Refractive error

Researchers are testing whether a newer LASIK technique, called ray-tracing-guided, can help people with nearsightedness and astigmatism see better in low light. The study will compare vision after surgery to vision with glasses before surgery, and also measure satisfaction with …

This study looks at whether giving free reading or distance glasses to older adults in rural areas can slow down memory and thinking problems. About 964 people aged 60-79 with poor eyesight but normal hearing and memory will take part. Half will get glasses, and the other half wi…

This trial tests whether individually customized bifocal spectacles with a peripheral defocus design can slow the progression of myopia (nearsightedness) in children aged 4 to 12 who have had surgery for congenital cataracts. Participants will be randomly assigned to wear either …

This study tests a new way to implant a corrective lens inside the eye for people with high myopia (severe nearsightedness). The new method uses a saltwater solution instead of a gel to keep the eye stable during surgery. Half of the participants will have the new method in one e…

This study tests whether a home-based computer program, called Gabor-based perceptual learning, can improve vision in adults with amblyopia (lazy eye). Participants aged 18-39 will be randomly assigned to either start training immediately or after a 12-week delay, with all receiv…

This study tests whether D.I.M.S. glasses, which have special lenslets that create blur in the peripheral vision, can slow the progression of myopia (nearsightedness) in children aged 6 to 15. Participants wear the glasses while awake and visit the clinic every six months for eye…

This study tests two treatments to slow the progression of myopia (nearsightedness) in children aged 5 to 12. One treatment uses special glasses with tiny lenslets that may reduce eye growth, and the other uses low-dose atropine eyedrops. Over 300 children will be followed for 2 …

This study is testing a new type of artificial lens, called the Clareon TruPlus, for people having cataract surgery. The lens is placed inside the eye to replace the cloudy natural lens and help restore clear vision. About 122 adults with cataracts and astigmatism will receive th…

This study tests if a special red light device can slow down damage to the back of the eye in people with severe nearsightedness (pathologic myopia). About 158 adults will use the device or a fake one for 3 minutes, twice a day, 5 days a week for a year. Researchers will check if…

This study tests a new type of eyeglass lens designed to slow down nearsightedness (myopia) in children aged 6 to 14. The new lens is compared to an older version to see which works better. Each child will wear both lenses over a year, and researchers will measure eye growth and …

This study tests whether T10430 eye drops can safely slow or stop the progression of nearsightedness (myopia) in children aged 6 to 12. Myopia often starts in childhood and can lead to serious eye problems later in life. The trial will enroll 200 children to check for side effect…

This study looks at three ways to correct nearsightedness in children: special glasses, regular glasses, and overnight contact lenses. It will track 90 kids aged 7–17 for one year to see how each method affects their quality of life, vision, and family costs. The goal is to help …

This study tests whether a very low dose of atropine eye drops (0.01%) given once nightly can slow the progression of nearsightedness (myopia) in children aged 4 to 16. Over 6 months, 60 children will either receive the drops or be in a control group. The goal is to see if the dr…

This study is testing whether providing free glasses to older adults in India who need them can slow down age-related cognitive decline. Over 800 people aged 60 and older with uncorrected vision problems will be randomly assigned to receive glasses or not. Researchers will track …

This phase 3 study tests whether low-dose atropine eye drops (0.025% and 0.05%) can slow the progression of myopia (nearsightedness) in children and teens aged 3 to 17. About 234 participants across Europe will use the drops once nightly for 2 years. The goal is to see if these d…

The DYMOND study is testing a digital app called TrackSight that may slow myopia (nearsightedness) in children aged 6 to 12. The app uses eye-tracking to keep central vision clear while slightly blurring the edges of the screen, based on principles that influence eye growth. Abou…

This study tests special glasses called MiYOSMART iQ that use tiny lens segments to create a blur signal on the side of the eye, which may slow down the worsening of nearsightedness in children. About 35 kids aged 8-11 will wear these glasses for 6 months, and their results will …

This study tests whether a low-level red-light device can slow the progression of myopia (nearsightedness) in children aged 8 to 13. Participants use the device for 3 minutes twice a day. The goal is to see if it reduces eye growth and prevents worsening vision, building on promi…

This study tests if a special red-light device, used at home for 3 minutes twice a day, can safely improve eye health in adults with nearsightedness (myopia). Fourteen adults aged 18-50 will use the light for 28 days. The goal is to see if the therapy thickens a layer in the eye …

