LEPTOMENINGEAL METASTASIS

This study tests the drug lorlatinib in people with a specific type of lung cancer (ALK-positive) that has spread to the brain or the lining of the brain and spinal cord. The goal is to see how well the drug shrinks these brain tumors. About 41 adults will take part, and the stud…

This early-phase study tests the safety of a drug called GDC-0084 when given together with radiation therapy. It is for people whose cancer has spread to the brain or the lining of the brain and who have a specific genetic change (PIK3CA mutation). The main goal is to find the hi…

This study tests a new treatment for people whose cancer has spread to the thin layer covering the brain and spinal cord (leptomeningeal metastasis). The treatment combines an immune-boosting drug (immune checkpoint inhibitor) with a chemotherapy drug (pemetrexed), both injected …

This early-phase study tests whether injecting two immunotherapy drugs directly into the spinal fluid, along with standard IV doses, is safe and can shrink tumors in the brain and spinal cord lining. It includes 26 adults with advanced lung cancer or melanoma that has spread to t…

This study tests a new, precise radiation technique for people whose cancer has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). The goal is to see if this approach can delay cancer growth in the central nervous system better than standard radiation.…

This study was designed to see if analyzing tiny particles called exosomes in spinal fluid could help doctors diagnose breast cancer that has spread to the lining of the brain. It planned to enroll breast cancer patients with suspected spread and compare the exosome protein patte…

This early-phase study tests the safety of adding the drug azeliragon to radiation therapy for adults whose cancer has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). About 21 participants with solid tumors or high-grade gliomas will receive the com…