Nyu Langone Health

This early-stage trial is testing whether adding ladarixin to the standard drug sotorasib can help people with advanced KRAS G12C mutant non-small cell lung cancer. About 40 adults whose cancer has spread or cannot be removed will receive both pills daily. The study will first ch…

This study tests whether using a portable air cleaner with a HEPA filter at home can lower blood pressure in people with hypertension living in New York City public housing. About 440 adults will use either a real air cleaner or a sham device for up to 6 months while measuring th…

This phase 2 trial is for men with unfavorable intermediate-risk prostate cancer. Participants choose between standard care (6 months of hormone therapy plus high-dose radiation) or radiation alone. The goal is to see if skipping hormone therapy still keeps cancer from returning.…

This study tests whether adding financial coaching to standard smoking cessation counseling helps low-income smokers quit. 602 participants will receive either standard counseling or integrated financial-smoking counseling, plus nicotine patches. The goal is to see if addressing …

This study tests a device called an auditory brainstem implant (ABI) in 20 children who are deaf because they are missing their cochleae or auditory nerves. Unlike a cochlear implant, which stimulates the inner ear, the ABI is surgically placed on the brainstem to send sound sign…

This study tests whether starting a monthly buprenorphine injection (Sublocade) in jail helps people with opioid use disorder stay on treatment after release. Two hundred men entering jail with a sublingual buprenorphine prescription will be randomly assigned to either switch to …

This study tests whether weekly diabetes education videos sent by text message, plus help from a community health worker, can improve blood sugar control in Chinese immigrants with type 2 diabetes. 270 participants in New York City will be randomly assigned to receive the program…

This phase 2 trial tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder who continue using illicit opioids even while on methadone. Up to 480 participants will receive either a low (1 mg), medium (20 mg), or…

This study compares standard meniscal repair surgery with and without the BEAR implant, a collagen-based scaffold that may help the torn meniscus heal better. Researchers will track knee function, pain, and repair failure in 80 participants over time. The goal is to see if adding…

This study tests whether transplanting a face and hands together can help people with severe injuries that standard surgery and prosthetics cannot fix. Ten adults aged 18-64 will receive the transplant and be monitored for changes in function and appearance using tests like EMG, …

This study tests whether a blood test that measures immune protection against a common virus (CMV) can safely shorten the time lung transplant recipients need to take antiviral medication. About 50 participants will have their antiviral treatment duration guided by the test resul…

This study tests whether using portable air filters at home can improve the health of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with blood pressure and heart-related blood markers. The study involves 255 adults in Indi…

This study compares e-cigarettes to standard nicotine replacement therapy (like patches) plus counseling, to see which helps smokers with opioid use disorder cut down on regular cigarettes. About 300 adults in methadone or buprenorphine treatment programs will participate. The go…

This study tests whether empagliflozin, a diabetes medicine, is safe and helps control body fluid levels in 60 adults who are starting hemodialysis for end-stage kidney disease. Participants will take either empagliflozin or a placebo for 12 weeks. The goal is to see if the drug …

This study is testing whether the Shingrix vaccine, which protects against shingles, is safe for people with systemic lupus erythematosus (SLE). Researchers want to see if the vaccine causes lupus flare-ups. The trial will involve 224 adults with lupus, who will receive either th…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supp…

This study tests whether pregnant women at high risk for fetal heart block can use a home monitor to catch early signs of the condition. If detected, they receive steroids and IVIG to try to reverse the block before it becomes permanent. The goal is to prevent stillbirth and the …

This study looks at whether checking and improving nutrition before surgery can help people with inflammatory bowel disease (IBD) recover better. About 150 adults having bowel surgery will be offered nutrition screening and special shakes. The goal is to see if this approach redu…

This study tests whether a culturally tailored harm reduction program helps Black and Latinx people who use drugs engage more with support services and reduce their drug use. Researchers will compare the new program to standard harm reduction services. The study involves 200 adul…

This study looks at whether taking probiotics alongside standard treatment can improve immune markers and recovery in people with a prosthetic joint infection (PJI) after hip or knee replacement. About 152 adults aged 18-90 who are scheduled for surgery and antibiotics will be ra…

