Medical University Of South Carolina

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Normally, some patients also get radiation afterward to lower the risk of cancer coming back. This trial tests whether it's safe to skip that radiation if a blood test two weeks after su…

This study tests whether a common stop-smoking medication (varenicline) plus financial incentives can help adults aged 18-40 who use both e-cigarettes and cannabis quit vaping. All 105 participants will receive the drug and rewards for 12 weeks. Researchers will also track how ca…

This study will compare three FDA-approved biologic drugs (dupilumab, omalizumab, and mepolizumab) in 504 adults with chronic sinusitis and nasal polyps. The goal is to see which drug works best for different patients and whether simple tests can predict who will improve the most…

This study compares a weekly dose of isotretinoin (a vitamin A derivative) to daily tetracycline antibiotics for treating moderate acne. Researchers want to see if the weekly approach works just as well, with fewer side effects and less reliance on antibiotics. The trial will enr…

This study tests a mix of five oral drugs (hydroxychloroquine, metformin, sirolimus, dasatinib, and nelfinavir) in people with advanced solid tumors or prostate cancer that has come back. The goal is to find the safest dose and see if the combination can stop the cancer from grow…

This study tests a 12-18 week treatment without anthracyclines (a type of chemo that can harm the heart) for people with triple-negative breast cancer who already have heart conditions or are at high risk for heart damage. The treatment combines two chemotherapy drugs (carboplati…

This study compares two chemotherapy regimens for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. One group gets NALIRIFOX (a mix of four drugs) every two weeks, while the other gets a modified version of gemcitabine, nab-paclitaxel, and ci…

This study compares two FDA-approved laser treatments for open-angle glaucoma: the standard SLT and a newer, non-contact version called DSLT. Both aim to lower eye pressure and prevent vision loss. About 172 adults with glaucoma or high eye pressure will be randomly assigned to o…

This study looks at whether a structured weight loss program, with or without added exercise, can improve physical function and emotional well-being in obese veterans who have had a stroke. Researchers will enroll 130 participants aged 35-85 who had a stroke at least 6 months ago…

This study tests whether adding a person's own bone marrow stem cells to their islet transplant can help the islets survive longer and work better. It includes 42 adults with chronic pancreatitis who are already scheduled for pancreas removal and islet auto-transplant. Participan…

This pilot study is testing whether mailing buprenorphine to people with opioid use disorder after a hospital stay can help them stay in treatment. The goal is to overcome common barriers like lack of transportation or trouble getting to a pharmacy. Researchers will track whether…

This study tests whether a special therapy program with a mobile app helps pregnant people stay on their buprenorphine medication for opioid use disorder, compared to just logging their doses. About 37 pregnant women will be randomly assigned to either the app-based therapy or da…

This study tests whether varenicline (Chantix), a drug already used to help people quit smoking, can also help them reduce cannabis use. Two hundred adults in South Carolina who smoke cigarettes and use cannabis will receive either varenicline or a placebo, plus counseling. The g…

This study is testing whether a type of brain stimulation called theta burst stimulation (TBS) can reduce heavy drinking and cravings in people with alcohol use disorder. Researchers will apply magnetic pulses to a brain region linked to drinking patterns, comparing real stimulat…

This study is testing whether e-cigarettes (nicotine vapes) can help people who are in treatment for substance use disorder quit smoking. Participants will either switch to e-cigarettes or use FDA-approved nicotine patches and lozenges, with weekly counseling. The goal is to see …

This study tests a 5-day course of radiation given before surgery for soft tissue sarcoma in the arms, legs, or trunk. The goal is to see if this shorter treatment is safe and effective at controlling the cancer while preserving more healthy tissue. About 40 adults will receive r…

This phase 2 trial tests fingolimod, a drug already used for multiple sclerosis, in 38 adults with advanced non-small cell or small cell lung cancer that worsened after chemo-immunotherapy. Participants take a 0.5 mg pill daily. The study first checks safety, then looks at whethe…

