New pill could slow MS progression in major trial
NCT ID NCT07225504
First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 4 times
Summary
This Phase 3 study tests whether the drug remibrutinib can slow disability worsening in people with secondary progressive multiple sclerosis (SPMS). About 1,275 adults aged 18-65 with SPMS and recent disability progression will receive either remibrutinib or a placebo. The main goal is to see if the drug delays confirmed disability progression over six months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Remibrutinib (a drug taken as a pill)
- What this could lead to
- If successful, remibrutinib could become a new treatment option to slow worsening disability in people with secondary progressive multiple sclerosis.
- What could go wrong
- This is a large Phase 3 trial, but remibrutinib may not prove more effective than placebo. Side effects are possible, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 1,275 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Jan 2034
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Signed informed consent must be obtained prior to any assessment performed. * Male or female participants aged 18-65 (inclusive) at Screening. * Diagnosis of MS according to the 2017 revised McDonald criteria (Thompson et al 2018), with current SPMS in accordance with the revised clinical course (Lublin et al 2014) at Screening * Absence of documented clinical relapses in the 24 months before Screening and randomization. * EDSS score of 3.0 to 6.0 (inclusive) at Screening. * Documented evidence of disability progression in the 12 months before Screening. Exclusion Criteria: * Unwilling or unable to undergo MRI scans as per protocol (for example, claustrophobia, or presents absolute contraindications to MRI (e.g., metallic implants, metallic foreign bodies, pacemaker, defibrillator)). * History of clinically significant central nervous system (CNS) disease (e.g. stroke, traumatic brain or spinal injury, history or presence of myelopathy) or neurological disorders which may mimic multiple sclerosis (MS). * Ongoing substance abuse (drug or alcohol) or any other factor (e.g. serious psychiatric condition) that may interfere with the participant's ability to cooperate and comply with the study procedures. * Participants with history of confirmed Progressive Multifocal Leukoencephalopathy (PML) or neurological symptoms consistent with PML. * Women of childbearing potential (WOCBP), unless they are using highly effective methods of contraception (failure rate \< 1% per year) while taking study treatment and for at least 1 week after stopping study treatment. * Significant bleeding risk or coagulation disorders, at Screening. * Use of exclusionary medication prior to Screening/randomization as listed in the protocol. Other protocol-defined inclusion/exclusion critria may apply
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Secondary progressive multiple sclerosis (SPMS) are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
256 sites in 32 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Locations
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AZ Integrated Neuro and Spine
RECRUITINGPhoenix, Arizona, 85037, United States
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Alabama Neurology Associates PC
RECRUITINGBirmingham, Alabama, 35209, United States
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Aqualane Clinical Research
RECRUITINGNaples, Florida, 34105, United States
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Axiom Brain Health
RECRUITINGTampa, Florida, 33609, United States
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Carum Research
RECRUITINGDallas, Texas, 75231, United States
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Center for Neurosciences
RECRUITINGTucson, Arizona, 85718, United States
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Citta Clinical Research
RECRUITINGSpokane, Washington, 99202, United States
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Comprehensive Neurology Clinic
RECRUITINGOrlando, Florida, 32825, United States
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Ctr for Neurology and Spine
RECRUITINGPhoenix, Arizona, 85018, United States
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Elliot Lewis MS Center
RECRUITINGWellesley, Massachusetts, 02481, United States
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Fullerton Neuro and Headache Ctr
RECRUITINGFullerton, California, 92835, United States
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Georgetown University Hospital
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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Hawaii Pacific Neuroscience LLC
RECRUITINGHonolulu, Hawaii, 96817, United States
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Homestead Assoc In Research Inc
RECRUITINGHomestead, Florida, 33033, United States
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Joi Life Wellness Group LLC
RECRUITINGSmyrna, Georgia, 30080, United States
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Medstar Washington Hosp Ctr
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Miami NS Ins Baptist Health S FL
RECRUITINGMiami, Florida, 33176, United States
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Michigan Institute of Neurological
RECRUITINGFarmington Hills, Michigan, 48334, United States
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Mid Atlantic Epilepsy and Sleep Ctr
RECRUITINGBethesda, Maryland, 20817-1807, United States
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Neuro Institute of New England P C
RECRUITINGFoxborough, Massachusetts, 02035, United States
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Neurology Associates PA
RECRUITINGMaitland, Florida, 32751, United States
Contact Email: •••••@•••••
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Neurology Associates of Ormond Beach
RECRUITINGOrmond Beach, Florida, 32174, United States
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Neurology Clinic PC
