Fudan University

This study tests three treatment plans for people with a specific type of colorectal cancer (MSI-H). The treatments use drugs that boost the immune system, with or without radiation, before any surgery. The goal is to shrink or eliminate the tumor, possibly allowing some patients…

This phase 3 trial studies the best timing for giving the immunotherapy drug toripalimab to people with stage II-IIIA non-small cell lung cancer that can be removed by surgery. It compares giving the drug before surgery, after surgery, or both before and after. The goal is to see…

This study tests a combination of three drugs (sintilimab, bevacizumab, and chemotherapy) in people with a rare and aggressive type of stomach cancer that produces a protein called AFP. The goal is to shrink the tumor enough so it can be removed by surgery. About 46 adults with a…

This study tests a new approach for people with high-risk locally advanced rectal cancer. It combines a shorter course of radiation with chemotherapy and an immunotherapy drug (serplulimab). The goal is to see if this combination can make the cancer disappear completely before su…

This phase 3 trial tests whether a shorter course of radiation followed by chemotherapy and an immunotherapy drug (Serplulimab) works better than the standard long-course chemoradiation for people with high-risk locally advanced rectal cancer. About 612 adults with specific high-…

This study tests a treatment called multimodal thermal therapy (MTT) that uses both freezing and heating to destroy liver tumors. The goal is to see if this approach is safe, effective, and can boost the body's immune response against cancer. About 120 adults with liver cancer or…

This study tests whether adding a traditional Chinese herbal formula (Qiqi Shengmai) to standard care can improve blood flow in the brains of people with moyamoya disease. About 66 adults aged 18 to 80 will receive either standard care alone or standard care plus the herbal formu…

This study tests whether adding all-trans retinoic acid (ATRA) to standard VAC chemotherapy helps people with intermediate-to-high-risk rhabdomyosarcoma live longer without the cancer growing. It includes 106 participants aged 14 to 60 who have not had prior treatment. The main g…

This study tests a combination of two drugs, anlotinib and benmelstobart, as a second treatment option for people with advanced thyroid cancer that has spread or cannot be removed by surgery. About 23 adults whose cancer did not respond to or got worse after first-line therapy wi…

This study looks at whether adding diabetes medication to standard chemotherapy can help people with metastatic pancreatic cancer and diabetes live longer. About 210 adults will receive either chemotherapy alone or chemotherapy plus active diabetes treatment. The main goal is to …

This study tests whether adding two experimental drugs (iparomlimab and tovorilimab) to standard chemotherapy and bevacizumab can shrink tumors in people with advanced mesothelioma who have not had prior treatment. About 37 adults aged 18-75 with confirmed advanced mesothelioma a…

This study tests whether using an indoor air purifier at home can improve lung health in people with chronic obstructive pulmonary disease (COPD). About 120 adults aged 50-80 who live in Shanghai will use either a real or fake purifier for a period of time. Researchers will measu…

This study tests whether women with a specific type of early-stage breast cancer (HR-positive, HER2-positive, no lymph node spread) can safely skip chemotherapy. Instead, they will receive a combination of hormone therapy, a CDK4/6 inhibitor, and anti-HER2 therapy. The goal is to…

This study tests whether a single, low dose of radiation to all visible tumors can help immunotherapy work again in people with advanced esophageal cancer that stopped responding to initial treatment. About 32 adults will receive the radiation and continue their current immunothe…

This study tests a combination of two drugs (becotatug vedotin and pucotenlimab) in 20 adults with advanced penile cancer that has spread and is EGFR-positive. Participants must have failed or be unable to tolerate chemotherapy. The goal is to see if the combo can shrink tumors o…

This study tests a combination of two drugs (sacituzumab tirumotecan and furmonertinib) in 45 adults with advanced non-small cell lung cancer that has a specific gene mutation (EGFR) and has stopped responding to the first treatment. The goal is to see if the combo can shrink tum…

This study tests whether adding bevacizumab to trastuzumab deruxtecan (T-DXd) helps control HER2-low breast cancer that has spread to the brain. About 140 adults with this condition will be randomly assigned to receive T-DXd alone or with bevacizumab. The main goal is to see how …

This study tests whether a combination of two drugs (imlunestrant and abemaciclib) given before surgery can shrink tumors in people with ER-positive, HER2-negative breast cancer. The treatment plan is adjusted based on a marker called Ki67 measured after two weeks. About 189 wome…

This study tests a new drug combination for people with advanced soft tissue sarcoma that has not responded to earlier treatments. The treatment includes an immunotherapy drug (epalrotokewali) plus chemotherapy, a targeted therapy, and radiation. The goal is to see if this combin…

This study tests different drug combinations before surgery for people with locally advanced colorectal cancer. The treatment is chosen based on the tumor's genetic and molecular features. The goal is to see if personalized neoadjuvant therapy can improve complete response rates …

This study tests if a targeted drug (CDK4/6 inhibitor) combined with hormone therapy can replace chemotherapy for women with small but high-risk ER-positive breast cancer. About 2,288 participants will either receive the new drug combo or standard chemo plus hormones. The goal is…

This study looks at whether a combination of ribociclib and hormone therapy can replace chemotherapy for certain people with early-stage HR+/HER2- breast cancer. About 388 women will be randomly assigned to get either the drug combo alone or chemo first, then the combo. The goal …

This study tests a new drug combination (RC48 plus chemotherapy) in 268 women with advanced HER2-positive breast cancer whose disease worsened or who couldn't tolerate a prior antibody-drug conjugate treatment. The goal is to see if the new combo works better than the current sta…

