New pill could slow MS progression in major trial

NCT ID NCT07225504

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This Phase 3 study tests whether the drug remibrutinib can slow disability worsening in people with secondary progressive multiple sclerosis (SPMS). About 1,275 adults aged 18-65 with SPMS and recent disability progression will receive either remibrutinib or a placebo. The main goal is to see if the drug delays confirmed disability progression over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Remibrutinib (a drug taken as a pill)
What this could lead to: If successful, remibrutinib could become a new treatment option to slow worsening disability in people with secondary progressive multiple sclerosis.
What could go wrong: This is a large Phase 3 trial, but remibrutinib may not prove more effective than placebo. Side effects are possible, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS (SPMS)

Contacts and locations

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Locations

AZ Integrated Neuro and Spine
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Phoenix, Arizona, 85037, United States
Alabama Neurology Associates PC
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Birmingham, Alabama, 35209, United States
Aqualane Clinical Research
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Naples, Florida, 34105, United States
Axiom Brain Health
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Tampa, Florida, 33609, United States
Carum Research
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Dallas, Texas, 75231, United States
Center for Neurosciences
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Tucson, Arizona, 85718, United States
Citta Clinical Research
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Spokane, Washington, 99202, United States
Comprehensive Neurology Clinic
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Orlando, Florida, 32825, United States
Ctr for Neurology and Spine
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Phoenix, Arizona, 85018, United States
Elliot Lewis MS Center
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Wellesley, Massachusetts, 02481, United States
Fullerton Neuro and Headache Ctr
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Fullerton, California, 92835, United States
Georgetown University Hospital
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Washington D.C., District of Columbia, 20007, United States
Hawaii Pacific Neuroscience LLC
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Honolulu, Hawaii, 96817, United States
Homestead Assoc In Research Inc
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Homestead, Florida, 33033, United States
Joi Life Wellness Group LLC
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Smyrna, Georgia, 30080, United States
Medstar Washington Hosp Ctr
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Washington D.C., District of Columbia, 20010, United States
Miami NS Ins Baptist Health S FL
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Miami, Florida, 33176, United States
Michigan Institute of Neurological
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Farmington Hills, Michigan, 48334, United States
Mid Atlantic Epilepsy and Sleep Ctr
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Bethesda, Maryland, 20817-1807, United States
Neuro Institute of New England P C
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Foxborough, Massachusetts, 02035, United States
Neurology Associates PA
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Maitland, Florida, 32751, United States

Contact Email: •••••@•••••
Neurology Associates of Ormond Beach
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Ormond Beach, Florida, 32174, United States
Neurology Clinic PC
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Cordova, Tennessee, 38018, United States
Neurology of Central FL Res Ctr
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Altamonte Springs, Florida, 32714, United States

