Nyu Langone Health

This study tests a new digital tool called iMatter2 that uses artificial intelligence to help people with type 2 diabetes track their symptoms and improve blood sugar control. About 353 adults with uncontrolled diabetes will use the tool or receive usual care for 12 months. The g…

This study tests whether using portable air filters at home can improve the health and daily function of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with blood pressure and heart-related blood markers. The goal is to see…

This study tests whether using a catheter to remove blood clots from the lungs, along with standard blood thinners, helps people recover better than blood thinners alone. It includes 500 adults with moderate-to-severe pulmonary embolism who have an enlarged right heart chamber. T…

This early-phase study tests whether adding a heat-based treatment (radiofrequency ablation) delivered via an endoscope to standard chemotherapy is safe for people with advanced pancreatic cancer that hasn't spread to other organs. About 15 participants who have not responded to …

This study tests a new radiation therapy that delivers treatment in just two sessions, with a higher dose to the main tumor. It includes 80 men with low to intermediate risk prostate cancer. The goal is to see if this approach is safe and causes fewer side effects than standard l…

This study tests whether empagliflozin, a drug typically used for diabetes, is safe and helps control fluid levels in people who have just started hemodialysis for end-stage kidney disease. About 60 adults will receive either the drug or a placebo for 12 weeks. The goal is to see…

This study looks at whether using portable air cleaners at home can improve blood sugar control and reduce inflammation in adults with prediabetes. Researchers will measure changes in glucose levels and inflammatory markers over 4 weeks. The goal is to see if reducing air polluti…

This study tests a precise radiation therapy for men with intermediate-risk prostate cancer. The treatment uses MRI scans to target the main tumor with a higher radiation dose while giving a lower dose to the rest of the prostate. The goal is to improve tumor control and reduce s…

This study is for people with unfavorable intermediate-risk prostate cancer. It compares standard care (6 months of hormone therapy plus precise radiation) against radiation alone. The goal is to see if skipping hormone therapy still controls the cancer while reducing side effect…

This study tests whether belatacept, an anti-rejection medication, is safe for adults who receive a heart transplant. About 12 participants will receive belatacept to prevent organ rejection. The goal is to see if it reduces serious complications like rejection, infection, or gra…

This study tests a special donor cell boost (CD34+ selected cells) for people whose stem cell transplant didn't work well or failed. The goal is to help their body make enough healthy blood cells again. About 21 adults who had a stem cell transplant from any donor type can join. …

This study looks at whether time-restricted eating (eating only during a set window each day) can help adults who recently lost weight keep it off. About 110 people aged 25 to 65 who lost at least 5% of their body weight in the last 3 months will be randomly assigned to either fo…

This study is collecting information from 300 men with early-stage prostate cancer who choose to have a treatment called HIFU (high-intensity focused ultrasound). HIFU uses sound waves to destroy cancer cells in the prostate without surgery. The goal is to better understand how w…

This early-phase study tests a new drug called XRD-0394 combined with radiation therapy for people with high-grade gliomas, a fast-growing type of brain tumor. The main goal is to find a safe dose and check for side effects. About 39 adults with newly diagnosed or returning tumor…

This study tests whether people aged 60 and older with stable lupus can safely stop taking hydroxychloroquine, a common medication that can cause eye damage over time. About 330 participants will either continue the drug or receive a placebo for one year. Researchers will monitor…

This study tests a modified MRI technique to reduce image distortion caused by metal hip implants. About 22 adults with a painful hip replacement will get both a standard and an optimized MRI to see which one shows clearer images. The goal is to help doctors better see bones, ten…

This study looks at whether the ROSE program can prevent postpartum depression in pregnant women. About 308 women in their second trimester will take part. They will receive the ROSE intervention and researchers will measure their satisfaction and changes in depression symptoms.

This study tests whether the drug guselkumab can prevent psoriatic arthritis in people with psoriasis who are at high risk. About 176 adults with long-term psoriasis and early signs of joint inflammation will receive either guselkumab or standard care. The goal is to see if the d…

This study compares two methods to increase cancer screening for breast, cervical, and colorectal cancer among 2,160 New Yorkers. One group gets culturally tailored education materials only; the other gets the same materials plus a community health worker who helps them schedule …

This study tests a new noise reduction algorithm designed to help cochlear implant users understand speech better in noisy environments. About 60 people aged 12 and older who use a cochlear implant will listen to sentences in quiet and noisy settings, with and without the algorit…

This study tests a 3-month mobile health program for people with chest pain and no blocked arteries (INOCA). Participants use an activity tracker, log exercise, and get weekly coaching. The goal is to see if this approach improves symptoms, daily function, and quality of life com…

