Refractive error

This trial tests whether special eyeglass lenses, called Stellest 2.0, can slow the progression of short-sightedness (myopia) in young adults compared with standard lenses. Participants will wear either the special lenses or standard ones for at least 12 hours a day for two years…

This trial tests a computer-based training method designed to improve stereo vision, or depth perception, in adults with conditions like amblyopia (lazy eye) or strabismus (misaligned eyes). Participants aged 18 to 39 with impaired depth perception will be randomly assigned to ei…

This trial compares two daily disposable multifocal contact lenses to see which provides better vision at near, intermediate, and far distances, and which is safer for the eyes. About 150 adults aged 40 to 70 who need multifocal lenses will wear each type and have their vision te…

Researchers are testing a new type of implantable lens, called a diffractive trifocal phakic ICL, in adults aged 21 to 60 with myopia (nearsightedness) with or without astigmatism. The lens is surgically placed inside the eye to correct distance vision while also aiming to improv…

Researchers are testing a new type of implantable lens, called an aspheric ICL, to correct or reduce nearsightedness (myopia) with or without astigmatism. The lens is placed inside the eye during surgery and is designed to improve vision. This small study will include 10 people a…

This trial evaluates Paragon CRT contact lenses with a 5mm optic zone diameter, worn overnight to temporarily reshape the cornea and correct myopia and astigmatism. Participants aged 6 to 35 will wear the lenses daily for a short period, and their comfort and visual performance w…

This trial tests whether dual-focus contact lenses, which have special rings to slow eye growth, can reduce the progression of myopia (nearsightedness) in young adults aged 18 to 30. Participants will wear either these lenses or standard single-vision lenses for 24 months. The st…

This trial studies children aged 8 to 16 who have used repeated low-level red light (RLRL) therapy for one year to control nearsightedness (myopia). Participants are randomly assigned to either continue the therapy, stop it completely, or gradually reduce it. The goal is to see h…

This study tests whether oral dietary supplements can improve the health of the back of the eye in children with nearsightedness (myopia). About 156 children aged 8-13 will take either a supplement or a placebo for a period, and researchers will measure changes in the thickness a…

This trial tests whether a device called OcuLign, which automatically adjusts for eye rotation during SMILE surgery, corrects astigmatism better than the standard manual marking method. Adults aged 18 to 40 with stable myopia and astigmatism will have one eye treated with each me…

This study tests whether special glasses called Kubota Glass can temporarily change the length of the eye, which is key to controlling nearsightedness (myopia). Participants aged 8 to 24 with mild to moderate myopia will try five different lens settings in a randomized, double-ma…

This study compares two types of spectacle lenses designed to slow the progression of myopia (nearsightedness) in children aged 6 to 10. The goal is to see if the new test lenses are as comfortable and easy to adapt to as the control lenses during the first two weeks of wear. Chi…

This study compares two types of special glasses (DIMS and DOT) to control nearsightedness in children aged 6 to 12 who also have intermittent exotropia (a type of eye misalignment). Researchers want to see which lens works better and whether the glasses affect eye coordination. …

This study tests two types of daily disposable contact lenses designed to slow the progression of myopia (nearsightedness) in children aged 7 to 12. Over two years, 126 Hong Kong Chinese children will wear either a special lens or a standard single-vision lens, with their eyes me…

This study tests two types of modified spectacle lenses designed to slow the progression of myopia (nearsightedness) in children aged 6 to 13. Over one year, researchers will measure changes in the back of the eye (choroid), eye length, and prescription strength. The goal is to s…

This study tests whether special research glasses can reduce the difference in prescription between the two eyes in children aged 6 to 13 with myopic anisometropia (when one eye is much more nearsighted than the other). Twenty children will wear the study glasses and have their e…

This study tests two new types of multifocal glasses designed to manage myopia (nearsightedness) in children aged 8 to 15. Twenty kids who already wear myopia-control glasses will try each new design for a short time to see how well they see and how comfortable they feel. The goa…

This study will enroll about 3,890 children aged 8-12 who still have rapidly worsening nearsightedness (myopia) even after using orthokeratology (Ortho-K) lenses. Researchers will compare four approaches: continuing Ortho-K alone, adding low-dose atropine eye drops, using lenses …