This early-phase trial is testing a new version of CAR T-cell therapy that has been modified to improve its energy use, potentially making the cells more effective. It is for adults with certain types of B-cell lymphoma or chronic lymphocytic leukemia that have come back or not r…

This study looks at what happens when adults with cannabis use disorder cut back on cannabis. Over 8 weeks, participants get counseling, computer-based therapy, and small rewards for reducing use. The goal is to see if cutting back leads to fewer cannabis-related problems, better…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This phase 2 trial tests whether taking simvastatin, a common cholesterol drug, for 8 weeks before prostate surgery can improve the immune system's ability to fight prostate cancer. Half of the 36 men with localized prostate cancer will receive the drug, while the other half will…

This study tests whether an electronic visit (e-visit) can help people in rural areas quit smoking. Participants are randomly assigned to receive the e-visit or standard care. The e-visit asks about smoking history and preferences, and may lead to a prescription for quit-smoking …

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 mon…

This study tests whether parent coaching via video calls (Tele-PCIT) can help young children with disruptive behavior who are also at risk for trauma. About 50 families with children aged 2 to 6 will receive weekly one-hour coaching sessions over 12-16 weeks. The goal is to impro…

This study tests whether taking the drug sirolimus just once a week can safely treat venous and lymphatic malformations—abnormal clusters of blood vessels or lymph vessels that can cause pain and swelling. Current daily dosing works but often causes side effects like low white bl…

This study tests a new telehealth program called B-FIT, which adds a family member or friend to standard therapy for veterans with alcohol use disorder. The goal is to see if involving a loved one helps veterans drink less and improve family relationships. About 400 veterans and …

This phase 2 trial compares two standard radiation approaches for people with large brain metastases (tumors that spread from other cancers). One method gives two radiation doses a month apart; the other gives three daily doses. The study will track tumor control, side effects, a…

This phase 2 trial tests a new radiation approach for men with high-risk or locally advanced prostate cancer. It combines hypofractionated radiotherapy (fewer, larger doses) with a microboost that delivers extra radiation to the most aggressive tumor spots. The goal is to improve…

This study tests whether formoterol, a drug already used for asthma, can help control diabetic kidney disease. About 120 adults with type 2 diabetes and kidney problems will be randomly assigned to add formoterol to their usual care or continue usual care alone. The main goal is …

This study tests a proactive approach to help people living with HIV quit smoking. A pharmacist calls participants, offers counseling, and sends cessation medication unless they opt out. The goal is to see if this method works better than standard care. The trial involves 231 adu…

This phase II trial tests whether combining two drugs that affect cell cleanup (hydroxychloroquine and nelfinavir) with standard maintenance therapy (bevacizumab) can help keep ovarian cancer from growing back. About 38 women with recurrent high-grade serous ovarian cancer will t…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This trial tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery. The program provides education, social support, and better coordination among doctors. Researchers will compare it to usual care in 532 adults w…

This study is for people having a stroke caused by a blocked artery in the brain. It compares different methods of removing the clot (thrombectomy) to find which works best. About 1600 adults will take part, and the goal is to reduce long-term disability.

This study looks at how cannabis use and stress affect each other in young adults aged 18-25 with cannabis use disorder. Researchers will test whether a single dose of cannabidiol (CBD) can reduce withdrawal symptoms and stress, and delay the urge to use cannabis again. The goal …

This study tests whether a dye called ICG can help surgeons see tumor tissue more clearly during head and neck cancer surgery. About 30 adults with squamous cell carcinoma who are at risk of recurrence will receive the dye before surgery, and doctors will use a special camera to …

This study tests new, faster MRI techniques to get detailed images of the heart muscle in people with heart conditions like cardiomyopathy, myocarditis, and ischemic heart disease. The goal is to improve diagnosis and treatment planning. About 240 adults who already need a heart …

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This study tests whether a dark operating room with a star projector on the ceiling can reduce anxiety in children ages 2 to 6 having outpatient surgery. Some children will get this calming environment plus a parent present, others will receive standard anxiety medicine (midazola…

