses a patient's own immune cells, modified to target and attack faulty…

This study tests whether a medicine called Panzyga can prevent major infections in people with autoimmune or rheumatic conditions who have low antibody levels after receiving B-cell depletion therapy. About 360 adults will receive either Panzyga or a placebo, and researchers will…

This study looks at whether the experimental drug remibrutinib can reduce inflammation in the brain and spinal cord of people with relapsing multiple sclerosis (MS). Participants, aged 40 to 70, will have PET scans, MRIs, and blood and spinal fluid samples taken before and six mo…

This study tests whether taking a daily probiotic supplement for six months can improve immune function in people with relapsing-remitting multiple sclerosis (MS). Eighty adults aged 18-55 will be randomly assigned to receive either the probiotic or a placebo, alongside their usu…

This early study tests a new treatment called S103 (BCMA-CAR T cells) in 9 adults with progressive or hard-to-treat multiple sclerosis (MS). The main goal is to see if the treatment is safe and to find the best dose. Researchers will also look for early signs that it might help c…

This trial tests whether a six-month program of high-intensity exercise delivered through an immersive virtual reality headset can improve mobility, strength, and thinking skills in people with multiple sclerosis (MS). Participants will be randomly assigned to either the VR exerc…

This study tests an implanted electrical stimulation device designed to improve movement, standing, and walking in people with paralysis from spinal cord injury, stroke, multiple sclerosis, or traumatic brain injury. The device sends electrical signals to muscles in the trunk and…

This Phase 3 study tests whether the drug remibrutinib can slow disability worsening in people with secondary progressive multiple sclerosis (SPMS). About 1,275 adults aged 18-65 with SPMS and recent disability progression will receive either remibrutinib or a placebo. The main g…

This early-phase trial is testing an oral drug called VT7208 in healthy volunteers and people with multiple sclerosis (MS). The study has three parts: first, checking safety and how the drug moves through the body in healthy adults; second, seeing how food affects the drug; and t…

This phase 2 trial tests whether NLY01, a drug similar to those used for diabetes, can slow brain and retinal shrinkage in people with multiple sclerosis. About 120 adults with stable MS will receive either NLY01 or a placebo for 96 weeks. The main goal is to see if the drug redu…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This study looks at Portuguese adults with relapsing multiple sclerosis who are taking ofatumumab (Kesimpta). It compares those who started the drug within three years of diagnosis to those who started later. The goal is to see if earlier treatment leads to less disease activity,…

This trial investigates a Functional Balance Intervention (FBI) — a structured exercise program — for people aged 55 to 80 with multiple sclerosis. The program includes agility, strength, balance, and dual-task exercises done twice a week for four months, either in a lab or at ho…

This study tests whether clemastine fumarate, a common allergy medicine, can help repair the protective coating around nerves (myelin) in people with multiple sclerosis. About 74 adults with relapsing-remitting MS will receive either the drug or a placebo, and advanced MRI scans …

This study follows 30 adults in Taiwan with relapsing-remitting multiple sclerosis who are starting fingolimod (Gilenya), a daily pill that helps control the disease. Over 12 months, researchers will watch for specific side effects like slow heart rate, vision problems, liver iss…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study looks at whether people with relapsing-remitting multiple sclerosis (RRMS) who are over 40 and have been stable on strong anti-CD20 drugs for at least 3 years can safely switch to milder treatments. The goal is to see if this de-escalation approach prevents disease act…

This study is testing a new blood filter called the Plasma Filter PX2. It is used in a procedure called therapeutic plasma exchange, which removes harmful substances from the blood of people with autoimmune diseases. About 46 adults will take part, and the study will check if the…

This Phase 2 trial tests an experimental mRNA therapy called mRNA-1195 in 180 adults aged 18 to 55 with relapsing multiple sclerosis. Participants receive either the mRNA shot or a placebo, and researchers monitor safety and measure new brain lesions on MRI scans over about 2.5 y…

This early study tests a single dose of GC012F CAR-T cell injection in 9 people with multiple sclerosis. The main goal is to check safety and tolerability, not yet to see if it works. Researchers will monitor side effects for up to 15 years and measure how the cells behave in blo…

This study tests a new treatment called MB-CART2019.1 for people with active multiple sclerosis (MS) that hasn't responded to other therapies. The treatment uses a patient's own immune cells, modified to target and attack harmful immune cells driving MS. The goal is to see if it …

This early-phase study tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and calm the immune system in people with neurological autoimmune diseases like multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinat…

This early-phase trial is testing a new cell therapy called QH103 for people with severe autoimmune diseases like multiple sclerosis and myasthenia gravis that haven't responded to standard treatments. The therapy uses specially engineered immune cells to target and attack the fa…

This early-stage study tests a new treatment called HBI0101 CAR T for people with severe autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis that haven't improved with standard treatments. The main goal is to find a safe dose and check for side effects in…

This early-stage study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't improved with standard care. The therapy works by directing the body's immune cells to attack and control overactive immune cells causing the disease. The study will…

This early-stage trial is testing a new treatment called obe-cel, a type of cell therapy (CAR T-cell), for people with progressive multiple sclerosis (MS) that hasn't improved with standard treatments. The main goal is to see if it's safe, but researchers will also look for any s…

This study looks at whether adding GLP-1 agonists (a type of diabetes drug) to the MS medication ocrelizumab can reduce disability progression in people with multiple sclerosis. Researchers will track 100 adults with MS over 72 weeks, measuring changes in walking, hand function, …

This early-stage trial tests a cell therapy called TRX319 in 39 adults with progressive multiple sclerosis (MS). The goal is to see if it is safe and to find the best dose. Participants receive TRX319 infusions, sometimes after a chemotherapy drug called bendamustine, and are fol…

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study tests whether rituximab, a drug used for certain cancers and autoimmune diseases, can improve thinking and hand function in people with advanced secondary progressive multiple sclerosis (SPMS). About 46 participants with high disability will receive either rituximab or…

This study tests whether a 3-month exercise program combining aerobic, strength, and balance training can improve disease activity and daily function in people with multiple sclerosis. Forty participants will do exercises either in person or via video at home. The goal is to see …

This study tests a drug called Ublituximab (Briumvi) given twice a year to people with early relapsing multiple sclerosis. Researchers want to see if it is safe and how it affects a nerve damage marker in the blood. About 40 adults with mild disability will take part for about on…

