Predicting vision recovery after eye surgery for high myopia
NCT ID NCT07774637
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This study looks at whether certain eye features can predict how well people recover after surgery for myopic foveoschisis, a complication of severe nearsightedness that can threaten sight. Researchers will follow 30 adults aged 40-90 who need vitrectomy, a standard procedure to relieve traction on the retina. Over 12 months, they will measure vision, retinal structure, and other functions to see which factors are linked to successful outcomes. The goal is to better understand when surgery is most beneficial and what predicts visual recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- pars plana vitrectomy with internal limiting membrane peel or flap
- What this could lead to
- If successful, this could help doctors predict which patients with myopic foveoschisis benefit most from early surgery, potentially preserving vision.
- What could go wrong
- This is a small pilot study, so findings may not apply broadly. Surgery carries usual risks like infection or bleeding, and outcomes may vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jun 2024
- Expected to finish
-
Jun 2029
An estimate. End dates often move.
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 90 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
The target population is 30 adults with high myopia and MFS requiring vitrectomy. inclusion critieria * Be 40-90 years old. * Have high myopia, defined as refractive error worse than -6 dioptres and axial length longer than 26 mm. * Be mentally competent to provide informed consent. * Have MFS that meets clinical criteria for surgical intervention, specifically:progressively worsening vision that correlates with structural OCT deterioration over six months; and/or foveal detachment. exclusion criteria * patients with ocular disorders, prior treatments, or other conditions that could affect structural imaging or functional measurements * corneal opacity * uveitis * dense cataract * vitreous haemorrhage * central serous chorioretinopathy * prior retinal laser photocoagulation or photodynamic therapy * previous or concurrent retinal detachment * retinal dystrophies * macular scarring * retinal vascular occlusion * ocular ischaemic syndrome * ungradable OCT/OCTA imaging. * Patients who are cognitively impaired or prisoners are excluded. * Patients considered poor highly myopic surgical candidates are also excluded, including those with myopic choroidal neovascularisation, macular scar, or complete macular atrophy according to the ATN classification. * Participants may also be discontinued from study assessments if OCT imaging is unsatisfactory or ungradable, or if they are unable to complete functional tests such as microperimetry, contrast sensitivity testing, or M-chart assessment.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Myopic foveoschisis are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Singapore National Eye Centre
RECRUITINGSingapore, Singapore, 168751, Singapore