Medical University Of South Carolina

This study is testing whether tobacco-free nicotine pouches can help people switch from smoking cigarettes. Researchers will give 50 adult smokers either low or high nicotine pouches to use for 4 weeks instead of cigarettes. They'll track how many people completely switch, reduce…

This study is testing a new version of a cancer treatment called CAR T-cell therapy for adults with certain B-cell lymphomas or leukemias that have come back or not responded to other treatments. The researchers are modifying a patient's own immune cells in the lab to potentially…

This study is testing whether citicoline, an over-the-counter supplement, can affect brain function, thinking skills, and inflammation in teens and young adults with alcohol use disorder. Researchers will compare citicoline to a placebo pill in 56 participants aged 16-22. The goa…

This study is testing if adding a patient's own bone marrow stem cells to a special pancreas transplant helps the insulin-producing cells survive and work better. It's for adults with severe chronic pancreatitis who are scheduled to have their pancreas removed and their own insul…

This study is testing if taking the medication sirolimus just once a week can safely shrink painful vascular malformations (abnormal tangles of veins or lymph vessels). Researchers hope this weekly schedule will work as well as daily dosing but cause fewer side effects. The trial…

This study aims to find out if switching completely to e-cigarettes (vapes) is a better way to help people quit smoking while they are in treatment for substance use disorders, compared to using standard nicotine patches and lozenges. It involves 240 adults in South Carolina who …

This study is testing if taking a common cholesterol-lowering drug (simvastatin) for 8 weeks before prostate cancer surgery can help the body's immune system fight the tumor. Researchers want to see if the drug changes certain immune cells inside the prostate to make them less pr…

This study is testing which of two chemotherapy combinations works better for people with advanced pancreatic cancer that hasn't been treated before. Researchers will compare NALIRIFOX (a newer combination) against mGAP (a modified version of three existing drugs) in 52 patients.…

This study is testing a support program called REPOSE, which uses a patient navigator to help families overcome barriers to care for children with sleep-disordered breathing (like sleep apnea). The navigator works with 80 families to coordinate appointments, provide resources, an…

This study is testing whether adding oxytocin, a natural hormone, to a proven therapy can help Veterans who are struggling with both post-traumatic stress disorder (PTSD) and alcohol use disorder. Researchers want to see if oxytocin, given as a nasal spray before weekly therapy s…

This large national trial aims to find the best ways to treat stroke patients who have blocked brain arteries. It will test different emergency procedures, devices, and care methods to help patients recover better. The study is enrolling 1,600 stroke patients at 38 major hospital…

This study is testing a new combination therapy for infants (8-24 months old) who have weakness on one side of their body, often an early sign of cerebral palsy. Researchers will pair a gentle nerve stimulation treatment (taVNS) with intensive hand-and-arm play therapy (CIMT) to …

This study is testing a new therapy called HOPE for people who have both opioid addiction and post-traumatic stress disorder (PTSD). Participants must already be taking medication for their opioid addiction. The research will compare whether adding this 10-12 week therapy to stan…

This study is testing whether an online smoking cessation program, delivered through primary care clinics, helps people in rural areas quit smoking. About 288 adult smokers will be randomly assigned to either complete the online program or receive usual care. The program involves…

This study tests whether switching medications early can help smokers who struggle to quit. Participants receive free quit-smoking products for 12 weeks, and the treatment plan adjusts based on their initial progress. The study is conducted entirely remotely with 544 smokers acro…

This study is testing whether adding a brief family support program to standard alcohol therapy helps veterans drink less. 400 participants (200 veterans and a supportive family member or friend) will be randomly assigned to receive either the standard therapy alone or the standa…

This early-stage trial is testing whether combining up to five existing oral medications is safe and can help control advanced solid tumors or prostate cancer that has returned after treatment. The study will first determine the safest combination of drugs, then see if that combi…

This study is testing whether helping adults with cannabis use disorder reduce their cannabis use leads to improvements in their daily lives. 176 participants will receive 8 weeks of counseling, online therapy, and small rewards for reducing use. Researchers will measure changes …

