Chronic kidney disease

People with end-stage kidney disease need a reliable blood vessel connection, called a fistula, for hemodialysis. This study tests a device called the ePATH System, which creates that connection from inside the blood vessels rather than through open surgery. Researchers will foll…

This study tests whether a citrate-based dialysis fluid with extra magnesium can slow or prevent blood vessel hardening in adults on long-term hemodialysis. Eighty stable patients will receive either the new fluid or a standard one for 12 months. Researchers will measure blood ma…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

People with advanced chronic kidney disease often avoid nuts because of concerns about phosphorus and potassium. Researchers at Shahid Beheshti University of Medical Sciences are testing whether a daily 30-gram serving of pistachios, added to a standard kidney diet, changes level…

Researchers are testing whether a multidisciplinary care model helps people with type 2 diabetes and chronic kidney disease start and adjust five classes of heart and kidney protective medicines within four months. The trial enrolls about 570 adults at high or very high risk of k…

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This trial tests whether using a wearable cuffless blood pressure monitor to guide treatment can help more hemodialysis patients achieve target blood pressure than standard office-based measurements. Adults on maintenance hemodialysis with high blood pressure will be randomly ass…

This study tests whether medically tailored meals, prepared to support kidney and heart health, can improve blood pressure and kidney function in Veterans with chronic kidney disease. About 100 participants will be randomly assigned to receive these meals or usual care for three …

This trial tests a new feature called FlexPoint on a peritoneal dialysis machine used at home. The feature adjusts fluid volume and dwell time during treatment. Researchers will compare three different settings in 24 adults with chronic kidney disease to see which works best for …

This early-phase trial tests whether a genetically modified pig kidney combined with thymus tissue can work as a transplant in 4 adults with end-stage kidney disease. The goal is to see if the organ can keep them off dialysis safely for at least 6 months. Participants must be on …

Researchers are testing whether personalized nutrition, including special milk formulas, can improve growth, body composition, and muscle strength in children with chronic kidney disease. The study will enroll 128 children aged 6 to 12 with any stage of the disease. The goal is t…

This trial compares three approaches for treating painful diabetic neuropathy: oral medications, topical treatments, and cognitive behavioral therapy. Researchers will enroll 600 adults with diabetes and nerve pain, randomly assigning them to one of these options for four months.…

This phase IIa trial tests whether OM336, a T-cell engager, can safely reduce the immune antibodies that make it hard for highly sensitized kidney patients to find a compatible donor. Twelve adults awaiting a kidney transplant will receive weekly injections for four weeks, with a…

This trial is testing whether dorzagliatin, an experimental oral medication, can improve blood sugar control in people with type 2 diabetes who also have moderate to severe chronic kidney disease. Participants will be randomly assigned to receive either dorzagliatin or linaglipti…

This trial tests whether low-level laser therapy or isometric handgrip exercises can help arteriovenous fistulas mature faster in people on hemodialysis. A fistula is a surgically created connection between an artery and vein that needs to grow and widen before it can be used for…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This study tests two drugs, finerenone and empagliflozin, in 30 African American veterans with diabetic kidney disease. The goal is to see if these drugs reduce kidney cell damage by measuring specific proteins in urine. Participants will take one or both drugs for 4 months to ch…

This trial tests whether apixaban, a blood thinner, can reduce the risk of stroke or blood clots in adults on dialysis who also have atrial fibrillation (an irregular heartbeat). Participants are randomly assigned to receive either apixaban or no oral anticoagulant, while continu…

This clinical trial aims to find the safest and most effective hepatitis C treatment for people with chronic kidney disease (CKD). Researchers will compare two drug combinations based on how well the kidneys are working: one for patients with moderate kidney function and another …

This trial tests whether a daily maqui berry supplement can improve gut health, reduce inflammation, and lower oxidative stress in people with stage 3-4 chronic kidney disease. Half of the 30 participants will take the maqui powder, while the other half receives a placebo, for th…

This study looks at whether adding tenapanor to standard phosphate binders helps people on hemodialysis lower their blood phosphorus levels. High phosphorus is common in dialysis patients and can lead to bone and heart problems. The trial will follow about 200 adults who are alre…

This trial is testing whether adding two newer medications—finerenone and mazdutide—to a standard two-drug regimen can better protect the kidneys in people with type 2 diabetes and early kidney disease. About 820 adults will be randomly assigned to one of four treatment groups, a…

This trial tests whether finerenone, a drug already used for chronic kidney disease, is safe and tolerable for people hospitalized with acute kidney injury (AKI). About 72 adults with moderate-to-severe AKI will receive either finerenone or a placebo once daily for up to 45 days,…

This Phase 2 study will test whether empagliflozin (Jardiance), a drug already used for diabetes, can improve blood vessel health and exercise tolerance in 52 veterans with non-diabetic chronic kidney disease. Participants will take either the drug or a placebo for a period, and …

This early study tests a new medicine called TNX-1500 in 5 people who get a kidney transplant. The goal is to see if it is safe and can help prevent the body from rejecting the new kidney. Participants will be followed for one year to check for side effects and signs of rejection…

This study tests whether people on hemodialysis can safely eat a diet that includes more potassium-rich whole foods like fruits, vegetables, and nuts, instead of the usual strict low-potassium diet. Half of the 148 participants will follow this 'liberalized' diet for 12 weeks, wi…

This trial compares three different negative-pressure wound dressings (NPseal, PICO, and Prevena) applied after total knee replacement surgery. The study enrolls adults at higher risk for wound problems, such as those with diabetes, obesity, or chronic kidney disease. Participant…

This trial tests whether infusions of stem cells from human umbilical cord blood can safely help people with type 2 diabetic nephropathy, a serious kidney complication of diabetes. Participants receive multiple intravenous infusions of these stem cells alongside their standard ca…