This study tests whether special spectacle lenses can slow the progression of myopia (nearsightedness) in European children aged 6 to 12. A total of 180 kids will wear one of three lens designs for two years. The main goal is to measure changes in eye length and prescription stre…

This study tests if low-intensity red light therapy can slow or stop the worsening of high and extreme myopia (severe nearsightedness) in adults aged 18 to 45. The treatment has shown promise in children, but its effects in adults are unknown. The goal is to prevent vision loss a…

This trial tests a red light device that uses LED light to control myopia (nearsightedness) in children aged 6 to 18. About 206 kids will use either the real device or a fake one to see if the red light can slow eye growth and reduce the need for stronger glasses. The study focus…

This study tests whether low-dose atropine eye drops (0.05%) can slow down worsening nearsightedness in children aged 1 to 7 who have had cataract surgery with an artificial lens implant. Fifty children will receive the drops for 12 months, and researchers will measure changes in…

This study tests if using a special LED red light device twice a day, along with glasses that have defocus lenses, can slow the progression of nearsightedness (myopia) in children aged 6 to 14. About 364 kids will be randomly assigned to different groups to find the best treatmen…

This study tests whether repeated low-intensity red light can treat myopia (nearsightedness) in adults aged 18 to 35. Thirty participants will use a red light device 1 to 3 times daily. Researchers will measure changes in eye length and prescription strength to see if the treatme…

This trial tests whether an enhanced monofocal intraocular lens, set for monovision (one eye for distance, one for near), improves vision without glasses in people with both cataracts and high myopia. Sixty-six participants will receive the lens in both eyes and be followed for o…

This study tests whether low-dose atropine eye drops (0.05%) can slow the progression of myopia (nearsightedness) in children. Forty-five kids with worsening myopia will receive one drop of atropine in one eye and a placebo drop in the other eye every night for 24 months. The mai…

Researchers are testing a new device called SmartEyes that measures refractive errors, which are vision problems like nearsightedness. The study involves 200 children and teens aged 6 to 17 who need eye exams. The trial compares SmartEyes with standard equipment and subjective re…

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study tests a new device designed to measure nearsightedness and astigmatism. Researchers will compare its accuracy to standard tools used by eye doctors. Thirty adults aged 18-39 who wear glasses will participate. The goal is to see if the new device works as well as curren…

This study checks if a Turkish version of the DDIVAT digital vision test gives the same results as the standard Snellen eye chart. About 200 Turkish-speaking adults, with or without glasses, will take both tests. No drugs or procedures are involved, and there are no risks.

This study will test a new artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, glaucoma, and age-related macular degeneration. Researchers will collect 2000 eye scans from patients at Peking Union Medi…

This study tests whether ZEISS MyoActive lenses, designed to send a specific optical signal to the eye, can prevent or delay the onset of short-sightedness (myopia) in children who are not yet myopic but are at risk. Children aged 6 to 12 with mild farsightedness will be randomly…

This trial tests whether special glasses with defocus lenses, aided by artificial intelligence, can prevent myopia in children aged 3 to 6 who are at high risk. The glasses are worn for at least 10 hours a day, and a smartwatch reminds kids to spend time outdoors. The study measu…

This trial tests whether combining a daily 18-minute virtual reality training session with low-dose atropine eye drops can slow the worsening of nearsightedness in children aged 6 to 12. Participants will also wear special glasses that provide defocus to the peripheral vision. Th…

This trial investigates whether a new type of eyeglass lens, called a With-the-Rule Astigmatic Defocus Lens, can prevent the development of myopia (nearsightedness) in children aged 6 to 9 who have low hyperopia (farsightedness). The lens creates a 'defocus' signal around the ret…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study tests whether special glasses lenses can prevent nearsightedness (myopia) in children aged 6 to 8 who are not yet nearsighted. About 255 children will wear either a new type of lens or a standard lens for at least 8 hours a day for one year. Researchers will check thei…

This study tests whether pressing tiny pellets on ear points can delay or prevent nearsightedness (myopia) in children aged 4 to 14 who are at high risk. It compares ear acupressure, low-dose atropine eye drops, and a combination of both. The goal is to find a safe, non-drug way …

