Refractive error

This study tests whether pupil size changes can predict how well peripheral defocus spectacle lenses slow myopia progression in children. Researchers will measure pupil responses and track eye growth over 24 months in 14 kids with progressive myopia. The goal is to see if a simpl…

This study compares two special contact lenses (MiSight 1 Day and Abiliti 1-Day) to see which one better slows the worsening of nearsightedness in Chinese children aged 6-12 living in New Zealand. Each child will wear a different lens in each eye for 6 months. The goal is to find…

This phase 3 trial tests whether an experimental eye drop called CTO0308 can slow the progression of myopia, or nearsightedness, in children aged 5 to 12. Participants receive either the active drop or a placebo once daily in each eye for 12 months. Researchers measure changes in…

This study tests whether Essilor Stellest spectacle lenses can slow the progression of myopia (nearsightedness) in children and teens aged 6 to 16. One hundred fifty participants will wear the lenses for at least 12 hours a day over 24 months. Researchers will measure changes in …

This trial tests whether alternating two common myopia treatments—nightly ortho-k contact lenses and low-dose atropine eye drops—can slow the progression of nearsightedness in children and teens more effectively than using ortho-k lenses alone. The study will enroll 112 participa…

This study looks at whether the way a toric intraocular lens is implanted during cataract surgery affects how well it stays in place. Toric lenses correct astigmatism, but if they rotate after surgery, vision can blur. The trial compares two techniques: one using a gel-like subst…

This study tests whether contact lenses with A.R.R.E.S.T.® technology can slow the progression of myopia (nearsightedness) in children compared to standard single-vision lenses. About 80 children aged 7 to 15 will wear either the special or standard lenses for 12 months, with sev…

This trial tests whether implanting a fresh, donated corneal lenticule — a thin layer of corneal tissue — can safely correct residual farsightedness in people who already have an artificial lens implant after cataract surgery. The procedure uses a femtosecond laser to create a po…

This trial tests whether implanting a fresh corneal lenticule — a thin layer of donor cornea — can improve vision in people with high hyperopia (farsightedness) and high astigmatism. The lenticule is placed using a femtosecond laser, aiming to increase visual acuity and reduce as…

This trial tests whether implanting a fresh, donated corneal lenticule into the eye can reshape the cornea and reduce irregular astigmatism in people who have already had a full cornea transplant. The goal is to improve visual acuity and stabilize the cornea's shape. Twenty-four …

This trial tests whether a laser procedure called Relex-Smile can correct leftover nearsightedness or farsightedness in people who had cataract surgery six months earlier. About 130 participants with blurry vision after receiving a trifocal lens implant will undergo the laser tre…

This study tests special glasses called D.D.C dual-control lenses to see if they can slow down worsening nearsightedness (myopia) in children aged 6 to 14. Over 24 months, 316 kids will wear either the new lenses or standard glasses. The goal is to measure changes in eye prescrip…

This trial tests three approaches to slow the progression of nearsightedness (myopia) in children aged 5 to 12: daily atropine eye drops, MiSight contact lenses, and NaturalVue multifocal contact lenses. Over two years, researchers will measure changes in eye length and prescript…

This study tests whether special spectacle lenses called DIMS (defocus incorporated multiple segment) can slow the progression of nearsightedness (myopia) in university students aged 18 to 23. Participants wear either the DIMS lenses or standard single-vision glasses for comparis…

This study tests whether taking branched-chain amino acid (BCAA) supplements for six months can slow the progression of myopia (nearsightedness) in young adults aged 18 to 25. Participants either receive BCAA supplements plus standard glasses or a placebo plus glasses. The goal i…

This trial tests whether special spectacle lenses called Diffusion Optics Technology (DOT) lenses can slow the progression of nearsightedness (myopia) in Chinese children aged 6 to 13. Over 12 months, 195 children will wear either the DOT lenses or standard single-vision lenses. …

This study tests whether MiSight 1 Day contact lenses can slow the progression of myopia (nearsightedness) in children aged 8 to 12. Participants wear either MiSight 1 Day or standard Proclear 1 day lenses for three years, then all switch to Proclear for one year to see if the ef…

This study looks at the safety of MiSight 1 Day contact lenses in children aged 8 to 12 with nearsightedness (myopia). Participants wear the lenses daily for three years, and researchers track eye infections and other problems. The goal is to confirm that these lenses are safe fo…

