Nyu Langone Health

This phase II trial tests whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy and radiation can help people with muscle-invasive bladder cancer avoid bladder removal. The study enrolls 60 patients who cannot or choose not to have surgery. The m…

This study tests whether a structured diet, exercise, and lifestyle program can help prevent uterine fibroids from returning after surgery. Researchers will follow 100 women aged 18-50 who recently had fibroids removed and are currently fibroid-free. The goal is to see if the pro…

This study compares two ways to treat alcohol use disorder in Black adults: a computer-based therapy offered in a Black church versus traditional care at a specialty clinic. Researchers want to see which setting gets more people to start and stay in treatment, and leads to more d…

This study tests a precise type of radiation called VMAT for people whose cancer has spread to the lining of the brain and spine (leptomeningeal metastasis). The goal is to see if this approach can delay cancer growth in the central nervous system better than older radiation meth…

This study looks at how to help people with opioid use disorder stay in treatment longer and, if appropriate, stop their medication without relapsing. Over 1,500 adults will try different combinations of medication and counseling. The goal is to find which strategies work best fo…

This study tests a drug called Lutathera, which delivers radiation directly to tumor cells, in 32 adults with a type of brain tumor called meningioma that is growing or hard to treat. Participants receive four doses of the drug through an IV, 8 weeks apart. The main goal is to se…

This study tests a new, 15-minute MRI scan that measures the types of fat in breast tissue. Researchers want to see if women with breast cancer have more saturated fat in their breasts than women with benign lumps. About 190 postmenopausal women will get the extra scan during the…

This study uses advanced PET and MRI scans to look for brain inflammation and blood vessel problems in 30 people with long COVID who have brain fog, anxiety, or depression. The goal is to develop better ways to diagnose these lingering symptoms, not to test a treatment. Participa…

This study compares a telehealth version of the Diabetes Prevention Program (DPP) tailored for older adults to the standard in-person program. About 238 seniors aged 65+ with prediabetes will be randomly assigned to either 16 weekly sessions plus monthly support via video or in p…

This study tests whether wearing cold gloves during chemotherapy can prevent peripheral neuropathy (nerve damage causing numbness, tingling, or pain) in colon cancer patients. Forty adults with stage III colon cancer who are about to start a common chemo regimen (CAPOX) will be r…

This study tests a package of strategies to help permanent supportive housing buildings adopt proven overdose prevention practices. Researchers will work with 20 buildings in New York, involving 1350 tenants and staff. The program includes a toolkit, trained champions, and learni…

This study looks at whether helping communities switch to cleaner cookstoves can lower indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will take part. Some families get extra support to use the new stoves, while others just receive informat…

This small pilot study tests whether low-intensity focused ultrasound, guided by MRI, can safely and precisely target a deep brain region called the thalamus in people with treatment-resistant schizophrenia. The goal is to see if this noninvasive technique can reduce symptoms lik…

This study tests a new, non-invasive treatment called transcranial photobiomodulation (t-PBM) for people with mild cognitive impairment or early Alzheimer's disease. 196 participants aged 65-85 will receive either real or fake light therapy to the forehead for 8 weeks. The goal i…

This study explores whether a few phone-based mindfulness sessions before spine surgery can help people who worry a lot about pain. Researchers will first adapt the therapy with a small group, then test it in 20 people scheduled for surgery. The goal is to see if it's practical a…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study looks at whether wearing a splint and going to formal physical therapy are necessary after surgery for a broken wrist. About 230 adults with a specific type of wrist fracture will be followed to see if early movement (no splint) leads to better outcomes and lower costs…

This study tests a medicated film placed under the tongue to quickly ease severe episodes (autonomic crises) in people with familial dysautonomia. The film contains dexmedetomidine, a drug that calms the body's stress response. Researchers will check if it reduces symptoms like h…

This study tests whether a stellate ganglion block—an injection of anesthetic near nerves in the neck—can reduce PTSD symptoms and change brain activity. 79 adults with chronic PTSD will receive either the real injection or a placebo (saline). Brain scans and symptom checklists b…

This study tests whether giving magnesium sulfate during prostate surgery can lower pain and reduce the need for strong painkillers. About 68 adults having robotic prostate surgery will either receive magnesium or not, as part of their standard anesthesia. Researchers will compar…