This study tests whether clemastine fumarate, a drug originally approved for allergies, can help repair nerve damage in people with acute optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. Researchers …

This early-stage study tests a new cell therapy called CNCT19 in 18 adults with relapsed or treatment-resistant autoimmune neurological diseases like neuromyelitis optica. The goal is to see if it is safe and can help control the disease by targeting certain immune cells. Partici…

This early-stage trial tests a personalized cell therapy called KYV-101 for people with progressive forms of multiple sclerosis (MS) that are not responding to standard treatments. The therapy uses a patient's own immune cells, modified to target and destroy certain immune cells …

This study offers continued access to ocrelizumab for up to 500 people with multiple sclerosis who were already taking the drug in a previous Roche-sponsored trial. It aims to understand how MS affects daily physical activities like walking and using hands, from the patient's own…

This early-phase study tests whether ublituximab, a drug for relapsing multiple sclerosis, can improve walking function and reduce fall risk. Twenty-five participants will receive the drug for 48 weeks, with walking, disability, and thinking tests before, during, and after treatm…

This phase 3 trial tests whether rituximab, a less expensive drug, works as well as ocrelizumab for people with relapsing-remitting multiple sclerosis. About 386 participants will receive either drug and be followed for 2 years. The main goal is to see if rituximab can keep the d…

This early-phase study tests a new treatment called RD06-05, which uses a patient's own immune cells modified to target and reset the immune system in autoimmune diseases like lupus, multiple sclerosis, and vasculitis. The goal is to check safety and how well the body tolerates i…

This study tests whether a daily supplement of indole-3-propionic acid (IPA), a substance naturally made by gut bacteria, can help people with relapsing-remitting multiple sclerosis (RRMS). Over 27 months, 220 adults will take either IPA or a placebo. The main goal is to see if I…

This study is testing a supplement made from a broccoli compound (bioactivated GRA) in 300 people with Parkinson's disease, relapsing-remitting multiple sclerosis, or certain childhood nerve diseases. Participants will take the supplement daily for 6 months. Researchers will trac…

This early-stage trial tests a new treatment for people with autoimmune diseases like lupus and multiple sclerosis that haven't responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target and destroy the faulty cells causing the d…

This study looks at how well the drug ofatumumab works and how safe it is for people with relapsing multiple sclerosis (RMS) in China. Researchers will measure a nerve damage marker called sNfL in the blood to see if the drug helps protect nerves. About 80 adults with RMS will ta…

This early-phase trial is testing whether repeated injections of stem cells from donated fat tissue are safe for people with primary progressive multiple sclerosis (MS). Ten participants will receive the cells directly into the spinal canal. The main goal is to check for serious …

This study tests whether giving the drug natalizumab (Tyruko) within two weeks of first MS symptoms can help repair nerve damage. Forty adults with a first episode of MS-like inflammation will receive either the drug or a placebo. The main goal is to see if early treatment improv…

This study tests a new medicine called BCD-281 in people with relapsing-remitting multiple sclerosis (RRMS). The goal is to see if it reduces brain lesions and relapse rates better than the current standard drug. About 292 adults aged 18-55 with mild to moderate disability are be…

This early-stage study tests a new treatment using specially engineered immune cells (CAR T-cells) that target two proteins, CD19 and BCMA, to calm overactive immune attacks in people with severe autoimmune diseases like multiple sclerosis, myasthenia gravis, and neuromyelitis op…

This pilot study is testing whether metformin, a common diabetes drug, can safely protect the nervous system in people aged 55 to 75 with multiple sclerosis (MS). Thirty participants will receive either metformin or a placebo for 9 months, and researchers will use brain scans to …

This pilot study tests efgartigimod alfa (Vyvgart Hytrulo) against placebo in 20 adults having their first episode of moderate to severe optic neuritis, an inflammation of the optic nerve that can cause vision loss. Participants get two injections over a week, plus standard stero…

This study tests whether following the MIND diet—rich in olive oil, fish, vegetables, and whole grains—for one year can protect brain health and reduce symptoms in people with multiple sclerosis. One hundred participants will be randomly assigned to either the diet or continue th…

This study tests whether metformin, a widely used diabetes drug, is safe and feasible for children and young adults (ages 10-25) with multiple sclerosis. Participants take metformin daily for 3 to 9 months, with the start time randomly assigned. The main goal is to see if the dru…

This study looks at whether people with stable relapsing multiple sclerosis can safely switch from anti-CD20 therapies (like rituximab or ocrelizumab) to ozanimod (Zeposia), an oral pill. About 100 participants who have had no new MS activity for at least two years will be follow…

This early-stage trial tests a new long-acting naltrexone injection (IVL3004) against the approved drug Vivitrol in 40 healthy men. The goal is to compare how the drug moves through the body and check for safety. It does not yet test if it helps treat opioid or alcohol dependence…

This study is testing a smartphone app that records and analyzes speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

This trial tests whether an AI tool called icobrain ms can help radiologists detect signs of multiple sclerosis (MS) activity on brain MRI scans. The study involves over 1,300 people with MS or early signs of it, who are already on treatment. The AI analyzes scans and creates str…

This study tests a new portable, low-field MRI scanner for imaging the brain and limbs in 50 people with suspected multiple sclerosis. The goal is to see if this cheaper, smaller device can produce images good enough to help diagnose MS, especially in places where standard MRI ma…

This study tests whether a tablet-based eye-tracking app (eVOG) can detect subtle eye movement problems in people with brain MRI abnormalities (white matter lesions). The goal is to see if these eye movement patterns can help diagnose multiple sclerosis or related conditions. Res…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This study compares the 2024 and 2017 McDonald criteria for diagnosing multiple sclerosis (MS) in 100 patients with symptoms suggestive of MS. Researchers will see if the newer criteria catch more cases early without extra tests. The goal is to improve diagnosis and guide future …

This study follows 40 people with multiple sclerosis (MS) for 48 months to see if two MRI markers—the central vein sign and paramagnetic rim lesions—can improve how doctors diagnose and monitor the disease. Participants will have brain scans and disability tests at the end of the…

This study is testing a new, 10-minute MRI sequence (3D FGAPSIR) to see if it can find more spinal cord lesions in people with multiple sclerosis than standard scans. Researchers will enroll 200 adults already scheduled for a spinal MRI. The goal is to improve detection of spinal…