This trial tests whether sending a letter and fact sheet to adults in Manitoba who are at high risk for kidney failure can encourage them to see a kidney specialist. The goal is to catch advanced chronic kidney disease earlier and reduce the number of people who progress to dialy…

This trial tests a new type of vascular graft, called STARgraft, for people with end-stage kidney disease who need hemodialysis. The graft is placed in the arm to create a reliable access point for dialysis. The study compares STARgraft to a standard graft to see if it works bett…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial tests three experimental antibodies—REGN9933, REGN7508, and REGN9533—in people with end-stage kidney disease who are on hemodialysis. The goal is to see if these antibodies can safely reduce blood clot risk during dialysis, potentially offering an alternative to standa…

This study tests whether providing fruits and vegetables along with cooking and nutrition education can improve kidney health in adults with chronic kidney disease. Participants are randomly assigned to receive either fruits and vegetables alone or fruits and vegetables plus a 12…

This trial asks whether an oral medication called daprodustat can match the effectiveness of the injectable drug epoetin alpha in treating anemia linked to chronic kidney disease. Adults with stage 3-5 kidney disease who are not on dialysis and have low hemoglobin levels will rec…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This early-stage trial tests whether giving kidney transplant recipients a special treatment made from their donor's cells, combined with a light-based therapy called photopheresis, can safely reduce the risk of organ rejection. About 24 adults receiving their first kidney transp…

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

People on maintenance hemodialysis face a high risk of heart disease, and standard cholesterol drugs often fail to help. This trial tests whether high-dose fish oil (4 grams daily for 8 weeks) can improve the function of HDL, the 'good' cholesterol, which may become faulty in kid…

This study tests whether elderly patients starting dialysis for kidney failure can receive treatments twice a week instead of the usual three times, without increasing hospitalizations or death. The goal is to see if fewer sessions allow patients to spend more days at home and im…

This trial tests whether reducing the dialysate flow rate during hemodialysis from the standard 500 mL/min to 400 mL/min can maintain adequate blood cleansing while cutting water use. About 250 adults on chronic hemodialysis will each try both flow rates for one month. The main g…

This study tests two common methods to treat metabolic acidosis—a condition where blood becomes too acidic—in people on long-term hemodialysis for kidney failure. One group takes oral sodium bicarbonate capsules, while the other gets a higher bicarbonate concentration in their di…

This phase 2 trial tests whether spironolactone, a drug usually used for heart failure and high blood pressure, can help treat anemia in children aged 6–18 who are on hemodialysis. Participants take spironolactone daily for 12 weeks alongside standard care, and researchers measur…

This study tests whether an oral medication that removes lead from the body can slow kidney function decline in people with type 2 diabetes and high lead levels. Participants take dimercaptosuccinic acid (DMSA) capsules for up to 3 months, then are followed for 12 months. The goa…

This study tests whether a drug that removes lead from the blood can slow the worsening of kidney function in people with type 2 diabetes who also have higher-than-normal lead levels. Participants receive intravenous infusions of calcium disodium edetate, and their kidney functio…

This study tests a smart computer system that helps primary care doctors screen for and manage diabetic kidney disease in adults with type 2 diabetes. The tool automatically calculates kidney function, reminds doctors to order urine tests, and gives personalized treatment advice.…

This trial tests whether tocilizumab, an anti-inflammatory drug, can stop the progression of calciphylaxis—a rare condition where calcium buildup blocks skin blood vessels, causing painful, non-healing wounds. Ten adults with calciphylaxis and end-stage kidney disease will receiv…

This early-stage trial tests whether two immune-engaging drugs, blinatumomab and teclistamab, can safely lower blood-group antibodies in people awaiting a living-donor kidney transplant that is not blood-type compatible. The goal is to see if these drugs can prepare the body to a…

This study tests whether a dietary supplement called nicotinamide riboside (a form of vitamin B3) can be safely taken by adults with moderate chronic kidney disease. The main goal is to see if it's feasible for participants to take the supplement daily and complete study procedur…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This trial tests whether a prehabilitation program — combining exercise, nutrition advice, and psychological support — can improve fitness and recovery in people with advanced chronic kidney disease awaiting a kidney transplant. Researchers compare an in-person, hospital-based pr…

This study tests whether a supplement called Ketosteril, added to the usual diet, can help people who are starting hemodialysis (a treatment for kidney failure) stay on a less frequent schedule longer. The trial includes 70 adults beginning incremental hemodialysis, where session…

This trial investigates whether adding Naoxintong Capsule, a traditional Chinese medicine made from 16 herbal and animal ingredients, to standard therapy can slow the progression of diabetic nephropathy in people with type 2 diabetes. The study involves 410 participants who will …

This trial tests a home-based program of exercise, breathing exercises, nutrition advice, and emotional support for people waiting for a kidney transplant. Participants start the program at least 4 weeks before surgery and continue for 18 weeks after leaving the hospital. The goa…

This trial tests two BiTE drugs (blinatumomab and teclistamab) in 20 adults with end-stage kidney disease who have very high antibody levels (cPRA ≥90%) and have waited over 5 years for a transplant. The goal is to safely lower these antibodies enough to make a kidney transplant …

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This trial tests a self-management program that uses education, WhatsApp reminders, and a diary to help hemodialysis patients control weight gain between sessions. The program aims to improve fluid adherence and stabilize blood pressure. Participants are adults on maintenance hem…

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This study tests whether adding extra bicarbonate and magnesium to the fluid used during dialysis can improve how well the body handles minerals like calcium and phosphate. It involves adults with end-stage kidney disease who have been on dialysis for at least three months. Each …