This study is testing whether a special reflex training system can help people with chronic spinal cord injuries walk better and regain independence. Researchers are recruiting 25 people with leg spasticity to participate in about 45 training sessions over 6 months. The goal is t…

This study is testing whether a stronger dose of a safe, non-invasive brain stimulation technique can be used to treat depression. Participants with major depression will receive mild electrical stimulation through a headset for 5 days while researchers closely monitor for side e…

This study is testing whether a patient navigation program called ENDURE helps people with head and neck cancer start their necessary radiation therapy sooner after surgery. It will compare the new program to the usual way patients are scheduled for treatment. The goal is to see …

This study is testing whether a brain stimulation training method can improve arm and hand movement in people with chronic cervical spinal cord injuries. Researchers will use a non-invasive magnetic brain stimulator to try to strengthen the weakened brain-to-muscle connections th…

This study is testing a decision-making tool designed to help emergency room patients with opioid addiction understand and choose buprenorphine treatment. The tool will be compared to standard care to see if it improves patient knowledge, reduces decision-making stress, and incre…

This study is testing whether adding formoterol, a medication commonly used for asthma, to standard care can help people with diabetic kidney disease. About 120 participants will be randomly assigned to receive either formoterol plus their usual care or just their usual care alon…

This study is testing whether a simple text-message system can help cancer survivors who have symptoms of depression get connected to mental health care. The goal is to see if this approach is easy to use and helpful for patients. Researchers will enroll 60 adult cancer survivors…

This study is testing whether an online questionnaire can help people quit smoking. About 672 adult smokers will be randomly assigned to either complete the online visit or not. The online visit asks about smoking habits and motivation to quit, and may lead to a prescription for …

This study compares two standard radiation techniques for treating large brain tumors that have spread from other cancers. It aims to see which method—delivering radiation in two sessions spaced weeks apart versus delivering it in three to five daily sessions—is better at control…

This study is testing a step-by-step support program called TRRP to help people get mental health care after a serious physical injury. It will involve 350 patients at a Washington D.C. hospital who are at risk for PTSD or depression. The program provides education, check-ins via…

This study is testing whether a therapy program with a supporting mobile app can help pregnant people stay on their prescribed medication for opioid use disorder. It compares this app-based support to simply tracking medication use in a diary. The goal is to see which approach is…

This trial is testing a new treatment combination for an aggressive type of breast cancer (triple-negative) in patients who have heart problems and cannot safely receive the usual chemotherapy drugs. The goal is to see if a 12-18 week regimen of three different drugs (carboplatin…

This study aims to find the most effective way to deliver smoking cessation support to people living with HIV. Researchers are comparing a new, proactive outreach program that contacts patients directly with the standard clinic-based approach. The goal is to help more people quit…

This study is testing whether a modified version of cardiac rehabilitation—a standard heart recovery program—can help stroke survivors improve their physical function and mental well-being. Researchers will enroll 76 stroke survivors, including those with and without depression, …

This program provides continued access to the drug vatiquinone for patients with inherited mitochondrial diseases, such as Leigh or Alpers syndrome. It is specifically for people who previously took the drug in a related clinical trial and, in their doctor's opinion, would benefi…

This study is testing whether varenicline (Chantix), a medication approved for quitting smoking, can also help people reduce or stop using marijuana. Researchers want to see if the medication works better than a placebo pill when combined with counseling for 200 adults in South C…

This study is testing three different treatments to help people who have been taking prescription opioids for chronic pain for a long time. The goal is to see if adding a buprenorphine patch, a type of counseling called cognitive behavioral therapy, or a non-invasive brain stimul…

This study is testing a new radiation technique for men with high-risk or locally advanced prostate cancer. It combines shorter, more intense radiation treatments with an extra 'microboost' dose focused on the most aggressive tumor areas. Researchers want to see if this approach …