RECRUITINGCordova, Tennessee, 38018, United States
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Neurology of Central FL Res Ctr
RECRUITINGAltamonte Springs, Florida, 32714, United States
Contact Email: •••••@•••••
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611, United States
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Novartis Investigative Site
RECRUITINGCABA, Buenos Aires, C1428AQK, Argentina
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RECRUITINGCapital Federal, Buenos Aires, 1424, Argentina
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RECRUITINGBuenos Aires, Buenos Aires F.D., 1221, Argentina
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RECRUITINGBombal, Mendoza Province, M5500DXO, Argentina
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RECRUITINGSan Juan, San Juan Province, J5402DIL, Argentina
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RECRUITINGRosario, Santa Fe Province, 2000, Argentina
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RECRUITINGRosario, Santa Fe Province, S2000DSW, Argentina
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RECRUITINGSantiago del Estero, Santiago del Estero Province, G4200AIR, Argentina
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RECRUITINGSan Miguel de, Tucumán Province, T4000, Argentina
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RECRUITINGBuenos Aires, C1012AAR, Argentina
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RECRUITINGCaba, C1055AAF, Argentina
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RECRUITINGCABA, C1181ACH, Argentina
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RECRUITINGCaba, C1182, Argentina
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RECRUITINGCaba, C1424BYD, Argentina
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RECRUITINGKogarah, New South Wales, 2217, Australia
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RECRUITINGNew Lambton Heights, New South Wales, 2305, Australia
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RECRUITINGWestmead, New South Wales, 2145, Australia
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RECRUITINGClayton, Victoria, 3168, Australia
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RECRUITINGHeidelberg, Victoria, 3084, Australia
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RECRUITINGMurdoch, Western Australia, 6150, Australia
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RECRUITINGSouthport, 4215, Australia
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RECRUITINGInnsbruck, Tyrol, 6020, Austria
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RECRUITINGLinz, Upper Austria, 4020, Austria
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RECRUITINGLinz, 4020, Austria
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RECRUITINGVienna, 1180, Austria
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RECRUITINGLeuven, Vlaams Brabant, 3000, Belgium
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RECRUITINGRoeselare, West-Vlaanderen, 8800, Belgium
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RECRUITINGBonheiden, 2820, Belgium
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RECRUITINGBrussels, 1070, Belgium
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RECRUITINGPorto Alegre, Rio Grande do Sul, 90430-001, Brazil
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RECRUITINGPorto Alegre, Rio Grande do Sul, 90560-032, Brazil
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RECRUITINGPorto Alegre, Rio Grande do Sul, 90620-130, Brazil
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RECRUITINGJoinville, Santa Catarina, 89202-165, Brazil
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RECRUITINGSanto André, São Paulo, 09040 010, Brazil
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RECRUITINGSão Paulo, São Paulo, 04076-004, Brazil
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RECRUITINGPleven, 5800, Bulgaria
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RECRUITINGSofia, 1113, Bulgaria
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RECRUITINGSofia, 1309, Bulgaria
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RECRUITINGSofia, 1407, Bulgaria
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RECRUITINGSofia, 1408, Bulgaria
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RECRUITINGSofia, 1431, Bulgaria
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RECRUITINGSofia, 1510, Bulgaria
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RECRUITINGSofia, 1606, Bulgaria
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RECRUITINGVancouver, British Columbia, V6T 2A1, Canada
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RECRUITINGHalifax, Nova Scotia, B3H 4K4, Canada
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RECRUITINGOttawa, Ontario, K1H 8L6, Canada
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RECRUITINGLévis, Quebec, G6W 0M5, Canada
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RECRUITINGMontreal, Quebec, H2X 1R9, Canada
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RECRUITINGMontreal, Quebec, H3A 2B4, Canada
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RECRUITINGMontreal, Quebec, H4A 3T2, Canada
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RECRUITINGQuébec, Quebec, G1J 1Z4, Canada
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RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
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RECRUITINGGuangzhou, Guangdong, 510080, China
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RECRUITINGZhengzhou, Henan, 450003, China
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RECRUITINGWuhan, Hubei, 430030, China
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RECRUITINGWuhan, Hubei, 430060, China
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RECRUITINGHohhot, Inner Mongolia, 010017, China
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RECRUITINGSuzhou, Jiangsu, 215004, China
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RECRUITINGChangchun, Jilin, 130021, China
