Fudan University

This study tests whether adding retinoic acid (a vitamin A derivative) to an immune checkpoint inhibitor can help shrink or control HER2-negative breast cancer that has stopped responding to immunotherapy alone. About 10 adults with metastatic or locally advanced disease will rec…

This study tests a chemotherapy regimen (R-CDOP) plus a drug injected into the spine (intrathecal methotrexate) in 83 adults with untreated diffuse large B-cell lymphoma who have a high risk of the cancer spreading to the central nervous system. The goal is to see if this combina…

This study tests whether adding a liver-directed chemotherapy infusion (HAIC) to a combination of two drugs (sintilimab and bevacizumab) can help people with advanced liver cancer live longer without their disease getting worse. About 164 adults with liver cancer that cannot be r…

This study tests whether adding a drug called IL-11 to the standard G-CSF can help blood cells recover faster after a stem cell transplant in people with blood cancers like multiple myeloma or lymphoma. The goal is to shorten the time for platelets and red blood cells to return t…

This study tests personalized fertility-sparing treatments for young women (ages 18-45) with endometrial cancer. Researchers will use the tumor's genetic profile to assign the best therapy, such as hormone therapy or immunotherapy, aiming to eliminate cancer while preserving the …

This study tests a combination of two drugs—sintilimab and chidamide—in about 51 adults with a rare blood cancer called peripheral T-cell lymphoma that has returned or not improved after prior therapy. The goal is to see if the combination can control the cancer longer and with m…

This study tests whether adding a drug called narlumosbart and precise radiation (SBRT) to standard chemotherapy and immunotherapy can shrink tumors better in people with advanced lung cancer that has spread to the bones. The trial will enroll 27 adults who have not had prior tre…

This study tests whether a new drug (serplulimab) combined with chemotherapy works better than a standard drug (nivolumab) combined with chemotherapy before surgery for people with stage II to IIIa squamous non-small cell lung cancer. About 116 adults aged 18 to 75 who can have s…

This study tests a new drug called Becotatug vedotin (MRG003) in people with advanced liver cancer that has gotten worse after at least one prior treatment. The goal is to see if the drug can shrink tumors. About 40 adults with confirmed liver cancer will take part. The drug is g…

This study tests a combination of several drugs (including sodium cromoglicate, choline, efavirenz, and others) given with an immunotherapy drug to treat advanced triple-negative breast cancer that has stopped responding to previous immunotherapy. The goal is to see if this new m…

This study looks at whether adding chemotherapy to standard radiation therapy after thymic cancer surgery helps keep the cancer from coming back. About 172 adults who had their tumor completely removed will receive either radiation alone or radiation plus four cycles of chemother…

This study tests whether adding targeted radiation to a four-drug combination (immunotherapy, anti-VEGF, and chemotherapy) can help people with advanced EGFR-mutant lung cancer whose cancer has stopped responding to standard pills. About 53 adults will receive the drug combo firs…

This study tests a mix of targeted radiation, chemotherapy, immunotherapy, and targeted drugs in 44 adults whose rectal cancer has returned locally after prior oxaliplatin treatment. The goal is to see if this combination can shrink pelvic tumors enough to allow for surgical remo…

This study tests whether giving radiation only to the parts of the neck that need it (based on where cancer has spread) is as effective as the standard approach of radiating a larger area. About 462 adults with nasopharyngeal cancer will be randomly assigned to either personalize…

This study tests a combination of two drugs (fruquintinib and serplulimab) in 50 adults with advanced colorectal cancer that has not spread to the liver and has stopped responding to standard treatments. The goal is to see if the combination can shrink tumors or slow the disease.…

This early study tests a new cell therapy called RGL-305 in 12 adults with lymphoma who still have signs of disease after standard treatment. The goal is to see if it is safe and can help control the cancer. Participants receive a single infusion of the therapy and are monitored …

This study tests whether adding the drug VEGFR BP102 to standard chemotherapy helps people with a specific subtype of advanced triple-negative breast cancer (called BLIS) live longer without their cancer growing. About 134 participants who have not had prior treatment for metasta…

This study tests whether a transplant of donated umbilical cord blood can help people aged 14 to 80 with serious diseases caused by the Epstein-Barr virus, such as certain lymphomas or chronic active infection. The goal is to control the disease and improve survival, but lifelong…

This study looks at whether giving radiation therapy after surgery helps prevent thyroid cancer from coming back in people with a high risk of recurrence. About 80 adults with certain types of thyroid cancer will receive standard care plus radiation. Researchers will track how lo…

This study looks at women with early-stage breast cancer that has spread to 1 or 2 lymph nodes. It compares two types of radiation after surgery: one that treats a larger area of lymph nodes and one that treats only the nearby armpit area. The goal is to see if the smaller radiat…

This phase 3 trial tests whether adding immunotherapy to a special type of radiation (that spares tumor-draining lymph nodes) plus chemotherapy works better than radiation and chemotherapy alone for adults with advanced esophageal squamous cell cancer. About 432 participants will…

This study tests two drugs together for people with a rare and aggressive type of thyroid cancer that has spread or cannot be removed by surgery. About 60 adults will receive the combination every three weeks. The goal is to see if the treatment shrinks tumors and is safe.