This study tests whether a real-time continuous glucose monitor (CGM) helps people with type 2 diabetes and chronic kidney disease keep their blood sugar in a healthy range. Thirty adults will either use the CGM or stick with standard fingerstick checks for three months. The goal…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This pilot study tests whether adding a Chinese herbal formula called CKD-1 to standard care can improve kidney function in people with stage 3-4 non-diabetic chronic kidney disease. About 66 adults will be randomly assigned to receive either standard care alone or standard care …

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This pilot study will test whether adding a traditional Chinese herbal formula (DKD-1) to standard care can improve kidney function in people with diabetic kidney disease. Sixty-six adults with type 2 diabetes and moderate-to-severe chronic kidney disease will be randomly assigne…

This pilot study tests a new dialysis catheter coated with Endexo technology, designed to resist blood clots and reduce infections. Researchers will compare its performance to older catheters in 50 adults with end-stage kidney disease. If successful, it could improve quality of l…

This Phase 2 trial tests whether the drug SAL0140 can reduce protein in the urine, a sign of kidney damage, in 249 adults with chronic kidney disease. Participants will receive either SAL0140 or a placebo for 16 weeks. The goal is to see if the drug can help control the disease a…

This study compares two common ways to access the blood for dialysis: a tunneled catheter (a tube placed in a large vein) versus a surgically created fistula (connecting an artery to a vein). The trial will enroll 220 patients aged 60 or older (or younger but with multiple health…

This Phase 3 trial tests whether BHV-1400 can safely reduce protein in the urine and preserve kidney function in 420 adults with IgA nephropathy. Participants are randomly assigned to receive either the drug or a placebo by injection. The main goal is to see if BHV-1400 lowers pr…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This study tests whether giving specific blood pressure drugs based on a patient's circulation type during kidney transplant surgery improves how the body responds to fluids. Researchers will monitor 255 adults and assign drugs like vasopressin or norepinephrine based on real-tim…

This study tests a new medicine called ABP-671 in 80 adults with chronic kidney disease and high uric acid levels. Participants will receive either the drug or a placebo for 40 weeks. The main goal is to see if the drug reduces protein in the urine, a sign of kidney damage.

This large Phase 3 study tests whether the drug HRS-7535 can help people with chronic kidney disease (CKD) avoid serious outcomes like kidney failure, dialysis, or heart-related death. About 3690 adults with CKD will receive either the drug or a placebo, added to their usual care…

This phase 3 trial tests whether a combination of two drugs (balcinrenone and dapagliflozin) works better than dapagliflozin alone for people with advanced chronic kidney disease (stages 3b and 4). About 2,800 participants will take the combination or a placebo daily, alongside s…

This early-stage study tests a new drug called PMG1016 in 30 healthy adults to see if it is safe and how the body processes it. The drug is given as a single IV infusion. This is the first time PMG1016 is being tested in humans, and it aims to gather safety data before moving to …

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study will test whether a supplement made from jaboticaba peel can reduce inflammation, oxidative stress, and gut bacteria imbalances in people with chronic kidney disease. Thirty adults will take either the jaboticaba extract or a placebo for one month. Researchers will mea…

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage, better than standard care. Participants must already be on stable blood pressure medication and have mod…

This study tests whether adding a weekly injection called dulaglutide to two standard pills (SGLT-2 inhibitors and finerenone) can better protect the kidneys of Chinese adults with type 2 diabetes and mild-to-moderate chronic kidney disease. About 468 participants will be randoml…

This study tests whether adding pea fiber to the daily diet of people on dialysis can lower harmful waste products in their blood. 72 adults on dialysis will eat baked goods with or without pea fiber for 8 weeks. Researchers will measure changes in toxin levels and heart health m…

This early-stage trial tests whether treating a donor kidney with a drug called SYN002 before transplant can safely reduce the risk of passing cytomegalovirus (CMV) to the recipient. About 12 adults waiting for a kidney transplant will receive a treated organ. The main goal is to…

This study tests whether a combination of a controlled diet, structured exercise, and a symbiotic supplement can reduce inflammation and harmful gut toxins in young people with early chronic kidney disease (stages 1-3). Two hundred participants will receive either the multimodal …

This study tests a Traditional Chinese Medicine (TCM) herbal formula, Jiajian Yishen Xiaozheng Qufeng Granules, combined with AI-driven diagnostics to treat diabetic nephropathy (kidney disease from type 2 diabetes). About 198 adults with mild-to-moderate kidney damage will recei…

This early-stage study tests whether injecting human umbilical cord stem cells can prevent narrowing of the arm vein used for dialysis in people with end-stage diabetic kidney disease. About 54 participants will receive the stem cell treatment after fistula surgery. The goal is t…

This study tests whether a daily synbiotic supplement (probiotics plus prebiotics) can lower inflammation and improve digestive symptoms in adults with chronic kidney disease stages 3 to 5 who are not yet on dialysis. One hundred participants will receive either the supplement or…

This study tests a traditional Chinese herbal formula for people on dialysis who often have dangerously low blood pressure during treatment. About 100 adults with kidney failure will either get the herbs or stay on a waitlist. The goal is to see if the herbs reduce low blood pres…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether adding a low-dose blood thinner (apixaban) to the standard heparin lock can help dialysis catheters stay functional longer. Fifty-four adults with end-stage kidney disease and a new catheter will be followed for up to 24 months. The goal is to see if this…

This pilot study tests whether an AI-based system can help doctors choose the right doses of immunosuppressant drugs for kidney transplant patients. The goal is to protect the new kidney from damage and rejection. The study will enroll 34 adults who have received a deceased donor…

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either the drug or standard care for 2 years. Researchers will track kidney funct…

This study tests whether giving amino acids through the dialysis machine twice a week for a year can help protect the heart and blood vessels in people with kidney failure. About 120 adults on stable dialysis will receive either amino acids or a placebo (saline). Researchers will…

