Nanoparticles + radiation + immunotherapy: a new triple attack against advanced cancers enters human testing
NCT ID NCT03589339
First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 27 times
Summary
This early-phase study tests a new treatment for people with advanced cancers that have not responded well to standard care. The treatment combines NBTXR3 (tiny particles injected into the tumor), radiotherapy, and an immunotherapy drug (anti-PD-1). The goal is to see if this triple combination is safe and can shrink tumors. About 145 adults with various advanced cancers, including head and neck, lung, liver, and melanoma, are participating.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Christus St. Vincent Regional Cancer Center
Santa Fe, New Mexico, 87505, United States
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Emory University
Atlanta, Georgia, 30308, United States
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Henry Ford Cancer Institute
Detroit, Michigan, 48202, United States
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Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21287, United States
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Northwell Health
Manhasset, New York, 11030, United States
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Sanford Cancer Center
Sioux Falls, South Dakota, 57104, United States
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St Luke's University Health Network
Bethlehem, Pennsylvania, 18015, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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University of North Carolina, School of Medicine
Chapel Hill, North Carolina, 27516, United States
Conditions
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