This study is testing whether a special MRI sequence called MP2RAGE can find more spinal cord lesions in people with multiple sclerosis than the standard scans currently used. Researchers will compare the number of lesions seen on MP2RAGE images versus conventional MRI in 196 adu…

This study tests whether people with multiple sclerosis can learn to prevent falls by practicing on a treadmill that unexpectedly slips or trips. 64 participants aged 45 and older will be split into two groups: one gets the slip-and-trip training, the other just walks on the trea…

This study tests a smartphone app designed to help people who use wheelchairs or scooters prevent and manage falls. Researchers will compare the app to standard fall prevention information in 120 adults with spinal cord injury or multiple sclerosis. The goal is to see which appro…

This study is testing whether the shingles vaccine (RZV) works and is safe for adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus who are taking immune-suppressing drugs. Two hundred participants will receive two doses of the vaccine. Researchers will me…

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This study tests whether mentally practicing walking while watching videos of people walking can improve gait in people with multiple sclerosis. Twenty participants will either watch walking videos and imagine themselves walking, or watch nature scenes. Researchers will measure m…

This study tests whether balance training tailored to each person's difficulty level is feasible for people with multiple sclerosis during a three-week inpatient rehabilitation stay. Participants are randomly assigned to either standard group training or individually tailored bal…

This study tests a 16-week exercise program designed specifically for Hispanic people with multiple sclerosis who have walking problems. About 66 participants will either join the exercise group or a waitlist. The goal is to see if the program improves walking ability and quality…

This trial tests whether a mild electric current applied to a brain area linked to memory can improve verbal recall in people with relapsing-remitting multiple sclerosis. Participants will receive either active or sham stimulation during cognitive tasks, and their performance wil…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study looks at how two parts of cannabis, THC and CBD, affect thinking and bladder symptoms in people with Multiple Sclerosis (MS). Thirty adults with MS will take either THC or CBD oil for 15 weeks and complete tests and questionnaires. The goal is to see if one compound he…

This study tests whether a short, intense cycling workout, known as high-intensity interval training (HIIT), can help people with multiple sclerosis (MS) walk farther and feel better in daily life. The trial includes 30 adults with MS at different disability levels, from mild to …

This study tests an experimental oral drug, BMS-986368, for treating muscle stiffness (spasticity) in people with multiple sclerosis. About 200 participants will receive one of three doses of the drug or a placebo. The goal is to see if the drug safely reduces muscle tightness an…

This study is testing a full-body suit that delivers mild electrical pulses to muscles. The goal is to see if it safely reduces spasticity, overactive reflexes, and pain in people with neurological conditions like multiple sclerosis or fibromyalgia. Fifteen adults will try both t…

This trial tests whether individualized transcranial electrical stimulation (tES), a non-invasive brain stimulation technique, combined with cognitive training can improve thinking skills in people with central nervous system inflammatory demyelinating diseases like multiple scle…

This study tests whether a 12-week online ukulele learning program, called Music-4-MS, can improve cognitive function in people with multiple sclerosis (MS). Half the participants will learn to play the ukulele, while the other half will simply listen to music they enjoy. The goa…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This study tests whether combining a memory retraining technique (KF-mSMT) with aerobic exercise and virtual reality can improve learning and memory in people with multiple sclerosis (MS). 78 participants with mild-to-moderate mobility disability will be enrolled. The approach fo…

This trial tests whether a device called sacral neuromodulation (InterStim X) can improve bladder, bowel, and sexual function in people with multiple sclerosis who have not responded to standard treatments. Participants who show at least 50% improvement during a test period will …

This study tests whether taking dalfampridine (a drug that helps some people with MS walk faster) along with physical therapy improves mobility more than either treatment alone. Forty-eight adults with MS will first take the drug for 6 weeks, then stop for 2 weeks, and then be ra…

This study investigates whether cannabidiol (CBD), a compound from cannabis, can improve sleep and reduce pain in people with multiple sclerosis (MS) who also have chronic pain. About 166 participants take CBD or a placebo for several weeks while their sleep is measured in a lab …

This study tests whether a 6-month personalized exercise program can improve physical and cognitive function in people with multiple sclerosis (MS) who primarily use a wheelchair. Participants will follow a low-impact, resistance-based routine designed to build muscle without inc…

This study tests whether virtual reality dance games, like 'Just Dance', can help people who have had a stroke improve their balance and movement. Researchers will compare this fun, home-friendly approach to standard physical therapy. The goal is to see if it's safe, enjoyable, a…

This study tests whether adding music-like sounds (sonification) to standard walking rehabilitation can improve gait, balance, and quality of life. 120 adults with Parkinson's disease, stroke, or multiple sclerosis will be randomly assigned to standard rehab or rehab with sonific…

This study tests whether exercise paired with simple mental tasks (like counting backwards) can improve walking, balance, and thinking in people with multiple sclerosis. Forty adults with MS will do supervised workouts twice a week for 8 weeks. The goal is to find better rehab st…

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real …

This early-phase study tests a 4-week training program that uses mixed reality to guide precise movements, like stacking virtual objects. The goal is to see if this can improve walking speed, balance, and thinking in people with multiple sclerosis. Thirty adults with MS will part…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce fatigue in people with multiple sclerosis. About 70 adults with MS and insomnia will receive CBT-I or an active control. The goal is to see if this talk therapy approach can ea…

This study tests whether solriamfetol (Sunosi), a drug used for sleepiness, can reduce fatigue in people with multiple sclerosis who also have excessive daytime sleepiness. About 46 participants will receive either the drug or a placebo for four weeks, then switch after a washout…

This study looks at whether two different exercise programs can help reduce depression in people with multiple sclerosis (MS) who also have major depressive disorder. Researchers will enroll 146 adults aged 18 to 64. One group will do a structured exercise program, while the othe…

This study tests whether silodosin, a drug typically used for enlarged prostate, can help women with multiple sclerosis who have bothersome urinary symptoms. Sixty female participants will take either silodosin or a placebo daily for 8 weeks. Researchers will use symptom question…

This study tests whether dry needling—a treatment using thin needles to target tight muscles—can reduce chronic lower-limb pain in people with multiple sclerosis. Twenty-four participants will receive either real or sham dry needling over six sessions. Researchers also hope to se…