This study tests whether dual focus contact lenses (MiSight) can slow the progression of nearsightedness (myopia) in university students aged 18 to 21. Participants wear either the test lenses or standard single vision lenses for at least 10 hours a day. Researchers measure chang…

This study compares two common laser eye surgeries—KLEx and FS-LASIK—for treating nearsightedness and astigmatism. Researchers will follow 80 adults aged 21 and older to see which procedure provides better vision without glasses and has fewer side effects. Both surgeries reshape …

This study tests two types of eyeglass lenses designed to slow the progression of nearsightedness (myopia) in children aged 6 to 13. Over 6 months, researchers will measure changes in eye length and thickness to see how the lenses affect eye growth. The goal is to find a better w…

This study compares two types of contact lenses for slowing myopia (nearsightedness) in children aged 8 to 14. Over three years, researchers will measure changes in eye length and vision to see if the new lens works as well as the existing one. The goal is to help kids maintain b…

This study tests special spectacle films designed to slow down myopia (nearsightedness) in children. About 210 kids aged 6 to 14 are taking part. The films use a new technology called S.T.O.P.® that creates changing visual cues, which may help control how fast the eye grows and p…

This pilot study tests whether combining low-dose atropine eye drops (0.01% or 0.025%) with ear acupressure can safely slow myopia progression in 420 children aged 6-12. Participants are randomly assigned to one of six groups, including placebo, and are followed for 12 weeks. The…

This study tests a new type of eyeglass lens designed to slow down nearsightedness (myopia) in children. Fifty kids aged 6 to 15 will wear the special lenses for six months. Researchers will measure changes in the eye's thickness and length to see if the lens works and is safe.

This study tests a special lens implant that corrects cataracts, presbyopia (need for reading glasses), and astigmatism (blurry vision from an irregularly shaped cornea). The goal is to see if this lens stays stable in the eye and provides good vision at all distances. About 100 …

This study tests whether eye pressure-lowering medication can slow the progression of severe nearsightedness (high myopia) in adults. Researchers will measure changes in eye length and vision over time. The trial includes 152 participants aged 18 to 65 with worsening high myopia …

This study tests whether a special film applied to glasses can slow the progression of nearsightedness (myopia) in children aged 6 to 14. The film uses A.R.R.E.S.T.® technology, which is designed to send specific light signals to the eye to control its growth. Over two years, res…

This study tests whether special glasses with P.A.U.S.E. technology can slow the progression of nearsightedness (myopia) in children. About 205 Vietnamese children aged 6-14 will wear either the special lenses or regular glasses for one year, then all will wear the special lenses…

This study tests special glasses with Diffusion Optics Technology to see if they can slow the progression of nearsightedness (myopia) in children. About 200 kids who completed a previous study will wear these glasses for up to 3 years. Researchers will measure changes in eye leng…

This 3-year study tests whether a new type of spectacle lens can slow the progression of nearsightedness (myopia) in children aged 6 to 10. A total of 266 kids will wear either the novel lenses or standard lenses, and researchers will measure changes in eye length and prescriptio…

This study tests whether special new spectacle lenses can slow the worsening of nearsightedness (myopia) in children. About 342 kids aged 7 to 13 will wear either the new lenses or standard single-vision glasses for one year, then all switch to the new lenses for another year. Th…

This study tests whether combining special glasses (that create optical defocus) with low-dose atropine eye drops can better control myopia (nearsightedness) in children aged 7 to 12. Over 18 months, researchers will measure changes in eye prescription and eye length. The goal is…

This study tests a new type of spectacle lens (DG2) designed to slow down nearsightedness (myopia) in children whose vision is getting worse quickly. 118 children aged 4–13 will wear these lenses for 4 years. Researchers will measure changes in their eye prescription and eye leng…

This study tests two types of special glasses (DIMS and D2 lenses) to see if they can slow down worsening nearsightedness in children whose vision is getting worse quickly. About 59 children will wear these glasses for 4 years, and researchers will measure changes in their eyesig…

This study tests two types of advanced lens implants (IOLs) for people having cataract surgery in both eyes. The lenses are designed to help see clearly at far, arm's length, and near distances. Researchers will check safety and how well the lenses work in 110 participants over t…

This study tests whether specially designed eyeglass lenses can slow the progression of myopia (nearsightedness) in children aged 6 to 14. Researchers will measure changes in eye length and prescription over time, while also checking for safety and comfort. The goal is to find a …

This study tests whether new spectacle lenses can safely slow the progression of myopia (nearsightedness) in children. About 249 kids will wear either the novel lenses or standard single vision glasses for 36 months. Researchers will measure changes in eye length and prescription…