This study tests imlifidase, a drug that temporarily disables the immune system's antibodies, allowing highly sensitized patients to receive a kidney from a deceased donor they would otherwise reject. The trial will follow 450 patients in France to see how many get transplanted a…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This study tests whether using two daily exchanges of a special dialysis fluid called icodextrin can better control fluid buildup and blood pressure in children on chronic peritoneal dialysis. Ten children aged 5-18 will be enrolled. The goal is to see if this approach improves f…

This early-phase study tests whether adding the drug venetoclax to standard transplant preparation is safe for people with chronic kidney disease and a blood cancer. Only 3 adults aged 18-70 will take part. The goal is to see if the combination helps the new stem cells and kidney…

This study tests whether taking a laxative (bisacodyl) for two days before getting a peritoneal dialysis catheter can prevent blockages. About 398 adults needing dialysis will be randomly assigned to receive the laxative or usual care. The goal is to see if this simple step reduc…

This study will test whether SGLT2 inhibitors, a type of diabetes drug, can help correct anemia in people with chronic kidney disease (CKD). Anemia is common in CKD and often requires iron or hormone injections, which have side effects. The trial will enroll 60 adults with CKD st…

This early study will test whether gentle ultrasound pulses applied to the kidneys can improve kidney function in 20 adults with chronic kidney disease (CKD). Participants will receive the ultrasound treatment three times a week for four weeks. Researchers will measure changes in…

This study tests whether the drug finerenone can slow kidney function decline and lower heart failure risk in 120 adults with type 2 diabetes and chronic kidney disease. Participants must already be on standard blood pressure medications. The study will measure changes in kidney …

This early-stage trial tests whether a single intravenous infusion of stem cells from donated umbilical cord tissue can safely improve kidney function in 32 adults with stage 3 or 4 chronic kidney disease caused by diabetes or high blood pressure. Participants will be randomly as…

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or obesity. Participants receive weekly injections for three months. The goal is to see if this drug can help manage weight and …

This study looks at whether roxadustat, a drug for anemia in chronic kidney disease, can also help people with heart failure. Researchers will review medical records of 200 patients who took roxadustat for at least a year. They will check heart function, symptoms, and major event…

This study looks at whether giving extra nutrition during dialysis sessions helps people on long-term hemodialysis build muscle and manage blood pressure. Researchers will compare the effects of this special nutrition with usual care in 16 adults who have been on dialysis for at …

This study looks at whether eating more protein can help people on dialysis avoid hospital stays. Dialysis removes nutrients like protein from the blood, and current guidelines are based on old research. The study will give some participants a high-protein diet or supplements and…

This study tests whether the drug finerenone can protect the retina (the light-sensitive layer at the back of the eye) in people with chronic kidney disease. Researchers will measure changes in retinal nerve thickness over time in 40 adults with stage 2-4 kidney disease. The goal…

This study tests whether adding ganagliflozin tablets to standard care can slow kidney disease progression in 1,244 adults with type 2 diabetes and chronic kidney disease. Participants will take either ganagliflozin or a placebo daily for 120 weeks. The main goal is to measure ch…

This phase 2 trial tests whether combining dapagliflozin (a diabetes drug) with SC0062 (a blood vessel drug) can better protect kidneys in adults with type 1 diabetes and chronic kidney disease. Thirty-six participants will try each treatment alone and together in a cross-over de…

This study tests a weekly injection called survodutide in 120 people with chronic kidney disease and high protein in their urine. The goal is to see if the drug can lower protein levels and protect kidney function over 36 weeks. Participants must be on stable standard treatments …

This study tests two different drug combinations to prevent cytomegalovirus (CMV) infection in kidney transplant patients who are at high risk. Thirty adults who are CMV-positive before transplant will receive either tacrolimus plus mTOR inhibitors with early antiviral treatment,…

This study tests whether adding levocarnitine injections to standard care can lower the amount of anemia medication needed by people on hemodialysis. About 94 adults with kidney failure and anemia will receive either levocarnitine after each dialysis session or usual care alone f…

This study tests whether roxadustat, a drug currently used to treat anemia in kidney disease, can also improve sarcopenia (muscle loss) in patients on hemodialysis. Sixty adults with end-stage kidney disease and anemia will receive either roxadustat or standard erythropoietin. Re…

This trial tests a new drug called QRX3 in 3,000 people with chronic kidney disease whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow the need for dialysis. Participants take QRX3 capsules, and researchers measure changes in kidne…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

Researchers are testing whether an open-source artificial intelligence model can measure coronary artery calcium on routine chest CT scans that were not originally taken for heart imaging. The study uses existing scans from about 1,950 people at a German hospital, including patie…

Peritoneal dialysis uses the belly lining as a natural filter for people with kidney failure, but over time this membrane can scar and stop working. This study tests whether levels of a protein called DKK3 in blood, urine, and dialysis fluid can serve as an early warning sign of …

This study tests whether blood samples collected at home using small capillary devices, like finger pricks, give the same results as traditional blood draws from a vein. Researchers will compare both methods in about 1,000 people with chronic conditions such as kidney disease, au…

This study looks at whether routine blood test markers—like the Systemic Immune-Inflammation Index and platelet ratios—can help identify diabetic kidney disease in people with type 2 diabetes. Researchers will compare these markers across patients with different levels of albumin…

This pilot study tests a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow in tiny vessels of transplanted kidneys. The goal is to see if changes in these vessels can predict how well the kidney will work early after transplant, includin…

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study looks at whether measuring a hormone called irisin in the blood can help find diabetic kidney disease early and track how it gets worse. Researchers will compare irisin levels in 200 adults with type 2 diabetes to healthy people. The goal is to see if irisin can be a s…