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Northwestern Memorial Hospital
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Chicago, Illinois, 60611, United States
Novartis Investigative Site
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CABA, Buenos Aires, C1428AQK, Argentina
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Capital Federal, Buenos Aires, 1424, Argentina
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Buenos Aires, Buenos Aires F.D., 1221, Argentina
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Bombal, Mendoza Province, M5500DXO, Argentina
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San Juan, San Juan Province, J5402DIL, Argentina
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Rosario, Santa Fe Province, 2000, Argentina
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Rosario, Santa Fe Province, S2000DSW, Argentina
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Santiago del Estero, Santiago del Estero Province, G4200AIR, Argentina
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San Miguel de, Tucumán Province, T4000, Argentina
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Buenos Aires, C1012AAR, Argentina
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Caba, C1055AAF, Argentina
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CABA, C1181ACH, Argentina
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Caba, C1182, Argentina
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Caba, C1424BYD, Argentina
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Kogarah, New South Wales, 2217, Australia
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New Lambton Heights, New South Wales, 2305, Australia
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Westmead, New South Wales, 2145, Australia
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Clayton, Victoria, 3168, Australia
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Heidelberg, Victoria, 3084, Australia
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Murdoch, Western Australia, 6150, Australia
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Southport, 4215, Australia
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Innsbruck, Tyrol, 6020, Austria
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Linz, Upper Austria, 4020, Austria
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Linz, 4020, Austria
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Vienna, 1180, Austria
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Leuven, Vlaams Brabant, 3000, Belgium
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Roeselare, West-Vlaanderen, 8800, Belgium
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Bonheiden, 2820, Belgium
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Brussels, 1070, Belgium
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Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
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Porto Alegre, Rio Grande do Sul, 90560-032, Brazil
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Porto Alegre, Rio Grande do Sul, 90620-130, Brazil
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Joinville, Santa Catarina, 89202-165, Brazil
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Santo André, São Paulo, 09040 010, Brazil
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São Paulo, São Paulo, 04076-004, Brazil
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Pleven, 5800, Bulgaria
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Sofia, 1113, Bulgaria
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Sofia, 1309, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1408, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1510, Bulgaria
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Sofia, 1606, Bulgaria
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Vancouver, British Columbia, V6T 2A1, Canada
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Halifax, Nova Scotia, B3H 4K4, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Lévis, Quebec, G6W 0M5, Canada
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Montreal, Quebec, H2X 1R9, Canada
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Montreal, Quebec, H3A 2B4, Canada
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Montreal, Quebec, H4A 3T2, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Guangzhou, Guangdong, 510080, China
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Zhengzhou, Henan, 450003, China
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Wuhan, Hubei, 430030, China
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Wuhan, Hubei, 430060, China
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Hohhot, Inner Mongolia, 010017, China
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Suzhou, Jiangsu, 215004, China
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Changchun, Jilin, 130021, China
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Shenyang, Liaoning, 110011, China
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Yinchuan, Ningxia, 750004, China
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Xianyang, Shaanxi, 712000, China
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Taiyuan, Shanxi, 030001, China
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Hangzhou, Zhejiang, 310002, China
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Hangzhou, Zhejiang, 310016, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 100034, China
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Beijing, 100070, China
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Chongqing, 400016, China
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Shanghai, 200040, China
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Tianjin, 300052, China
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Barranquilla, Atlántico, 080020, Colombia
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Bogotá, 111321, Colombia
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Medellín, 050001, Colombia
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Medellín, 050034, Colombia
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Varaždin, Varaždin County, 42000, Croatia
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Brno, 602 00, Czechia
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Hradec Králové, 500 05, Czechia
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Jihlava, 586 01, Czechia
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Prague, 140 59, Czechia
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Prague, 150 06, Czechia
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Teplice, 415029, Czechia
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Aarhus N, 8200, Denmark
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Esbjerg, 6700, Denmark
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Tallinn, 11315, Estonia
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Tartu, 51014, Estonia
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Limoges, Haute Vienne, 87000, France
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Ajaccio, 20090, France
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Amiens, 80054, France
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Clermont-Ferrand, 63003, France
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Gonesse, 95500, France
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Grenoble, 38043, France
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Lille, 59000, France
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Lille, 59037, France
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Montpellier, 34090, France
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Nancy, 54035, France
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Nice, 06000, France
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Nîmes, 30029, France
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Orsay, 91400, France
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Paris, 75013, France
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Paris, 75940, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Rouen, 76031, France
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Strasbourg, 67000, France
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Toulouse, 31059, France
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Tours, 37044, France
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Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Mannheim, Baden-Wurttemberg, 68167, Germany
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Munich, Bavaria, 81377, Germany
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Unterhaching, Bavaria, 82008, Germany
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Cottbus, Brandenburg, 03048, Germany
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Halle, Saxony-Anhalt, 06120, Germany
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Erfurt, 99089, Germany
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Giessen, 35392, Germany
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Greifswald, 17475, Germany
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Heidelberg, 69120, Germany
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Ibbenbueren, 49477, Germany