This pilot study tests whether adding brief guided mindfulness exercises (via a smartphone app) between sessions of accelerated brain stimulation (aiTBS) is feasible and acceptable for people with major depression. Twenty adults already receiving aiTBS as standard care will pract…

This study looks at whether adding a modified form of cognitive behavioral therapy (a type of talk therapy) to standard occupational or speech therapy can improve emotional well-being and daily functioning in stroke survivors. The trial will enroll 80 adults who had a stroke at l…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) can help with Parkinson's symptoms like walking and balance problems. Sixteen adults with Parkinson's will use the device at home for one hour daily over eight weeks. Researchers will check if it'…

This study compares two ways to treat depression in cancer survivors: a mobile app called Moodivate that tracks activities and mood, and 8 sessions of telehealth therapy with a mental health provider. About 45 adults who have had cancer and currently feel depressed will take part…

This study tests a program called SNAP that helps head and neck cancer survivors and their caregivers after radiation treatment. The program includes a needs assessment, a personalized care plan, and a mobile app. Researchers want to see if it reduces symptoms for survivors and e…

This study tests whether a fast, non-invasive brain stimulation method called iTBS can help women with post-partum depression. About 40 new mothers will receive up to 10 or 12 sessions per day over 5-6 days. The goal is to see if the treatment is practical, well-tolerated, and re…

This study tests a mobile app called Moodivate that helps people with incurable cancer track their daily activities and mood, and suggests new activities to improve their mood. About 279 participants will be randomly assigned to use the app or receive usual care for 8 weeks, with…

This study tests whether combining a non-invasive brain stimulation technique called accelerated iTBS with computerized cognitive training can help people with mild cognitive impairment (MCI). Fifty adults aged 60-85 will receive the brain stimulation and be randomly assigned to …

This study tests whether a higher dose of a gentle brain-zapping technique called tDCS can safely help people with major depression. About 20 adults will receive mild electrical pulses on their scalp over 5 days. Researchers will check for side effects and see if mood improves.

This study is testing a smartphone app designed to help people who are starting medication for opioid use disorder get better sleep. The app uses proven sleep therapy techniques and daily sleep diaries. Researchers will enroll 40 adults who are stable on buprenorphine and have po…

This study tests whether a powered exoskeleton can help stroke survivors walk with better balance. Twenty-one people who had a stroke at least six months ago will walk on a treadmill with and without the exoskeleton at different support levels. Researchers will measure how well t…

This study tests a special sock called the ZIDA Control Sock that gives mild electrical pulses near the ankle to help people with overactive bladder who still have leaks despite taking medicine. About 20 adults will use the sock at home once a week for 12 weeks while staying on t…

This pilot study will put a portable transcranial magnetic stimulation (TMS) device into a van and test it at three locations in South Carolina. Thirty adults with treatment-resistant depression will receive five days of TMS. Researchers will check if this mobile approach is feas…

This study tests whether trauma-focused therapy delivered via telehealth can reduce PTSD symptoms in underserved youth aged 7-18 in Puerto Rico. Eighty participants who have experienced trauma and have significant PTSD symptoms will receive the therapy remotely. The goal is to se…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will enroll 48 adults with persistent pain and track changes in pain scores, opioid use, and quality of life over 6 months. The goal is to see if…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to brain areas involved in craving and self-control. The trial involves 64 smokers who will receive either real or…

This study compares two brief behavioral interventions for emerging adults aged 18-25 who use cannabis frequently (at least 20 days per month). Participants attend two 40-50 minute sessions a week apart and are followed for 6 months. The goal is to see if either program helps red…

This study tests whether using a gentle nerve-stimulating device on the ear, combined with computer-based brain training, can improve thinking skills and mood in adults aged 45 to 80 who have noticed changes in their memory or attention. Participants will do 10 sessions at home a…

This study aims to find the best dose of a safe, non-invasive brain stimulation technique called accelerated TMS to improve both depression and thinking skills in people aged 60-85 with mild cognitive impairment and depression. About 60 participants will receive different doses o…