This study tests whether a custom-made lens implanted during cataract surgery can better correct vision in people with irregularly shaped corneas. Fifteen adults with significant astigmatism will receive the special lens. The goal is to reduce total astigmatism and improve visual…

This study is checking the long-term safety of the IC-8 Apthera lens, which is implanted during cataract surgery. It focuses on a common complication called posterior capsule opacification (PCO), where the lens capsule becomes cloudy. Researchers will follow 435 people for 24 mon…

This study tests whether low-dose atropine eye drops (0.025%) can safely slow the progression of myopia (nearsightedness) in children aged 5 to 10. Over two years, 144 children will receive either the active drops or a placebo. The goal is to see if the drops reduce how quickly t…

This study tests two types of special glasses (D.S.D.O. lenses) designed to slow the progression of nearsightedness (myopia) in children aged 6 to 14. About 120 children will wear the glasses daily for one year and have regular eye checkups. The goal is to see if these lenses can…

This study tests whether special spectacle lenses can slow the progression of myopia (nearsightedness) in children aged 6 to 8. About 150 kids will wear either the test lenses or regular lenses for up to 3 years. Researchers will measure changes in eye focus and eye length to see…

This study tests special spectacle lenses designed to slow the progression of nearsightedness (myopia) in Chinese children. About 175 children who completed a prior study will wear the lenses for 12 months. Researchers will measure changes in eye length to see if the lenses help …

This study tests whether a probiotic called MR-61 can help slow the worsening of nearsightedness (myopia) in children and teens aged 3 to 18. Participants will take either the probiotic or a placebo daily for a period, and researchers will measure changes in their vision and eye …

This study tests whether making tiny arcuate incisions on the cornea during cataract surgery, combined with a special light-adjustable lens, can better correct pre-existing astigmatism. About 60 adults will receive this treatment and be followed to see how much their vision impro…

This study compares two types of trifocal toric lens implants used during cataract surgery to correct both cataracts and astigmatism. About 138 adults with cataracts and regular astigmatism will receive one of the two lenses. The main goal is to see which lens provides better int…

This study tests whether wearing specialized soft contact lenses for short periods each day can slow the progression of nearsightedness (myopia) in children. Eighty kids who already wear contacts will use one of two lens types daily for a year. Researchers will measure changes in…

This study compares a new type of LASIK (Ray-Tracing Guided) with three other common laser eye surgeries (SMILE, Wavefront Optimized LASIK, and Topography Guided LASIK) to see which one provides the best vision after surgery. Researchers will enroll 120 people with nearsightednes…

This study tests whether specially designed spectacle lenses can slow the progression of myopia (nearsightedness) in children aged 6 to 12. Over two years, 185 children will wear either the special lenses or standard single-vision lenses. The goal is to see if the special lenses …

This study tests two types of atropine eye drops and special glasses with tiny lenslets to slow myopia (nearsightedness) in children aged 3-6. About 508 kids will use one of these treatments nightly or daily. The goal is to see if these methods can prevent rapid worsening of eyes…

This study compares two approaches to control myopia (nearsightedness) in children aged 7 to 9: low-dose atropine eye drops and special glasses called DIMS lenses. Over 24 months, researchers will measure changes in vision and eye structure to see which treatment works better for…

This study tests whether low-dose atropine eye drops (0.02% or 0.04%) combined with special glasses (DIMS) can slow the progression of moderate to high myopia (nearsightedness) in children aged 6 to 12. About 410 children will be assigned to different treatment groups and followe…

This study tests a machine learning model that predicts how much nearsightedness a person has without using dilating eye drops. The model uses standard eye measurements like autorefraction and corneal shape. If accurate, it could make eye exams quicker and more comfortable for ad…

This study will enroll 500,000 people with high myopia and cataracts to develop an artificial intelligence model that helps doctors calculate the correct lens power and grade cataracts more accurately. The goal is to improve vision outcomes and reduce complications after surgery.…

This study tests whether a computer program (a deep neural network) can accurately predict the best lens size and position for people having surgery to correct nearsightedness. About 326 adults aged 18-45 will have their eyes scanned before surgery, and the AI's predictions will …

This study is testing whether artificial intelligence can analyze eye images to better detect and predict vision-threatening changes in people with high myopia (severe nearsightedness). Researchers will collect eye scans from 1,000 patients and use AI to identify a condition call…

This study is testing a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of 168 volunteers, including healthy people and those with keratoconus or post-LASIK ectasia, t…

