Ancient herbs take on kidney disease: new trial begins
NCT ID NCT07657338
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether adding a Chinese herbal formula called CKD-1 to standard care can improve kidney function in people with stage 3-4 non-diabetic chronic kidney disease. About 66 adults will be randomly assigned to receive either standard care alone or standard care plus the herbal formula for 12 weeks. Researchers will measure changes in kidney filtration rate, urine protein, and quality of life to see if the herbs offer any benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Chinese herbal formula CKD-1 (Astragalus, Salvia, Poria, Moutan, Scutellaria, Lonicera, Alisma)
- What this could lead to
- If it works, this could point toward a safe herbal add-on to help slow kidney decline in non-diabetic patients.
- What could go wrong
- This is a very small pilot study (66 people) with no blinding, so results may be unreliable. The herbal mix may not outperform standard care or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 66 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged ≥18 years. * Patients diagnosed with stage 3-4 chronic kidney disease (CKD), confirmed by a nephrologist and classified as ICD-10-CM codes N18.3-N18.4. * Ability to understand the study procedures and provide written informed consent. * Willingness to comply with study procedures and follow-up visits. Exclusion Criteria: * Acute kidney injury or major kidney-related surgery within 3 months prior to enrollment. * Participation in another clinical trial within 3 months that may affect renal function. * Alanine aminotransferase (ALT) levels greater than 3 times the upper limit of normal. * Pregnancy or breastfeeding. * History of diabetes mellitus. * Malignancy currently receiving chemotherapy, radiotherapy, or other systemic anticancer treatment. * End-stage disease defined under palliative care regulations. * Known allergy to any components of the CKD-1 herbal formula, including Astragalus membranaceus, Salvia miltiorrhiza, Poria cocos, Moutan cortex, Scutellaria baicalensis, Lonicera japonica, or Alisma orientale.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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China Medical University Beigang Hospital
Yunlin, Taiwan, Taiwan
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