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—for people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions at home and attend three clinic visits over 12 weeks. The goal is to se…

This early study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive brain s…

This study tests whether a fast form of brain stimulation (called accelerated TMS) can help with apathy—a lack of motivation—in people with Parkinson's disease. Fifteen participants will receive 48 stimulation sessions over two weeks. Researchers will check if the treatment is sa…

This study tests a special mental health program for people who have been in the ICU. It includes coaching, digital tools, and psychiatric support to help with anxiety, depression, and PTSD. The goal is to see if this program works better than usual care. About 150 adults who vis…

This pilot study tests a behavioral health program designed to support family members of ICU survivors. The program includes telehealth check-ins and a digital platform to track mood and stress. Researchers want to see if this approach is practical and helpful for reducing anxiet…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) for depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive daily rTMS sessions for four weeks. The go…

This study tests an online questionnaire (e-visit) to help people quit smoking. About 672 adults who smoke daily will be randomly assigned to receive the e-visit or not. The e-visit asks about smoking history and preferences, and may lead to a prescription for quit-smoking medica…

This study tests whether a high-frequency TENS device can reduce pain when an IUD is placed. About 86 women will be randomly assigned to receive either TENS or a placebo device during the procedure. Researchers will measure pain scores right at insertion to see if TENS helps.

This study tests whether giving a single intravenous dose of methadone during hip replacement surgery reduces pain and the need for extra opioids right after the operation. Researchers will compare pain scores and opioid use in 162 adults receiving either methadone or a placebo. …

This study tests whether a gentle electrical stimulation of the vagus nerve (taVNS) during breastfeeding can help premature or sick infants learn to breastfeed better. Ten infants in the NICU will receive taVNS paired with breastfeeding for up to 14 days. Researchers will measure…

This study tests a mobile app called SUPPORT-T that helps patients with progressive pulmonary fibrosis and their caregivers access palliative care from home. The app includes nurse-guided telehealth visits and virtual support groups over one year. Researchers want to see if the a…

Depression is common among cancer survivors, but many don't get help. This pilot study tests a text-based referral platform that sends tailored messages and a video to encourage survivors to take up a mental health referral. The study will enroll 60 cancer survivors with depressi…

This study tests whether a small, wearable device that stimulates the ear with mild electricity can reduce long-term pain after a stroke. Researchers will enroll 24 adults who have had a stroke at least 6 months ago and still have pain in their upper arm. Participants will use th…

This study tests whether giving a single dose of methadone during knee replacement surgery can lower pain and reduce the need for other opioid painkillers right after the operation. About 162 adults having elective knee replacement will take part. Half will receive methadone and …

This study tests whether a personalized brain stimulation method called rTMS, combined with walking exercises, can help people with Parkinson's disease who experience freezing of gait—a feeling of being stuck when trying to walk. Up to 15 adults aged 50-80 will receive 6 treatmen…

This study tests whether a web-based mobile app can help 272 teens and young adults with sickle cell disease learn to manage their symptoms and care for themselves. Participants use the app to track symptoms and get tips, and researchers measure how well they take charge of their…

This study tests whether a modified cardiac rehabilitation program—combining aerobic and strength exercises—can improve physical function and reduce depression in people who had a stroke at least six months ago. Researchers will enroll 76 participants, some with depression and so…

This study tests whether combining a mild nerve stimulation (taVNS) with intensive hand therapy (CIMT) can improve arm function in infants aged 8-24 months who have one-sided weakness due to brain injury. Ten infants will receive 40 hours of therapy over two weeks, and researcher…

This study tests a therapy called HOPE for people who have both opioid use disorder and PTSD. Participants must already be on medication for opioid use disorder (like Suboxone or methadone). Over 10-12 weeks, they will attend therapy sessions and complete surveys to see if their …

This study tests a new device that gently stimulates a nerve in the ear while babies practice bottle feeding. The goal is to help infants with brain injury or feeding delays learn to eat by mouth, so they can go home sooner and avoid feeding tubes. About 88 babies will take part …

