RADIOTHERAPY

This study tests whether giving radiation to the chest area can prevent or delay symptoms from getting worse in people with stage IV non-small cell lung cancer. Participants will receive radiation along with their usual cancer treatments. The goal is to see if this approach helps…

This study tests two different radiation schedules (short-course vs long-course) given together with an immunotherapy drug (Adebrelimab) and chemotherapy before surgery for people with locally advanced rectal cancer. About 208 participants will be randomly assigned to one of the …

This study tests a new treatment plan for people with advanced liver cancer that has spread to the main blood vessel or to a few other spots in the body. The treatment combines chemotherapy directly into the liver, two immunotherapy drugs, a targeted therapy, and precise radiatio…

This study is for people with kidney cancer that has spread and is starting to grow again in just a few places while on standard drug therapy. Instead of switching to a new drug right away, doctors will use precise, high-dose radiation (stereotactic radiotherapy) to target only t…

This study looks at the best time to give radiation for people having surgery to remove brain metastases (cancer that has spread to the brain). It compares three options: radiation before surgery, during surgery, or after surgery. The goal is to see which timing best prevents the…

This study tests whether a special type of radiation given in very small, frequent doses before CAR-T cell therapy can safely and effectively treat people with relapsed or refractory diffuse large B-cell lymphoma. About 20 adults who have not responded to at least two prior treat…

This study tests whether adding radiotherapy to a drug combination (fruquintinib and sintilimab) can help control colorectal cancer that has spread to the liver and hasn't responded to two prior treatments. About 62 adults with a specific cancer subtype (MSS/pMMR) will be randoml…

This study compares two radiation therapy schedules for men with localized prostate cancer. One uses fewer, stronger doses (ultra-hypofractionated) and the other uses slightly more, moderate doses. Both are combined with a brachytherapy boost. The goal is to see which approach ca…

This study looks at women with breast cancer that has spread to 1 or 2 lymph nodes. It compares giving radiation to a larger area of the armpit versus a smaller area. The goal is to see if the smaller area works just as well to prevent the cancer from coming back. About 1,600 wom…

This study tests whether adding a new immunotherapy drug (cadonilimab) and low-dose radiation to standard chemotherapy can help people with advanced nasopharyngeal cancer live longer without the cancer coming back. About 380 adults aged 18-70 with newly diagnosed, advanced cancer…

This study tests a new immunotherapy drug (iparomlimab and tuvonralimab) combined with radiation and chemotherapy for people with advanced head and neck cancer that hasn't spread. The goal is to see if this combination can keep the cancer from coming back for at least one year. A…

This study tests whether adding immunotherapy to a special type of radiation (that spares key immune nodes) plus chemotherapy can help adults with advanced esophageal cancer live longer without the disease getting worse. About 432 participants will receive either the full combo o…

This study tests whether a treatment plan called total neoadjuvant therapy (TNT) can help about half of rectal cancer patients avoid surgery and keep their rectum. Participants receive chemotherapy and radiation before deciding if they need surgery. Those who respond very well ar…

This study tests a special radiation method called lattice radiation therapy (LRT) combined with immunotherapy for people with advanced solid tumors that have not responded to standard treatments. The goal is to see if this combination can shrink tumors and control the disease be…

This study tests whether adding immunotherapy (a PD-1 inhibitor) after standard chemotherapy and radiation can help control advanced esophageal cancer for longer. About 452 adults with a specific type of esophageal cancer will receive either immunotherapy or monitoring after init…

This study is testing a special type of radiotherapy for people with kidney cancer that got worse after immunotherapy. The goal is to see if this treatment can control the cancer and how safe it is. About 35 adults will take part, and their tumors will be checked regularly for up…

This study tests whether a low dose of radiation to the intestine can help the immune system fight cancer again in people whose tumors have stopped responding to standard immunotherapy. About 48 adults with advanced lung, esophageal, or other solid cancers will receive one radiat…

This study tests whether adding immunotherapy to standard treatment (radiation and chemotherapy before surgery) can improve outcomes for people with locally advanced rectal cancer. It also compares a shorter course of radiation to a longer one. About 444 adults aged 18-75 with a …

This study tests whether adding radiation to a mix of chemotherapy and two immunotherapy drugs before surgery can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 adults with HER2-negative disease will be randomly assigned to recei…

This study tests a new approach for people with a common type of high-risk colon cancer that doesn't respond well to immunotherapy alone. The treatment combines a special type of radiation that spares lymph nodes, followed by chemotherapy and an immunotherapy drug. The goal is to…

This study compares a 1-week course of partial breast radiation to standard whole breast radiation in women with early-stage breast cancer. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back and causes fewer cosmetic side effect…

This study tests whether adding a natural supplement (β-hydroxybutyrate) to a standard treatment plan can help shrink or eliminate rectal cancer before surgery. The plan includes short-course radiation, immunotherapy, and chemotherapy. The goal is to see if more patients achieve …

This study looks at whether spending time with horses can improve quality of life and reduce anxiety in children and teens (ages 8 to 17) who are receiving radiation therapy for cancer. About 22 participants will take part in horse-assisted therapy sessions alongside their regula…

This study looks at whether a video call with a radiation therapist before starting radiotherapy helps breast cancer patients feel less worried and anxious compared to a standard phone call. About 130 people will take part and fill out questionnaires at three points: when they jo…

This study looks at whether offering a palliative care consultation early, when patients with bone metastases start radiotherapy, improves their care satisfaction and quality of life. About 246 adults with advanced cancer and bone pain will be randomly assigned to either get this…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to only a few places. The goal is to see if treatments like radiation or surgery, along with chemotherapy, help people live longer. Researchers want to find out which patients…

This study looks at whether testing for HPV (the virus that causes cervical cancer) can help find cancer that comes back after radiation treatment. Researchers will follow 120 women for two years after their radiotherapy, using both a cervical swab and a blood test to check for H…

This study is looking for biological markers that can predict whether a person with glioblastoma (a type of brain cancer) will survive at least 6 months after treatment with the drug bevacizumab. The study involves 170 adults whose cancer has returned after standard treatment. Re…

This study follows 150 people with radiation rectal injury to see how different types of the condition affect recovery. Researchers will collect medical records, test results, and follow-up data but will not change any treatments. The goal is to better understand which patients a…

This study is gathering detailed information from 500 people with small cell lung cancer to learn how to personalize their treatment. Researchers will track how well different combinations of radiation and immunotherapy work, and how they affect side effects. The goal is to find …

This study enrolls 80 people with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who are scheduled for peptide receptor radionuclide therapy (PRRT). Researchers will use advanced PET-MRI scans and genetic profiling before, during, and after treatment to identify…

This study tests a device that measures fluid in the body to see if it can better track swelling (edema) in cancer patients. Researchers will include 46 people with breast cancer or other cancers who have fluid buildup after treatment. Participants will have body measurements, bl…

This study looks at whether holding your breath during breast cancer radiation can lower the amount of radiation reaching the heart. Researchers will compare heart doses in 400 women who use a special breathing device versus those who breathe normally. The goal is to find a safer…

This study monitors the nutritional health of 57 head and neck cancer patients during radiotherapy. Researchers regularly check body composition, muscle strength, food intake, and quality of life to spot early signs of malnutrition. The goal is to understand nutrition-related cha…

This study compares two types of educational videos for people about to start radiation therapy: one made with an AI avatar and another using standard slides with voiceover. About 136 patients will watch one of the videos and answer questions about their anxiety and understanding…