This long-term study is looking for the best methods to detect glaucoma and track its worsening over time, especially in people with nearsightedness (myopia) and those of African or European descent. Researchers will use advanced eye imaging to monitor changes in the back of the …

This study tests whether a nightly drop of low-dose atropine in both eyes can delay the start of nearsightedness in children aged 6–11 who are not yet nearsighted. Over 600 kids will be randomly assigned to get either the atropine drops or placebo drops for two years. The main go…

This trial tests whether a wearable device that tracks and reminds children to spend more time outdoors can help prevent nearsightedness (myopia). Primary school students with adequate hyperopic reserve—a natural buffer against myopia—will be randomly assigned to either a program…

This trial tests whether auricular acupressure—small adhesive patches with seeds placed on specific ear points—can prevent myopia in children who are at higher risk. Primary school students in grades 1-4 with insufficient hyperopic reserve (a sign they may become nearsighted) wil…

This trial tests whether combining auricular acupressure (small seeds placed on the ear) with defocus spectacle lenses can slow the progression of nearsightedness (myopia) in primary school children. About 358 students in grades 1-4 with premyopia or myopia will be randomly assig…

This study tests whether dual focus contact lenses can prevent myopia (nearsightedness) in children aged 8 to 10 who are at risk. Over 2 years, researchers will check if these lenses stop the onset of myopia compared to standard lenses. If it works, it could offer a simple way to…

This study tests a device that makes reading feel like looking at something far away, to prevent myopia in children aged 6-12 who are at risk. Eighty kids will use the device for at least an hour daily during homework, and researchers will compare their eye changes to a group doi…

This study tests two ways to prevent or slow myopia (short-sightedness) in children aged 7 to 10. One group gets special classroom lights that mimic sunlight, another group's parents get a smartphone app that encourages more outdoor time, and a third group gets standard care. Ove…

This trial compares two types of laser eye surgery—SMILE and ray tracing-guided LASIK—in people with nearsightedness and astigmatism. Each participant will receive one technique in one eye and the other in the other eye, allowing a direct comparison. The goal is to see which meth…

This trial tests whether a small adjustment during SMILE laser surgery—compensating for the eye's natural offset (kappa angle)—can improve visual quality for people with nearsightedness. About 224 participants will receive either standard SMILE or SMILE with this compensation. Re…

This study tests two different methods of centering laser eye surgery (SMILE) in people with nearsightedness and a large angle kappa—a natural offset between the visual axis and pupil center. One method uses a 50% correction, the other 100%. Researchers want to see which approach…

This study tests if a newer laser method (PRESBYOND laser blended vision) is better than standard monovision LASIK for treating presbyopia, which makes it hard to see up close as you age. About 100 adults aged 40 to 55 will be randomly assigned to one of the two surgeries. They w…

This study looks at whether people who already wear INFUSE One-Day multifocal contact lenses for presbyopia (age-related blurry near vision) feel more comfortable and see better after switching to DAILIES TOTAL1 multifocal lenses. About 30 satisfied lens wearers, aged 40 and olde…

This study tests a small device called the VisAbility™ Micro Insert System, which is placed in the eye to help people with presbyopia (age-related trouble seeing up close) read without glasses. It involves 33 adults aged 45 to 60 and will track safety and vision improvement over …

This study tests whether Total30 multifocal toric contact lenses are more comfortable and provide better vision than current lenses for people with presbyopia (age-related blurry near vision). 32 adults aged 40 and older who already wear toric contacts will try the new lenses for…

This study looks at whether Systane COMPLETE artificial tears can improve dry eye symptoms and help doctors better predict cataract surgery outcomes. About 140 cataract patients with dry eye will use the drops before and after surgery. Researchers will measure changes in eye shap…

This study compares two daily disposable multifocal contact lenses for people with presbyopia, an age-related condition that makes it hard to see up close. About 35 adults who already wear soft contact lenses will test each lens for one week. The goal is to see which lens provide…

This study compares two laser platforms used in SMILE surgery to correct short-sightedness (myopia). The standard VISUMAX 500 will be tested against the newer VISUMAX 800 in 100 participants. Researchers want to see if the newer platform provides the same or better vision results…

This study looks at how comfortable daily disposable contact lenses are for people with astigmatism when worn for long hours. Researchers will ask 40 current soft toric lens wearers to rate their comfort. The goal is to see if these lenses work well for long days.