This study tests whether a non-invasive nerve stimulation device placed on the ankle can reduce bladder symptoms like urgency and frequent urination in people with multiple sclerosis. 72 participants will be randomly assigned to receive either real or sham stimulation over severa…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study tests whether a home-based program combining computer brain games with physical exercises can improve thinking and walking in people with multiple sclerosis (MS). Ninety adults with MS will be randomly assigned to different training groups. The goal is to see if the co…

This study tests whether using mixed reality (a blend of real and virtual environments) can improve hand strength, coordination, and quality of life in people with multiple sclerosis. Thirty participants will either receive standard physiotherapy or standard therapy plus mixed re…

This pilot study tests whether switching from ocrelizumab to ublituximab can reduce or delay the return of MS symptoms that some patients experience before their next scheduled infusion. Researchers will enroll 50 adults with relapsing MS who have been on ocrelizumab for at least…

This study tests whether doing thinking tasks (like counting backwards or matching colors) at the same time as physical exercises can improve walking, balance, and memory in teens with pediatric-onset multiple sclerosis. Twenty-two participants aged 12–18 will be randomly assigne…

This study tests a new 8-week program that combines motor imagery (mentally practicing movements) with vestibular rehabilitation (exercises for balance and dizziness) in 30 people with relapsing-remitting multiple sclerosis. The goal is to see if this combination improves balance…

This study tests whether a device that sends mild electrical currents to the brain (hi-tACS) can improve sleep in people with neuroimmune diseases like multiple sclerosis who also have insomnia. Eighty participants will receive 20 sessions of the stimulation or a sham treatment. …

This study tests whether low-intensity arm exercises combined with blood flow restriction (using a cuff to partially limit blood flow) can improve hand strength, coordination, and quality of life in people with multiple sclerosis. About 20 participants will be randomly assigned t…

This study tests whether listening to Quran recitation (Surah Yasin) for 30 minutes, three times a week for 4 weeks, can reduce fatigue and improve mental well-being in people with multiple sclerosis. 52 participants will be randomly assigned to either listen to the recitation or…

This study is testing whether laughter yoga—a program of breathing, stretching, and laughter exercises—can reduce pain, stress, and fatigue in people with multiple sclerosis. Researchers will measure changes in pain intensity and beta-endorphin levels in 72 participants. The goal…

This study tests the EXOPULSE Suit, a body garment with 50 electrodes that stimulate muscles to reduce stiffness and improve balance. 77 people with multiple sclerosis will use the suit for one hour every other day, either in active or sham mode, then switch. The goal is to see i…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce muscle stiffness (spasticity) and improve balance in people with multiple sclerosis. Researchers will compare real rTMS to a sham (fake) treatment in 24 adults aged 18-60 with MS. The goal …

This study explores whether combining virtual reality with wearable sensors can improve gait training for people with multiple sclerosis. Twelve participants will use a VR headset and a walking brace during two clinic sessions and a week at home. The goal is to see if this approa…

This study tests a non-invasive brain stimulation technique called rTMS to improve bladder symptoms in women with multiple sclerosis. Participants receive either real or sham treatment over 10 sessions. The goal is to see if targeting specific brain areas can reduce urinary urgen…

This study tests whether adding mild electrical stimulation to leg muscles or the spinal cord during balance exercises can improve mobility and reduce falls in people with multiple sclerosis (MS). Up to 24 participants will be randomly assigned to balance training alone, with fun…

This study tests whether relaxation training, activity planning, and cognitive therapy can reduce fatigue and improve daily functioning in adults with multiple sclerosis. About 112 participants will try these techniques via telehealth sessions. The goal is to find which component…

This study tests a smartphone app called ICanWALK that teaches people how to properly fit and use walking aids like crutches, canes, and walkers. Researchers will compare it to a breathing app in 52 adults with lower limb injuries or conditions like stroke or multiple sclerosis. …

This study tests whether a wearable device that gently vibrates arm muscles can improve arm and hand function in people with multiple sclerosis (MS). Fifteen adults with relapsing-remitting MS will use the device at home for 4 weeks. Researchers will measure dexterity, coordinati…

This study tests whether a daily 500 mg hesperidin supplement (found in citrus fruits) can reduce fatigue, improve mood, and sharpen thinking in people with multiple sclerosis. Sixty adults with MS will take either hesperidin or a placebo for 12 weeks. The main focus is on fatigu…

This study tests whether a mild electrical current applied to the front of the brain for 20 minutes a day over five days can reduce central fatigue in people with relapsing-remitting multiple sclerosis. Researchers will use brain scans and blood tests to see if the stimulation ch…

This study tests a strength training program using blood flow restriction (BFR) in people with advanced multiple sclerosis (MS) who need help walking or use a wheelchair. BFR uses a device that partially blocks blood flow to the exercising limb, allowing low-intensity exercise to…

This study explores whether using a virtual reality headset to experience nature scenes can help reduce depression in people with progressive multiple sclerosis. About 40 participants will use the Apple Vision Pro at home for short sessions over 8 weeks. The goal is to see if thi…

This study tests whether adding music to technology-based walking exercises helps people with multiple sclerosis walk better. Thirty-two participants with mild to moderate disability will do four weeks of gait training at home via telerehabilitation, either with or without music.…

This study is testing whether a full-body electrical stimulation suit, used at home, can reduce muscle stiffness (spasticity) and coordination problems (ataxia) in people with multiple sclerosis. Seventy participants will either use the suit for six weeks or receive usual care al…

This study tests whether sensor-based robotic arm rehabilitation can improve both thinking skills (like memory and attention) and physical movement in adults with Parkinson's disease, multiple sclerosis, or stroke. Participants will receive 25 sessions of either robotic therapy w…

This study tests whether a gentle magnetic pulse to a specific brain area can reduce fatigue in people with multiple sclerosis. Sixty participants will receive either real or fake stimulation for 30 minutes daily over five days. Researchers will track changes in fatigue, brain ch…

This study tests a home-based balance training program for people with multiple sclerosis (MS). The program combines stepping games, strength, and thinking tasks. Researchers will compare it to a simple stretching routine in 75 adults with MS to see if it improves physical functi…

This study tests whether a 12-week progressive resistance exercise program can reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist control group. The goal is to see if exercise provides a mea…

This study is testing a wearable suit called Mollii that uses mild electrical stimulation to improve mobility and quality of life in people who have had a stroke or have multiple sclerosis. Forty participants will wear the suit for one hour, three times a week for four weeks. Som…