This study compares two types of knee implants (medial congruent vs. posterior stabilized) in people having total knee replacement for arthritis. All surgeries will be done with the ROSA robotic system. Researchers will track 200 participants for up to 5 years to see which implan…

This early-phase study tests whether adding a heat-based treatment (radiofrequency ablation) to chemotherapy is safe for people with advanced pancreatic cancer that hasn't spread to other organs. About 15 participants will receive the procedure through an endoscope guided by ultr…

This study tests whether a smartphone app can help people reduce their use of illegal opioids while they are in treatment for opioid addiction. The app uses a short test to predict the chance of relapse in the next week and adjusts medication doses accordingly. About 225 adults w…

This study tests a drug called DRP-104 in people with advanced non-small cell lung cancer that has specific gene changes (NFE2L2 or KEAP1). The drug works by blocking glutamine, a nutrient cancer cells need to grow. The trial aims to see if the drug can shrink tumors or slow the …

This study looks at whether giving nutritional supplements to patients who are malnourished before and after hip or knee replacement surgery can improve their blood markers of nutrition. About 72 adults aged 55 to 95 with osteoarthritis will take part. The goal is to see if bette…

This study is testing whether a hand transplant from a deceased donor can help people who have lost part or all of one or both hands and forearms regain better function, appearance, and feeling. Participants will receive the transplant surgery and be followed closely with exams, …

This study tests a program where trained peers deliver blood pressure medications directly to patients' homes and use health technology to support adherence. The goal is to see if this approach helps people with uncontrolled high blood pressure take their pills regularly and lowe…

This study tests a precise type of radiation therapy for men with intermediate-risk prostate cancer. The treatment uses MRI to guide a high-dose radiation boost to the main tumor while giving a lower dose to the rest of the prostate. Researchers will check if this approach contro…

This early-phase trial is testing a new way to deliver radiation for low-to-intermediate risk prostate cancer. Instead of many sessions, it uses just two high-dose treatments, with an extra boost to the main tumor. The goal is to see if this approach is safe and feasible for abou…

This study tests a modified MRI technique designed to reduce image distortion caused by metal hip implants. Researchers will compare standard and modified scans in 22 adults with painful hip replacements. The goal is to see if the new method provides clearer pictures of the bone-…

This study looks at whether certain biomarkers can help find lung cancer early, when treatment may work better. About 3,600 people who are at high or low risk for lung cancer, or who have suspicious lung nodules, will provide samples and get yearly CT scans. The goal is to improv…

This study is testing a program called ROSE, which includes six group sessions and one individual session for pregnant women. The goal is to see if it can prevent postpartum depression, reduce stress, and increase social support. About 308 pregnant women receiving care at a speci…

This study tests a two-level train-the-trainer model to scale up a mental health program for teachers in Ugandan schools. The program, called mWEL-PD, trains teachers to support their own wellbeing and that of their students. Researchers will compare this new model with and witho…

This study is testing a mobile health toolkit (mWEL) designed to prevent depression and anxiety in teachers and caregivers in Uganda. About 1,180 participants will use the app as a self-help tool, with optional support from community health workers. The goal is to improve mental …

This study aims to find the best way to increase cancer screening rates for breast, cervical, and colorectal cancer in New York City. It compares giving people culturally tailored education materials alone versus adding a community health worker to help them schedule and get scre…

This study tests an 8-week online program called MENTOR that teaches mindfulness, exercise, and nutrition to people who had a traumatic brain injury at least a year ago. Researchers want to see if it improves emotional health, physical activity, and overall well-being. The trial …

This study tests whether wearing virtual reality goggles during a colonoscopy or upper endoscopy can help patients need less sedation. Ten adults aged 21 to 65 will receive minimal sedation and wear a VR headset during the procedure. Researchers will measure how much sedative is …

This study tests whether changing the frequency settings in a cochlear implant can improve sound quality and speech understanding for people who use both a cochlear implant and a hearing aid. Twenty-four experienced users will try a new frequency setting for one month and compare…

