New drug combo targets brain metastases in early trial
NCT ID NCT04192981
First seen Apr 23, 2026 · Last updated May 25, 2026 · Updated 6 times
Summary
This early-phase study tests the safety of a drug called GDC-0084 when given together with radiation therapy. It is for people whose cancer has spread to the brain or the lining of the brain and who have a specific genetic change (PIK3CA mutation). The main goal is to find the highest dose that causes few or mild side effects, and to see if the combination helps control the cancer.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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BAPTIST ALLIANCE - MCI (Data Collection Only)
Miami, Florida, 33143, United States
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Memorial Sloan Kettering Basking Ridge (Consent only)
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (Consent only)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All protocol activities)
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack (Consent only)
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (Consent only)
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester (All protocol activities)
Harrison, New York, 10604, United States
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University of Washington (Data Collection AND Data Analysis)
Seattle, Washington, 98109, United States
Conditions
Explore the condition pages connected to this study.