This study tests whether a more targeted neck surgery (selective neck dissection) works as well as the standard more extensive surgery (modified neck dissection) for papillary thyroid cancer that has spread to only 1 or 2 small lymph nodes in the side of the neck. About 250 peopl…

This study tests whether adding immunotherapy (a drug that helps the immune system fight cancer) after standard chemotherapy and radiation can keep esophageal cancer from growing. About 452 adults with advanced esophageal squamous cell carcinoma will be randomly assigned to recei…

This study tests three different treatment sequences for people with early-stage natural killer/T-cell lymphoma, a rare and aggressive cancer. About 210 participants will receive either a combination of immunotherapy and chemotherapy followed by radiation, or one of two standard …

This study tests two experimental oral drugs (SHR-0302 and SHR-2554) given together to people with a rare type of blood cancer called peripheral T-cell lymphoma that has returned or not responded to prior therapy. About 25 adults aged 18-70 will take part. The goal is to see if t…

This study tests whether metformin, a common diabetes medication, can improve memory and thinking in overweight or obese older adults with mild cognitive impairment (MCI). 54 participants will receive either metformin plus lifestyle advice or lifestyle advice alone for 26 weeks. …

This study tests whether adding a drug called SHR-1701 to targeted radiation can help control metastatic castration-resistant prostate cancer (mCRPC). About 66 men aged 18-80 whose cancer has worsened after at least one prior treatment will receive either the combination or stand…

This study is for people with advanced breast cancer who have already tried a type of targeted therapy called an antibody-drug conjugate (ADC). The goal is to see if giving another ADC can still shrink tumors or slow the disease. About 160 adults will take part, and researchers w…

This study tests a new drug (QL1706) combined with standard chemotherapy, with or without another drug (bevacizumab), as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if the combination can shrink tumors or cont…

This study tests a new approach for people with advanced breast, melanoma, or colorectal cancer that has spread to the liver. Doctors will use a special heat-based procedure to destroy some liver tumors, which may activate the immune system like a vaccine. Then, they add immunoth…

This study tests whether adding the drug cadonilimab (AK104) and radiotherapy to standard chemotherapy improves outcomes for people with a common type of colorectal cancer that has spread to the liver. About 73 participants will be randomly assigned to receive either the new comb…

This study tests whether adding an antivascular drug to standard chemotherapy helps prevent breast cancer from returning in people with a specific, high-risk type of triple-negative breast cancer. About 764 women with stage II to III cancer will receive either the combination or …

This study tests a combination of two drugs, SKB264 and inetetamab, in people with HER2-positive breast cancer that has spread and is no longer responding to a standard treatment called T-DXd. The goal is to see if this new combination can shrink tumors or slow the cancer. About …

This study tests whether adding probiotics (good bacteria) to standard chemoradiation and immunotherapy can improve outcomes for people with limited-stage small cell lung cancer. About 60 adults aged 18-80 will be enrolled. The goal is to see if this combination helps keep cancer…

This study tests new drug combinations (ADC drugs with or without HRS-4642 or immunotherapy) in 160 people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The goal is to find the safest and most effective doses to shrink tumors and control the dis…

This study tests two different treatment plans for people with locally advanced rectal cancer that hasn't spread. One group gets standard long-course chemoradiation followed by chemo. The other gets short-course radiation followed by chemo, an immunotherapy drug (PD-1 antibody), …

This study looks at different drug combinations for people with advanced stomach or gastroesophageal junction cancer that has not responded to first treatment. It involves 250 adults aged 18-80 whose cancer has spread or cannot be removed. The goal is to see how well these second…

This study tests two different radiation schedules (long vs short) combined with chemotherapy and immunotherapy in people with a specific type of locally advanced rectal cancer (MSS type). The goal is to see which approach leads to more complete tumor disappearance and helps more…

This study tests an oral drug called tunlametinib in people with advanced melanoma that has a specific NRAS gene mutation and has stopped responding to standard immunotherapy. About 110 adults will take the drug to see if it shrinks tumors and how safe it is. The goal is to offer…

This study tests a new combination of three drugs—chemotherapy (GEMOX), a targeted therapy (Donafenib), and an immunotherapy (Tislelizumab)—in people with advanced biliary tract cancer that cannot be removed by surgery. The goal is to see if this mix shrinks tumors and improves s…

