Can less radiation be just as effective for some breast cancers?
NCT ID NCT07469267
First seen Mar 21, 2026 · Last updated Jun 22, 2026 · Updated 17 times
Summary
This phase 3 trial is testing whether giving radiation only to the lower armpit lymph nodes works as well as giving radiation to a larger area of lymph nodes in breast cancer patients who have 1-2 positive sentinel nodes. The study plans to enroll 1608 women with early-stage breast cancer. The goal is to see if the smaller radiation field can prevent cancer from coming back while potentially causing fewer side effects.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cancer Hospital of Shandong First Medical University (Shandong Cancer Institute,Shandong Cancer Hospital)
NOT_YET_RECRUITINGJinan, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Changde Hospital, Xiangya school of Medicine, Central South University (The first people's hospital of Changde city)
NOT_YET_RECRUITINGChangde, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Chemoradiation Oncology, The Affiliated Lihuili Hospital of Ningbo University
NOT_YET_RECRUITINGNingbo, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Radiation and Medical Oncology, Affiliated Zhongshan Hospital of Dalian University
NOT_YET_RECRUITINGDalian, Liaoning, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Department of Radiation and Medical Oncology，Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Harbin Medical University Cancer Hospital
NOT_YET_RECRUITINGHarbin, Heilongjiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hunan cancer hospital/The affiliated cancer hospital of xiangya school of medicine,Central South university
NOT_YET_RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oncology Department, Guizhou Provincial People's Hospital
NOT_YET_RECRUITINGGuiyang, Guizhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITINGShijiazhuang, Hebei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital of Zhejiang University
NOT_YET_RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tianjin Medical University Cancer Institute and Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Zhejiang Cancer Hospital
NOT_YET_RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy
What this could lead to
If successful, this could show that a smaller radiation field is just as effective as full regional radiation, reducing side effects for many breast cancer patients.
What could go wrong
This is an ongoing phase 3 trial, so results are not yet known. It is possible that the smaller radiation field may lead to higher recurrence rates, and the study only includes a specific group of patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.