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RECRUITINGShenyang, Liaoning, 110011, China
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RECRUITINGYinchuan, Ningxia, 750004, China
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RECRUITINGXianyang, Shaanxi, 712000, China
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RECRUITINGTaiyuan, Shanxi, 030001, China
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RECRUITINGHangzhou, Zhejiang, 310002, China
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RECRUITINGHangzhou, Zhejiang, 310016, China
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RECRUITINGWenzhou, Zhejiang, 325000, China
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RECRUITINGBeijing, 100034, China
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RECRUITINGBeijing, 100070, China
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Novartis Investigative Site
RECRUITINGChongqing, 400016, China
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Novartis Investigative Site
RECRUITINGShanghai, 200040, China
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Novartis Investigative Site
RECRUITINGTianjin, 300052, China
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Novartis Investigative Site
RECRUITINGBarranquilla, Atlántico, 080020, Colombia
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Novartis Investigative Site
RECRUITINGBogotá, 111321, Colombia
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Novartis Investigative Site
RECRUITINGMedellín, 050001, Colombia
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Novartis Investigative Site
RECRUITINGMedellín, 050034, Colombia
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Novartis Investigative Site
RECRUITINGVaraždin, Varaždin County, 42000, Croatia
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Novartis Investigative Site
RECRUITINGBrno, 602 00, Czechia
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Novartis Investigative Site
RECRUITINGHradec Králové, 500 05, Czechia
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Novartis Investigative Site
RECRUITINGJihlava, 586 01, Czechia
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Novartis Investigative Site
RECRUITINGPrague, 140 59, Czechia
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Novartis Investigative Site
RECRUITINGPrague, 150 06, Czechia
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RECRUITINGTeplice, 415029, Czechia
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RECRUITINGAarhus N, 8200, Denmark
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Novartis Investigative Site
RECRUITINGEsbjerg, 6700, Denmark
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Novartis Investigative Site
RECRUITINGTallinn, 11315, Estonia
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Novartis Investigative Site
RECRUITINGTartu, 51014, Estonia
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Novartis Investigative Site
RECRUITINGLimoges, Haute Vienne, 87000, France
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RECRUITINGAjaccio, 20090, France
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RECRUITINGAmiens, 80054, France
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RECRUITINGClermont-Ferrand, 63003, France
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RECRUITINGGonesse, 95500, France
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Novartis Investigative Site
RECRUITINGGrenoble, 38043, France
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RECRUITINGLille, 59000, France
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RECRUITINGLille, 59037, France
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RECRUITINGMontpellier, 34090, France
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Novartis Investigative Site
RECRUITINGNancy, 54035, France
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RECRUITINGNice, 06000, France
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RECRUITINGNîmes, 30029, France
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Novartis Investigative Site
RECRUITINGOrsay, 91400, France
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Novartis Investigative Site
RECRUITINGParis, 75013, France
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Novartis Investigative Site
RECRUITINGParis, 75940, France
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Novartis Investigative Site
RECRUITINGPoitiers, 86021, France
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Novartis Investigative Site
RECRUITINGRennes, 35033, France
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Novartis Investigative Site
RECRUITINGRouen, 76031, France
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RECRUITINGStrasbourg, 67000, France
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Novartis Investigative Site
RECRUITINGToulouse, 31059, France
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Novartis Investigative Site
RECRUITINGTours, 37044, France
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Novartis Investigative Site
RECRUITINGFreiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Novartis Investigative Site
RECRUITINGMannheim, Baden-Wurttemberg, 68167, Germany
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Novartis Investigative Site
RECRUITINGMunich, Bavaria, 81377, Germany
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Novartis Investigative Site
RECRUITINGUnterhaching, Bavaria, 82008, Germany
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Novartis Investigative Site
RECRUITINGCottbus, Brandenburg, 03048, Germany
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Novartis Investigative Site
RECRUITINGHalle, Saxony-Anhalt, 06120, Germany
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Novartis Investigative Site
RECRUITINGErfurt, 99089, Germany
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Novartis Investigative Site
RECRUITINGGiessen, 35392, Germany
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Novartis Investigative Site
RECRUITINGGreifswald, 17475, Germany
