New pill could slow MS progression in major trial

NCT ID NCT07225504

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 study tests whether the drug remibrutinib can slow disability worsening in people with secondary progressive multiple sclerosis (SPMS). About 1,275 adults aged 18-65 with SPMS and recent disability progression will receive either remibrutinib or a placebo. The main goal is to see if the drug delays confirmed disability progression over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Remibrutinib (a drug taken as a pill)

What this could lead to

If successful, remibrutinib could become a new treatment option to slow worsening disability in people with secondary progressive multiple sclerosis.

What could go wrong

This is a large Phase 3 trial, but remibrutinib may not prove more effective than placebo. Side effects are possible, and results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS (SPMS)

Contacts and locations

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AZ Integrated Neuro and Spine
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Phoenix, Arizona, 85037, United States

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Alabama Neurology Associates PC
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Birmingham, Alabama, 35209, United States

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Aqualane Clinical Research
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Naples, Florida, 34105, United States

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Axiom Brain Health
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Tampa, Florida, 33609, United States

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Center for Neurosciences
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Tucson, Arizona, 85718, United States

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Citta Clinical Research
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Spokane, Washington, 99202, United States

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Comprehensive Neurology Clinic
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Orlando, Florida, 32825, United States

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Phoenix, Arizona, 85018, United States

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Fullerton, California, 92835, United States

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Georgetown University Hospital
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Washington D.C., District of Columbia, 20007, United States

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Hawaii Pacific Neuroscience LLC
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Honolulu, Hawaii, 96817, United States

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Homestead, Florida, 33033, United States

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Joi Life Wellness Group LLC
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Smyrna, Georgia, 30080, United States

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Washington D.C., District of Columbia, 20010, United States

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Miami, Florida, 33176, United States

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Farmington Hills, Michigan, 48334, United States

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Bethesda, Maryland, 20817, United States

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Foxborough, Massachusetts, 02035, United States

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Neurology Associates PA
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Maitland, Florida, 32751, United States

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Neurology Associates of Ormond Beach
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Ormond Beach, Florida, 32174, United States

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Neurology Clinic PC
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Cordova, Tennessee, 38018, United States

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Neurology of Central FL Res Ctr
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Altamonte Springs, Florida, 32714, United States

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Northwestern Memorial Hospital
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Chicago, Illinois, 60611, United States