This study is testing whether adding two existing drugs, hydroxychloroquine and nelfinavir, to standard maintenance therapy helps control ovarian cancer longer. It will involve 38 patients whose cancer has returned but initially responded well to platinum chemotherapy. The main g…

This study is testing a special filter in implanted heart defibrillators that aims to tell the difference between dangerous heart rhythms and harmless muscle movements. People who already have this specific defibrillator will do simple arm exercises during a routine checkup while…

This study is testing whether switching cancer patients who smoke to e-cigarettes is a helpful alternative when they refuse all standard quit-smoking treatments. Researchers will compare e-cigarette use to standard care in 208 patients to see which approach helps more people stop…

This trial is testing a new therapy called BabyStrong that pairs gentle ear stimulation with bottle feeding to help infants who struggle to learn how to eat. The goal is to help these babies feed fully by mouth so they can go home sooner and avoid needing feeding tubes. Researche…

This study is testing a brief, computerized treatment program designed to help teenagers aged 13-17 who are seeking help for cannabis and/or alcohol use. The program aims to reduce substance use by targeting automatic impulses to approach drugs and alcohol. Researchers will measu…

This study is testing a new computer alert system designed to help primary care doctors better identify patients with fatty liver disease (MASLD) who are at risk for serious liver scarring. The system works quietly in the background of electronic health records, prompting doctors…

This study is testing new, faster MRI scanning techniques to see if they can better detect and monitor damage in heart muscle diseases. Researchers will enroll 240 adults who already need a heart MRI for conditions like cardiomyopathy or myocarditis. The goal is to see if these n…

This study is testing a new way to screen for depression in people who have survived cancer. Researchers want to see if sending a short depression questionnaire via text message before a doctor's appointment is a practical and acceptable method. They will compare this text-based …

This study is testing whether a text message support program can help new mothers spot health problems early and avoid unnecessary trips to the emergency room. It will compare the usual in-person check-ups to the usual care plus a text-based program where a nurse checks in and he…

This study is developing and testing a virtual reality tool designed to help prevent HIV infection and reduce substance abuse among young people who have experienced trauma. It involves young men who have sex with men and adolescents with substance use issues, aged 15-30, from th…

This study is testing if a special low-level laser can help gums heal faster and with less pain after a tooth is pulled. Researchers will compare patients who get the laser treatment on days 1, 3, and 7 after their procedure to those who receive standard care. They will measure h…

This study is testing whether a simple, non-drug device can make getting an IUD less painful. Researchers are comparing a handheld electrical nerve stimulator to a placebo device in 86 women during their IUD insertion appointment. The goal is to find a safe, easy way to manage th…

This study is testing a faster version of a non-invasive brain stimulation treatment for women with postpartum depression. Researchers want to see if giving many short sessions over just 5-6 days is practical and tolerable, compared to the standard 6-week treatment. They will als…

This study is testing a mobile app called SUPPORT-T to see if it's a practical and helpful way to deliver supportive care to people with progressive pulmonary fibrosis (a scarring lung disease) and their caregivers. The app provides a 9-week guided program and virtual support gro…

This study is testing whether a gentle, tingling electrical stimulation on a baby's ear, given during breastfeeding, can help them learn the feeding skills of latching, sucking, and swallowing more effectively. It will involve 10 premature or sick term infants in the NICU who are…

This early study is exploring a new, intensive treatment approach for functional seizures, which are distressing episodes that resemble epileptic seizures but have a different cause. Researchers are testing if delivering magnetic pulses to a specific part of the brain over just 3…

This study is testing a smartphone app designed to help people who are starting medication treatment for opioid addiction get better sleep. The app uses proven techniques from sleep therapy. Researchers will enroll 40 people to see if the app is easy to use and if it helps improv…

This study is testing whether a non-invasive brain stimulation technique called rTMS can safely help people who have lost motivation and interest in life after a stroke. Researchers will deliver multiple short stimulation sessions over two weeks to a specific brain area linked to…

