RADIOTHERAPY

This early-phase study tests a new treatment for people with advanced cancers that have not responded well to standard care. The treatment combines NBTXR3 (tiny particles injected into the tumor), radiotherapy, and an immunotherapy drug (anti-PD-1). The goal is to see if this tri…

This study compares a 1-week radiation schedule to the standard 3-week schedule for women with node-positive breast cancer after surgery. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back while also reducing the risk of lymphed…

This study tests whether adding the drug olaparib to standard radiation and chemotherapy can help people with aggressive, inoperable brain tumors live longer. About 91 participants will receive the combination treatment. The goal is to find the best dose and see if it improves su…

This study tests whether a low dose of radiation to the intestine, combined with immunotherapy (tislelizumab) and chemotherapy, can shrink borderline or unresectable esophageal cancer enough to allow surgery. About 43 adults with a specific type of esophageal cancer will receive …

This study tests whether giving the immunotherapy drug camrelizumab along with standard radiation before surgery can help shrink tumors in people with esophageal cancer. About 25 adults with operable cancer will receive the combination, then have surgery 4-8 weeks later. The goal…

This study tests whether using smaller radiation targets after chemotherapy can still control cancer while causing fewer long-term side effects. About 445 people with advanced nasopharyngeal cancer will receive standard chemotherapy followed by either standard or reduced radiatio…

This study tests a treatment plan for muscle-invasive bladder cancer that aims to avoid bladder removal. About 71 participants will receive chemotherapy and an immunotherapy drug (toripalimab) before radiation therapy, plus more immunotherapy during radiation. The goal is to see …

This study looks at whether adding a weekly check by a specially trained radiation technologist (MERM) to the usual doctor visits can help find side effects from proton therapy more often. About 92 adults with brain or upper throat tumors will take part. The goal is to see if thi…

This study tests whether MRI scans and blood tests can help doctors adjust treatment for locally advanced rectal cancer. About 40 participants will be monitored during chemotherapy and radiation to see if their tumors respond. The goal is to develop a non-invasive way to predict …

This study is for people with a certain type of cervical cancer (adenocarcinoma) that has spread locally. Researchers want to see how well the cancer responds to standard radiation and chemotherapy, and then decide if additional surgery, more radiation, or systemic therapy is bes…