This study looks at how people with presbyopia (age-related blurry near vision) feel about wearing multifocal contact lenses compared to regular contact lenses plus reading glasses. About 30 adults aged 40 and older will try both options and report which they prefer. The goal is …

This study looks at how quickly and comfortably children aged 6 to 12 with nearsightedness (myopia) get used to special A.M.L. glasses. Forty children will wear the lenses for two weeks and report any discomfort. The goal is to see if most kids adapt within 4 to 6 days without pr…

This study compares two LASIK techniques to see which one corrects nearsightedness and astigmatism better. 70 adults aged 22 and older with healthy eyes will have one eye treated with each method. The goal is to find out if one approach leads to sharper vision without glasses.

This study is testing a new type of daily disposable contact lens called UNICON. It will involve 35 adults who already wear soft contact lenses. Participants will wear the test lenses for up to 13 weeks to see if they are safe and comfortable for correcting nearsightedness.

This study looks at whether people who are happy with their current Acuvue Oasys for Astigmatism contact lenses would like to switch to PRECISION7® for Astigmatism lenses. About 40 adults aged 18 to 40 who wear Acuvue Oasys lenses will try the new lenses and answer questions abou…

This study tests whether Wavelight Plus LASIK, an advanced laser eye surgery, improves vision in both normal and dim lighting for people with nearsightedness and astigmatism. Fifty adults will receive the surgery and be followed for 3 months. Researchers will measure visual sharp…

This study tracks how satisfied 52 people with nearsightedness and astigmatism are after getting Wavelight Plus LASIK, a personalized laser eye surgery. Researchers will measure vision quality, daily life impact, and any visual symptoms like glare or halos for up to 3 months afte…

This study looks at how nearsightedness (myopia) and other vision problems affect the quality of life of Swedish children and teens. Researchers will translate a vision questionnaire into Swedish and test it on 300 healthy kids aged 0-17. Participants will get a full eye exam and…

This pilot study looks at whether refractive surgeries like LASIK change the results of optical coherence tomography (OCT), a common eye scan used to monitor conditions like glaucoma. Researchers will measure the thickness of the retina and other eye layers before and after surge…

This study looks at how accurately different measurement modes capture corneal astigmatism in people who have had cataract surgery. Researchers will compare various device settings to find the most precise way to measure the eye's curvature. The goal is to optimize measurement te…

This study looks at whether certain eye features can predict how well people recover after surgery for myopic foveoschisis, a complication of severe nearsightedness that can threaten sight. Researchers will follow 30 adults aged 40-90 who need vitrectomy, a standard procedure to …

This study looks at whether the stiffness of the cornea influences how much astigmatism (blurring from an irregularly shaped cornea) develops after cataract surgery in people with pseudoexfoliation syndrome, a condition that weakens eye tissues. Researchers will measure corneal b…

This study asks whether the way streets look can change how children see and feel. Researchers will use virtual reality to show children aged 6 to 18 different street scenes and track their eye movements and emotional responses. The goal is to find out which street features matte…

This study looks at 200 highly myopic adults in France, the Netherlands, and Spain to understand why some develop a condition called posterior staphyloma, where the back of the eye bulges outward. Researchers will analyze blood samples and eye images to find genetic and molecular…

This observational study is measuring the eye length of 30,000 Chinese children aged 3 to 18 years to create standard growth charts for healthy eyes. Researchers will follow each child for three years with yearly check-ups. The goal is to better understand how eyes grow and when …

This study follows 100 children ages 4 to 8 who currently have perfect vision to see who develops nearsightedness (myopia) over 2 to 5 years. Researchers will track eye measurements and daily habits to uncover why some children become nearsighted while others don't. The goal is t…

This study investigates how the eye's focusing ability changes after 20 minutes of looking at a screen up close (25 cm) compared to looking at a distant object (10 m). Healthy adults aged 18-35 will perform focusing tasks while a wavefront sensor measures their eye's response. Th…

This pilot study is testing how well children aged 6 to 16 adapt to Essilor Stellest myopia-control spectacle lenses. The goal is to see if kids find them comfortable and easy to wear in real life, which is important for long-term use. Fifty children with progressive myopia will …

This study looks at whether dry eye disease affects the accuracy of corneal measurements needed for cataract surgery planning. 400 cataract patients will be divided into those with and without dry eye. Those with dry eye will use sodium hyaluronate eye drops for two weeks. Resear…