This study is testing whether a special mobile app can help teenagers and young adults with sickle cell disease better manage their symptoms and daily care. Researchers want to see if using the app improves quality of life, reduces pain interference, and helps with the transition…

This study is exploring whether a month of at-home ear stimulation can reduce chronic pain in people who have had a stroke. Researchers will enroll 24 adults with long-term arm pain following a stroke to test if this non-invasive treatment provides relief. They will also use brai…

This study is testing whether a non-invasive brain stimulation technique can help improve apathy (loss of motivation) in people with Parkinson's disease. Fifteen participants will receive multiple short magnetic stimulation sessions each day over two weeks. Researchers will measu…

This study is testing whether giving n-acetylcysteine (NAC) during a hysterectomy surgery can help reduce pain and the need for opioid painkillers afterward. It involves 240 women having laparoscopic or robotic hysterectomies. Participants will receive either NAC or a placebo dur…

This study is testing whether wearing special light-emitting glasses in the morning can help reduce symptoms of irritable bowel syndrome (IBS). Researchers will enroll 30 adults with IBS who also have disrupted sleep patterns. Participants will try both the active light glasses a…

This study is testing if giving a single dose of methadone during knee replacement surgery helps reduce pain and the need for strong opioid painkillers afterward. It involves 162 adults getting elective knee surgery under spinal anesthesia. The goal is to see if this method leads…

This study is testing a brief telehealth program called Project Support for families whose children are on a waitlist for trauma therapy. It aims to teach parents skills to better comfort and listen to their child during the waiting period. Researchers will compare this program t…

This study is testing whether a temporary, minimally invasive nerve stimulation device can safely and effectively reduce chronic lower back pain that comes from the sacroiliac joint. It will involve 10 adults who have not found relief from standard treatments like physical therap…

This study is testing if a smartphone app called 'Moodivate' can help reduce depression in people living with incurable cancer. About 279 participants will be randomly chosen to either use the app or not for 12 weeks. The goal is to see if this easy-to-access digital tool can imp…

This study is testing whether a special wearable sock can help adults who still have bladder leaks despite taking medication for overactive bladder. The ZIDA Control Sock delivers mild electrical stimulation near the ankle once a week at home for 12 weeks, while participants cont…

This study is testing a robotic hip exoskeleton to see if it can help improve walking balance in people who have had a stroke. Researchers will have 21 participants walk on a treadmill while wearing the device, which applies gentle forces to help stabilize their hips. The goal is…

This study is testing whether a non-invasive brain stimulation treatment called rTMS is safe and helpful for reducing depression in people with spinal cord injuries. Fourteen participants with depression and cervical or thoracic spinal cord injuries will receive magnetic stimulat…

This study compares two sedation medications, remimazolam and propofol, for patients undergoing laser treatment for burn scars. The main goal is to see which drug causes fewer breathing problems during the procedure. Participants will try both drugs in separate sessions to measur…

This study is testing whether a parenting therapy program delivered through video calls can help improve behavior in young children who have experienced stress or trauma. Researchers will compare 20 families receiving the video-call therapy to 20 families on a waitlist. The goal …

This study is testing whether giving a single dose of methadone during hip replacement surgery helps reduce pain and the need for opioid painkillers afterward. Researchers will compare methadone to standard pain control in 162 adults having elective hip replacement. The goal is t…

This study is testing whether training leg reflexes can reduce chronic nerve pain in people with spinal cord injuries. Researchers are recruiting 15 people with this type of pain to participate in about 50 training sessions over 6.5 months. The goal is to see if this specific tra…

This study is testing whether a combination of personalized brain stimulation and walking exercises is practical and tolerable for people with Parkinson's disease who experience sudden freezing while walking. Researchers want to see if this approach shows early signs of improving…

This small pilot study is testing a personalized brain stimulation technique to help improve hand-eye coordination and grip control in people with brain injuries. Researchers use a combination of brainwave monitoring and magnetic stimulation to try to improve how different brain …

