Brain-Lining cancer in breast cancer patients: could a reservoir pump chemo directly to the target?
NCT ID NCT06230055
First seen Jan 08, 2026 · Last updated Jun 20, 2026 · Updated 25 times
Summary
This study is for people with HER2-negative breast cancer that has spread to the lining of the brain (leptomeningeal metastasis). It compares standard chemotherapy given through the veins or by mouth to the same treatment plus extra chemotherapy delivered directly into the spinal fluid through a small device called an Ommaya reservoir, which is placed under the scalp. The goal is to see if the combination helps control the brain lining cancer longer and improves quality of life. About 37 participants will be randomly assigned to one of the two groups.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University
RECRUITINGShanghai, Shanghai Municipality, 200032, China
Contact Phone: •••-•••-••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Chemotherapy drugs (e.g., methotrexate) given through an Ommaya reservoir into the spinal fluid, plus standard systemic chemotherapy
What this could lead to
If it works, this approach could offer better control of cancer spread to the brain lining and improve quality of life for patients with this difficult-to-treat condition.
What could go wrong
This is a small, early-phase trial with only 37 participants, so results may not apply to everyone. The added procedure carries risks like infection or bleeding, and the benefit over standard care is not yet proven.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.