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Three eye scanners race to settle whether laser capsulotomy shifts the lens

NCT ID NCT07802145

Knowledge-focused Sponsor: Vienna Hospital Association Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

After cataract surgery, the membrane holding the artificial lens can turn cloudy, blurring vision. The standard fix is a quick laser procedure called Nd:YAG capsulotomy, but doctors disagree on whether it shifts the lens. This study measures the lens position in 80 people using three different imaging devices before and after the laser treatment. The goal is to see if the lens moves, how much, and whether any movement changes vision or glasses strength.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nd:YAG laser posterior capsulotomy, a standard laser procedure to clear a cloudy membrane behind an artificial lens after cataract surgery
What this could lead to
If it works, this could clarify whether the artificial lens shifts after laser capsulotomy and whether that shift changes vision or glasses prescriptions, helping doctors choose the best imaging method for follow-up.
What could go wrong
This is a small, observational study that does not change the laser treatment. Results may not apply to all patients, and the three imaging devices might not agree, leaving the question unresolved.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Consecutive pseudophakic patients presenting to the Department of Ophthalmology, Klinik Hietzing, Vienna, Austria, with visually significant posterior capsule opacification for which Nd:YAG laser posterior capsulotomy is clinically indicated. Patients are identified through the routine clinical workflow: the cataract follow-up clinic, referrals from external ophthalmologists, and self-presentation with visual complaints consistent with posterior capsule opacification. Enrolment is consecutive and unselected with respect to IOL model, axial length, time since cataract surgery and morphology of the opacification, so that the cohort reflects the general population of pseudophakic eyes undergoing capsulotomy at the study centre. The decision to perform the capsulotomy is made independently of the study.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pseudophakic eye with visually significant posterior capsule opacification for which Nd:YAG laser posterior capsulotomy is clinically indicated, defined as a subjective visual complaint attributable to the opacification (reduced visual acuity, glare or reduced contrast) together with objectively documented opacification on slit-lamp examination * Previous uneventful phacoemulsification with in-the-bag implantation of a posterior chamber intraocular lens; no restriction on IOL model * At least 3 months between the cataract surgery and the baseline study visit * Age 18 years or older at enrolment * Able to cooperate with the multi-device measurement protocol, including fixation for all three imaging devices and standardized subjective manifest refraction with Jackson cross-cylinder refinement * Written informed consent Exclusion Criteria: * Complicated cataract surgery, including posterior capsule rupture, vitreous loss, zonular dialysis, sulcus intraocular lens placement, anterior vitrectomy, or any other deviation from standard in-the-bag implantation * Previous intraocular lens exchange, repositioning, or secondary piggyback implantation * Previous Nd:YAG posterior capsulotomy of the study eye * Previous corneal refractive surgery of the study eye * Interval intraocular surgery of the study eye since the cataract surgery, including vitrectomy, glaucoma filtering surgery and corneal transplantation, or intravitreal injection within 4 weeks of a study visit; selective laser trabeculoplasty is not an exclusion criterion * Active anterior segment inflammation at the baseline visit * Clinically significant corneal pathology precluding reliable keratometry, including corneal oedema, band keratopathy, central corneal scarring, and Fuchs endothelial corneal dystrophy grade 3 or 4 with clinically evident oedema; grades 1 and 2 without oedema are eligible * Known intraocular lens instability before capsulotomy, including subluxation, decentration estimated above 1.0 mm, or pseudophacodonesis * Cognitive or physical limitations precluding standardized subjective manifest refraction

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Conditions

The condition(s) this trial relates to.

Pseudophakia refractive error

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Posterior capsule opacification Pseudophakia Refractive errors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Augenabteilung, Klinik Hietzing, Wiener Gesundheitsverbund

    Vienna, State of Vienna, 1130, Austria

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