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Cure My Disease

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New combo therapy aims to slow progressive MS disability

NCT ID NCT07282574

Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 4 times

Summary

This study tests whether adding a new drug (RO7268489) to the standard MS treatment ocrelizumab can slow disability progression in adults with progressive multiple sclerosis. About 360 participants will receive either the new drug or a placebo, and researchers will track walking speed, hand function, and cognitive changes over time. The goal is to find a better way to manage this challenging form of MS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 360 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

May 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * PMS, in accordance with the revised 2017 McDonald criteria * Expanded disability status scale (EDSS) at screening between 3.0 and 6.0 inclusive Exclusion Criteria: * MS relapse during the 6 months preceding the randomization date * Lack of peripheral venous access * History of alcohol or other drug abuse, in the opinion of the investigator, within 5 years prior to screening * Inability to complete an magnetic resonance imaging (MRI) * Contraindications to ocrelizumab mandatory pre-medications * Treatment with intravenous immunoglobulin (IV Ig) or plasmapheresis within 12 weeks prior to screening

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Progressive multiple sclerosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    108 sites in 11 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara City Hospital

    RECRUITING

    Ankara, 06800, Turkey (Türkiye)

  • Austin Health

    RECRUITING

    Heidelberg, Victoria, 3084, Australia

  • Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona

    RECRUITING

    Salerno, Campania, 84131, Italy

  • Azienda Ospedaliera Universitaria Federico II

    RECRUITING

    Naples, Campania, 80131, Italy

  • Azienda Ospedaliera Universitaria Policlinico Tor Vergata

    RECRUITING

    Roma, Emilia-Romagna, 00133, Italy

  • Azienda Ospedaliera Universitaria- Universit degli Studi della Campania Luigi Vanvitelli

    RECRUITING

    Naples, Campania, 80138, Italy

  • Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)

    RECRUITING

    Milan, Lombardy, 20162, Italy

  • Bajcsy-Zsilinszky Korhaz es Rendelointezet

    RECRUITING

    Budapest, 1106, Hungary

  • Box Hill Hospital

    RECRUITING

    Box Hill, Victoria, 3128, Australia

  • Brain and Mind Centre

    RECRUITING

    Camperdown, New South Wales, 2050, Australia

  • Budapesti Uzsoki Utcai Kórház

    RECRUITING

    Budapest, 1145, Hungary

  • CHU Hopital Gabriel Montpied

    RECRUITING

    Clermont-Ferrand, Puy De Dome, 63003, France

  • CHU Nancy Hôpital Central

    RECRUITING

    Nancy, Meurthe Et Moselle, 54035, France

  • CHU Nantes - Hopital Nord Laënnec

    RECRUITING

    Saint-Herblain, Loire Atlantique, 44800, France

  • CHU Rennes - Hopital Pontchaillou

    RECRUITING

    Rennes, 35033, France

  • CHU Strasbourg Hpital Hautepierre

    RECRUITING

    Strasbourg, Bas Rhin, 67098, France

  • COPERNICUS Podmiot Leczniczy Sp z o o

    RECRUITING

    Gda?sk, 80-803, Poland

  • Centro Hospitalar Entre o Douro e Vouga E.P.E. - Hospital de São Sebastião

    RECRUITING

    Santa Maria da Feira, 4520-211, Portugal

  • Centrum Medyczne Medyk

    RECRUITING

    Rzeszów, 35-055, Poland

  • Centrum Medyczne NeuroProtect

    RECRUITING

    Warsaw, 01-684, Poland

  • Centrum Medyczne Pratia Katowice I

    RECRUITING

    Katowice, Silesian Voivodeship, 40-081, Poland

  • Charing Cross Hospital

    RECRUITING

    London, Greater London, W6 8RF, United Kingdom

  • Charité Universitaetsmedizin Berlin - Campus Ch

    RECRUITING

    Berlin, 10117, Germany

  • Clinexpert Kft.

    RECRUITING

    Budapest, 1033, Hungary

  • Complejo Hospitalario Universitario de Albacete

    RECRUITING

    Albacete, 02008, Spain

  • Complejo Hospitalario Universitario de Santiago.