This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to rece…

This study tests a non-invasive treatment called transcutaneous tibial neuro-stimulation (TTNS) to help people with multiple sclerosis who have trouble emptying their bladder. Participants will use a device at home for 30 minutes each day for 12 weeks. The goal is to see if this …

This study tests a walking meditation program called iWalk for adults with neurodegenerative diseases like multiple sclerosis. The goal is to see if it's feasible and helps improve resilience, stress regulation, and thinking skills. Researchers will enroll 90 participants and mea…

This study tests whether a home-based virtual reality program can help people with multiple sclerosis improve hand function. 60 participants will either watch and imitate hand tasks in VR or watch landscapes before doing the same tasks. The program lasts 3 weeks with daily sessio…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve walking in people with Multiple Sclerosis who have leg stiffness and moderate walking difficulty. Sixty participants will receive either real rTMS or a sham (fake) treatment for six weeks,…

This study is testing whether a wearable robotic exoskeleton can improve both walking and thinking in people with multiple sclerosis who have trouble walking. Ten participants will either use the robotic suit or receive standard walking therapy for eight sessions. Researchers wil…

This study tests whether a coaching app that focuses on goal-directed behavior can make cognitive rehabilitation more effective for people with Multiple Sclerosis (MS). 126 participants will first use either the coaching app or a sham app for 12 weeks, then all will do 6 weeks of…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet virtually with a coach for 8 weekly sessions to learn problem-solving and relaxation skills. The goal is to improve quality of life…

This study tests two ways of delivering cognitive behavioral therapy for insomnia (CBT-I) to people with multiple sclerosis: one-on-one telehealth sessions or a self-guided web program. Researchers will compare these to usual care to see which improves sleep, reduces fatigue, and…

This study tests a wearable device called the Cionic Neural Sleeve that uses mild electrical pulses to help leg muscles contract at the right time during walking. Fourteen people with multiple sclerosis will wear the sleeve for six weeks and also do a walking program. Researchers…

This study compares two types of acupuncture—one using mild electrical currents and one using manual massage—for treating bladder dysfunction in women with multiple sclerosis. 150 women aged 18-60 will be randomly assigned to one of the two treatments plus routine care. The goal …

This study tests whether playing a special online game for 20 minutes, four times a week, can improve memory and thinking speed in people with multiple sclerosis. Researchers will compare the game group to a control group receiving standard care. The trial aims to enroll 150 adul…

This study investigates whether the bacteria causing Lyme disease can survive antibiotic treatment and cause ongoing symptoms. Researchers will follow 700 participants, including those with chronic Lyme disease, recovered individuals, and healthy volunteers, using blood tests, sp…

This study looks at how body awareness (knowing where your body is in space), trunk (core) stability, and arm function are related in people with multiple sclerosis (MS). Researchers will measure these abilities in 50 adults with MS and compare them to healthy volunteers. The goa…

This study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…

This long-term observational study uses MRI scans to track how multiple sclerosis (MS) changes over time in up to 3750 people. Researchers will compare brain images and immune system markers in untreated patients, those on approved therapies, and healthy volunteers. The goal is t…

This study will analyze DNA from up to 20,000 people, including those with immune disorders and their relatives, to find genetic variants linked to conditions like atopy, autoimmunity, and primary immunodeficiency. Researchers will also study how best to return genetic results to…

This observational study is recruiting 2400 people with immune-related central nervous system diseases, such as multiple sclerosis, along with healthy volunteers for comparison. Researchers will use MRI scans, lumbar punctures, blood tests, and neurological exams to track disease…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study follows 842 people with multiple sclerosis who are starting a new under-the-skin injection of ocrelizumab. Researchers will ask participants how satisfied they are with the injection after 1, 6, and 12 months. The goal is to understand patient experience, not to test t…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study is looking for simple ways to detect early signs of multiple sclerosis and Parkinson's disease in people who drive. Researchers will test 200 drivers with these conditions using computer-based attention and reaction tests. The goal is to find quick, easy tests that cou…

This registry follows pregnant women who have taken mycophenolate, a drug used to prevent organ rejection and treat autoimmune diseases. Researchers will collect data on pregnancy complications and birth defects up to one year after birth. The goal is to better understand the dru…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This registry study will follow 2000 people with relapsing multiple sclerosis who are prescribed BRIUMVI (ublituximab-xiiy) in real-world settings. Researchers aim to track safety, effectiveness (like relapse rates), and the overall treatment experience. Participants must not hav…

This study looks for early clues that someone might develop multiple sclerosis (MS) before they have any symptoms. Researchers will collect health data and samples from 1,000 adults who have risk factors like a family history of MS or past Epstein-Barr virus infection. The goal i…

This study tests three versions of a dual-task walking test in people with multiple sclerosis. The test combines the standard Timed Up and Go, where a person stands, walks three meters, turns, and sits, with a second task like counting backward, naming words, or carrying a ball o…

This study explores whether smartphone apps and wearable devices can objectively measure fatigue in people with multiple sclerosis (MS) and long COVID, compared to healthy volunteers. Fatigue is often reported through subjective questionnaires, which can be biased. Participants w…

This registry study follows pregnant women with multiple sclerosis (MS) who have taken BRIUMVI, comparing them to those who haven't taken the drug. The goal is to see if BRIUMVI increases the risk of major birth defects. Researchers will enroll about 728 participants across two g…

This study looks at how much of the multiple sclerosis drug BRIUMVI gets into breast milk. About 16 breastfeeding women with relapsing MS will provide milk samples after their regular treatment. The goal is to understand drug exposure for nursing infants, not to test a new treatm…

This registry study follows women with multiple sclerosis (MS) who become pregnant, comparing those who took the medication Vumerity (diroximel fumarate) with those who took other MS treatments or no treatment at all. The main goal is to estimate the risk of major birth defects i…

This study is a pregnancy registry that gathers information from women with chronic neurological conditions like multiple sclerosis, NMOSD, and myasthenia gravis who are planning pregnancy, currently pregnant, or within one year postpartum. Participants can contribute blood, brea…

This study tests whether a new MRI technique, called inhomogeneous Magnetisation Transfer (ihMT), can accurately measure myelin damage and repair in people with multiple sclerosis (MS). The researchers will compare ihMT scans with standard MRI measures in 85 adults with early-sta…