This study tests whether a new combination of immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy works better than another immunotherapy plus chemotherapy for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer. About 104 adults will…

This study tests the best order of two powerful targeted drugs (sacituzumab govitecan and trastuzumab deruxtecan) in people with HER2-low, TROP2-high metastatic breast cancer. About 216 participants will be randomly assigned to start with one drug and switch to the other upon pro…

This phase 3 trial tests whether adding famitinib to SHR-A1811 works better than SHR-A1811 alone for people with advanced HR+/HER2- breast cancer that no longer responds to CDK4/6 inhibitors. About 248 women aged 18-70 will take part. The main goal is to see how long the cancer s…

This study tests a personalized approach using MRI scans to guide chemotherapy and radiation, plus immunotherapy, for people with advanced esophageal cancer that cannot be removed by surgery. The goal is to see if this tailored treatment can help keep the cancer from growing for …

This study tests a combination of two drugs, envafolimab and lenvatinib, as the first treatment for people with a type of kidney cancer (clear cell renal cell carcinoma) that has spread to the liver. The goal is to see if the combination can shrink liver tumors and help patients …

This study tests a new drug, QLC5513, given alone or with another drug (QL1706) in people with advanced triple-negative breast cancer that has worsened after at least one prior treatment. The goal is to see if the treatment can shrink tumors or slow the disease. About 60 women wi…

This study tests whether adding the drug fluzoparib to standard treatment can help prevent breast cancer from coming back in women with early-stage breast cancer who have specific gene changes (HRR mutations). About 334 women will be randomly assigned to receive either fluzoparib…

This phase II trial tests whether combining multi-mode thermal therapy (using heat to target tumors) with immunotherapy can help control HER2-negative breast cancer that has spread to the liver. The study will enroll 30 women who have already tried at least one other treatment. T…

This study will check if artificial intelligence (AI) can accurately detect breast cancer using non-contrast chest CT scans, which are commonly done for other reasons. Researchers will compare the AI's results with mammograms or breast MRIs in 5,000 women. If successful, this cou…

This study tests a new method to identify where a metastatic tumor originally came from by analyzing its RNA. Researchers will collect tumor samples from 30 people with metastatic cancer and use a machine learning model to predict the tissue of origin. The goal is to improve diag…

This study tests whether finding and treating specific high-risk types of H. pylori bacteria can prevent stomach cancer. About 4,800 adults aged 40 and older who carry these high-risk bacteria will be followed for up to 10 years. The goal is to see if eradicating these bacteria l…

This study tests whether artificial intelligence (AI) can help more high-risk adults aged 40 to 64 in China get a colonoscopy, the best way to find colon cancer early. About 400 participants will either receive usual care or AI-assisted care from a team of specialists and general…

This study tests whether adding Huaier Granule to standard care can better treat proteinuria (excess protein in urine) in 120 adult women with breast cancer who developed this side effect from immunotherapy or anti-angiogenic drugs. Participants will either receive standard care …

This study tests whether adding the herbal Yueju Pill to standard cancer treatment helps people with advanced biliary tract cancer feel better and have a better quality of life. About 210 adults with this cancer will receive either the pill or a placebo, and researchers will trac…

This study tests whether Huaier Granules, a traditional Chinese medicine, can reduce protein in the urine (proteinuria) caused by the cancer drugs Bevacizumab or Anlotinib in lung cancer patients. About 40 adults will take the granules for 16 weeks to see if their protein levels …

This study will observe 460 adults with diabetes who take semaglutide to see if those with nerve damage are more likely to develop a condition called gastric retention, where the stomach doesn't empty properly. Participants will be split into two groups: those with neuropathy and…

This study will create a large database of 1,000 people with a specific type of pancreatic cancer (KRAS-mutant). Researchers will follow participants over time to see how long they live and how well their cancer is controlled while on targeted therapy. The goal is to better under…

This study will follow 400 adults with advanced HER2-negative breast cancer who have already been treated with antibody-drug conjugates. Researchers want to see how long patients stay cancer-free or alive after starting eribulin-based therapy. The goal is to gather real-world dat…

This study looks at 200 people with colorectal cancer that spread to the liver and who had surgery to remove all tumors. Researchers want to create a system that uses genetic and clinical information to better predict who is at high risk of the cancer coming back. The goal is to …

This study tests whether adding a clear plastic cap to the tip of a colonoscope helps doctors find more polyps (adenomas) in the lower part of the colon during a second look. About 614 adults aged 45 to 75 will be randomly assigned to either a standard second exam or one with the…

This study tests whether special PET/MRI scans using specific tracers can predict how well breast cancer treatments work. About 300 women with breast cancer will get these scans before and after two treatment cycles. The goal is to find which tracers best predict treatment succes…

This study observes how well the drug Toripalimab works as a first-line treatment for patients with extensive-stage small cell lung cancer. Researchers will track 1,200 participants in China to measure survival and tumor response in routine clinical practice. The goal is to gathe…

This observational study aims to see if a specific type of immune cell (Tpex) in cancer-free lymph nodes can predict how well PD-1 inhibitors work for people with advanced or recurrent esophageal cancer. Researchers will follow 158 participants to compare survival times based on …

This study looks at 100 people who had surgery to remove an infected mesh after hernia repair. It compares removing all the mesh versus only part of it, to see which approach leads to fewer hernia comebacks and infections. The goal is to help doctors choose the best treatment for…