This pilot study tests whether a device that gently stimulates a nerve in the ear (taVNS) is safe and tolerable for people with chronic kidney disease stages 3-5 who have autonomic nervous system dysfunction. Thirty participants will use the device daily for two weeks. The main g…

This study tests whether a special silk dressing (SYLKE®) causes fewer skin problems like rashes, blisters, or redness compared to standard skin glue (Dermabond®) after ACL knee surgery. About 100 people aged 14 to 60 having ACL reconstruction will be randomly assigned to one of …

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce anxiety, depression, and existential distress in people with advanced cancer. Two hundred participants will receive either psilocybin or an active…

This study tests whether adding an extra nerve block (IPACK) to a standard one (adductor canal block) can better control pain and reduce opioid use after knee realignment surgery. About 100 adults undergoing specific knee osteotomies will be randomly assigned to receive either th…

This study is testing whether changing the low-frequency settings on a cochlear implant can improve hearing for people who are deaf in one ear but have normal hearing in the other. Twenty-two adults will try four different sound maps during their first month after implant activat…

This study is testing whether cannabidiol (CBD) tablets can reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare pain levels between those taking CBD and those not taking it, alongside standard physical therapy. The study aims to enr…

This study tests if a gentle electrical stimulation device, used at home every other day for 8 weeks, can slow vision loss and improve daily function in people with optic neuropathy. Researchers will measure changes in eye structure, visual field, and quality of life in 70 adults…

This study looks at whether a behavioral program started before surgery and continued for six weeks after can improve swallowing and voice in people having anterior cervical discectomy and fusion (ACDF) surgery. Fifty adults will be enrolled. They will complete swallowing tests, …

This study tests whether heart rate data can help guide a non-invasive brain stimulation technique called tDCS for people with mild to moderate depression. One hundred participants will receive either real or sham tDCS at home over 10 sessions. Researchers will monitor heart rate…

This study is testing whether an 8-week telephone-based mindfulness program (MIND-BP) can help Black women with high blood pressure lower their blood pressure and reduce stress. Researchers will compare it to a support group (BOOST). The study involves 300 Black women who are alr…

This pilot study tests whether a custom splint called a Relative Motion Orthosis (RMO) can help people regain finger movement after an injury that causes stiffness. Sixty-four adults with a stiff middle finger joint will be randomly assigned to receive either standard therapy (st…

This study tests whether a special light therapy called photobiomodulation (PBM) can reduce swelling and tissue hardening caused by radiation treatment in head and neck cancer survivors. Sixty participants who completed radiation at least 3 months ago will be randomly assigned to…

This study tests whether shining a special light on the forehead (transcranial photobiomodulation) can improve blood flow and thinking skills in older adults who have had a traumatic brain injury. Seventy participants aged 55 to 85 will receive either real or sham light therapy f…

This study compares two self-management programs (UPLIFT and PACES) against usual care for adults with epilepsy. Researchers will track depression symptoms, quality of life, and seizures over 12 months in 108 participants. The goal is to see if these programs help people manage t…

This study is testing whether a standardized 6-week yoga program can reduce pain and disability in 200 adults with chronic back pain. Participants will be randomly assigned to yoga or a control group. The goal is to see if yoga offers a safe, non-drug way to manage this common co…

This pilot study tests whether empagliflozin, a diabetes medication, can reduce symptoms of major depression. Sixteen adults with moderate to severe depression will take the drug for six weeks. The idea is that the drug may help the brain use an alternative energy source, potenti…

This study tests whether a safe, mild electrical current applied to the scalp (tDCS) can make speech therapy work better for people who have trouble speaking after a stroke. 24 participants with apraxia of speech will receive both real and sham stimulation at different times to s…

This study compares two 8-week telephone support programs for 120 adults with epilepsy who have mild to moderate depression. One program teaches skills to manage depression, while the other offers group support. Researchers will track mood, quality of life, and seizures for a yea…

This study offers two proven trauma therapies—Trauma-Focused CBT and Trauma Systems Therapy—to children aged 5-17 with PTSD and their families. Researchers want to see how well these treatments work when children also face stress from racial trauma and adapting to a new culture. …

