Medical University Of South Carolina

This study tests whether citicoline, an over-the-counter supplement, can help young people ages 16 to 22 with alcohol use disorder. Over 4 weeks, participants receive either citicoline or a placebo. Researchers measure changes in immune markers, brain chemistry, and thinking skil…

This study tests a smartphone app that helps kidney transplant patients track their medications, blood pressure, and blood sugar. The goal is to improve health outcomes, especially for African American patients who often have worse results after a transplant. The study includes 1…

This study tests a simple alert built into hospital electronic health records. When a doctor writes a note for a patient who smokes, the alert automatically suggests prescribing nicotine replacement therapy and ordering lung cancer screening. The goal is to see if this reminder h…

This study looks at whether giving e-cigarettes to cancer patients who smoke—and who have turned down standard quitting help—can help them switch away from regular cigarettes. About 208 adults with cancer will either receive an e-cigarette and support to switch, or standard care …

This study tests a 6-month home-based program called FIT Families, designed to help African American teens with obesity and their caregivers lose weight. The program includes coaching sessions, family counseling, and small prizes for completing tasks. Researchers will measure cha…

This study looks at whether a therapy called RRFT, which treats substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with both conditions will be randomly assigned to RRFT or usual care, and tracked for a year. The …

This early-stage trial tests whether a single infusion of umbilical cord stem cells can safely preserve insulin production in adults newly diagnosed with type 1 diabetes. Sixty participants will receive either the stem cells or a placebo. The main goal is to see if the treatment …

This study tested a new approach for people with severe depression that hasn't improved with other treatments. A small wire was placed on the surface of the brain to send gentle electrical pulses to areas that control mood. The goal was to see if this is safe and could help reduc…

This program offered vatiquinone, an experimental liquid medication, to patients with inherited mitochondrial diseases like Leigh syndrome who had already completed a previous safety study. The goal was to continue treatment for those who might benefit, but enrollment is now clos…

This early-phase study tests whether a type of brain stimulation called rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Participants receive 50 sessions of stimulation over one week. Researchers will measure changes in thi…

This study tests whether an electronic visit (e-visit) can help adults aged 40+ in rural areas quit smoking and get screened for COPD. Participants are randomly assigned to receive the e-visit or standard care. The e-visit is like an online questionnaire about smoking history and…

This study tests a new way to deliver high-dose radiation (SABR) for low- and intermediate-risk prostate cancer. The technique, called SUPR-SABR, is designed to avoid the urethra, rectum, and pudendal artery to reduce urinary and bowel side effects. About 42 men will receive five…

This study tests a shorter, 5-day course of radiation before surgery for soft tissue sarcoma, instead of the usual several weeks. The goal is to see if patients choose this option and if it works as well for controlling the tumor. About 16 adults with sarcoma in an arm, leg, or t…

This study was designed to test a device called the Globus Reflect Tether for children and teens with scoliosis who are still growing. The device is surgically attached to the spine to hold the curve in place, allowing the other side to grow and gradually straighten the spine. Th…

This study tests if a new, automated laser treatment (DSLT) works as well as the standard laser treatment (SLT) for lowering eye pressure in people with open-angle glaucoma. About 51 adults will receive one of the two treatments and be followed for 12 months. The goal is to see i…

This study tests a short, high-dose form of brain stimulation called repetitive transcranial magnetic stimulation (rTMS) in 20 people who had a stroke at least 6 months ago. The goal is to see if it is safe and acceptable, and whether it can improve cognitive problems like memory…

This study looks at two new strategies for people who tried to switch from smoking to nicotine pouches but couldn't stop completely. Ten adults who already completed a related study will either use stronger nicotine pouches or add a nicotine patch to their pouches. The goal is to…

This early-stage trial tests a noninvasive device that uses magnetic pulses to stimulate nerves in the upper back. The goal is to reduce severe nausea, vomiting, and stomach pain in people with diabetic gastroparesis (stomach paralysis). About 48 adults with moderate-to-severe sy…

This study adapts Written Exposure Therapy (WET), a brief 5-session treatment, for adolescents aged 12-18 with PTSD. Researchers will first gather feedback from experts and teens, then test the adapted therapy against the standard 12-16 session treatment in 48 teens. The goal is …

This study tests whether bright light therapy can help ease depression symptoms in adults aged 60 and older who are hospitalized for unipolar depression. Twenty participants will receive either active light therapy or a dim placebo light. The main goals are to see if the treatmen…