This study tests whether low-dose atropine eye drops can prevent nearsightedness (myopia) in children aged 6 to 9 who are at risk. Over 12 months, children receive daily drops, with the dose adjusted based on how fast their eyes change. The goal is to find the best dose to keep t…

This study tests a special optical film called S.T.O.P®KIT that attaches to eyeglasses. The goal is to slow down the growth of the eye in children aged 6 to 10 with mild farsightedness, which may help prevent nearsightedness later. 180 children will be split into two groups: one …

This study tests a 24-week school program to prevent myopia, obesity, and mental health problems in children aged 8-11. The program includes animated videos, family activities, and health lessons. Researchers will compare these kids to those receiving standard health education, t…

This study tests whether sending regular health education messages about eye care to parents via WeChat can improve how children use their eyes and slow or prevent nearsightedness. About 1,330 third-grade students in China will take part, with their guardians receiving the messag…

This study tests whether replacing some regular gym classes with specialized physical education courses can prevent common health issues like nearsightedness, overweight, anxiety, and depression in junior high students. Two hundred students will be randomly assigned to either the…

This study explores whether a type of visual training called perceptual learning can improve uncorrected vision in children aged 6 to 10 with low myopia (mild nearsightedness). Thirty children will be randomly assigned to either a training group that uses a digital Vision Trainin…

This trial compares pain relief from bandage contact lenses soaked in the anti-inflammatory drug ketorolac versus plain lenses after photorefractive keratectomy (PRK), a type of laser eye surgery. PRK often causes significant pain in the first few days as the cornea heals. The st…

This early study tests a special contact lens that has a tiny pinhole built in. The idea is that the pinhole helps focus light better, improving vision for people with presbyopia (age-related blurry near vision) or keratoconus (a cone-shaped cornea). Sixteen adults will try the l…

This study tests whether placing surgical cuts in specific parts of the cornea during cataract surgery can reduce astigmatism (blurry vision from an irregularly shaped cornea) and lower the need for glasses afterward. About 100 people with cataracts and astigmatism will be random…

This study will test a new fitting experience for multifocal contact lenses in 25 people with presbyopia (age-related blurry near vision). Participants, who already wear certain contact lenses, will use an at-home trial kit with the new lens for 15 minutes daily. The goal is to s…

This study tests whether watching 3D movies, combined with standard patching therapy, improves depth perception and vision in children aged 4 to 14 with amblyopia (lazy eye). Half the children will receive patching alone, while the other half will also attend weekly 3D movie sess…

This study tests a special laser to help people who had cataract surgery with a standard lens implant see better up close or correct remaining blurry vision. About 12 participants will receive the laser treatment, and doctors will check if it safely improves near or distance visi…

This study tests a new excimer laser for LASIK surgery to correct mild nearsightedness (up to -1.00 diopter) with or without astigmatism. About 32 adults aged 22 and older will receive the treatment in one or both eyes. The goal is to see if the laser safely and accurately improv…

This study tests a new daily disposable contact lens called ST-1 against an existing lens, Miru 1day UpSide, in 63 people with nearsightedness. Participants will wear the lenses daily for 3 months and have their vision and eye comfort checked regularly. The goal is to see if the …

This early-stage trial tests a non-invasive device that uses controlled UV light to reshape the cornea, potentially reducing the need for reading glasses in people with presbyopia. The study will enroll 25 adults aged 40 to 65 with healthy corneas. The main goal is to see if the …

After cataract surgery, the membrane holding the artificial lens can turn cloudy, blurring vision. The standard fix is a quick laser procedure called Nd:YAG capsulotomy, but doctors disagree on whether it shifts the lens. This study measures the lens position in 80 people using t…

This study tests whether a software program called the Vision Trainer can guide eyeglass prescriptions as accurately as the traditional manual method performed by trained examiners. Adults with myopia (nearsightedness) will have their prescriptions determined both ways, and the r…

This study follows children aged 7-18 who have nearsightedness (myopia) in only one eye and are being treated with MiSight 1 Day contact lenses in that eye. The other, non-myopic eye is simply observed to see if and when it becomes nearsighted. If it does, standard myopia control…