This study looks at whether giving radiation therapy after completely removing a thymoma (a rare chest tumor) can help people with stage II or III disease live longer without the cancer coming back. About 238 adults aged 18-75 who had surgery within the last 3 months will be rand…

This study is testing a new blood test that looks at tiny DNA fragments to find pancreatic neuroendocrine tumors early and tell them apart from other pancreatic tumors. Researchers will enroll 1,000 adults who have not yet started cancer treatment. The goal is to see how accurate…

This study compares two ways to diagnose stomach cancer: a small sample taken during an endoscopy (biopsy) versus a larger sample from surgery. Researchers want to see if the biopsy is just as good at identifying cancer type, grade, and key markers like HER-2 and MSI status. The …

This study is testing whether using artificial intelligence (AI) to help read breast ultrasound and mammogram images can find breast cancer earlier and more accurately than standard screening. About 16,000 women aged 35 to 69 will be split into two groups: one gets AI-assisted im…

This study tests if limiting eating to a 10-hour window each day can prevent gestational diabetes in pregnant women at high risk. Researchers will compare the time-restricted eating group to a group that eats normally. The goal is to see if this simple dietary change reduces the …

This study tests a skin protectant called Pinoxin to see if it can prevent skin injuries caused by radiation therapy in cancer patients. About 202 adults with cancer who are starting radiation will be randomly assigned to use either Pinoxin or a placebo cream. The main goal is to…

This study looks at how patients with metastatic triple-negative breast cancer feel during treatment with sacituzumab govitecan or standard chemotherapy. It involves 300 Chinese adults whose cancer has worsened after first treatment. The goal is to see which option better maintai…

This study explores whether a blood test that tracks tumor DNA (ctDNA) can help doctors choose the best treatment for people with HER2-negative metastatic breast cancer. About 122 participants will receive antibody-drug conjugate therapy, and those whose cancer does not worsen wi…

This study looks at whether age-related differences in blood cells affect how well breast cancer treatment works. Researchers will compare blood samples from younger and older women with HR+HER2- breast cancer before and during treatment. The goal is to find blood markers that mi…

This study follows 3,000 adults aged 40 and older who carry H. pylori bacteria in their stomach. Researchers want to see if people with a high-risk genetic type of H. pylori are more likely to develop stomach cancer over 3 to 10 years compared to those with other types or no infe…

This study aims to understand why some lung cancers with a specific gene change (ROS1 fusion) stop responding to the drug entrectinib. Researchers will analyze tumor or blood samples from 38 people who have already taken entrectinib as part of their regular care. The goal is to i…

This study aims to understand how different types of HPV contribute to anal cancer in China and how common the disease is. Researchers will look at medical records and samples from 300 people diagnosed with anal cancer. The goal is to better understand the disease's impact and tr…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can help doctors monitor how well stomach cancer treatment is working. Researchers will collect blood samples from 600 people with stomach cancer at different stages of treatment. The goal is to see if ch…

This study tests whether a new blood test that looks for tumor DNA (ctDNA) can find returning colorectal cancer earlier than standard methods. About 584 people who had surgery for early-stage colorectal cancer will be randomly assigned to either ctDNA-guided monitoring or usual c…

This study looks at whether a blood test that tracks DNA from tumors (ctDNA) can better measure how well treatment is working and predict if cancer will come back in people with advanced colorectal cancer. About 497 participants will receive standard radiotherapy and chemotherapy…

This study looks at whether the bacteria in your gut can help predict how well a combination of immunotherapy and chemotherapy works for advanced stomach cancer. About 300 adults with metastatic or locally advanced stomach cancer who haven't had chemo or immunotherapy before will…

This study aims to find out what factors help predict whether CAR-T therapy will work for people with relapsed or refractory large B-cell lymphoma. Researchers will look at patient health records, tumor features, and immune system changes in 80 participants. The goal is to better…

This study tests whether a new type of PET scan (TROP2-PET) can predict if a targeted drug will work for people with advanced HER2-negative breast cancer. About 45 participants will get both a standard and a TROP2-PET scan before starting treatment. The goal is to see if the scan…

This study looks at how the pain medicine remifentanil behaves in low-weight intensive care patients who need a breathing machine. Researchers will measure drug levels in the blood and check blood pressure changes. The goal is to find the right dose for safer and more effective s…

This study will follow 3000 people in China with peripheral T-cell lymphoma, a rare blood cancer, to learn how the disease behaves and how it is currently treated. Researchers will collect medical records and test samples to understand what treatments work best and why some patie…

This study looks at how different types of anesthesia affect cancer cells and recovery in people having surgery for colorectal cancer. Ninety adults will be randomly assigned to receive opioid-free, opioid-sparing, or standard opioid-based anesthesia. Researchers will measure blo…