This study tests a new radioactive tracer called [18F]FZTA to see if it can spot inflammation in the brain using PET scans. Researchers will compare 80 people—some with Multiple Sclerosis and some healthy—to see if the tracer lights up differently in those with MS. The goal is to…

This observational study looks at how people with relapsing-remitting multiple sclerosis (RRMS) perform when crossing obstacles while also doing a mental task. Researchers want to see if this dual-task challenge is related to levels of fatigue and disability. Thirty participants …

This study is not testing a new drug. Instead, it will observe 800 people with relapsing multiple sclerosis in Germany who are already taking approved injectable or oral medications. Researchers will track how long patients stick with their prescribed treatment over up to four ye…

This study aims to discover biological markers (biomarkers) that could help doctors diagnose and track neurological autoimmune diseases such as multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome. Researchers will analyze samples from 50,000 people, including patie…

This study investigates whether the multiple sclerosis medication ozanimod is linked to a higher risk of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection caused by the John Cunningham virus. Researchers will review reported cases of PML in peop…

This study will test whether a special eye scan (OCT) can detect changes in the retina that show how well the MS drug ublituximab is working. Researchers will compare 15 people starting ublituximab with 15 people on other MS treatments. The goal is to find a new, non-invasive way…

This study will enroll 80 adults with multiple sclerosis and chronic pain to take part in an 8-week online Mindfulness-Based Cognitive Therapy (MBCT) program. Researchers want to understand what emotional, physical, and environmental factors make it easier or harder to practice m…

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study looks at why some people with multiple sclerosis (MS) start or stay on Ocrevus Zunovo, a high-efficacy therapy, while others do not. Researchers will survey and interview 150 MS patients, along with their families and healthcare providers, to identify barriers and faci…

This study is measuring a protein called STIM1 on the surface of immune cells in 670 people with various autoimmune diseases. The goal is to find which diseases have high levels of this protein, which could help researchers develop new antibody-based treatments. Participants prov…

This study is analyzing inflammatory markers in the blood and spinal fluid of 300 people who are being checked for multiple sclerosis (MS). The goal is to see if certain markers can help doctors tell MS apart from other autoimmune diseases that affect the brain and spinal cord. R…

This study is observing 40 adults with multiple sclerosis to see how clinical tests of balance and walking relate to detailed motion-capture measurements. Participants will attend one session where they walk on force plates and perform balance tasks while cameras track their move…

This study is testing whether monthly blood tests for a nerve damage marker (neurofilament light chain) can detect hidden disease activity in people with relapsing-remitting multiple sclerosis (MS) earlier than standard yearly MRI scans. The goal is to reduce the need for gadolin…

This study follows 100 women with neuroimmune diseases (like multiple sclerosis or myasthenia gravis) through pregnancy and up to five years after. Researchers will track disease activity, pregnancy complications, and baby health to learn how these conditions affect fertility and…

This study examines how spinal posture and movement relate to balance in 30 adults with relapsing-remitting multiple sclerosis. Researchers will measure spinal angles and mobility, then compare them with balance tests. The goal is to identify links that could inform future rehabi…

This observational study follows 170 people with multiple sclerosis, neuromyelitis optica, and similar conditions, plus healthy volunteers, for up to 6 years. Researchers use MRI scans, blood tests, and spinal fluid analysis to monitor brain lesions and understand how the disease…

The CLUE study is a research project that follows 1,000 people with neuroinflammatory diseases like multiple sclerosis and neuromyelitis optica. Participants undergo detailed MRI and PET scans at the start and after one year to see how their brain, spinal cord, and optic nerves c…

This study looks at whether special breathing exercises can help the brains of people with multiple sclerosis or cancer, as well as their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connection bet…

This study follows 160 people with relapsing multiple sclerosis in Greece who are already taking ofatumumab (Kesimpta®) as part of their routine care. Researchers will track how many patients have no signs of disease activity—like relapses, new brain lesions, or worsening disabil…

This study tests a new type of MRI that looks at energy use in the brain to see if it can predict how well multiple sclerosis (MS) patients will respond to a common therapy. Researchers will scan 40 adults with relapsing-remitting MS before and after they start treatment. The goa…

This study follows 20 adults with multiple sclerosis who are already scheduled for a stem cell transplant. Researchers will measure levels of an immune-suppressing drug called ATLG and track how the immune system rebuilds itself afterward. The goal is to learn more about immune r…

This pilot study tests whether a radioactive tracer called 89Zr-Df-crefmirlimab can help PET scans detect certain immune cells (CD8+ T cells) in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults w…

This study follows 250 adults with multiple sclerosis (or similar conditions) for years, using yearly MRI scans and other tests to track brain and spinal cord changes. After a participant passes away, researchers examine donated brain and spinal cord tissue to see how the MRI fin…

This study is testing whether an advanced MRI technique called Quantitative Susceptibility Mapping (QSM) can better tell apart brain lesions caused by multiple sclerosis (MS) from those due to normal aging or small vessel disease. Researchers will scan 1,000 people aged 50-70 wit…

This observational study looks at how sleep quality influences cognitive flexibility, physical activity, body awareness, and reaction time in people with multiple sclerosis. Researchers will compare those with good and poor sleep using questionnaires, computer tests, and a wearab…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study from Mayo Clinic looks at how multiple sclerosis (MS) affects the autonomic nervous system, which controls things like blood pressure, skin blood flow, and bladder health. Researchers will compare 13 people with MS to healthy volunteers using simple lab tests. The goal…

This study looks at immune cells in the gut to understand how they might be linked to multiple sclerosis, Parkinson's disease, and REM sleep behavior disorder. Researchers will collect colon tissue samples from 100 adults during colonoscopy. The goal is to map these cells and the…

This study is trying to figure out what makes someone more likely to develop multiple sclerosis (MS). Researchers are looking at a mix of genetic, environmental, and immune factors in 5,000 people in the US, including relatives of MS patients and others at higher risk. The goal i…

This study looks at whether a new eye-tracking device can help doctors see how well multiple sclerosis (MS) treatment is working. About 224 Canadian adults with relapsing-remitting MS will use the device during routine care. The goal is to find out if eye movement changes can rep…

This study looks at how multiple sclerosis (MS) affects hearing. Researchers will test hearing and analyze spinal fluid from 30 adults with MS to see if hearing problems are linked to inflammation in the body. The goal is to better understand MS, not to test a new treatment.