This study will check if a new urine test can find early signs of chronic kidney disease and track its progress. Researchers will also look at how well common diabetes drugs (SGLT2 inhibitors) help protect the kidneys. About 300 adults with mild-to-moderate kidney disease will ta…

This study looks at whether the triglyceride-glucose (TyG) index, a simple measure from a blood test, can predict insulin resistance in people with pre-diabetes and chronic kidney disease. Researchers will enroll 60 adults with and without kidney problems to see how well the TyG …

This study will test a new handheld device that measures creatinine (a kidney health marker) from a fingerstick blood sample at home. Researchers will compare its accuracy to standard lab tests and ask 200 adults with kidney disease to try the device and rate how easy it is to us…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests an 8-week health literacy program designed to help people aged 55-74 who take 5 or more medications daily. The goal is to see if the program improves their understanding of medication management and reduces their risk of developing chronic kidney disease. Half of…

This study compares two treatments—Plazepod and electrical stimulation—to see which better reduces fall risk in people on hemodialysis. Sixty men aged 40 to 50 with end-stage kidney disease will be followed for changes in balance, leg strength, and mobility. The goal is to find a…

This study tests whether a simple home exercise program can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4-5). 124 participants will either do low-intensity walking and strength exercises or receive standard care. …

Researchers test whether adding inspiratory muscle training to a walking program helps adults on hemodialysis who also have atrial fibrillation. Participants do breathing exercises through a mouthpiece and walk for six minutes, while the study tracks heart rate, blood pressure, k…

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random …

People with advanced kidney disease often face fatigue, itching, pain, and sleep problems that disrupt daily life and strain caregivers. Researchers are testing a nurse-led program called COMFORT that helps patients and their informal caregivers recognize and manage these symptom…

Researchers are testing whether a breathing muscle training program done during hemodialysis can improve breathing strength and physical function in adults with advanced kidney disease. Participants train with a handheld electronic device three times a week for 12 weeks while rec…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study tests whether a structured family conversation program, called Family TIME, can be delivered successfully to adults receiving hemodialysis for chronic kidney disease and their family members. Participants either receive usual care or usual care plus three family conver…

This trial tests whether a super high-flux dialyzer, a more efficient filter used during hemodialysis, can remove more middle-molecule toxins from the blood than standard high-flux dialyzers. The study includes 40 adults with end-stage kidney disease who are on maintenance dialys…

This trial compares two drug-free therapies—leg massage and mechanical vibration—against standard care for reducing muscle cramps and improving comfort in people undergoing hemodialysis. About 160 patients on maintenance dialysis will be randomly assigned to receive either 20-min…

This trial tests whether nalfurafine, an oral drug that acts on opioid receptors in the body, can reduce the severe itching that often plagues people with chronic kidney disease who are on hemodialysis. Researchers will compare the drug against a placebo in adults aged 18 to 65 w…

This trial tests whether light therapy glasses can reduce depression in people with end-stage kidney disease who undergo hemodialysis three times a week. Participants wear either active glasses (1000 lux) or a sham device (50 lux) for 30 minutes each session over five weeks. The …

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This early-stage study tests whether bupropion, a medicine used for smoking cessation and depression, can reduce severe tiredness in people with end-stage kidney disease on dialysis. Sixteen participants will take bupropion three times a week for 8 weeks and report their fatigue …

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

This study tests whether acupuncture laser therapy can reduce neck pain and improve quality of life in people undergoing hemodialysis. Sixty participants will either receive standard care or standard care plus laser therapy three times a week for four weeks. Researchers will meas…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This trial tests whether adding palliative care to standard treatment helps people with advanced chronic kidney disease (stages 4 and 5, including those on dialysis) feel better. Participants are randomly assigned to receive either usual kidney care or usual care plus integrated …

This study investigates whether a simple breathing exercise called the 4-7-8 technique can reduce fatigue and improve sleep in people undergoing hemodialysis for chronic kidney disease. Eighty adult patients are randomly assigned to either practice the breathing exercise twice da…

This study tests whether a 4-7-8 breathing exercise can reduce pain when needles are inserted into the arm for hemodialysis. About 80 adults on dialysis will either learn the breathing technique or receive standard care. The goal is to see if this easy, drug-free method makes the…

This study tests whether doing simple handgrip exercises at home for 8 weeks can lower blood pressure in people with chronic kidney disease (CKD). Researchers will measure changes in resting blood pressure, blood vessel function, and stiffness. The study involves 50 adults aged 4…

This early study tests a new device that lets dialysis patients use just one needle instead of two for their blood cleaning treatments. The goal is to see if it is safe and works well for people who already have a mature vein connection (fistula). About 20 adults who need dialysi…

This study looks at whether coloring mandalas (circular patterns) can improve mindfulness, mood, and reduce psychological distress in people undergoing hemodialysis for kidney failure. Sixty adults aged 18-50 will be split into two groups: one colors mandalas, the other does free…

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This study tests whether Anakinra, a drug that reduces inflammation, can prevent dangerous drops in blood sugar after meals in a patient who had his stomach removed. The 52-year-old man also has kidney failure and needs dialysis. Over 10 weeks, he will receive either Anakinra or …

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether using virtual reality (VR) during arteriovenous fistula surgery—a procedure for dialysis patients—can lower pain, anxiety, and the need for anesthesia. About 64 adults with end-stage kidney disease will be randomly assigned to receive VR or standard care …

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This trial tests whether the drug difelikefalin can reduce severe itching in people with chronic kidney disease who are on hemodialysis. About 106 adults will receive either the drug or a placebo after each dialysis session for 6 weeks. The main goal is to see if itching scores i…