This study compares two sedatives, remimazolam and propofol, given during laser treatment for burn scars. The goal is to see which drug causes fewer breathing problems. About 136 adults will take part, each receiving both drugs in separate sessions. The results could help doctors…

This study tests a device called the SPRINT PNS System for chronic pain in the sacroiliac joint, a common cause of lower back pain. The device uses mild electrical pulses to block pain signals. Ten adults with severe pain will receive the treatment and be followed for several mon…

This study tests whether applying low-level laser light to the gums after tooth extraction and socket preservation can improve healing and reduce pain. About 39 adults will receive either standard care or standard care plus laser treatment on days 1, 3, and 7 after surgery. Resea…

This study is testing three treatments one after another for people with chronic pain who are already taking long-term opioids. First, participants try a low-dose buprenorphine patch (a safer opioid) without going through withdrawal. Then, they receive a brief cognitive behaviora…

This study tests whether a fast form of brain stimulation, called accelerated rTMS, can safely improve apathy—loss of motivation and withdrawal—in people who have had a stroke. About 40 adults who had a stroke at least 6 months ago and have significant apathy will receive either …

This study tests whether giving n-acetylcysteine (NAC) during hysterectomy surgery can lower the amount of opioids needed for pain afterward. About 240 women having laparoscopic or robotic hysterectomy will receive either NAC or a placebo. Researchers will track pain scores and o…

This study tests whether training a spinal reflex can reduce neuropathic pain in people with spinal cord injury. Fifteen participants will undergo about 50 sessions of reflex training over 6.5 months. The goal is to see if changing this reflex can lower pain and improve sensation…

This study tests a brief video-based cognitive behavioral therapy (BRIGHT) to reduce body image distress in 180 head and neck cancer survivors. Participants are randomly assigned to either BRIGHT or a supportive care control group. The goal is to see if BRIGHT can help survivors …

This early study tests whether an accelerated form of transcranial magnetic stimulation (TMS) is feasible and tolerable for people with functional seizures (also called psychogenic non-epileptic seizures). Thirty adults will receive up to 30 TMS sessions over 3–5 days, targeting …

This study tests a behavioral training program that teaches people with chronic spinal cord injury to reduce a specific leg reflex. The goal is to decrease spasticity and improve walking speed and distance. 25 participants will train for about 6 months, with researchers measuring…

This early-stage trial is testing whether cannabidiol (CBD), a compound from cannabis, can affect breast cancer cell growth. Up to 84 women with invasive breast cancer will take either a low or high dose of CBD or a placebo for 5 to 56 days before their surgery. Researchers will …

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study looks at young adults aged 18 to 25 who use both tobacco/nicotine products and cannabis. Researchers want to understand what happens to cannabis use when participants try to quit nicotine. All participants receive remote counseling and incentives to stop using nicotine…

This study tests a program called Project Support for families with children waiting for trauma-focused therapy. About 100 families will either receive Project Support or continue with usual care. The goal is to see if the program improves parenting confidence and supportive pare…

This study aims to develop a method to adjust the strength of transcranial focused ultrasound (tFUS) for each person. Researchers will test how tFUS affects vision in 30 healthy adults aged 18-70. The goal is to find the right dose for each individual to make future treatments mo…

This study looks for brain scan markers that might predict thinking and memory changes after Deep Brain Stimulation (DBS) in people with Parkinson's disease. Researchers will use MRI scans before surgery and cognitive tests after surgery in 55 Parkinson's patients, plus compare t…

This study looks at how social behaviors and feelings of connection impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and a close friend or family member over several weeks. The goal is to find patterns that could lead to more pers…

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goa…

This study is evaluating a hospital-based violence intervention program called Turning the Tide for people treated after a violent injury. Researchers will track 220 patients to see if the program reduces PTSD, depression, and repeat injuries, and improves self-esteem and access …