This study is testing a new, non-invasive magnetic therapy applied to the back to see if it can reduce symptoms of diabetic gastroparesis, a condition where the stomach empties too slowly. Researchers will compare the real treatment to a sham (fake) treatment in 48 adults with mo…

This study is testing whether a brief video-based therapy program can help head and neck cancer survivors who are struggling with body image distress. The trial will enroll 180 survivors who have finished cancer treatment and randomly assign them to either the new therapy program…

This study aims to understand how social relationships and daily interactions affect treatment success for people with opioid addiction. Researchers will follow 100 patient-caregiver pairs for 12 weeks, using smartwatch apps and daily surveys to track social behaviors, medication…

This study aims to understand how a non-invasive brain stimulation device (rTMS) might change how people with anxiety disorders react to and cope with fearful situations. Researchers are recruiting 80 adults currently in treatment for anxiety to measure brain activity, heart rate…

This early-stage study aims to see if taking cannabidiol (CBD) causes biological changes in breast cancer tumors before a patient's scheduled surgery. Researchers will enroll 60 people with breast cancer and randomly give them either CBD or a placebo pill for 5 to 56 days before …

This study aims to understand why some Parkinson's patients experience thinking and memory problems after deep brain stimulation (DBS) surgery. Researchers will use MRI brain scans on 55 patients who have had the surgery, comparing brain activity with the stimulation turned on an…

This study aims to understand how a gentle electrical stimulation to the ear can reduce pain. Researchers are testing if this method works by triggering the body's own natural pain-relieving chemicals, called endogenous opioids. They will test this in 136 healthy volunteers by co…

This study aims to understand how a potential government ban on menthol in cigarettes and e-cigarettes would affect current menthol smokers. Researchers will give 240 adult smokers different combinations of menthol or non-menthol products for 7 weeks and track their daily use. Th…

This study is a large international registry collecting information on patients who have surgery for brain conditions like stroke or aneurysms. It aims to gather data on outcomes and complications from 40,000 patients to help doctors predict results and compare different surgical…

This study aims to understand how well a hospital-based violence intervention program works in the Southeastern United States. Researchers will gather information from young patients who were injured by violence, their family members, and healthcare providers. The goal is to lear…

This study aims to understand how different types of support from family and friends—like emotional encouragement or practical help—affect a person's ability to manage their COPD symptoms day-to-day. Researchers will survey and interview about 111 adults with COPD to learn what s…

This study is investigating whether a non-invasive technology called transcranial focused ultrasound (tFUS) can temporarily change activity in deep brain areas involved in anxiety. Researchers are recruiting 40 people who recently started treatment for anxiety to complete tasks a…

This study aims to understand how a fast-acting depression treatment called accelerated TMS affects brain activity. Researchers will use MRI scans to track brain changes in 20 people with depression before and after one week of treatment. The goal is to see if brain imaging can s…

This research aims to better understand how heavy drinking and post-traumatic stress disorder (PTSD) together might influence conflict and aggression between partners. The study will observe 70 couples, some with PTSD, in both a controlled lab setting and their daily lives over 2…

This study aims to understand how gentle electrical stimulation on the ear affects brain activity. Researchers will use MRI scans to see which brain areas become active when different ear nerves are stimulated in 96 healthy volunteers. The goal is to learn how this non-drug appro…

This study aims to understand how stress and cannabis withdrawal affect young men and women differently. Researchers will observe 148 young adults with frequent cannabis use as they temporarily stop using it and undergo a controlled stress test. The goal is to gather information …

This study aims to find out if the standard fasting rules before surgery are safe for people taking GLP-1 medications like Ozempic or Mounjaro. Researchers will compare two groups: one following the usual 8-hour fast and another on a 24-hour liquid-only diet. Using an ultrasound,…

This study aims to understand how the brain processes emotions and thoughts in both healthy people and those with depression. Researchers will use brain scans and gentle magnetic stimulation while participants do computer tasks. The goal is to gather information that could lead t…