New hope for progressive MS: phase 3 trial of remibrutinib launches

NCT ID NCT07225504

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 06, 2025 · Last updated May 16, 2026 · Updated 19 times

Summary

This study tests whether the drug remibrutinib can slow disability worsening in people with secondary progressive multiple sclerosis (SPMS). About 1,275 adults aged 18-65 with SPMS will receive either the drug or a placebo. The main goal is to see if remibrutinib delays confirmed disability progression over 6 months.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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AZ Integrated Neuro and Spine
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Phoenix, Arizona, 85037, United States

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Alabama Neurology Associates PC
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Birmingham, Alabama, 35209, United States

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Aqualane Clinical Research
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Naples, Florida, 34105, United States

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Axiom Brain Health
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Tampa, Florida, 33609, United States

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Center for Neurosciences
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Tucson, Arizona, 85718, United States

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Citta Clinical Research
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Spokane, Washington, 99202, United States

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Comprehensive Neurology Clinic
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Orlando, Florida, 32825, United States

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Fullerton Neuro and Headache Ctr
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Fullerton, California, 92835, United States

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Georgetown University Hospital
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Washington D.C., District of Columbia, 20007, United States

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Hawaii Pacific Neuroscience LLC
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Honolulu, Hawaii, 96817, United States

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Homestead Assoc In Research Inc
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Homestead, Florida, 33033, United States

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Joi Life Wellness Group LLC
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Smyrna, Georgia, 30080, United States

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Medstar Washington Hosp Ctr
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Washington D.C., District of Columbia, 20010, United States

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Miami NS Ins Baptist Health S FL
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Miami, Florida, 33176, United States

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Michigan Institute of Neurological
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Farmington Hills, Michigan, 48334, United States

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Mid Atlantic Epilepsy and Sleep Ctr
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Bethesda, Maryland, 20817-1807, United States

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Neuro Institute of New England P C
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Foxborough, Massachusetts, 02035, United States

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Neurology Associates PA
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Maitland, Florida, 32751, United States

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Neurology Associates of Ormond Beach
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Ormond Beach, Florida, 32174, United States

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Neurology Clinic PC
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Cordova, Tennessee, 38018, United States

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Neurology of Central FL Res Ctr
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Altamonte Springs, Florida, 32714, United States