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Novartis Investigative Site
RECRUITINGHeidelberg, 69120, Germany
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Novartis Investigative Site
RECRUITINGIbbenbueren, 49477, Germany
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Novartis Investigative Site
RECRUITINGItzehoe, 25524, Germany
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Novartis Investigative Site
RECRUITINGTübingen, 72076, Germany
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Novartis Investigative Site
RECRUITINGUlm, 89073, Germany
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Novartis Investigative Site
RECRUITINGAthens, 115 28, Greece
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Novartis Investigative Site
RECRUITINGChaïdári, 124 62, Greece
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Novartis Investigative Site
RECRUITINGIoannina, 455 00, Greece
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Novartis Investigative Site
RECRUITINGPécs, Baranya, 7623, Hungary
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Novartis Investigative Site
RECRUITINGBudapest, 1033, Hungary
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Novartis Investigative Site
RECRUITINGBudapest, 1044, Hungary
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Novartis Investigative Site
RECRUITINGBudapest, 1106, Hungary
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Novartis Investigative Site
RECRUITINGKistarcsa, 2143, Hungary
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Novartis Investigative Site
RECRUITINGTatabánya, H 2800, Hungary
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Novartis Investigative Site
RECRUITINGGurugram, Haryana, 122011, India
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Novartis Investigative Site
RECRUITINGMangalore, Karnataka, 575003, India
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Novartis Investigative Site
RECRUITINGKochi, Kerala, 682025, India
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Novartis Investigative Site
RECRUITINGNew Delhi, National Capital Territory of Delhi, 110029, India
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Novartis Investigative Site
RECRUITINGNew Delhi, National Capital Territory of Delhi, 110060, India
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Novartis Investigative Site
RECRUITINGChandigarh, Punjab, 160012, India
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Novartis Investigative Site
RECRUITINGVellore, Tamil Nadu, 632 004, India
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Novartis Investigative Site
RECRUITINGHyderabad, Telangana, 500082, India
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Novartis Investigative Site
RECRUITINGAshkelon, 7830604, Israel
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RECRUITINGHadera, 3820302, Israel
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RECRUITINGHaifa, 3436212, Israel
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RECRUITINGJerusalem, 9112001, Israel
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RECRUITINGRamat Gan, 5265601, Israel
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Novartis Investigative Site
RECRUITINGRehovot, 7661041, Israel
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Novartis Investigative Site
RECRUITINGTel Aviv, 6423906, Israel
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RECRUITINGẔerifin, 7030000, Israel
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Novartis Investigative Site
RECRUITINGAncona, AN, 60020, Italy
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Novartis Investigative Site
RECRUITINGBergamo, BG, 24127, Italy
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RECRUITINGFoggia, FG, 71122, Italy
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Novartis Investigative Site
RECRUITINGPozzilli, IS, 86077, Italy
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RECRUITINGPavia, PV, 27100, Italy
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RECRUITINGRoma, RM, 00133, Italy
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Novartis Investigative Site
RECRUITINGRoma, RM, 00189, Italy
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Novartis Investigative Site
RECRUITINGGallarate, VA, 21013, Italy
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RECRUITINGNaples, 80138, Italy
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RECRUITINGKaunas, 3007, Lithuania
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RECRUITINGChihuahua City, Chihuahua, 31203, Mexico
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RECRUITINGBenito Juárez, Mexico City, 03100, Mexico
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Novartis Investigative Site
RECRUITINGMexico City, Mexico City, 06700, Mexico
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Novartis Investigative Site
RECRUITINGSan Luis Potosí City, 78216, Mexico
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RECRUITINGArnhem, Gelderland, 6815 AD, Netherlands
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RECRUITING's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands
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Novartis Investigative Site
RECRUITINGAmsterdam, North Holland, 1081 HV, Netherlands
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RECRUITINGLeiden, 2334 CN, Netherlands
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RECRUITINGKrakow, Lesser Poland Voivodeship, 30-727, Poland
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RECRUITINGKrakow, Poland, 31 531, Poland
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RECRUITINGBydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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RECRUITINGChojnice, 89-600, Poland
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RECRUITINGKatowice, 40-081, Poland
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RECRUITINGKatowice, 40-686, Poland
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RECRUITINGLodz, 93-113, Poland
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RECRUITINGLublin, 20-410, Poland