This small pilot study is testing whether walking on a treadmill with virtual reality feedback can help people with traumatic brain injury improve their balance, reduce fear of falling, and lower fall risk. The study involves 20 adults aged 18 to 90 who have had a TBI at least on…

This study tests if a shorter course of radiation (3 doses over 5 days) is as safe and works as well as the standard 5-dose schedule for women with early-stage breast cancer. About 284 post-menopausal women with small, low-risk tumors took part. The main goal is to see if the sho…

This study tests if a gentle, non-invasive nerve stimulation device can help manage symptoms of multiple sclerosis (MS), like fatigue and pain. Thirty women with MS will use the device at home for a few weeks. The goal is to see if it's practical and if it reduces symptom burden,…

This study tests a surgical technique called breast neurotization, which aims to restore nipple sensation in women undergoing implant-based breast reconstruction after mastectomy. Six women having both breasts reconstructed will receive the nerve reconnection on one breast only, …

This study looks at how stimulating a nerve in the ear affects pupil size during cochlear implant surgery. Researchers will measure pupil dilation in 30 adults to learn more about the vagus nerve's role in hearing. The goal is to gather knowledge, not to treat hearing loss direct…

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive strategy (like stents or bypass surgery) plus medication, or medication alone. Researchers want to see which approach leads to better survival over 10 years. The goa…

This pilot study is testing a program that gives Chinese American families in New York City monthly boxes of whole grains, legumes, and produce, along with recipes and children's books. The goal is to see if this culturally tailored program can improve diet and family togethernes…

This study planned to test whether giving patients an information pamphlet that also shows how their clinic's screening rate compares to others (a social norm nudge) would increase the number of people completing a take-home colorectal cancer screening test (FIT). The study was a…

This study tests a new device called Napoleon that measures the opening between the stomach and small intestine in people who had gastric bypass surgery but regained weight. Doctors currently estimate this opening by eye, which can be inaccurate. The Napoleon device uses a tiny r…

This study looks at two ways to give lifestyle advice to pregnant women: one using text messages and online videos, and the other using community health workers for group or individual sessions. Researchers want to see which method is more widely adopted and followed. About 1,050…

This study looks at 200 male FDNY rescue workers who were exposed to dust and toxins after the World Trade Center attacks. Many developed acid reflux, which can lead to Barrett's esophagus and even cancer. Researchers will use simple, noninvasive tests like saliva samples and que…

This study looks at 15 people who had a heart attack but whose arteries were not blocked. Using special cameras inside the arteries (OCT) and heart MRIs, researchers hope to find hidden plaque ruptures or other damage. The goal is to better understand why these heart attacks occu…

This study examines tissue from people who died after a COVID-19 infection to understand why some develop Long COVID. Researchers will look for signs of inflammation, scarring, blood clots, and tissue death in the body. The goal is to learn more about the long-term effects of the…

This study tests new MRI software to see how the heart and lungs interact during breathing. About 100 adults with heart disease will get extra scans during their regular MRI. The goal is to see if the new method gives clearer pictures and is easy for doctors to use.

This study looks at why some people do not develop enough protection after getting the hepatitis B vaccine. Researchers will compare the standard vaccine with a newer one that seems to work better. By studying the immune responses of 101 adults, they hope to find clues that could…

This study tests a new technique that lets a cochlear implant stimulate the entire cochlea without needing a longer electrode. The goal is to see if this improves speech understanding and sound quality for people with hearing loss. About 40 adults who already qualify for a cochle…

This study looks at whether a 15-week program of device-guided breathing can improve heart rate variability and quality of life in people with takotsubo syndrome, also known as broken heart syndrome. It includes 10 people who have had takotsubo and 10 healthy volunteers. The goal…

This study looks at women with stable heart disease who have chest pain but no major artery blockages. Researchers want to understand if tiny blood vessel problems, inflammation, or blood cell activity are the cause. About 206 women will be observed during a heart catheterization…

This study looks at whether sending cardiologists quarterly emails about their prescribing habits can help more patients get the right medications for heart failure and atrial fibrillation. About 7,000 patients will be included. The goal is to see if this simple feedback strategy…