This study tests whether doing progressive relaxation exercises at times matched to each patient's natural circadian rhythm can help manage symptoms, improve sleep quality, increase comfort, and boost mental well-being in people receiving hemodialysis. Researchers will enroll 75 …

This study looks at whether hydromorphone sustained-release tablets can safely relieve moderate to severe cancer pain in elderly patients who also have kidney issues. Researchers will compare these patients to those with normal kidney function, monitoring pain relief, kidney func…

This study tests whether combining relaxation exercises with listening to a specific Quran chapter (Surah Ar-Rahman) can reduce anxiety and improve sleep in people undergoing kidney dialysis. 76 adult Muslim patients will be split into two groups: one doing the relaxation and Qur…

This study looks at whether doing joint range-of-motion exercises and Benson relaxation techniques during dialysis can improve how well the treatment works, help patients follow their care plan, and boost quality of life. About 72 adults on long-term hemodialysis will take part. …

This study will test whether a sodium bicarbonate enema can help relieve constipation and reduce harmful waste products in people with chronic kidney disease (CKD). The researchers believe the gut can act as an extra filter to remove toxins that build up when kidneys fail. They p…

This study tests whether adding a special breathing feedback device to standard breathing exercises can reduce symptoms and improve quality of life in adults with chronic kidney disease. Twenty-four participants will practice the exercises three times daily for six weeks. The goa…

This study compares a new 'tubeless' anesthesia method (using a laryngeal mask and lighter sedation) to standard breathing-tube anesthesia in 60 kidney transplant patients. The goal is to see if it reduces the need for muscle relaxants and other drugs, and improves recovery. Part…

This study looks at whether doing aerobic or free exercises during dialysis sessions can reduce fatigue, improve walking ability, and help thinking in people with kidney failure. Sixty-nine adults aged 50 to 60 on maintenance hemodialysis will be assigned to different exercise ro…

This study tests whether doing virtual reality exercise during dialysis can help patients with end-stage kidney disease keep their electrolytes (sodium, potassium, calcium, phosphorus) in a healthier range. Forty adults on regular dialysis will either do 30 minutes of VR cycling …

This study tests whether breathing low-oxygen air during exercise (simulated high-altitude training) can improve walking ability and reduce fatigue in people with stage 3-4 chronic kidney disease. Sixty adults aged 40-65 will be split into three groups: simulated altitude trainin…

This study tests whether a smartphone app with artificial intelligence can help people on hemodialysis take better care of themselves. The app provides education on diet, fluid intake, and fistula care, and sends reminders. 76 patients will be randomly assigned to use the app or …

This study tests whether a relaxation method called autogenic training can help people on hemodialysis who suffer from restless leg syndrome, poor sleep, and fatigue. About 54 adults aged 45-55 will practice guided relaxation exercises for 8 weeks. Researchers will measure change…

This study tests whether taking probiotics daily can help chronic kidney disease patients on dialysis better respond to anemia medication (erythropoietin). About 80 adults will receive either erythropoietin alone or erythropoietin plus probiotics for 3 months. Researchers will tr…

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults who have been on dialysis for at least three months will be randomly assigned to use the app daily for four…

This study tests whether therapeutic touch—a gentle, non-invasive technique—can lower stress and boost comfort in people on hemodialysis. About 60 patients will be randomly assigned to receive touch sessions or standard care only. Researchers will measure stress and comfort level…

This study tests a mobile app designed for people on hemodialysis. The app helps with medication, diet, fluid limits, and symptom tracking. 72 adults will be split into two groups: one uses the app, the other gets standard care. Researchers will check if the app improves treatmen…

This study looks at whether listening to music during dialysis sessions can help reduce fatigue, improve sleep quality, and boost mental well-being. Sixty adults on hemodialysis will receive 30 minutes of music therapy after the second hour of each session for four weeks. Researc…

This study will test a mobile app called Smart Kidney that helps adults with chronic kidney disease track and manage their symptoms remotely. Sixty participants in Vietnam will use the app for 6 weeks. The goal is to see if the app is easy to use and helpful for symptom managemen…

This study will test whether a 16-week Pilates exercise program can reduce restless leg syndrome, improve physical function, and boost self-perception in 100 older adults (65+) who are on maintenance hemodialysis. Participants will do supervised resistance exercises two to three …

Researchers at Assiut University Hospitals compare adults with kidney failure who receive hemodialysis twice a week versus three times a week. The study tracks health-related quality of life, dialysis adequacy, urine output, and hospitalizations over time. About 130 participants …

Researchers at Assiut University are studying how common secondary hyperparathyroidism is among people with end-stage kidney disease who receive hemodialysis three times a week. The study also checks whether the quality of dialysis, measured by standard clearance formulas, relate…

Researchers at Assiut University Hospital survey adults with advanced chronic kidney disease about arteriovenous fistula creation, the surgically connected vein and artery used for hemodialysis. The study includes pre-dialysis patients and people already on maintenance hemodialys…

People with advanced chronic kidney disease often develop calcium buildup in their coronary arteries, which raises the risk of heart problems. Researchers want to know whether a protein called CXCR2 on white blood cells can predict whose arteries will harden fastest. About 100 ad…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

Researchers are testing whether people with rheumatoid arthritis have early, symptom-free kidney problems more often than healthy people of the same age and sex. The study compares kidney function and urine protein levels between 120 participants, including those with rheumatoid …

Researchers are studying how a single injection of the experimental medicine NNC0537-1482 moves through the body in people with different levels of kidney function. About 54 participants with normal, mildly, moderately, or severely reduced kidney function receive one dose under t…

This study looks at how the amount of phosphorus in food affects phosphorus and calcium balance in people with moderate chronic kidney disease (CKD). Fourteen participants will follow two different controlled diets (low phosphorus then high phosphorus, or vice versa) for 19 days …