    RECRUITING

    Santiago de Compostela, LA Coruna, 15706, Spain

  • Debreceni Egyetem Klinikai Kozpont Kenezy Gyula Campus

    RECRUITING

    Debrecen, 4031, Hungary

  • Ege University Medical Faculty

    RECRUITING

    Izmir, 35100, Turkey (Türkiye)

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    RECRUITING

    Milan, Lombardy, 20133, Italy

  • Fondazione Istituto Neurologico Nazionale Casimiro Mondino

    RECRUITING

    Pavia, Lombardy, 27100, Italy

  • Fondazione Università G. D'Annunzio

    RECRUITING

    Chieti, Abruzzo, 66013, Italy

  • Gazi University Medical Faculty

    RECRUITING

    Ankara, 06500, Turkey (Türkiye)

  • Groupe Hospitalier Pellegrin

    RECRUITING

    Bordeaux, Gironde, 33800, France

  • Groupe Hospitalier Pitie-Salpetriere

    RECRUITING

    Paris, 75013, France

  • Hacettepe University of Medicine

    RECRUITING

    Ankara, 06100, Turkey (Türkiye)

  • Hopital Caremeau

    RECRUITING

    Nîmes, Gard, 30029, France

  • Hopital Gui de Chauliac

    RECRUITING

    Montpellier, Herault, 34295, France

  • Hopital Neurologique Pierre Wertheimer

    RECRUITING

    Bron, 69500, France

  • Hopital Purpan

    RECRUITING

    Toulouse, Haute Garonne, 31059, France

  • Hospital Alvaro Cunqueiro

    RECRUITING

    Vigo, Pontevedra, 36312, Spain

  • Hospital Clinic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos

    RECRUITING

    Madrid, 28040, Spain

  • Hospital General Universitario Gregorio Maranon

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Regional Universitario de Malaga

    RECRUITING

    Málaga, 29010, Spain

  • Hospital Santa Caterina

    RECRUITING

    Salt, Girona, 17190, Spain

  • Hospital Universitari Arnau de Vilanova

    RECRUITING

    Lleida, Lerida, 25198, Spain

  • Hospital Universitari Vall d Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitari de Bellvitge

    RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Hospital Universitari i Politecnic La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario Quironsalud Madrid

    RECRUITING

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, 41009, Spain

  • Hospital Universitario Virgen de La Arrixaca

    RECRUITING

    El Palmar, Murcia, 30120, Spain

  • Hospital Universitario de la Princesa

    RECRUITING

    Madrid, 28006, Spain

  • Hospital de Braga

    RECRUITING

    Braga, 4710-243, Portugal

  • Hospital de Cruces

    RECRUITING

    Barakaldo, Vizcaya, 48903, Spain

  • Hospital de Egas Moniz

    RECRUITING

    Lisbon, 1349-019, Portugal

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, 08041, Spain

  • Hospital del Mar

    RECRUITING

    Barcelona, 08003, Spain

  • IRCCS AOM Azienda Ospedaliera Metropolitana

    RECRUITING

    Genoa, Liguria, 16132, Italy

  • Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.

    RECRUITING

    Lublin, 20-410, Poland

  • Istanbul University Cerrahpasa Medical Faculty

    RECRUITING

    Istanbul, 34098, Turkey (Türkiye)

  • Istanbul University Istanbul Medical Faculty

    RECRUITING

    Istanbul, 34093, Turkey (Türkiye)

  • John Hunter Hospital

    RECRUITING

    New Lambton Heights, New South Wales, 2305, Australia

  • Klinikum rechts der Isar der TU Muenchen

    RECRUITING

    Munich, Bavaria, 81675, Germany

  • Kocaeli University Medical Faculty

    RECRUITING

    Kocaeli, Izmit, 41380, Turkey (Türkiye)

  • LMU-Campus Grosshadern

    RECRUITING

    Munich, Bavaria, 81377, Germany

  • M.A. LEK A.M.Maciejowscy SC.

    RECRUITING

    Katowice, 40-571, Poland

  • Morriston Hospital

    RECRUITING

    Swansea, SA6 6NL, United Kingdom

  • NEURO-CARE Sp. z o.o. Sp. Komandytowa

    RECRUITING

    Katowice, Silesian Voivodeship, 40-749, Poland

  • NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partn. Lek

    RECRUITING

    Poznan, Greater Poland Voivodeship, 61-853, Poland

  • Neurocentrum Bydgoszcz sp z o.o

    RECRUITING

    Bydgoszcz, 85-796, Poland

  • Nmedis sp. z o.o.