This study tests a new surgical technique to close macular holes in people with high myopia without using a gas bubble. The standard approach requires a gas bubble that blurs vision and forces patients to keep their head down for days. The new method uses a gel-like substance to …

This study tests whether a special lens called Blue Star MAX-5 can slow the progression of nearsightedness (myopia) in children aged 8 to 11. Two hundred kids will wear either the new lens or standard glasses and be checked every six months for two years. The goal is to see if th…

This study tests whether Essilor Stellest spectacle lenses can slow the progression of nearsightedness (myopia) in adults aged 18 to 40. Each participant wears a Stellest lens in one eye and a standard lens in the other, allowing direct comparison. The trial measures changes in e…

This study tests a software program that predicts how much vision improvement a special laser treatment can provide for people with irregularly shaped corneas causing astigmatism. About 45 participants with vision quality issues will have their eyes treated, and the software's pr…

This study tracks 75 nearsighted young adults over 12 months to see how low-dose atropine eye drops or soft multifocal contact lenses affect the shape of the eye. Participants are randomly assigned to one of these treatments or no treatment. Researchers will take eye photos and m…

This study tests a new eye drop called SHJ002 to see if it can safely slow down worsening nearsightedness (myopia) in children ages 3 to 12. The drop works by targeting a specific molecule in the eye. Researchers will compare it to a standard treatment, atropine, and measure chan…

This study tests special 3D-designed defocus lenses to see if they can slow down myopia (nearsightedness) in children aged 6 to 14. The lenses are meant to control how the eye grows, reducing the need for stronger glasses over time. Researchers will track changes in vision and ey…

This study tests whether special open-ring spectacle lenses can slow the progression of nearsightedness (myopia) in Chinese children aged 6 to 12. A total of 180 children will wear one of three lens designs for 12 months, with some continuing for another year. The goal is to see …

This study tests whether special glasses with a double helix lens design can slow the progression of myopia (nearsightedness) in children and adolescents aged 6 to 13. About 236 participants will wear either the new glasses or standard single-vision glasses for over 10 hours a da…

This study looks at how removing a pterygium (a fleshy growth on the eye) and replacing it with a small piece of the patient's own eye tissue changes the shape of the cornea. Researchers will measure the cornea's curve before and one month after surgery in 130 adults aged 30 to 7…

This study tests whether NaturalVue multifocal contact lenses can slow the progression of myopia (nearsightedness) in children aged 7 to 12. Over three years, 144 kids will wear either standard single-vision lenses or the multifocal lenses. Researchers will measure changes in the…

This study tests whether combining low-dose atropine eye drops with special glasses (DIMS lenses) can slow the worsening of nearsightedness in children better than atropine alone. About 111 kids aged 4–16 with progressing myopia will be randomly assigned to one of two groups. The…

This study compares a new AI system, called AEYE, against a human eye doctor in diagnosing keratoconus and deciding who is eligible for laser vision correction. The AI analyzes patient history, eye scans, and other data to make its recommendations. Researchers will check if the A…

This trial tests whether giving free glasses to short-sighted middle school children in rural China helps more of them continue to academic high school. Researchers will randomly assign 111 schools to either provide glasses with teacher support or just give prescriptions. The mai…

This study tests whether taking vitamin B2 (riboflavin) daily and spending time outdoors in sunlight can slow the progression of myopia (nearsightedness) in children aged 6 to 12. Participants will be randomly assigned to receive different doses of riboflavin or a placebo, and al…

This trial tests whether providing free corrective glasses to young motorcycle drivers with myopia (nearsightedness) can reduce the number of crashes and near-misses. Participants are university students in Ho Chi Minh City who drive regularly and have uncorrected or under-correc…

This study tests whether special 'peripheral focus-out' glasses can prevent nearsightedness (myopia) in Chinese children aged 6 to 8. Over two years, 160 children will wear the glasses at least 8 hours a day. Researchers will measure changes in their vision to see if the glasses …

This study tests whether special glasses can prevent nearsightedness (myopia) in children aged 6 to 9 who are not yet nearsighted but are at risk. About 388 children will wear the glasses for at least 8 hours a day for one year. Researchers will track how many children become nea…

This study looks at whether using a special red light device twice a day can help prevent or control nearsightedness (myopia) in children aged 5 to 16. Researchers are following 3,000 kids who have used the therapy for at least a year, some for up to three years or more. The goal…