This study follows adults having cataract surgery who choose either a trifocal or monofocal intraocular lens implant. It asks whether one type leads to more difficulty or visual disturbances, like glare or halos, when driving at night. Participants must be licensed drivers with r…

This study checks how accurately eight different formulas predict the lens power needed for people with very short or very long eyes after cataract surgery. Researchers will measure the actual vision result and compare it to what each formula predicted. The goal is to find which …

This study follows 1,000 preschool children (ages 0-6) with refractive errors like nearsightedness, farsightedness, or astigmatism. Researchers aim to map how these conditions progress, identify related health issues, and find the best ways to correct vision early. The goal is to…

This study surveys about 2,800 adults aged 65 and older in Xinxing County, China, to measure how many have untreated vision or hearing problems. Participants receive eye exams, hearing tests, and questionnaires. The goal is to provide local health services with data to improve ca…

This study compares how various myopia control methods—like special glasses, contact lenses, eye drops, and light therapy—affect eye strain in children and adolescents aged 6 to 18. Researchers will survey 600 participants to see which approaches cause the least visual fatigue. T…

This study will use a special imaging device (AS-OCT) to measure the thickness of the cornea's outer layer in 360 adults with nearsightedness, farsightedness, astigmatism, or normal vision. The goal is to see if different vision problems have unique thickness patterns. Participan…

This study looks at why many people in rural Assam who are referred for eye care don't make it to the hospital for treatment. Researchers will test new ways to help patients complete their referrals, like providing transport and reminders. The goal is to increase the number of pe…

This study looks at whether a new, objective way to fit toric contact lenses (for astigmatism) gives the same results as the traditional subjective method. About 45 adults with astigmatism will have their lens prescription checked both ways. The goal is to see if the new method c…

This study looks at whether giving eye doctors AI-generated measurements from retinal images helps them write more accurate and complete reports. About 29 ophthalmologists and trainees will be randomly assigned to use AI tools or just the original images. A panel of senior expert…

This study will measure how eye pressure changes after common laser vision correction surgeries like PRK, LASIK, and femtosecond laser. Researchers will compare two measurement methods—Corvis CT and the standard applanation tonometer—in 50 people aged 19 to 35 with mild to modera…

This study will measure how pupil size and eye shape affect visual quality in 300 people with normal eyes or after refractive surgery. Researchers will use questionnaires and special instruments to track symptoms and eye measurements. The goal is to better understand what influen…

This study will compare 40 nearsighted children to 40 children with normal vision, all aged 8 to 13. Researchers will measure how much oxygen the retina uses and look at blood flow and eye structure. The goal is to learn whether low oxygen plays a role in causing myopia. No treat…

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…

This study tests a special program designed to improve critical thinking, reflective thinking, and motivation to learn in nursing students. About 243 students will take part in the program, which focuses on building skills like problem-solving and open-mindedness. Researchers wil…

This study will check the eyes of 3,000 people in Xinxing County, including schoolchildren, seniors, and people with diabetes. The goal is to measure how common vision problems like nearsightedness and cataracts are, and how well they are being treated. Participants will have sim…

This study looks at how well REVIVE samfilcon B custom toric contact lenses work for people with astigmatism. About 30 adults will wear the lenses, and eye doctors will rate their satisfaction after 14 days. The goal is to see if these lenses provide clear vision and are easy to …

This study looks at how the length of the eye and the amount of nearsightedness or farsightedness relate to the health of the optic nerve and surrounding layers. Researchers will use a special camera (OCT) to take detailed images of the eye in 266 adults. The goal is to better un…

This study will analyze corneal tissue that is normally thrown away during a common myopia surgery called CLEAR (or SMILE). Researchers will test the tissue's strength and structure to learn more about how the cornea behaves. The goal is to improve future eye surgeries by underst…

The goal of this clinical trial is to investigate over a one-year period the effect of myopia control spectacle lenses on astigmatism in children aged 6 to 13 years with myopia and astigmatism. The main question it aims to answer is: \- How does the eye respond at each timepoin…