This study looks at how drinking problems and posttraumatic stress disorder (PTSD) together may lead to violence between partners. Researchers will observe 70 couples in a lab and track their daily experiences for 28 days. The goal is to better understand these connections, not t…

This study tests whether a simple electronic health record alert can help primary care doctors identify patients with fatty liver disease who may have advanced liver scarring. The alert prompts doctors to calculate a risk score and, if needed, order a special ultrasound to check …

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This study is developing and testing a simple decision aid for people with opioid use disorder who visit the emergency department. The tool helps them understand their options for starting buprenorphine treatment. About 20 adults will try the aid and share whether it helped them …

This study looks at what happens when menthol is removed from cigarettes and e-cigarettes. Researchers will give 240 adult menthol smokers either menthol or non-menthol products for 7 weeks and track how much they smoke or vape. The goal is to help the FDA understand the real-wor…

This study looks at whether people taking GLP-1 or GIP medications (like Ozempic or Mounjaro) have more food left in their stomach after standard fasting before surgery. Researchers will use ultrasound to measure stomach volume in 150 adults who either fasted for 8 hours or had a…

This study compares standard postpartum care to a technology-based program called H.E.A.R. for Mamas, which uses text messages and phone calls to screen new mothers for complications. About 2,900 Medicaid-insured women in South Carolina will take part. The goal is to see if this …

This study tests a program called REPOSE, where a patient navigator helps families overcome barriers to getting specialist care for children with sleep-disordered breathing. The navigator provides support, resources, and coordinates care between doctors and parents. The goal is t…

This study explores how emotional, practical, and social support affects the ability of people with COPD to manage their own health. Researchers will survey 111 adults aged 40 and older with COPD, and interview 20 of them in depth. The goal is to understand what helps or hinders …

This study looks at a feature in a heart device (subcutaneous ICD) that might tell the difference between muscle movement and dangerous heart rhythms. About 71 adults who already have the device will do simple arm exercises while the feature is turned on and off. The goal is to s…

This study is a registry that gathers medical information from up to 40,000 people who have had surgery for stroke, brain aneurysm, or other brain blood vessel problems. Researchers will look at this data to find patterns that help predict recovery and compare different treatment…

This study in 136 healthy adults tests whether a 30-minute nerve stimulation on the ear (tAN) reduces pain by releasing the body's natural opioids. Half the participants get a drug (naloxone) that blocks opioid effects, while the other half get a placebo. By comparing pain thresh…

This study looks at how mild electrical stimulation of two different nerves in the ear affects brain activity. 96 healthy adults will have their brains scanned with MRI while receiving stimulation to one or both nerves, or a sham (fake) stimulation. The goal is to see if stimulat…

This study tests whether a brain stimulation training can strengthen the connections between the brain, spinal cord, and muscles in people with chronic cervical spinal cord injury. Researchers will enroll 15 adults with incomplete injuries at or above C6 who are at least one year…

This pilot study tests whether personalized brain stimulation can improve hand-eye coordination in people with brain lesions. Researchers will use a technique called repetitive transcranial magnetic stimulation (rTMS) timed to each person's natural brain rhythms. Twenty adults wi…

This study uses MRI scans to observe how the brain changes in people with depression during a 5-day accelerated transcranial magnetic stimulation (TMS) treatment. Researchers aim to see if a new imaging method called INSCAPE can track individual recovery patterns. Twenty adults w…

This study tests whether a technology called transcranial focused ultrasound (tFUS) can temporarily change brain activity linked to anxiety. Researchers will recruit 40 adults with anxiety disorders who recently started treatment. Participants will undergo brain imaging and then …

This study looks at why deep brain stimulation (DBS) for Parkinson's disease can sometimes cause thinking problems. Researchers will scan the brains of 55 people with DBS implants while their device is on or off. The goal is to understand how stimulation affects brain networks, w…

This study tests a stepped care program called the Trauma Resilience and Recovery Program (TRRP) for people hospitalized after a traumatic injury. It includes education, symptom tracking, and referrals to mental health services. Researchers will follow 350 participants for 12 mon…