This study tests whether a nutritional supplement (complex carbohydrates and essential amino acids) taken for three weeks after hip fracture surgery can reduce muscle loss in adults aged 65 and older. Participants are randomly assigned to receive either the supplement or standard…

This study tests whether shining a special near-infrared light on the forehead can change blood flow in the brains of people with major depression. Researchers will measure brain activity and mood changes in 120 adults aged 18-65. The goal is to see if this non-invasive light tre…

This study tests a remote behavioral program called RELAXaHEAD for people with migraines. About 356 adults will use the app to learn skills that may reduce migraine-related disability and improve quality of life. The goal is to see if this approach works better than usual care, a…

This study looks at whether educational videos and role-play exercises can help breast cancer patients and their doctors better recognize and manage side effects from certain targeted therapies (antibody drug conjugates). The study involves 30 patients and their clinicians. Resea…

This study adapts PlayReadVIP, a program that coaches parents on positive interactions during reading and play, for use in family child care homes. Researchers will enroll 240 providers to see if the program improves provider confidence and children's literacy behaviors. The goal…

This study looks at 48 adults with advanced lung cancer who are about to start immunotherapy. Researchers will collect samples from the lungs, stool, and blood before and after treatment to see if certain bacteria are linked to better outcomes. The goal is to understand why some …

This early-phase study is looking at how the drug belzutifan changes a marker called CAIX on kidney cancer cells. Twelve people with advanced clear cell kidney cancer will get a special PET scan before and after four weeks of belzutifan. The goal is to see if belzutifan lowers CA…

This study tests whether a computer algorithm can help doctors give more accurate recommendations for when patients should have their next colonoscopy. Researchers will compare the algorithm's suggestions to traditional methods, looking at both accuracy and the time it takes to m…

This study is testing a new, low-dose food challenge given over several days to diagnose FPIES, a food allergy that causes vomiting and diarrhea. Researchers want to find the safest dose that can still trigger symptoms in people with FPIES. The study involves 72 people aged 1 to …

This study gives 250 adults in East Flatbush, NYC, a free box of fresh vegetables each week for 20 weeks. Participants choose their veggies from a variety of options. Researchers will measure changes in food security, diet quality, and social connections to see if the program hel…

This study aims to understand how the hippocampus, a brain region key for memory and navigation, behaves when people look around and explore. Researchers will record brain activity in 56 adults with epilepsy who already have electrodes implanted for medical reasons. Participants …

This study will follow 300 men with early-stage prostate cancer who choose to be treated with high-intensity focused ultrasound (HIFU). Researchers will collect data on cancer control, side effects, and urinary and sexual function for years after treatment. The goal is to better …

This study aims to improve how children with cochlear implants perceive sound by testing new sound coding strategies. Researchers will compare hearing performance between children and adults, and between those with implants and those with normal hearing. The goal is to understand…

This study looks at the bacteria living in the lungs of smokers with and without early-stage COPD. Researchers will use a bronchoscopy to collect samples and analyze how these bacteria and the body's immune response differ between the two groups. The goal is to better understand …

This study looks at why people struggle with self-control, especially when trying to resist tempting foods. Researchers will ask 300 healthy adults to complete tasks that measure how much they would pay to avoid temptation, while also undergoing brain scans and stress tests. The …

This study uses gentle brain stimulation (TMS or tDCS) to explore how the brain creates the intention to move. Researchers will compare healthy volunteers and people with psychogenic movement disorders or non-epileptic seizures. The goal is to better understand these conditions, …

This study creates a research registry to track the health of up to 40,000 people exposed to World Trade Center dust after 9/11. Participants include local residents, cleanup workers, and responders. The goal is to better understand respiratory, mental, and general health effects…

This study looks at how stress and anxiety affect learning and decision-making. Researchers will have participants do tasks like putting a hand in ice water or warm water, then measure how they value rewards and predict emotions. The goal is to understand the link between stress,…

This study looks at whether offering genetic testing for cancer-related genes during regular gynecology visits is practical and acceptable for women aged 25 to 39. Researchers will track how many participants choose to get tested and how many have genetic changes that increase ca…