This study gives free reading glasses and basic smartphone training to older adults in Bangladesh who receive government benefits. The goal is to see if better vision helps them use mobile banking more often and independently. About 571 people aged 48 to 70 with presbyopia (age-r…

This study tests new versions of Clareon Vivity Pro intraocular lenses (IOLs) to see if they improve vision better than current lenses. About 231 adults with cataracts in both eyes will receive one new lens and one current lens to compare results. The main goal is to measure how …

This trial tests whether Relex-Smile laser surgery can safely and effectively correct residual nearsightedness in people who still have blurry distance vision six months after cataract surgery. Participants will undergo the laser procedure and have their vision and refraction mea…

This trial tests whether creating a small pocket inside the cornea using the SMILE module can improve near vision in people with presbyopia who want to avoid glasses. The procedure aims to increase the eye's ability to focus on close objects. Researchers are measuring how much ne…

This study looks at how well SMILE PRO laser surgery corrects high astigmatism in people with nearsightedness. 113 patients aged 18 to 40 will have the procedure and be followed for a year to check vision sharpness, stability, and safety. The goal is to see if this advanced laser…

This study tests the safety and effectiveness of the TENEO 317 excimer laser used in LASIK surgery to treat farsightedness (hyperopia) with or without astigmatism. About 140 adults aged 22 and older will receive the laser treatment in one or both eyes and be followed for 12 month…

This study compares two methods of removing the outer layer of the cornea during PRK laser eye surgery. One method uses a laser to remove the layer, while the other uses a manual tool. The goal is to see which approach leads to better vision and faster healing. About 100 people a…

This study compares how well two types of daily disposable multifocal contact lenses work for people with nearsightedness (myopia). Researchers will measure things like sharpness of vision, reading ability, and eye coordination. About 30 people aged 9 to 30 who already wear conta…

This study tests a new device called CorVision, a tiny lens made from collagen that is placed inside the cornea to improve near vision in people with presbyopia (age-related difficulty seeing up close). 110 adults aged 40-65 will receive the implant in one eye through a minimally…

This study examines protein differences in the tears of nearsighted children who use special overnight contact lenses (orthokeratology) to slow down worsening vision. Researchers want to understand why some children get better control of their myopia than others. The study involv…

This study compares three types of progressive lenses to see which provides the widest clear vision at distances from 4 meters down to 25 centimeters. About 26 presbyopic participants will test each lens in a random, double-blind order. The goal is to help eye doctors choose the …

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study looks at how a new type of eyeglass lens affects the back layer of the eye (the choroid) in children with worsening nearsightedness. Ten children already in a larger study will have their eye thickness measured with a special camera. The goal is to understand if the le…

This study looks at how well children with nearsightedness (myopia) see when wearing special glasses. The 51 participants are already part of a larger study on myopia progression. Researchers will measure reading speed and vision in different lighting to see how the lenses perfor…

This study follows 90 children who previously wore special spectacle lenses to slow nearsightedness (myopia). After stopping the lenses, researchers measure how much their vision changes over 12 months. The goal is to see if the benefits of the lenses last after use ends.

This study looks at how the eye focuses (lag of accommodation) when children with nearsightedness wear special DOT pattern spectacle lenses compared to regular glasses. About 30 kids aged 6 to 18 will have their vision measured at distance and close-up with each lens type. The go…

This study tests whether special spectacle lenses called Diffusion Optics Technology (DOT) lenses can change the thickness of the choroid, a layer of blood vessels in the eye. Researchers will measure these changes in 30 children aged 8-14 with normal vision after wearing the len…

This study uses artificial intelligence to predict true eye pressure after corneal refractive surgery like LASIK or SMILE. Standard eye pressure measurements can be falsely low after these surgeries, masking glaucoma risk. Researchers will analyze data from over 10,000 participan…

This study was designed to compare two newer technologies for cataract surgery: a femtosecond laser and a special handpiece that monitors eye pressure. The goal was to see if these tools cause less damage to the cornea and use less energy than standard methods. However, the study…

This study was designed to check the long-term safety and performance of AcrySof IQ Vivity lens implants in people who had them in both eyes for 3 to 5 years. It was a real-world observation, not a treatment test. However, the study was withdrawn before enrolling any participants…

LASIK (laser-assisted in situ keratomileusis) is a type of refractive surgery for correction of myopia, hyperopia and astigmatism. Yet approximately 30% of operated patients have symptoms like glare, halos, dry eyes and especially residual hypermetrop refractive errors. Residual…