LEPTOMENINGEAL METASTASIS

This study is testing whether a combination of three cancer drugs can help people with a specific type of advanced breast cancer that has spread to the lining of the brain and spinal cord. The main goal is to see if more patients are alive one year after starting this treatment. …

This study is testing if giving a higher dose of the lung cancer drug furmonertinib every other day is better at controlling cancer that has spread to the lining of the brain and spinal cord. It will enroll 42 adults with advanced lung cancer that has this specific spread and has…

This study compares two treatment approaches for HER2-negative breast cancer that has spread to the membranes surrounding the brain and spinal cord. Researchers want to see if delivering chemotherapy directly into the spinal fluid through a small implanted device, combined with s…

This study is testing a more intensive treatment for people with advanced lung cancer where the disease has spread to the lining of the brain and spine, and has gotten worse despite standard targeted therapy. About 30 participants will receive a higher dose of their targeted pill…

This study is testing whether radiation therapy followed by two targeted cancer drugs delivered directly into the spinal fluid is safe and can help people live longer. It's for patients with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. T…

This study is testing a new combination treatment for a serious complication where lung cancer spreads to the lining of the brain and spinal cord. It involves injecting a chemotherapy drug directly into the spinal fluid, alongside a targeted oral medication, for patients whose pr…

This study is testing a chemotherapy drug injected directly into the spinal fluid to treat lung cancer that has spread to the membranes surrounding the brain. It's for patients whose cancer has continued to grow despite receiving high doses of targeted therapy drugs. Researchers …

This trial is testing if a two-part treatment works better than pills alone for a serious complication where lung cancer spreads to the fluid-filled linings of the brain and spinal cord. It will compare standard targeted pills (like osimertinib) against those same pills plus a ch…

This study aims to find out if the cancer drug trastuzumab deruxtecan (T-DXd) can get into brain tumors when given through an IV. Researchers will measure how much of the drug reaches the tumor during surgery in 30 adults with certain HER2-positive brain cancers or recurrent glio…

This early-stage study is testing a new way to treat a serious complication of lung cancer where it spreads to the lining of the brain and spinal cord. Doctors are injecting two cancer drugs directly into the spinal fluid to see if it is safe and if it helps patients live longer.…

This early-stage study is testing the safety of combining an oral drug called azeliragon with full brain and spine radiation in patients with aggressive cancer that has spread to the lining of the brain and spinal cord. The main goal is to find out if this combination is safe and…