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Novartis Investigative Site
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Capital Federal, Buenos Aires, 1424, Argentina
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Bombal, Mendoza Province, M5500DXO, Argentina
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Buenos Aires, C1012AAR, Argentina
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Caba, C1055AAF, Argentina
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CABA, C1181ACH, Argentina
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Caba, C1182, Argentina
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Caba, C1424BYD, Argentina
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Santiago del Estero, 4200, Argentina
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Kogarah, New South Wales, 2217, Australia
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New Lambton Heights, New South Wales, 2305, Australia
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Westmead, New South Wales, 2145, Australia
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Clayton, Victoria, 3168, Australia
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Heidelberg, Victoria, 3084, Australia
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Linz, 4020, Austria
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Vienna, 1180, Austria
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Pleven, 5800, Bulgaria
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Sofia, 1113, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1510, Bulgaria
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Sofia, 1606, Bulgaria
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Vancouver, British Columbia, V6T 2A1, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Lévis, Quebec, G6W 0M5, Canada
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Montreal, Quebec, H2W 1T8, Canada
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Montreal, Quebec, H3A 2B4, Canada
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Montreal, Quebec, H4A 3T2, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Guangzhou, Guangdong, 510030, China
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Zhengzhou, Henan, 450003, China
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Wuhan, Hubei, 430030, China
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Hohhot, Inner Mongolia, 010017, China
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Suzhou, Jiangsu, 215004, China
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Changchun, Jilin, 130021, China
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Yinchuan, Ningxia, 750004, China
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Xianyang, Shaanxi, 712000, China
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Taiyuan, Shanxi, 030001, China
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Hangzhou, Zhejiang, 310016, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 065001, China
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Beijing, 100034, China
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Chongqing, 400016, China
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Shanghai, 200040, China
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Tianjin, 300052, China
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Barranquilla, Atlántico, 080020, Colombia
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Bogotá, 111321, Colombia
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Medellín, 050001, Colombia
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Medellín, 050034, Colombia
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Jihlava, 586 01, Czechia
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Prague, 140 59, Czechia
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Prague, 150 06, Czechia
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Teplice, 415 29, Czechia
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Esbjerg, 6700, Denmark
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Limoges, Haute Vienne, 87000, France
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Ajaccio, 20090, France
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Amiens, 80054, France
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Clermont-Ferrand, 63003, France
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Gonesse, 95500, France
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Grenoble, 38043, France
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Lille, 59000, France
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Lille, 59037, France
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Montpellier, 34090, France
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Nancy, 54035, France
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Nice, 06000, France
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Nîmes, 30029, France
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Orsay, 91400, France
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Paris, 75013, France
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Paris, 75940, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Rouen, 76031, France
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Strasbourg, 67000, France
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Toulouse, 31059, France
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Tours, 37044, France
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Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Mannheim, Baden-Wurttemberg, 68167, Germany
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Munich, Bavaria, 81377, Germany
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Unterhaching, Bavaria, 82008, Germany
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Halle, Saxony-Anhalt, 06120, Germany
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Erfurt, 99089, Germany
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Giessen, 35392, Germany
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Greifswald, 17475, Germany
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Heidelberg, 69120, Germany
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Itzehoe, 25524, Germany
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Tübingen, 72076, Germany
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Chaïdári, 124 62, Greece
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Budapest, 1044, Hungary
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Kistarcsa, 2143, Hungary
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Gurugram, Haryana, 122011, India
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Mangalore, Karnataka, 575003, India
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Kochi, Kerala, 682025, India
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New Delhi, National Capital Territory of Delhi, 110029, India
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New Delhi, National Capital Territory of Delhi, 110060, India
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Chandigarh, Punjab, 160012, India
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Vellore, Tamil Nadu, 632 004, India
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Hyderabad, Telangana, 500082, India
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Haifa, 3436212, Israel
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Jerusalem, 9112001, Israel
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Ramat Gan, 5265601, Israel
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Rehovot, 7661041, Israel
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Tel Aviv, 6423906, Israel
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Ẕerifin, 7030000, Israel
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Bergamo, BG, 24127, Italy
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Foggia, FG, 71122, Italy
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Pozzilli, IS, 86077, Italy
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Pavia, PV, 27100, Italy
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Roma, RM, 00133, Italy
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Arnhem, Gelderland, 6815 AD, Netherlands
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Leiden, 2334 CN, Netherlands
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Bydgoszcz, Woj Kujawsko Pomorskie, 85-796, Poland
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Chojnice, 89-600, Poland
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Katowice, 40-081, Poland
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Katowice, 40-686, Poland
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Rzeszów, 35-323, Poland
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Skorzewo, 60-185, Poland
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Zabrze, 41-800, Poland
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Żory, 44-240, Poland
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Braga, 4710243, Portugal
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Lisbon, 1349-019, Portugal
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Porto, 4200 319, Portugal
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Constanța, ROM, 900123, Romania
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Bucharest, 040215, Romania
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Campulung Muscel, 115100, Romania
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Bratislava, 851 01, Slovakia
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Komárno, 945 05, Slovakia
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Nitra, 950 01, Slovakia
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Trnava, 917 02, Slovakia
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Cape Town, Western Cape, 7405, South Africa
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Pozuelo de Alarcón, Madrid, 28223, Spain
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Torrejón de Ardoz, Madrid, 28850, Spain
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El Palmar, Murcia, 30120, Spain
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Castilleja de la Cuesta, Sevilla, 41950, Spain
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Valencia, Valencia, 46017, Spain
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Barakaldo, Vizcaya, 48903, Spain
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Alicante, 03010, Spain
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Barcelona, 08035, Spain
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Las Palmas GC, 35010, Spain
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Lleida, 25198, Spain
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Madrid, 28009, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Salamanca, 37007, Spain
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Valencia, 46026, Spain
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Bern, 3010, Switzerland
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Lausanne, 1011, Switzerland
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Brighton, East Sussex, BN2 5BE, United Kingdom
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Coventry, CV2 2DX, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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Leeds, LS1 3EX, United Kingdom
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Nottingham, NG7 2UH, United Kingdom
Orlando Health Clinical Trials
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Orlando, Florida, 32806, United States

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Premier Neurology
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Greenville, South Carolina, 29605, United States

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Regina Berkovich MD PhD Inc
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West Hollywood, California, 90048, United States

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Saturn Research Solution
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Plano, Texas, 75024, United States

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UF Health Cancer Center
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Gainesville, Florida, 32610, United States

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University of Kansas Hospital
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Kansas City, Kansas, 66160, United States

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University of New Mexico Hospital
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Albuquerque, New Mexico, 87106, United States

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Conditions

Explore the condition pages connected to this study.

SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS (SPMS) SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS (SPMS)