This study will explore whether sleep apnea makes multiple sclerosis worse. Researchers will collect sleep studies, MRIs, and lab results from 800 adults with MS to see if there is a link. The goal is to better understand how sleep problems might affect the brain and overall heal…

This study looks at how people with mild multiple sclerosis adjust their walking when faced with obstacles or sudden changes, compared to healthy adults. Researchers will use motion sensors and brain activity monitors to measure these skills. The goal is to find better ways to de…

This study looks at how difficult childhood experiences might impact the course of multiple sclerosis (MS). Researchers will work with 300 young adults with relapsing-remitting MS, focusing on Black, Hispanic, and low-income groups often left out of research. Participants will ha…

This study aims to find early brain scan markers that can predict when multiple sclerosis (MS) will get worse. Researchers will use powerful MRI machines to look at brain chemistry and structure in 50 adults with MS. The goal is to identify signs of nerve damage before permanent …

This study is building a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, severe asthma, and psoriasis. Researchers will collect blood samples and track disease activity over time using standard medical scores. The goa…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study looks at whether low levels of immunoglobulin G (IgG), a type of antibody, are linked to fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue scores and infection rates between MS patients with low IgG and those with normal IgG. The goal is …

This observational study at Washington University will use special PET scans to look at ongoing inflammation in the brains of 25 people with relapsing-remitting multiple sclerosis. Researchers want to understand why inflammation persists even after standard treatment. Participant…

This study looks at how mood and sleep problems relate to the stress of caring for someone with multiple sclerosis. Researchers will survey 50 patients and their caregivers to measure depression, anxiety, insomnia, and caregiver burden. The goal is to better understand the challe…

This study collects and freezes testicular tissue from boys and young men who are at risk of becoming infertile due to cancer, autoimmune disorders, or their treatments. The tissue is stored in a research bank, with the hope that future medical advances will allow it to be used t…

This study looks at whether a 10-minute video about palliative care can help people with multiple sclerosis (MS) understand their options and make decisions that match their values. Half of the 50 participants will watch the video, and the other half will read a standard informat…

This study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…

This study looks at how multiple sclerosis affects the autonomic nervous system, which controls automatic body functions like heart rate and sweating. Researchers will use skin biopsies and heart tests to measure nerve damage in 60 people with relapsing-remitting or primary progr…

This study aims to understand how to better coordinate care for people with multiple sclerosis (MS). Researchers will hold focus groups with patients, carers, and healthcare professionals to identify what works and what doesn't in current care pathways. The goal is to propose imp…

This study looks at how muscle stiffness (spasticity) patterns in the arms and legs of people with multiple sclerosis relate to their quality of life. Researchers will classify these patterns and measure their impact using patient surveys and physical tests. The goal is to better…

This study looks at how aging and multiple sclerosis (MS) affect muscle and heart health in people over 60. Researchers will compare older adults with MS to those without MS, and test how their bodies respond to a 4-month exercise program. The goal is to understand differences in…

This study looks at two new tests—a walking adaptability ladder test and a foot tap test—to see if they can detect subtle walking and movement problems in people with mild multiple sclerosis (MS). Researchers will compare results from 100 participants (people with mild MS and hea…

This study tests a new eye-tracking app to monitor multiple sclerosis (MS). Researchers will ask 168 adults with MS to complete simple cognitive tests and eye movement tasks. The goal is to develop software that can track MS progression and related cognitive changes over 48 month…

This study looks at why some women with multiple sclerosis have trouble controlling their bladder. Researchers will measure pelvic floor muscle activity and ask about quality of life, fatigue, and physical activity. The goal is to better understand the problem, not to test a new …

This study looks at why some people with multiple sclerosis (MS) have trouble controlling their bladder. Researchers will measure pelvic floor muscle activity and ask about symptoms in 47 participants. The goal is to better understand the link between MS and urinary incontinence,…

This study looks at how multiple sclerosis (MS) affects the way people walk. Researchers will use motion cameras and wearable sensors to measure walking patterns in 30 people with MS and healthy adults. The goal is to better understand gait changes, not to test a treatment.

This study tests whether breathing short bursts of low-oxygen air (like at high altitude) can improve ankle strength and brain activity in people with multiple sclerosis. Twenty-one adults with relapsing forms of MS will undergo 15 cycles of low oxygen followed by normal air in o…

This study is collecting blood, saliva, and stool samples from 130 people with multiple sclerosis (MS) and healthy volunteers. Researchers will analyze the genetic activity of immune cells to understand why some patients have a mild form of MS while others become severely disable…

This study aims to better understand walking difficulties in people with multiple sclerosis (MS). Researchers will use a small wearable device to measure each person's unique walking pattern and compare it to MRI scans of their brain and spine. About 100 adults with MS will parti…

This study follows 100 people with multiple sclerosis who had a special MRI scan years ago. Researchers will take blood samples and offer a new MRI to see if iron rims around brain lesions are linked to worsening disability. They also want to find genetic factors that might cause…

This study uses a special PET-MRI scan to measure brain inflammation in people with multiple sclerosis (MS). Researchers will scan 41 adults with active MS and compare the results to healthy volunteers. The goal is to better understand inflammation patterns and improve how we pre…

This pilot study is testing a new MRI technique called AMIRA to see if it can find spinal cord lesions in people with multiple sclerosis better than standard MRI. Ten participants will undergo both the new and standard scans. The goal is to improve how doctors detect and monitor …

This study looks at how bladder sensations during filling are linked to overactive bladder severity in people with multiple sclerosis. Researchers will perform repeated cystometries, including a test with a distracting task, to assess sensation reliability. The goal is to better …

This study uses advanced MRI scans to measure how well the brains of children with multiple sclerosis (MS) can repair myelin, the protective coating around nerve cells. Researchers will compare these repair levels with thinking and memory test scores. The goal is to understand if…

This study looks at how sleep issues contribute to tiredness and thinking problems in people with multiple sclerosis (MS). About 382 MS patients and a control group without MS will have overnight sleep tests, thinking assessments, and questionnaires. The goal is to better underst…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study tests whether a breathing technique called Acute Intermittent Hypoxia (AIH) can help improve arm and hand function in people with multiple sclerosis (MS). Participants will breathe short bursts of low-oxygen air while researchers measure brain signals and muscle streng…

This study looks at how pelvic floor problems in people with multiple sclerosis (MS) are connected to core endurance, hip muscle strength, and activation of certain leg muscles. Researchers will assess 73 participants using questionnaires and physical tests. The goal is to better…

This study is building a patient registry for 2000 people with multiple sclerosis. Researchers will collect health records and survey data to understand disability and cognitive challenges. The goal is to find better ways to manage MS and improve quality of life through collabora…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study follows about 70 people who have already received KYV-101, a CAR T-cell therapy, for autoimmune diseases like lupus and multiple sclerosis. Researchers will monitor participants for up to 15 years to track any delayed side effects, new cancers, or other health problems…

This study compares brain aging in 200 healthy volunteers and people with multiple sclerosis using advanced MRI scans. Researchers aim to find patterns that predict how quickly the brain ages in MS. Participants undergo MRI and clinical assessments, but no treatment is given.

