Could two doses of a dialysis fluid help Kids' hearts and kidneys?
NCT ID NCT07168343
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using two daily exchanges of a special dialysis fluid called icodextrin can better control fluid buildup and blood pressure in children on chronic peritoneal dialysis. Ten children aged 5-18 will be enrolled. The goal is to see if this approach improves fluid removal and reduces the need for blood pressure medications, while also checking if it adds extra burden on caregivers.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- icodextrin
- What this could lead to
- If it works, this could point toward a better way to manage fluid overload and blood pressure in children on dialysis, potentially reducing hospital visits.
- What could go wrong
- This is a very small, early trial with only 10 children. The added exchange may increase caregiver burden and might not improve outcomes. Results may not apply to all children on dialysis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Children 5-18 years of age 2. Receiving CAPD or CCPD for at least the preceding 4 weeks, and not likely to change from CAPD to CCPD during the study period 3. 24-hour mean arterial pressure (MAP; measured by ambulatory blood pressure monitoring (ABPM) above the 95th percentile for age, sex, and height 4. 24-hour urine output less than 200ml/day Exclusion Criteria: 1. Children under 5 years of age (as younger children are more prone to hyponatremia) 2. Children with systolic BP \< 50th centile for age, sex, and height in the preceding 4 weeks) 3. Children who are polyuric or those prone to hypotension (defined as \> 2 episodes of systolic BP \< 5th centile in the 4 weeks preceding the study) 4. Known allergy to starch 5. Pregnant women 6. Patients with maltose or isomaltose intolerance, glycogen storage disease, pre-existing severe lactic acidosis, uncorrectable mechanical defects that prevent effective PD or increase the risk of infection and documented loss of peritoneal function or extensive adhesions that compromise peritoneal function
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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National University Hospital
Singapore, Singapore
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