This study follows 190 adults with chronic kidney disease who are not yet on dialysis. Over 24 months, researchers track clinical and lab measures to see who experiences a rapid drop in kidney function, defined as a sustained decline of more than 5 mL/min per year. The goal is to…

This phase 1 trial examines how severe kidney impairment or end-stage kidney disease affects the levels of ribupatide, an experimental drug, after a single injection. Researchers compare drug exposure in 32 participants: some with normal kidney function and others with severe kid…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This study looks at whether children with chronic kidney disease, especially those on dialysis, have higher levels of PFAS chemicals in their blood. PFAS are found in many everyday products and may interfere with bone development. The study compares PFAS levels in children with k…

This study looks at whether eating a high-protein meal changes kidney function in a way that can be measured by a skin sensor. Researchers will give 25 adults an injection of a fluorescent dye and track how quickly it clears from the body before and after the meal. The goal is to…

This study looks at how the experimental drug golcadomide is processed by the body in people with severe kidney impairment or end-stage renal disease compared to those with normal kidney function. The goal is to understand how kidney function affects drug levels and safety after …

This study tests whether a pop-up alert in electronic medical records helps doctors prescribe more recommended medications for chronic kidney disease (CKD). About 1,000 patients with CKD will be included, and their doctors will either see the alert or not. The goal is to see if t…

This study looks at whether two blood markers—DEL-1, an anti-inflammatory protein, and thromboxane A2, a sign of platelet activity—are linked to diabetic nephropathy, a common kidney complication of diabetes. Researchers will measure these markers in 80 adults, including patients…

This study planned to test whether kidneys with small, low-risk tumors could be removed from donors, have the tumor taken out, and then be transplanted into patients with kidney failure. The goal was to increase the number of available donor kidneys. However, the study was withdr…

This trial is testing whether a connected urine test strip device, called URIKI, can help people with stage 4 or 5 chronic kidney disease monitor their diet from home. Participants will use the device daily for 10 days, logging meals and other health information in a mobile app. …

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study examines how the severity of chronic kidney disease (CKD) affects the breakdown of a protein called FGF23, which is linked to bone health, anemia, and heart problems. Researchers will measure different forms of FGF23 in blood samples from 80 men with CKD stages 3a to 5…

Researchers are refining a computer model that estimates the risk of chronic kidney disease progression in adults over 65. Using existing health records from 18,000 patients, the study aims to make the model more accurate and easier for doctors to explain. No new treatments are b…

This study investigates whether psychological well-being and social support influence how well people with diabetic kidney disease manage their own health. Adults with type 2 diabetes and diabetic kidney disease who are not on dialysis will fill out questionnaires about their emo…

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study follows 425 adults with type 2 diabetes and chronic kidney disease who are taking finerenone, a standard medication. Researchers collect blood and urine samples over four months to look for biomarkers that predict whether the drug helps reduce kidney damage. The goal i…

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This study follows thousands of people with chronic kidney disease (stages 3 to 5) to understand how the disease progresses and leads to complications. Researchers will collect data from medical records and existing patient groups to build models that could help doctors make bett…

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This study looks at whether using a patient's permanent dialysis access (a fistula or graft) instead of a temporary catheter is safe and effective for delivering continuous kidney replacement therapy in the ICU. Researchers will enroll 50 adults with end-stage kidney disease who …

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study explores how Black and Caucasian patients with kidney disease communicate with their transplant doctors during evaluation visits. Researchers will record these conversations and survey patients to find out which communication styles lead to more living donor referrals …

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study follows 150 adults waiting for a kidney transplant to track how their physical and emotional health changes over time. Researchers will use a mobile app and interviews to measure frailty and quality of life. The goal is to identify patients who need extra support and i…

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This study looks at two ways to prevent blood clots during dialysis in people with end-stage kidney disease. Twenty adults will try both methods—one using standard heparin and the other using a citrate-based approach—to see which causes less inflammation and removes waste better.…

This study looks at why dialysis patients often have heart problems that are hard to detect. Researchers will use a special heart test during a routine procedure to check for tiny blood vessel issues in 30 adults who have been on dialysis for at least 6 months. The goal is to fin…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This study looks at whether a blood test measuring the ratio of two substances (IGF-1 and albumin) can help identify muscle loss (sarcopenia) in people with end-stage kidney disease on dialysis. Researchers will compare the test results to standard muscle assessments in 110 adult…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This study will measure the thickness of the carotid artery wall in 100 adults on hemodialysis. The goal is to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to artery thickness. No new t…

This very early study (Phase 1) will give a single dose of a radioactive-labelled drug called HRS-1780 to 6 healthy men. The goal is not to treat disease but to track exactly how the drug is absorbed, broken down, and eliminated from the body. Results will help design future stud…

This study looks at whether men and women on hemodialysis have different dynamic balance, measured by simple tests like standing up and walking. About 155 patients aged 20-60 will participate. No treatment is given—just observation to gather information.