This study tests whether placing a cochlear implant's ground electrode near a nerve in the ear (the vagus nerve) works as well as the standard placement under a muscle. Twelve adults getting a cochlear implant will take part. The goal is to see if this new spot helps people under…

This study tests a virtual program that teaches mindfulness, exercise, and nutrition skills to people who have had a traumatic brain injury (TBI) at least one year ago. The goal is to see if it helps improve emotional well-being, physical activity, and healthy eating. About 138 p…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with alcohol use disorder drink less. Researchers will use brain scans to see how psilocybin changes the brain's response to alcohol cues and negative emotions. 200 adults will receive …

This study tests a light therapy called transcranial photobiomodulation (tPBM) in 70 older adults (ages 55-85) who had a moderate or severe traumatic brain injury 1-2 years ago. The goal is to see if shining light on the head can increase blood flow to the brain and improve think…

This study tests whether a behavioral program (exercises and strategies) started one week before neck surgery and continued for six weeks after can improve swallowing and voice. Fifty adults having anterior cervical discectomy and fusion (ACDF) will participate. They will have sw…

This study tests whether empagliflozin, a medication used for diabetes, can reduce symptoms of depression. The drug helps the body produce ketones, which may provide extra energy to the brain and improve mood. Researchers will enroll 16 adults with moderate to severe major depres…

This study compares standard ACL reconstruction using a bone-tendon-bone graft to the same surgery plus an internal brace. Researchers want to see if the brace helps the knee heal more stably. About 90 people aged 18 to 35 having ACL surgery will take part. The main goal is to me…

This study looks at whether a mindfulness program done over Zoom can help Black women with high blood pressure lower their numbers. Researchers will compare a mindfulness group to a support group. About 300 women from the Jackson Heart Study will take part. The goal is to see if …

This study observes 67 adults with lumbar spinal stenosis and low back pain to see how many have a directional preference—meaning a specific movement (like bending forward or sideways) that eases their pain. Participants will be tracked during outpatient physical therapy at NYU L…

This study looks at how exercise affects the brain in adults with anxiety disorders. Researchers will measure specific brain chemicals from blood samples to understand the connection between physical activity and reduced anxiety. The study involves 30 sedentary adults aged 18-50,…

This study looks at how people with cochlear implants understand speech in everyday situations. Researchers will measure listening effort using eye tracking and memory tests in 460 adults (both with and without hearing loss). The goal is to find what helps or hinders communicatio…

This study tests whether a culturally tailored education program helps more people complete colorectal cancer screening. About 50 adults aged 45-75 who are not up-to-date with screening will participate. The program aims to improve screening rates by addressing beliefs and barrie…

This study looks at whether remote exercise programs—using a smartphone app or live video classes—can help people at risk for heart disease become more active. Thirty adults over age 45 who are not meeting exercise guidelines will be randomly assigned to one of four exercise grou…

This study aims to see if a special type of scan (PSMA PET/MRI) is better than a standard MRI at finding prostate cancer that comes back after a focused ultrasound treatment called HIFU. About 60 men with localized prostate cancer will get both scans one year after HIFU, and the …

This study is looking for biological markers (biomarkers) that can show whether phage therapy is working against hard-to-treat bacterial lung infections. Researchers will collect blood and airway samples from 100 adults with nontuberculous mycobacterial lung disease who are being…

This study looks at 48 adults with advanced lung cancer who are starting immunotherapy. Researchers will collect samples from the lungs, stool, and blood before and after 8 weeks of treatment. The goal is to see if certain bacteria in the gut or airways are linked to how well the…

This study looks at how a part of the brain called the hippocampus behaves when people with epilepsy look around and explore. Researchers will monitor brain activity while participants do simple visual tasks, like looking at pictures or dots. No new treatment is being tested—the …

This study looks at the bacteria living in the lungs of smokers, both those with early-stage COPD and those without. Researchers want to understand how these bacteria and the body's immune response are linked to COPD. The goal is to learn more about the disease, not to test a new…

This early-phase study looks at how the drug belzutifan affects a protein called CAIX in clear cell kidney cancer that has spread. Twelve patients will get PET scans before and after four weeks of belzutifan to measure changes. The goal is not to treat the cancer directly, but to…

This study aims to understand how the collection of bacteria living in your body (the microbiome) relates to health and diseases like cancer and heart disease. Researchers will collect health information and samples from 16,000 adults over age 40. The goal is to build a large res…

This research study is for adults and children (ages 2 and up) who are deaf and use a cochlear implant or auditory brainstem implant. The goal is to understand how these devices help people hear and process sounds like speech and pitch. Participants will complete listening tasks …