This study uses a special PET scan to look at a brain chemical system in people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if damage to this system is linked to MS symptoms like fatigue and thinking problems. About 19 people will take part. The study …

This study looks at blood and spinal fluid from 150 people with multiple sclerosis or early symptoms. Researchers want to find which types of B and T cells cause damage in different forms of MS. The goal is to discover new targets for future treatments, especially for progressive…

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This study looks at whether adding brain-function (neuropsychological) support to standard rehabilitation helps people with multiple sclerosis keep working and feel better. Twenty adults with MS will get testing and coaching, then be followed for two years. The goal is to see if …

This study uses special PET scans to look for brain inflammation in people with multiple sclerosis (MS) and Alzheimer's disease. Researchers will compare two radioactive tracers, [F-18]PBR06 and [C-11]PBR28, to see which works better. Up to 250 participants, including healthy vol…

This study looks at people with radiologically isolated syndrome (RIS) — a pre-symptomatic stage of multiple sclerosis — and compares them to MS patients with normal neurological exams. Researchers will use digital tools, MRI scans, and biological tests to find better ways to tra…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at how the brain uses sugar (glucose) in people with multiple sclerosis (MS) compared to healthy volunteers. Researchers will use a special PET scan to measure brain activity and compare it with MRI scans and blood tests. The goal is to find better ways to diagno…

This study tests whether a short burst of aerobic exercise on a stationary bike and a 30-minute nap can improve how people with multiple sclerosis learn and remember a hand motor skill. Twenty adults with relapsing-remitting MS will take part. Researchers will measure brain and m…

This observational study looks at how gut bacteria relate to brain structure and function in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will use brain scans, stool samples, blood tests, and cognitive assessments in 200 part…

This study aims to understand how brain connections (synapses) are lost in progressive multiple sclerosis (MS). Researchers will use a new type of PET scan to measure synaptic density in 30 people with progressive MS, relapsing-remitting MS, and healthy volunteers. The goal is to…

This registry follows 1,500 women with multiple sclerosis (MS) or related conditions through pregnancy and after childbirth. Researchers will track relapses, use of disease-modifying drugs, and outcomes for both mothers and children. The goal is to better understand how MS and it…

This study looks at two ways to treat multiple sclerosis (MS) when it first appears after age 50. One approach starts with a moderate-strength drug and only switches to a stronger one if needed. The other starts with a strong drug right away. Researchers will compare how often re…

This study looks at whether a substance in urine, called S1P, can help doctors check bladder function in people with multiple sclerosis (MS). Many MS patients have overactive bladder, but the standard test is invasive and uncomfortable. Researchers will measure S1P levels in 400 …

This study follows 7,500 people with multiple sclerosis and healthy volunteers over 30 years to learn why the disease affects people differently and why some respond better to treatments. Researchers will collect health data and track changes over time to help create more persona…

This study is collecting health data, smartphone app measurements, and biological samples from 100 people with multiple sclerosis. Researchers aim to find new biomarkers and digital tools to better understand how MS progresses and when it changes form. The goal is to improve moni…

This study gathers health data from 7,000 people with multiple sclerosis (MS) and related conditions. The goal is to use this information to train artificial intelligence (AI) tools that can help doctors diagnose MS earlier and predict how the disease will progress. No new treatm…

This study looks at whether special brain scans (MRI and PET) can predict how multiple sclerosis (MS) will affect a person's disability over many years. Researchers will follow 80 adults with MS who were in earlier studies to see if certain brain changes can forecast worsening sy…

This study looks at whether multiple sclerosis (MS) affects a woman's egg supply (ovarian reserve). Researchers will compare blood hormone levels and ultrasound results between 160 women with MS and healthy women aged 25 to 35. The goal is to understand if MS itself impacts ferti…

This study follows about 1,200 pregnant women with multiple sclerosis who take the drug ZEPOSIA (ozanimod). Researchers will track health outcomes for mothers and their babies, such as birth defects and pregnancy complications. The goal is to help patients and doctors make inform…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This long-term study follows up to 50,000 people with multiple sclerosis to learn how the disease changes over time and what factors affect it. Participants fill out surveys twice a year online or by mail. No treatment or medication is given; the goal is to gather information for…

This study looks at whether short selfie videos taken on a phone can accurately measure walking and speech changes in people with multiple sclerosis (MS). About 300 adults with MS will record 5 videos every 3 months for a year and also attend some in-person visits. The goal is to…

This study looks at whether measuring certain proteins (free light chains) in spinal fluid can help predict how multiple sclerosis (MS) will progress. Researchers will follow 100 people with MS or optic neuritis, tracking their disability, relapses, and vision recovery. The goal …

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…

This study looks at whether Botox injections in the thigh muscle (to treat stiff knee gait) affect a person's balance and risk of falling. Stiff knee gait can happen after a stroke, brain injury, or multiple sclerosis. The researchers will test balance before and after the inject…

This study follows 400 people with relapsing-remitting multiple sclerosis to see how their brains change over three years. Researchers will use MRI scans and blood tests to compare those on high-efficacy treatments versus medium-efficacy ones. The goal is to understand which trea…

This study follows 100 people with relapsing-remitting multiple sclerosis who are taking anti-CD20 drugs like ofatumumab or rituximab. Researchers will track changes in immune cells, proteins, and brain scans over time to understand how these therapies work long-term. The goal is…

This study is testing whether the antibiotic vancomycin can change the gut bacteria and immune system of people with newly diagnosed multiple sclerosis (MS). The researchers will give vancomycin or a placebo to 12 people and measure changes in gut bacteria, blood markers, and bra…