This study follows 60 children aged 7-12 for three years to measure their daily visual environment, including how far they look, light brightness and color, and eye movements. Researchers want to find which factors most influence the development and worsening of nearsightedness (…

This study is creating a large database of eye measurements from 3,000 people with inflammatory eye diseases like diabetic retinopathy and age-related macular degeneration. Researchers will use advanced imaging to collect detailed information from both the front and back of the e…

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…

This study tests whether using a special calculation tool (called a nomogram) helps doctors correct astigmatism more precisely during laser eye surgery. One hundred adults with astigmatism will be treated, and their vision will be checked over three months. The goal is to see if …

This study follows 60,000 people with cataracts, including those with high myopia (severe nearsightedness), to see how their vision changes after cataract surgery. Researchers will also look at genetic and environmental factors that might affect cataract development and surgical …

This study tracks where children aged 7 to 14 look through special spectacle lenses designed to slow nearsightedness (myopia). Researchers want to see if kids look through different parts of the lens depending on what they're doing, like reading or playing. The goal is to underst…

This study looks at whether special glasses for slowing down nearsightedness (myopia) affect how children move and react in daily life. Twenty kids aged 6 to 12 will wear both regular and myopia-control lenses while researchers measure their reaction time, movement speed, and wal…

This study looks at a new way to provide eye care to children in rural China. It will involve about 20,000 kids aged 3 to 18 from schools in several counties. The goal is to see if a coordinated program across local health centers and schools can improve eye screening rates and h…

This observational study looks at whether different eyeglass prescriptions change how close teenagers hold objects during everyday tasks. It includes 100 adolescents aged 12-17, both with and without myopia. Participants wear motion-capture and eye-tracking gear while performing …

This study looks at the structure of children's eyes using MRI and standard eye exams. The goal is to understand why some kids respond better to myopia treatments than others. By collecting detailed images and measurements from 100 children, researchers hope to pave the way for m…

This observational study in 120 healthy young adults aged 21-25 examines whether facial features are linked to eye measurements like eye length, which affects nearsightedness or farsightedness. Participants undergo non-invasive eye exams and 3D facial scans. The goal is to better…

This study tracks 400 adults with cataracts to see how three different toric intraocular lenses rotate after surgery. Rotation is measured at several follow-up visits over three months. The goal is to find which lens stays most stable and help doctors choose the best option for e…

This study looks at how different types of artificial lighting affect how well people see after having presbyopia (age-related blurry near vision) corrected with special extended-depth-of-focus lens implants. Researchers will measure the minimum light needed for clear distance vi…

This early-stage trial is testing whether IVMED-85 eye drops are safe for healthy adults aged 18 to 49. About 36 participants will use the eye drops or a placebo twice daily for 6 weeks. The study focuses on vision changes and eye discomfort, not on treating any disease.

This study is testing whether a computer program called EpiMaster can accurately predict how well laser eye surgery (PTK-PRK) will correct nearsightedness. Researchers will compare the software's predictions to the actual vision results in 150 patients six months after surgery. T…

This study follows 1,000 myopic children in Europe for 5 years, measuring their eye growth every 6 months. The goal is to understand how nearsightedness progresses in this population, since most research has been done in Asia. Participants will have regular eye exams, including a…

This study tests three AI chatbots—ChatGPT 4o, GPT-5, and DeepSeek—on their ability to read eye scans from 100 cataract patients. The AI will try to extract key measurements, recommend the right lens implant, and predict vision after surgery. No treatment is given; the goal is to…

This study looks at whether a special eye scanner (AO-SLO) can reliably measure cone cells in the retina. It also compares people who have used repeated low-level red-light therapy for myopia with those who haven't. The goal is to see if the therapy changes cone cell density. 180…

This study is testing whether a special eye scanner (OCT) can help fit scleral contact lenses more accurately than the usual method. Researchers will enroll 258 people with conditions like keratoconus or scarred corneas. Each participant will have lenses fitted both the standard …

This study is testing whether three different prototype soft contact lenses can cause a short-term change in the thickness of the choroid (a layer at the back of the eye) in people with nearsightedness (myopia). Twenty volunteers aged 18 to 25 will wear each lens for one hour, an…

This study will compare different laser techniques used in eye surgeries for cataracts and myopia. Researchers want to see which method causes less inflammation and oxidative stress, and leads to better vision recovery. 1,000 patients will be followed for three months after surge…