This study compares a text message-based mental health and substance use screening program (Listening to Women & Pregnant and Postpartum People) to standard in-person screening. Over 10,000 pregnant and postpartum people will participate. The goal is to see if the text-based appr…

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both alcohol use disorder and PTSD. About 175 veterans will get either oxytocin or a placebo along with therapy. The goal is to see if oxytocin helps the…

This study tests an accelerated version of a brain stimulation treatment called TMS for people with depression and anxiety. Researchers want to find the best dose to reduce symptoms. About 70 adults will take part, and the study measures changes in mood using standard questionnai…

This study tests whether blocking certain arteries in the knee (geniculate artery embolization) can reduce pain and the need for opioid painkillers in people with knee osteoarthritis. Twelve participants will receive the procedure and be followed for a year with MRI scans and pai…

This study tests whether Qutenza 8% capsaicin skin patches can safely and effectively treat nerve-related lower back pain and leg pain (sciatica). Fifty adults with symptoms lasting over three months will receive up to four patches per visit over five visits in a year. The main g…

This study tests whether a cream containing rapamycin, applied daily for six months, can help restore skin color in people with vitiligo. Twenty participants aged 13 and older with nonsegmental vitiligo will apply the cream to one patch of skin and a placebo to another. The goal …

This study looks at whether adding art therapy to physical therapy can help children aged 5 to 18 recover emotionally and physically after a stem cell transplant. For two weeks, some children receive both art and physical therapy daily, while others get only physical therapy. Res…

This small pilot study tested whether low-intensity focused ultrasound can safely ease symptoms in people with treatment-resistant depression. The device targets a brain region linked to mood. Only 1 person was enrolled, and the trial is currently suspended, so results are very l…

This early-phase study tests whether a noninvasive technique called transcranial focused ultrasound (tFUS) can improve memory in people with mild neurocognitive disorder and in healthy older adults. Using MRI guidance, the device sends sound waves to specific brain areas. The tri…

This study looks at whether using text messages to screen for depression is practical and well-liked by cancer survivors. About 60 adults with cancer will be asked to respond to a short depression questionnaire via text. The goal is to see if this method works better than the usu…

This study looks at how Transcranial Magnetic Stimulation (TMS) changes the brain in people with major depression. Researchers will use MRI scans to track these changes over 6 weeks. The goal is to better understand how TMS works, not to test a new treatment. 40 adults aged 18-65…

This study looks at whether stopping overnight neurological checks in stroke patients can help prevent delirium, a common and serious complication. Researchers will compare patients who continue standard overnight checks with those who have them stopped, measuring rates of deliri…

This pilot study tests whether a newer type of CT scanner (photon counting detector CT, or PCD-CT) can improve the quality of PET images for people with head and neck cancer. Twenty adults who are already scheduled for a standard PET-CT scan will also receive a PCD-CT scan. Resea…

This study explores how the brain changes old movement memories, like a bad golf swing or piano technique. Researchers will use EEG to measure brain activity and apply gentle electrical stimulation to see if they can help people learn a new movement. The goal is to understand the…

This study tests a program called ENHANCE-TTS that trains pharmacists at HIV clinics to provide tobacco treatment. Researchers will see if the program helps pharmacists offer more smoking cessation services and if it helps patients quit. About 172 people from six clinics will tak…

This study aimed to see if personalized, noninvasive brain stimulation could improve working memory in healthy adults aged 50 to 85. Researchers planned to test different stimulation settings and measure brain activity changes. However, the study was withdrawn before any particip…

This study aimed to see if personalizing the dose of a gentle brain stimulation technique called tDCS could make it work better for improving movement. It planned to include healthy people and stroke survivors, but was withdrawn before anyone joined. No results are available.

This study looks at whether lead stored in bones is linked to worse mental health or weaker responses to brain stimulation therapies like TMS and tDCS. Researchers will test bone lead levels in 500 psychiatric patients and compare them with cognitive tests and psychiatric symptom…

This study was designed to see if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could temporarily alter how healthy people make rational decisions. Participants would have undergone two sessions of either real or sham stimul…

This study planned to use focused ultrasound to stimulate a deep brain region involved in alertness. Researchers wanted to see if it could improve reaction time and change brain wave patterns. The trial was withdrawn before any participants were enrolled, so no results are availa…