New drug combo may help women with early uterine cancer keep fertility

NCT ID NCT05247268

Recruiting now Disease control Sponsor: Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 07, 2026 · Last updated Jun 17, 2026 · Updated 5 times

Summary

This study tests whether a combination of two hormone drugs (GnRHa and letrozole) works better than standard hormone pills (megestrol or medroxyprogesterone) to make early-stage endometrial cancer disappear while preserving the ability to have children. About 104 women with stage I, low-grade cancer who want to keep their fertility will be enrolled. The main goal is to see if more women achieve a complete response within 16 weeks with the new combination.

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Contacts and locations

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Locations

Obstetrics and Gynecology Hospital, Fudan University
RECRUITING

Shanghai, 200011, China

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

endometrial cancer endometrial carcinoma endometrium neoplasm stage I endometrioid carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL NEOPLASM MALIGNANT STAGE I