    RECRUITING

    Rzeszw, Podkarpackie Voivodeship, 35-323, Poland

  • Optimal Clinical Trials - Central

    RECRUITING

    Auckland, 1010, New Zealand

  • Optimal Clinical Trials - Christchurch

    RECRUITING

    Christchurch Central City, South Island, 8011, New Zealand

  • Ospedale San Raffaele

    RECRUITING

    Milan, Lombardy, 20132, Italy

  • Pecsi Tudomanyegyetem Klinikai Kozpont

    RECRUITING

    Pécs, Baranya, 7623, Hungary

  • Penta Hospitals Przychodnie, Wroclaw Wejherowska

    RECRUITING

    Wroc?aw, 54-239, Poland

  • ProNeuro Centrum Medyczne

    RECRUITING

    ?ory, 44-240, Poland

  • Queen Elizabeth University Hospital

    RECRUITING

    Glasgow, Strathclyde, G51 4TF, United Kingdom

  • Resmedica NZOZ Kielce

    RECRUITING

    Kielce, 25-726, Poland

  • Royal Cornwall Hospital

    RECRUITING

    Truro, Cornwall, TR1 3HD, United Kingdom

  • Royal London Hospital

    RECRUITING

    London, E1 2AT, United Kingdom

  • S-Medicon Egeszsegugyi Szolgaltato Kft.

    RECRUITING

    Budapest, 1045, Hungary

  • SOMED - Lodzkie Centrum Osteoporozy

    RECRUITING

    ?ód?, 90-368, Poland

  • Salford Care Organisation

    RECRUITING

    Salford, M6 8HD, United Kingdom

  • Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanislawa SzyszkoSUM w Katowicach

    RECRUITING

    Zabrze, 41-800, Poland

  • Samodzielny Publiczny Zakad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie

    RECRUITING

    Krakow, 31-503, Poland

  • Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital

    RECRUITING

    Istanbul, 34785, Turkey (Türkiye)

  • Selcuk Universitesi Selcuklu Tip Fakultesi Hastanesi

    RECRUITING

    Konya, 42075, Turkey (Türkiye)

  • Southern Neurology

    RECRUITING

    Kogarah, New South Wales, 2217, Australia

  • St. Josef-Hospital Universitaetsklinikum

    RECRUITING

    Bochum, North Rhine-Westphalia, 44791, Germany

  • Studienzentrum Neuropoint GmbH,

    RECRUITING

    Ulm, Baden-Wurttemberg, 89073, Germany

  • Szpital Specjalistyczny im. L. Rydygiera w Krakowie

    RECRUITING

    Krakow, 31-826, Poland

  • ULS São José - Hospital de Sto António dos Capuchos;CRI Esclerose Múltipla

    RECRUITING

    Lisbon, 1169-050, Portugal

  • ULS de Coimbra, EPE - Hospitais da Universidade de Coimbra

    RECRUITING

    Coimbra, 3004-561, Portugal

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    RECRUITING

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Duesseldorf

    RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Universitaetsklinikum Erlangen

    RECRUITING

    Erlangen, Bavaria, 91054, Germany

  • Universitaetsklinikum Freiburg

    RECRUITING

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    RECRUITING

    Hamburg, 20246, Germany

  • Universitaetsklinikum Leipzig

    RECRUITING

    Leipzig, Saxony, 04103, Germany

  • Universitaetsklinikum Tuebingen

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitaetsklinikum Ulm

    RECRUITING

    Ulm, Baden-Wurttemberg, 89081, Germany

  • Universitaetsklinkm Essen

    RECRUITING

    Essen, North Rhine-Westphalia, 45122, Germany

  • Universitaetsmedizin Mannheim

    RECRUITING

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • University Hospital of Wales

    RECRUITING

    Cardiff, CF14 4XW, United Kingdom

  • Zanamed Medical Clinic sp z o o

    RECRUITING

    Lublin, 20-601, Poland

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Other studies related to the condition(s) this trial covers.