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (CKD). Researchers will test 100 adults to see if standard diagnostic methods work well for these patients. The goal is to improve accuracy so doctors can treat the right cause…

This study tests whether a short course of belimumab, a drug used for lupus, can improve detection of immune cells that cause transplant rejection. The goal is to help highly sensitized kidney transplant candidates—people whose immune systems are very picky about donor organs—get…

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease may be related. Researchers will examine mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role in the link between the two conditions. The goal is to bett…

This study will survey 160 adults on long-term hemodialysis at Sohag University Hospital to find out how many experience anxiety or depression. Researchers will also look for links to age, gender, and other health factors. The goal is to better understand the mental health needs …

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study tests whether shorter or standard-length dialysis sessions using expanded hemodialysis can remove waste products from the blood as well as a more intensive technique called high-volume hemodiafiltration. Fifteen adults with end-stage kidney disease will try three diffe…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study will follow 225 adults with end-stage kidney disease who are on regular dialysis. Researchers want to see if missing a dialysis session raises the risk of heart problems like heart attack or stroke within the next 72 hours. Participants will have heart tests after a mi…

This study will follow 290 Mexican adults with advanced chronic kidney disease who are on dialysis (hemodialysis or peritoneal dialysis). Researchers will track how many patients die, how often they are hospitalized, and how many infections they get. The goal is to better underst…

This pilot study will test whether a potassium-containing salt substitute is safe for people with end-stage kidney disease on hemodialysis. Twenty participants will use the salt substitute for 16 days and regular table salt for 16 days, with a break in between. Researchers will m…

This study looks at whether a new way of measuring kidney function (using an injection of iohexol and finger-prick blood tests) can better predict when people with advanced kidney disease will start feeling sick from kidney failure. It also checks if this method can accurately me…

This study surveys 200 adults (patients and caregivers) to learn what matters most when moving from peritoneal dialysis at home to hemodialysis in a clinic. The goal is to improve care and support during this transition. No treatments or medications are tested—only opinions and p…

This observational study looks at whether a diet that promotes inflammation can make gum disease worse in people with chronic kidney disease. Researchers will assess the diets and gum health of 100 adults with kidney disease. The goal is to understand if eating more inflammatory …

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study looks at whether ultrasound can help predict a sudden drop in blood pressure when ICU patients start a type of dialysis. Researchers will monitor 80 adults using heart and body scans before and during treatment. The goal is to find early warning signs to prevent compli…

This study tests whether a digital program (videos, texts, and optional phone support) can help people with kidney failure get more inquiries from potential living donors. About 430 adults referred for a kidney transplant will be randomly assigned to get the program with or witho…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with chronic kidney disease (stages 3B-5). Participants will try four different 10-day diets, all provided for free, to see which foods …

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This observational study will check how common left ventricular hypertrophy (thickening of the heart muscle) is in people with chronic kidney disease. It will also look at whether treating anemia with erythropoietin can reduce that thickening. About 100 adults with moderate to se…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at 270 adults with diabetic kidney disease to see if gut bacteria and blood chemicals influence blood sugar swings and disease progression. Researchers will track participants over time using continuous glucose monitors and stool/blood samples. The goal is to fin…

This observational study will follow 200 hospitalized adults with chronic kidney disease to see how diabetes and related metabolic problems affect their outcomes. Researchers will track deaths, need for dialysis, and major heart events during the hospital stay. The goal is to bet…

This early study tests a wearable device that listens to the sound of blood flow in the arm of people on dialysis. The goal is to see if the device can accurately measure the same signals as a standard stethoscope. Six adults with mature fistulas will wear the device weekly for 8…

This study will collect data from 300 kidney transplant patients who receive kidneys from older or higher-risk donors. The kidneys are kept on a machine that pumps cold fluid through them before transplant. Researchers will see if the machine's readings (like flow and pressure) c…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This study looks at two standard methods of stitching the kidney artery during a living donor kidney transplant: interrupted sutures and continuous sutures. Researchers will review past cases and follow 70 new adult patients at Assiut University to see which technique leads to sh…

This study will use advanced MRI scans and blood tests to explore how SGLT2i medications protect the kidneys in 100 people with diabetic kidney disease who are at risk of worsening. Participants will already be taking SGLT2i as part of their routine care. The goal is to identify …

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will measure levels of lipoprotein A, a type of fat in the blood, in 300 people with stage 4 chronic kidney disease. Researchers want to see if high levels are linked to future heart attacks, strokes, or worsening kidney function over 18 months. The goal is to find a b…

This study will examine why some people with chronic kidney disease in Spain may have a harder time getting a kidney transplant than others. Researchers will survey 3,000 patients and interview doctors and patients to understand barriers like age, income, or where someone lives. …

This study will test 200 adults on regular hemodialysis at Sohag University Hospital for latent tuberculosis infection (LTBI) using a simple skin test. The goal is to find out how many dialysis patients carry the bacteria without symptoms, so doctors can better prevent active TB …

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This observational study tests whether tiny chemicals in breath, called VOCs, can show if a hemodialysis session is effective. About 22 dialysis patients and 23 healthy adults will provide breath and blood samples. The goal is to find a simple, non-invasive way to assess dialysis…

This study will use echocardiography (ultrasound of the heart) to look at how common and how severe diastolic dysfunction—a type of heart stiffness—is in 100 adults with end-stage kidney disease who are on regular hemodialysis. Researchers will also check if certain clinical fact…

This study will check if certain blood markers—like MCP-1, NLR, and hsCRP—can help detect kidney disease early in people with type 2 diabetes. Researchers will measure these markers in 80 adults and compare them to standard kidney tests. The goal is to find a simpler way to ident…

This study looks at how eating habits relate to the progression of chronic kidney disease in 160 adults with type 2 diabetes. Researchers will track changes in kidney function over 6 months. The goal is to find dietary patterns that might help protect the kidneys.

This study looks at how CMV (a common virus) changes the immune system in people who have had a kidney transplant. Researchers will take blood samples from 60 patients to compare immune responses in those with and without CMV infection. The goal is to understand why CMV may incre…

This study will check 100 adults on long-term hemodialysis for thyroid problems, abnormal cholesterol, and high uric acid. Researchers want to see how common these issues are and how they relate to each other. The goal is to better understand the health challenges faced by people…

This study will examine how quality of life changes after parathyroid surgery in 60 adults with kidney failure and secondary hyperparathyroidism. Researchers will use a database to compare quality-of-life scores, anxiety, and depression before and after surgery. The goal is to be…