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RECRUITINGRzeszów, 35-323, Poland
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RECRUITINGSkorzewo, 60-185, Poland
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RECRUITINGWarsaw, 01-684, Poland
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RECRUITINGZabrze, 41-800, Poland
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RECRUITINGŻory, 44-240, Poland
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RECRUITINGBraga, 4710243, Portugal
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RECRUITINGLisbon, 1169-050, Portugal
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RECRUITINGLisbon, 1349-019, Portugal
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RECRUITINGLisbon, 1649-035, Portugal
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RECRUITINGPorto, 4200 319, Portugal
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RECRUITINGConstanța, ROM, 900123, Romania
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RECRUITINGBucharest, 040215, Romania
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RECRUITINGCampulung Muscel, 115100, Romania
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RECRUITINGBratislava, Slovakia, 826 06, Slovakia
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RECRUITINGTrnava, Slovakia, 917 02, Slovakia
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RECRUITINGBratislava, 851 01, Slovakia
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RECRUITINGKomárno, 945 05, Slovakia
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RECRUITINGNitra, 950 01, Slovakia
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Novartis Investigative Site
RECRUITINGCape Town, Western Cape, 7405, South Africa
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RECRUITINGBarcelona, Barcelona, 08035, Spain
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RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08907, Spain
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RECRUITINGJerez de la Frontera, Cadiz, 11407, Spain
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RECRUITINGAlbacete, Castille-La Mancha, 02006, Spain
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RECRUITINGLogroño, La Rioja, 26006, Spain
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RECRUITINGPozuelo de Alarcón, Madrid, 28223, Spain
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RECRUITINGTorrejón de Ardoz, Madrid, 28850, Spain
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Novartis Investigative Site
RECRUITINGEl Palmar, Murcia, 30120, Spain
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RECRUITINGCastilleja de la Cuesta, Sevilla, 41950, Spain
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Novartis Investigative Site
RECRUITINGValencia, Valencia, 46017, Spain
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RECRUITINGBarakaldo, Vizcaya, 48903, Spain
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RECRUITINGAlicante, 03010, Spain
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RECRUITINGLas Palmas GC, 35010, Spain
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RECRUITINGLleida, 25198, Spain
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RECRUITINGMadrid, 28006, Spain
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RECRUITINGMadrid, 28009, Spain
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RECRUITINGMadrid, 28034, Spain
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RECRUITINGMadrid, 28040, Spain
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RECRUITINGMálaga, 29010, Spain
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RECRUITINGSalamanca, 37007, Spain
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RECRUITINGValencia, 46026, Spain
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RECRUITINGBern, 3010, Switzerland
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RECRUITINGLausanne, 1011, Switzerland
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RECRUITINGBrighton, East Sussex, BN2 5BE, United Kingdom
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RECRUITINGRomford, Essex, RM7 0AG, United Kingdom
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RECRUITINGCoventry, CV2 2DX, United Kingdom
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RECRUITINGGlasgow, EH9 1LF, United Kingdom
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RECRUITINGLeeds, LS1 3EX, United Kingdom
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RECRUITINGLondon, E1 2AT, United Kingdom
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Novartis Investigative Site
RECRUITINGNottingham, NG7 2UH, United Kingdom
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Orlando Health Clinical Trials
RECRUITINGOrlando, Florida, 32806, United States
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Premier Neurology
RECRUITINGGreenville, South Carolina, 29605, United States
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Regina Berkovich MD PhD Inc
RECRUITINGWest Hollywood, California, 90048, United States
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Saturn Research Solution
RECRUITINGPlano, Texas, 75024, United States
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U Mass Memorial Medical Center
RECRUITINGWorchester, Massachusetts, 01605, United States
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UC Health Neuroscience Ctr
RECRUITINGAurora, Colorado, 80045, United States
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UF Health Cancer Center
RECRUITINGGainesville, Florida, 32610, United States
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University Of South Florida
RECRUITINGTampa, Florida, 33612, United States
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University of Kansas Hospital
RECRUITINGKansas City, Kansas, 66160, United States
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University of New Mexico Hospital
RECRUITINGAlbuquerque, New Mexico, 87106, United States
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