Can lupus patients safely get the shingles vaccine? new trial aims to find out

NCT ID NCT05559671

Recruiting now Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the shingles vaccine (Shingrix) is safe and triggers a good immune response in people with lupus, a condition that affects the immune system. About 224 adults with lupus will receive either the vaccine or a placebo, and researchers will monitor for lupus flare-ups over 24 weeks. The goal is to see if the vaccine is as safe as a placebo and if it produces enough antibodies to protect against shingles.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Herpes Zoster Subunit (HZ/su) Vaccine (Shingrix)
What this could lead to: If successful, this could show that the shingles vaccine is safe for people with lupus, helping protect them from shingles without causing serious disease flare-ups.
What could go wrong: This is a Phase 4 study, so the vaccine is already approved for others, but it's still uncertain how it will affect lupus patients. There is a risk of lupus flares or that the vaccine may not work as well in this group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Oklahoma Medical Research Foundation
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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