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Itzehoe, 25524, Germany
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Tübingen, 72076, Germany
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Ulm, 89073, Germany
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Athens, 115 28, Greece
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Chaïdári, 124 62, Greece
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Ioannina, 455 00, Greece
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Pécs, Baranya, 7623, Hungary
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Budapest, 1033, Hungary
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Budapest, 1044, Hungary
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Budapest, 1106, Hungary
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Kistarcsa, 2143, Hungary
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Tatabánya, H 2800, Hungary
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Gurugram, Haryana, 122011, India
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Mangalore, Karnataka, 575003, India
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Kochi, Kerala, 682025, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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New Delhi, National Capital Territory of Delhi, 110060, India
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Chandigarh, Punjab, 160012, India
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Vellore, Tamil Nadu, 632 004, India
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Hyderabad, Telangana, 500082, India
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Ashkelon, 7830604, Israel
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Hadera, 3820302, Israel
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Haifa, 3436212, Israel
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Jerusalem, 9112001, Israel
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Ramat Gan, 5265601, Israel
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Rehovot, 7661041, Israel
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Tel Aviv, 6423906, Israel
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Ẕerifin, 7030000, Israel
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Ancona, AN, 60020, Italy
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Bergamo, BG, 24127, Italy
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Foggia, FG, 71122, Italy
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Pozzilli, IS, 86077, Italy
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Pavia, PV, 27100, Italy
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Roma, RM, 00133, Italy
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Roma, RM, 00189, Italy
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Gallarate, VA, 21013, Italy
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Naples, 80138, Italy
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Kaunas, 3007, Lithuania
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Chihuahua City, Chihuahua, 31203, Mexico
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Benito Juárez, Mexico City, 03100, Mexico
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Mexico City, Mexico City, 06700, Mexico
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San Luis Potosí City, 78216, Mexico
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Arnhem, Gelderland, 6815 AD, Netherlands
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's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands
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Amsterdam, North Holland, 1081 HV, Netherlands
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Leiden, 2334 CN, Netherlands
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Krakow, Lesser Poland Voivodeship, 30-727, Poland
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Krakow, Poland, 31 531, Poland
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Chojnice, 89-600, Poland
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Katowice, 40-081, Poland
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Katowice, 40-686, Poland
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Lodz, 93-113, Poland
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Lublin, 20-410, Poland
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Rzeszów, 35-323, Poland
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Skorzewo, 60-185, Poland
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Warsaw, 01-684, Poland
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Zabrze, 41-800, Poland
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Żory, 44-240, Poland
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Braga, 4710243, Portugal
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Lisbon, 1169-050, Portugal
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Lisbon, 1349-019, Portugal
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Lisbon, 1649-035, Portugal
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Porto, 4200 319, Portugal
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Constanța, ROM, 900123, Romania
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Bucharest, 040215, Romania
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Campulung Muscel, 115100, Romania
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Bratislava, Slovakia, 826 06, Slovakia
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Trnava, Slovakia, 917 02, Slovakia
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Bratislava, 851 01, Slovakia
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Komárno, 945 05, Slovakia
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Nitra, 950 01, Slovakia
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Cape Town, Western Cape, 7405, South Africa
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Barcelona, Barcelona, 08035, Spain
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Jerez de la Frontera, Cadiz, 11407, Spain
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Albacete, Castille-La Mancha, 02006, Spain
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Logroño, La Rioja, 26006, Spain
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Pozuelo de Alarcón, Madrid, 28223, Spain
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Torrejón de Ardoz, Madrid, 28850, Spain
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El Palmar, Murcia, 30120, Spain
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Castilleja de la Cuesta, Sevilla, 41950, Spain
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Valencia, Valencia, 46017, Spain
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Barakaldo, Vizcaya, 48903, Spain
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Alicante, 03010, Spain
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Las Palmas GC, 35010, Spain
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Lleida, 25198, Spain
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Madrid, 28006, Spain
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Madrid, 28009, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Salamanca, 37007, Spain
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Valencia, 46026, Spain
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Bern, 3010, Switzerland
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Lausanne, 1011, Switzerland
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Brighton, East Sussex, BN2 5BE, United Kingdom
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Romford, Essex, RM7 0AG, United Kingdom
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Coventry, CV2 2DX, United Kingdom
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Glasgow, EH9 1LF, United Kingdom
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Leeds, LS1 3EX, United Kingdom
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London, E1 2AT, United Kingdom
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Nottingham, NG7 2UH, United Kingdom
Orlando Health Clinical Trials
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Orlando, Florida, 32806, United States
Premier Neurology
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Greenville, South Carolina, 29605, United States
Regina Berkovich MD PhD Inc
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West Hollywood, California, 90048, United States
Saturn Research Solution
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Plano, Texas, 75024, United States
U Mass Memorial Medical Center
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Worchester, Massachusetts, 01605, United States
UC Health Neuroscience Ctr
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Aurora, Colorado, 80045, United States
UF Health Cancer Center
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Gainesville, Florida, 32610, United States
University Of South Florida
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Tampa, Florida, 33612, United States
University of Kansas Hospital
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Kansas City, Kansas, 66160, United States
University of New Mexico Hospital
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Albuquerque, New Mexico, 87106, United States

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