LEPTOMENINGEAL METASTASIS
Clinical trials for LEPTOMENINGEAL METASTASIS explained in plain language.
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Spinal injection combo targets tough brain metastases in lung cancer
Disease control Recruiting nowThis early-phase study tests whether injecting two drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe and helps people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. About 19 adults whose cancer has not respo…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE1 • Sponsor: Shanghai Chest Hospital • Aim: Disease control
Last updated May 26, 2026 05:56 UTC
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Brain-Directed chemo combo shows promise for tough breast cancer spread
Disease control Recruiting nowThis study looks at whether giving chemotherapy directly into the fluid around the brain (via a small device called an Ommaya reservoir) along with standard body-wide chemo works better than standard chemo alone for people with HER2-negative breast cancer that has spread to the b…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE4 • Sponsor: Fudan University • Aim: Disease control
Last updated May 26, 2026 05:47 UTC
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New combo tackles tough brain cancer spread in lung patients
Disease control Recruiting nowThis study tests a combination of higher-dose targeted therapy, an anti-angiogenesis drug, and chemotherapy injected into the spine for people with advanced lung cancer that has spread to the lining of the brain and is no longer responding to standard treatment. About 30 adults w…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: NA • Sponsor: Second Affiliated Hospital of Nanchang University • Aim: Disease control
Last updated May 26, 2026 05:42 UTC
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Pulsing drug doses may outsmart brain metastases in lung cancer
Disease control Recruiting nowThis study tests whether taking a higher dose of the targeted drug furmonertinib every other day can better control lung cancer that has spread to the lining of the brain (leptomeningeal metastasis). About 42 adults with a specific EGFR gene mutation will choose either the high-d…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: NA • Sponsor: Guangzhou University of Traditional Chinese Medicine • Aim: Disease control
Last updated May 26, 2026 04:38 UTC
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New hope for advanced breast cancer patients with brain metastases: Triple-Drug trial launches
Disease control Recruiting nowThis study tests whether a combination of two oral drugs (tucatinib and capecitabine) plus a chemotherapy given directly into the spinal fluid (intrathecal trastuzumab) can help people with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. Ab…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: UNICANCER • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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New hope for brain lining cancer: spinal tap chemo after targeted drug fails
Disease control Recruiting nowThis study tests a chemotherapy drug called pemetrexed, given directly into the spinal fluid, for people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. The cancer has stopped responding to a higher dose of a targeted therapy. The g…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: Guangzhou Medical University • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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Promising combo therapy for brain metastases in lung cancer patients
Disease control Recruiting nowThis study tests whether adding a chemotherapy drug (pemetrexed) given directly into the spinal fluid to a standard targeted therapy pill (like osimertinib) works better than the pill alone for lung cancer that has spread to the brain and spine. About 100 adults with a specific g…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: NA • Sponsor: Guangzhou Medical University • Aim: Disease control
Last updated May 22, 2026 13:50 UTC
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New hope for lung cancer patients with brain spread after standard treatment fails
Disease control Recruiting nowThis study tests a new treatment for people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) and has stopped responding to the drug osimertinib. The treatment combin…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: Taipei Veterans General Hospital, Taiwan • Aim: Disease control
Last updated May 18, 2026 12:08 UTC
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New combo therapy aims to fight deadly breast cancer spread to the brain
Disease control Recruiting nowThis study tests if radiation therapy followed by two targeted drugs (trastuzumab and pertuzumab) given directly into the spinal fluid is safe and helps people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). About 39 p…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE1, PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 14, 2026 12:06 UTC
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Can a targeted drug reach brain tumors? new study aims to find out.
Knowledge-focused Recruiting nowThis study looks at how much of the drug T-DXd gets into brain tumors in people with HER2-positive brain cancer or glioblastoma. About 30 adults will receive the drug before surgery, and researchers will measure drug levels in the tumor during the operation. The goal is to unders…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated May 22, 2026 13:51 UTC