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Novartis Investigative Site
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Capital Federal, Buenos Aires, 1424, Argentina
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Buenos Aires, Buenos Aires F.D., 1221, Argentina
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Bombal, Mendoza Province, M5500DXO, Argentina
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Rosario, Santa Fe Province, 2000, Argentina
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Rosario, Santa Fe Province, S2000DSW, Argentina
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Santiago del Estero, Santiago del Estero Province, 4200, Argentina
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San Miguel de, Tucumán Province, T4000, Argentina
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Buenos Aires, C1012AAR, Argentina
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Caba, C1055AAF, Argentina
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CABA, C1181ACH, Argentina
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Caba, C1182, Argentina
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Caba, C1424BYD, Argentina
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Kogarah, New South Wales, 2217, Australia
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New Lambton Heights, New South Wales, 2305, Australia
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Westmead, New South Wales, 2145, Australia
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Clayton, Victoria, 3168, Australia
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Heidelberg, Victoria, 3084, Australia
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Murdoch, Western Australia, 6150, Australia
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Southport, 4215, Australia
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Innsbruck, Tyrol, 6020, Austria
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Linz, Upper Austria, 4020, Austria
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Linz, 4020, Austria
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Vienna, 1180, Austria
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Leuven, Vlaams Brabant, 3000, Belgium
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Roeselare, West-Vlaanderen, 8800, Belgium
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Bonheiden, 2820, Belgium
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Brussels, 1070, Belgium
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Santo André, São Paulo, 09040 010, Brazil
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Pleven, 5800, Bulgaria
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Sofia, 1113, Bulgaria
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Sofia, 1309, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1408, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1510, Bulgaria
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Sofia, 1606, Bulgaria
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Vancouver, British Columbia, V6T 2A1, Canada
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Halifax, Nova Scotia, B3H 4K4, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Lévis, Quebec, G6W 0M5, Canada
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Montreal, Quebec, H2X 1R9, Canada
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Montreal, Quebec, H3A 2B4, Canada
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Montreal, Quebec, H4A 3T2, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Guangzhou, Guangdong, 510080, China
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Zhengzhou, Henan, 450003, China
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Wuhan, Hubei, 430030, China
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Wuhan, Hubei, 430060, China
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Hohhot, Inner Mongolia, 010017, China
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Suzhou, Jiangsu, 215004, China
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Changchun, Jilin, 130021, China
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Shenyang, Liaoning, 110011, China
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Yinchuan, Ningxia, 750004, China
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Xianyang, Shaanxi, 712000, China
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Taiyuan, Shanxi, 030001, China
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Hangzhou, Zhejiang, 310002, China
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Hangzhou, Zhejiang, 310016, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 065001, China
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Beijing, 100034, China
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Chongqing, 400016, China
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Shanghai, 200040, China
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Tianjin, 300052, China
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Barranquilla, Atlántico, 080020, Colombia
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Bogotá, 111321, Colombia
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Medellín, 050001, Colombia
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Medellín, 050034, Colombia
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Varaždin, 42000, Croatia
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Brno, 602 00, Czechia
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Hradec Králové, 500 05, Czechia
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Jihlava, 586 01, Czechia
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Prague, 140 59, Czechia
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Prague, 150 06, Czechia
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Teplice, 415 29, Czechia
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Aarhus N, 8200, Denmark
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Esbjerg, 6700, Denmark
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Tallinn, 11315, Estonia
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Limoges, Haute Vienne, 87000, France
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Ajaccio, 20090, France
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Amiens, 80054, France
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Clermont-Ferrand, 63003, France
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Gonesse, 95500, France
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Grenoble, 38043, France
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Lille, 59000, France
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Lille, 59037, France
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Montpellier, 34090, France
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Nancy, 54035, France
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Nice, 06001, France
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Nîmes, 30029, France
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Orsay, 91400, France
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Paris, 75013, France
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Paris, 75940, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Rouen, 76031, France
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Strasbourg, 67000, France
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Toulouse, 31059, France
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Tours, 37044, France
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Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Mannheim, Baden-Wurttemberg, 68167, Germany
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Munich, Bavaria, 81377, Germany
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Unterhaching, Bavaria, 82008, Germany
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Halle, Saxony-Anhalt, 06120, Germany
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Erfurt, 99089, Germany
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Giessen, 35392, Germany
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Greifswald, 17475, Germany
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Heidelberg, 69120, Germany
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Itzehoe, 25524, Germany
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Tübingen, 72076, Germany
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Athens, 115 28, Greece
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Chaïdári, 124 62, Greece
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Ioannina, 455 00, Greece
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Budapest, 1044, Hungary
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Kistarcsa, 2143, Hungary
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Gurugram, Haryana, 122011, India
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Mangalore, Karnataka, 575003, India
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Kochi, Kerala, 682025, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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New Delhi, National Capital Territory of Delhi, 110060, India
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Chandigarh, Punjab, 160012, India
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Vellore, Tamil Nadu, 632 004, India
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Hyderabad, Telangana, 500082, India
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Ashkelon, 7830604, Israel
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Haifa, 3436212, Israel
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Jerusalem, 9112001, Israel
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Ramat Gan, 5265601, Israel
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Rehovot, 7661041, Israel
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Tel Aviv, 6423906, Israel
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Ẕerifin, 7030000, Israel
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Bergamo, BG, 24127, Italy
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Foggia, FG, 71122, Italy
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Pozzilli, IS, 86077, Italy
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Pavia, PV, 27100, Italy
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Roma, RM, 00133, Italy
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Kaunas, 3007, Lithuania
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Arnhem, Gelderland, 6815 AD, Netherlands
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's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands
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Leiden, 2334 CN, Netherlands
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Krakow, Lesser Poland Voivodeship, 30-727, Poland
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Krakow, Poland, 31 531, Poland
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Chojnice, 89-600, Poland
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Katowice, 40-081, Poland
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Katowice, 40-686, Poland
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Lodz, 93-113, Poland
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Rzeszów, 35-323, Poland
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Skorzewo, 60-185, Poland
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Warsaw, 01-684, Poland
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Zabrze, 41-800, Poland
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Żory, 44-240, Poland
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Braga, 4710243, Portugal
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Lisbon, 1169-050, Portugal
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Lisbon, 1349-019, Portugal
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Porto, 4200 319, Portugal
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Constanța, ROM, 900123, Romania
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Bucharest, 040215, Romania
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Campulung Muscel, 115100, Romania
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Trnava, Slovakia, 917 02, Slovakia
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Bratislava, 851 01, Slovakia
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Komárno, 945 05, Slovakia
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Nitra, 950 01, Slovakia
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Cape Town, Western Cape, 7405, South Africa
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Barcelona, Barcelona, 08035, Spain
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Jerez de la Frontera, Cadiz, 11407, Spain
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Pozuelo de Alarcón, Madrid, 28223, Spain
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Torrejón de Ardoz, Madrid, 28850, Spain
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El Palmar, Murcia, 30120, Spain
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Castilleja de la Cuesta, Sevilla, 41950, Spain
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Valencia, Valencia, 46017, Spain
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Barakaldo, Vizcaya, 48903, Spain
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Alicante, 03010, Spain
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Las Palmas GC, 35010, Spain
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Lleida, 25198, Spain
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Madrid, 28009, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Salamanca, 37007, Spain
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Valencia, 46026, Spain
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Bern, 3010, Switzerland
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Lausanne, 1011, Switzerland
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Brighton, East Sussex, BN2 5BE, United Kingdom
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Romford, Essex, RM7 0AG, United Kingdom
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Coventry, CV2 2DX, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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Leeds, LS1 3EX, United Kingdom
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London, E1 2AT, United Kingdom
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Nottingham, NG7 2UH, United Kingdom
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Orlando, Florida, 32806, United States

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Premier Neurology
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Greenville, South Carolina, 29605, United States

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Regina Berkovich MD PhD Inc
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West Hollywood, California, 90048, United States

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Plano, Texas, 75024, United States

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Worchester, Massachusetts, 01605, United States

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Gainesville, Florida, 32610, United States

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University Of South Florida
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Tampa, Florida, 33612, United States

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University of Kansas Hospital
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Kansas City, Kansas, 66160, United States

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University of New Mexico Hospital
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Albuquerque, New Mexico, 87106, United States

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Seattle, Washington, 98133, United States

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