This study follows people with familial dysautonomia (FD) to learn how the disease changes over time. Researchers will collect routine medical test results and optional blood samples to find biological markers that could help diagnose and treat FD better. The study is observation…

This study is testing whether a non-invasive light sensor (NIRS) can detect early signs of kidney injury in very premature babies (born before 30 weeks). Researchers will monitor kidney oxygen levels continuously for the first week of life in 100 infants. The goal is to see if th…

This study looks at whether people with chronic hepatitis B who have undetectable virus levels in their blood also have undetectable levels in other body fluids like saliva or semen. Researchers will compare treated patients with suppressed virus to untreated patients with active…

This small pilot study is testing a device that gently stimulates a nerve in the ear to see if it is safe and tolerable for people with chronic kidney disease (CKD). The study will involve 20 adults with moderate to advanced CKD. The goal is to gather early data to help design a …

This study works with over 126,000 adults and clinic staff to improve how primary care clinics identify and accommodate patients with communication disabilities, such as speech or hearing problems. Researchers will test tools to help clinics record these needs in electronic healt…

This study tests a program where Black women perinatal nurses guide Black birthing people through pregnancy and postpartum care. The nurses help with medical, social, and emotional needs, and connect patients to resources. Researchers will survey and interview 55 participants to …

This study tracks 500 people diagnosed with takotsubo (broken heart) syndrome to better understand what causes it and how it affects patients over time. Researchers will monitor heart events, quality of life, and stress levels through medical records and questionnaires. No new tr…

This study tests a web-based decision aid for people with small kidney tumors (up to 4 cm). The tool provides personalized information about treatment options and their risks and benefits. Researchers will enroll 40 patients to see if the tool improves knowledge, satisfaction, an…

This study looks at how the number of 'likes' on social media food ads affects what Black and White teenagers (ages 13-17) choose to buy. Researchers will show teens ads with many or few likes and featuring Black or White individuals, then ask them to pick snacks in a hypothetica…

This study will create a database to record what happens to men with localized prostate cancer who choose cryotherapy (freezing the tumor). Researchers will track complications and how long it takes for PSA levels to rise again, which could signal the cancer's return. Up to 1,000…

This study looks at ways to improve how researchers, families, and community members work together in child health research. About 480 people will take part. The goal is to see if a set of engagement strategies helps studies run better and include more voices.

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study looks at how harm reduction programs in New York City homeless shelters affect overdose deaths and health care use. Researchers will analyze data from shelter records, Medicaid, and vital statistics for people who entered shelters between 2021 and 2026. No participants…

This study works with community partners and NYC public hospitals to help people with limited English get better access to language services. The goal is to make sure everyone can use preventive care like screenings and vaccines. Researchers will develop and test new approaches w…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study looks at blood cells called platelets in people who have had a heart attack. Researchers want to understand how these cells work and what genes are involved. They will compare heart attack patients with healthy people and those with stable chest pain. The goal is to le…

This study aims to find the genes responsible for Hirschsprung disease, a condition where nerve cells are missing from parts of the intestine. Researchers will collect DNA samples from 3,000 people with the disease and their close family members. By analyzing common and rare gene…

This study looks at different ways communities respond to crises, like sending mental health workers instead of police, to see if they reduce violence among young people. Researchers will study 15 U.S. cities that use these models and compare crime rates before and after they sta…

This study looks at how reducing cholesterol levels affects blood cells and blood vessels in people with type 1 diabetes. Researchers will follow 125 participants for one to two months to measure changes in platelet activity, immune cell function, and blood vessel health. The goa…

This study looks at whether treating depression with a common antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memory prob…

This study looks at whether a new quality measurement strategy can improve treatment for opioid use disorder in New York State. Researchers will interview patients, families, and providers, and survey clinics to see how the strategy affects care. About 35 adults aged 18 and older…

This study is looking for biological markers (biomarkers) in blood and airway samples that can show whether phage therapy—using viruses that attack bacteria—is working against stubborn lung infections caused by nontuberculous mycobacteria. Researchers will compare samples from 10…